| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Marialaura Amadio, Alessia Pascale, Jun Wang, Lap Ho, Alessandro Quattrone, Sam Gandy, Vahram Haroutunian, Marco Racchi, Giulio Maria Pasinett. nELAV proteins alteration in Alzheimer's disease brain: a novel putative target for amyloid-beta reverberating on AbetaPP processing. Journal of Alzheimer's disease : JAD. vol 16. issue 2. 2009-06-17. PMID:19221430. |
neuronal elav (nelav) proteins are rna-binding proteins which play a physiological role in controlling gene expression in memory formation, and their alteration may contribute to cognitive impairment associated with neurodegenerative pathologies such as alzheimer's disease (ad). |
2009-06-17 |
2023-08-12 |
human |
| M G Giovannini, F Cerbai, A Bellucci, C Melani, C Grossi, C Bartolozzi, D Nosi, F Casament. Differential activation of mitogen-activated protein kinase signalling pathways in the hippocampus of CRND8 transgenic mouse, a model of Alzheimer's disease. Neuroscience. vol 153. issue 3. 2009-06-08. PMID:18406062. |
these findings may pose a molecular basis for the memory disruption of alzheimer's disease, since proper functioning of the basal forebrain cholinergic neurons and of erk2 is critical for memory formation. |
2009-06-08 |
2023-08-12 |
mouse |
| C Nocjar, M D Hammonds, S S Shi. Chronic lithium treatment magnifies learning in rats. Neuroscience. vol 150. issue 4. 2008-04-08. PMID:17996377. |
thus chronic lithium treatment may improve learning and memory in alzheimer's disease, and do so not only by blocking the formation of beta-amyloid and neurofibrillary tangles as suggested by previous research, but also by enhancing mechanisms involved in basal learning and memory formation, such as hippocampal synaptic plasticity. |
2008-04-08 |
2023-08-12 |
rat |
| Junko Fujio, Hiroaki Hosono, Koichi Ishiguro, Shiro Ikegami, Shinobu C Fujit. Tau phosphorylation in the mouse brain during aversive conditioning. Neurochemistry international. vol 51. issue 2-4. 2007-10-25. PMID:17597257. |
these results suggest involvement of tau and tpki/gsk3beta phosphorylation in an early phase of memory formation in the hippocampus and amygdala, raising a possibility that a dysregulation of tau phosphorylation may underlie memory impairment in incipient alzheimer's disease. |
2007-10-25 |
2023-08-12 |
mouse |
| O V Forlenza, E L Schaeffer, W F Gatta. The role of phospholipase A2 in neuronal homeostasis and memory formation: implications for the pathogenesis of Alzheimer's disease. Journal of neural transmission (Vienna, Austria : 1996). vol 114. issue 2. 2007-06-13. PMID:17131232. |
the role of phospholipase a2 in neuronal homeostasis and memory formation: implications for the pathogenesis of alzheimer's disease. |
2007-06-13 |
2023-08-12 |
rat |
| Timothy M Shepherd, Evren Ozarslan, Michael A King, Thomas H Mareci, Stephen J Blackban. Structural insights from high-resolution diffusion tensor imaging and tractography of the isolated rat hippocampus. NeuroImage. vol 32. issue 4. 2006-11-30. PMID:16806988. |
the hippocampus is a critical structure for learning and memory formation injured by diverse neuropathologies such as epilepsy or alzheimer's disease. |
2006-11-30 |
2023-08-12 |
rat |
| Kathryn A Collister, Benedict C Albens. Potential therapeutic targets in the NF-kappaB pathway for Alzheimer's disease. Drug news & perspectives. vol 18. issue 10. 2006-05-18. PMID:16491164. |
one characteristic of alzheimer's disease is a deficit in new memory formation. |
2006-05-18 |
2023-08-12 |
Not clear |
| Kathryn A Collister, Benedict C Albens. Potential therapeutic targets in the NF-kappaB pathway for Alzheimer's disease. Drug news & perspectives. vol 18. issue 10. 2006-05-18. PMID:16491164. |
this short review summarizes past studies with creb, describes nf-kappab functioning and highlights new data on the potential role of nf-kappab in new memory formation and alzheimer's disease. |
2006-05-18 |
2023-08-12 |
Not clear |
| Angel Barco, Christopher Pittenger, Eric R Kande. CREB, memory enhancement and the treatment of memory disorders: promises, pitfalls and prospects. Expert opinion on therapeutic targets. vol 7. issue 1. 2006-05-01. PMID:12556206. |
