| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yuxiao Zhang, Yan Chen, Yushi Xin, Beibei Peng, Shuai Li. Norepinephrine system at the interface of attention and reward. Progress in neuro-psychopharmacology & biological psychiatry. 2023-03-18. PMID:36933778. |
the lc receives reward related sensory, perceptual, and visceral inputs, releases ne, glutamate, dopamine and various neuropeptides, forms reward memories, drives attentional bias and selects behavioral strategies for reward. |
2023-03-18 |
2023-08-14 |
Not clear |
| Peixia Shi, Linlin Hu, Hui Ren, Qin Da. Reward enhances resilience to chronic social defeat stress in mice: Neural ECs and mGluR5 mechanism Frontiers in psychiatry. vol 14. 2023-03-06. PMID:36873216. |
it has been reported that the endogenous cannabinoid system (ecs) and downstream metabolic glutamate receptor 5 (mglur5) are closely related to stress and reward, which might be the potential cerebral mechanism between reward and stress resilience, but there is a lack of direct evidence. |
2023-03-06 |
2023-08-14 |
mouse |
| