| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Song S Wang, Joseph W Lewcock, Paul Feinstein, Peter Mombaerts, Randall R Ree. Genetic disruptions of O/E2 and O/E3 genes reveal involvement in olfactory receptor neuron projection. Development (Cambridge, England). vol 131. issue 6. 2004-05-03. PMID:14993187. |
interestingly, both o/e2 and o/e3 knockout mice as well as o/e2/o/e3 double heterozygous animals share a common phenotype: olfactory neurons (orn) fail to project to dorsal olfactory bulb. |
2004-05-03 |
2023-08-12 |
mouse |
| Sarah K Williams, Robin J M Franklin, Susan C Barnet. Response of olfactory ensheathing cells to the degeneration and regeneration of the peripheral olfactory system and the involvement of the neuregulins. The Journal of comparative neurology. vol 470. issue 1. 2004-03-29. PMID:14755525. |
in this study we examined the proliferative response of olfactory ensheathing cells (oecs) to olfactory receptor neuron injury induced by zinc sulfate (znso4) irrigation and related the response of oecs within the peripheral system to the inflammatory response induced by injury and the expression profile of neuregulins. |
2004-03-29 |
2023-08-12 |
Not clear |
| M L Getchell, D S Shah, S K Buch, D G Davis, T V Getchel. 3-Nitrotyrosine immunoreactivity in olfactory receptor neurons of patients with Alzheimer's disease: implications for impaired odor sensitivity. Neurobiology of aging. vol 24. issue 5. 2003-09-12. PMID:12885574. |
these results demonstrate increased oxidative stress and modification of orn proteins that may contribute directly to olfactory impairment in ad patients. |
2003-09-12 |
2023-08-12 |
Not clear |
| David B Conley, Alan M Robinson, Michael J Shinners, Robert C Ker. Age-related olfactory dysfunction: cellular and molecular characterization in the rat. American journal of rhinology. vol 17. issue 3. 2003-09-10. PMID:12862407. |
the question addressed in this study is whether this age-related failure of olfactory sensation is a result of a decrease in neuronal proliferation or an increase in orn cell death. |
2003-09-10 |
2023-08-12 |
rat |
| Deborah R S Cohen, Valéry Matarazzo, Amy M Palmer, Yajun Tu, Ok-Hee Jeon, Jonathan Pevsner, Gabriele V Ronnet. Expression of MeCP2 in olfactory receptor neurons is developmentally regulated and occurs before synaptogenesis. Molecular and cellular neurosciences. vol 22. issue 4. 2003-07-11. PMID:12727440. |
the timing of mecp2 expression was defined by using detergent ablation (to remove the orns) and unilateral olfactory bulbectomy (to remove the orn target), both of which increase neurogenesis. |
2003-07-11 |
2023-08-12 |
Not clear |
| Carole J Burns, Monica L Vette. Xath5 regulates neurogenesis in the Xenopus olfactory placode. Developmental dynamics : an official publication of the American Association of Anatomists. vol 225. issue 4. 2003-06-30. PMID:12454929. |
the olfactory system is an ideal tissue in which to study the role of these genes in regulating the acquisition of neuronal cell fate, particularly that of the olfactory receptor neuron (orn). |
2003-06-30 |
2023-08-12 |
xenopus_laevis |
| Carole J Burns, Monica L Vette. Xath5 regulates neurogenesis in the Xenopus olfactory placode. Developmental dynamics : an official publication of the American Association of Anatomists. vol 225. issue 4. 2003-06-30. PMID:12454929. |
collectively, our data argue that hlh genes are expressed in a cascade during olfactory placode development and that the activity of an atonal homologue, xath5, can promote orn fate but only in the appropriate developmental context. |
2003-06-30 |
2023-08-12 |
xenopus_laevis |
| Lindsay A Carter, A Jane Roskam. Neurotrophins and their receptors in the primary olfactory neuraxis. Microscopy research and technique. vol 58. issue 3. 2003-01-29. PMID:12203697. |
the focus of this review is to highlight what is known about the actions of neurotrophins in the primary olfactory pathway, and to pinpoint future directions that will enable us to further understand their role in olfactory receptor neuron development and turnover. |
2003-01-29 |
2023-08-12 |
Not clear |
| Catherine M Cowan, A Jane Roskam. Apoptosis in the mature and developing olfactory neuroepithelium. Microscopy research and technique. vol 58. issue 3. 2003-01-29. PMID:12203699. |
during the last 30 years, researchers investigating olfactory receptor neuron cellular and developmental biology have focussed on the regeneration of the neuronal population within the olfactory neuroepithelium, following the induced death of the mature neuronal population. |
2003-01-29 |
2023-08-12 |
Not clear |
| Thomas V Getchell, Nishikant K Subhedar, Dharmen S Shah, Grant Hackley, James V Partin, Goutam Sen, Marilyn L Getchel. Chemokine regulation of macrophage recruitment into the olfactory epithelium following target ablation: involvement of macrophage inflammatory protein-1alpha and monocyte chemoattractant protein-1. Journal of neuroscience research. vol 70. issue 6. 2003-01-24. PMID:12444600. |