the treatment of memory disorders, such as the gradual weakening of memory with age, the ravages of alzheimer's disease and the cognitive deficits in various forms of mental retardation, may greatly benefit from a better understanding of the molecular and cellular mechanisms of memory formation. |
2006-05-01 |
2023-08-12 |
Not clear |
| E L Schaeffer, F Bassi, W F Gatta. Inhibition of phospholipase A2 activity reduces membrane fluidity in rat hippocampus. Journal of neural transmission (Vienna, Austria : 1996). vol 112. issue 5. 2006-02-16. PMID:15830123. |
this finding is of interest because reduction of brain membrane fluidity impairs memory formation and both decreased pla2 activity and reduced membrane fluidity have been reported in the brain from patients with alzheimer's disease. |
2006-02-16 |
2023-08-12 |
rat |
| Jamie G Bunce, Helen R Sabolek, James J Chroba. Intraseptal infusion of the cholinergic agonist carbachol impairs delayed-non-match-to-sample radial arm maze performance in the rat. Hippocampus. vol 14. issue 4. 2004-08-09. PMID:15224982. |
these findings are discussed with regard to multi-stage models of hippocampal-dependent memory formation and the further development of therapeutic strategies in the treatment of mild cognitive impairment as well as age-related cognitive decline and alzheimer's dementia. |
2004-08-09 |
2023-08-12 |
rat |
| J G Bunce, H R Sabolek, J J Chroba. Intraseptal infusion of oxotremorine impairs memory in a delayed-non-match-to-sample radial maze task. Neuroscience. vol 121. issue 2. 2003-12-19. PMID:14521985. |
these findings are discussed with regards to multi-stage models of hippocampal-dependent memory formation and the further development of therapeutic strategies in the treatment of mild cognitive impairment as well as age-related decline and alzheimer's dementia. |
2003-12-19 |
2023-08-12 |
rat |
| T Harkany, T Hortobágyi, M Sasvári, C Kónya, B Penke, P G Luiten, C Nyaka. Neuroprotective approaches in experimental models of beta-amyloid neurotoxicity: relevance to Alzheimer's disease. Progress in neuro-psychopharmacology & biological psychiatry. vol 23. issue 6. 2000-02-03. PMID:10621945. |
1. beta-amyloid peptides (a beta s) accumulate abundantly in the alzheimer's disease (ad) brain in areas subserving information acquisition and processing, and memory formation. |
2000-02-03 |
2023-08-12 |
Not clear |
| N Patel, E L Spangler, N H Greig, Q S Yu, D K Ingram, R C Meye. Phenserine, a novel acetylcholinesterase inhibitor, attenuates impaired learning of rats in a 14-unit T-maze induced by blockade of the N-methyl-D-aspartate receptor. Neuroreport. vol 9. issue 1. 1998-07-08. PMID:9592071. |
the present study evaluated the interaction of the glutamatergic and acetylcholinergic systems in memory formation, with an overall emphasis on developing multi-system approaches for treating age-related cognitive decline and alzheimer' s disease. |
1998-07-08 |
2023-08-12 |
rat |
| M Dragunow, P Hughes, S E Mason-Parker, P Lawlor, W C Abraha. TrkB expression in dentate granule cells is associated with a late phase of long-term potentiation. Brain research. Molecular brain research. vol 46. issue 1-2. 1997-08-05. PMID:9191102. |
thus, both bdnf and its receptor trkb are induced in granule cells by stimulation that produces durable ltp, suggesting that this neurotrophin and its receptor play an important role in memory formation and may be suitable targets for the development of cognitive-enhancing drugs in the treatment of diseases, such as alzheimer's. |
1997-08-05 |
2023-08-12 |
Not clear |
| E Doyle, M T Bruce, K C Breen, D C Smith, B Anderton, C M Rega. Intraventricular infusions of antibodies to amyloid-beta-protein precursor impair the acquisition of a passive avoidance response in the rat. Neuroscience letters. vol 115. issue 1. 1990-11-14. PMID:2120637. |
thus the amyloid precursor protein, which is aberrantly processed in alzheimer's disease, appears to be directly involved in memory formation. |
1990-11-14 |
2023-08-11 |
rat |