target ablation by olfactory bulbectomy synchronizes the degenerative cell death of olfactory receptor neurons (orns), infiltration of macrophages, and proliferation of progenitor cells, leading to neurogenesis, orn replacement, and regeneration of the sensory epithelium. |
2003-01-24 |
2023-08-12 |
Not clear |
| S Sarkar, N Subheda. Seasonal changes in beta-endorphin-like immunoreactivity in the olfactory system of the female catfish, Clarias batrachus (Linn). General and comparative endocrinology. vol 123. issue 2. 2002-12-30. PMID:11482933. |
in the olfactory system of the catfish clarias batrachus, beta-endorphin-like immunoreactivity was seen in several olfactory receptor neurons (orn) and their fiber projections extending caudally over the olfactory nerve to the olfactory bulb (ob). |
2002-12-30 |
2023-08-12 |
Not clear |
| C D Herzog, T Ott. Administration of transforming growth factor-alpha enhances anatomical and behavioral recovery following olfactory nerve transection. Neuroscience. vol 113. issue 3. 2002-11-13. PMID:12150777. |
orn lesioned animals receiving injections of tgf-alpha during recovery were found to display enhanced conditioned responding to an olfactory stimulus compared to untreated subjects. |
2002-11-13 |
2023-08-12 |
human |
| Sigrun Korschin. Olfactory maps and odor images. Current opinion in neurobiology. vol 12. issue 4. 2002-10-09. PMID:12139985. |
selective optical imaging of odor-induced presynaptic and postsynaptic glomerular activity in the olfactory bulb/antennal lobe has visualized odorant-responsive receptor repertoires and shown a more confined odor image at the level of projection neurons compared to their olfactory receptor neuron input. |
2002-10-09 |
2023-08-12 |
Not clear |
| Nicola Illing, Sihaam Boolay, Jenny S Siwoski, Diana Casper, Mary T Lucero, A Jane Roskam. Conditionally immortalized clonal cell lines from the mouse olfactory placode differentiate into olfactory receptor neurons. Molecular and cellular neurosciences. vol 20. issue 2. 2002-08-29. PMID:12093156. |
when morphologically mature, op6 and op27 express the mature orn chemosensory signaling components, olfactory g-protein (g(olf)), type iii adenylate cyclase (aciii), ocnc1, and the olfactory marker protein (omp). |
2002-08-29 |
2023-08-12 |
mouse |
| S G Gon. Characterization of olfactory nerve abnormalities in Twirler mice. Differentiation; research in biological diversity. vol 69. issue 1. 2002-05-24. PMID:11776395. |
in tw homozygotes at 14.5 days of embryonic development, the presence of many mature orn found randomly in the mesenchyme suggests the loss of olfactory pathfinding cues to the ob. |
2002-05-24 |
2023-08-12 |
mouse |
| Thomas V Getchell, Dharmen S Shah, James V Partin, Nishikant K Subhedar, Marilyn L Getchel. Leukemia inhibitory factor mRNA expression is upregulated in macrophages and olfactory receptor neurons after target ablation. Journal of neuroscience research. vol 67. issue 2. 2002-02-21. PMID:11782968. |
after target ablation by olfactory bulbectomy (obx), the murine olfactory epithelium (oe) undergoes degenerative changes leading to apoptosis of olfactory receptor neurons (orns) followed by regenerative changes that include proliferation of progenitor cells leading to neurogenesis and orn replacement. |
2002-02-21 |
2023-08-12 |
mouse |
| M Z Levine, P J Harrison, W W Walthall, P C Tai, C D Derb. A CUB-serine protease in the olfactory organ of the spiny lobster Panulirus argus. Journal of neurobiology. vol 49. issue 4. 2002-02-04. PMID:11745665. |
immunocytochemistry showed that csp is present in olfactory (aesthetasc) sensilla around auxiliary cells (glia that surround the inner dendrites of olfactory receptor neurons, orns) and orn outer dendrites. |
2002-02-04 |
2023-08-12 |
lobster |
| G S Jefferis, E C Marin, R F Stocker, L Lu. Target neuron prespecification in the olfactory map of Drosophila. Nature. vol 414. issue 6860. 2001-12-07. PMID:11719930. |
we demonstrate that projection neurons are prespecified by lineage and birth order to form synapses with specific incoming orn axons, and therefore to carry specific olfactory information. |
2001-12-07 |
2023-08-12 |
mouse |
| E Sánchez-Islas, M León-Ole. Histochemical and immunohistochemical localization of neuronal nitric oxide synthase in the olfactory epithelium of the axolotl, Ambystoma mexicanum. Nitric oxide : biology and chemistry. vol 5. issue 4. 2001-10-18. PMID:11485369. |
unilateral olfactory axotomy was conducted to confirm that labels were at orn. |
2001-10-18 |
2023-08-12 |
Not clear |
| E Sánchez-Islas, M León-Ole. Histochemical and immunohistochemical localization of neuronal nitric oxide synthase in the olfactory epithelium of the axolotl, Ambystoma mexicanum. Nitric oxide : biology and chemistry. vol 5. issue 4. 2001-10-18. PMID:11485369. |
this last anatomical localization suggests that in the a. mexicanum no might be involved in functions other than only olfactory transduction, such as regulation of local blood flow, glandular secretion, and orn development. |
2001-10-18 |
2023-08-12 |
Not clear |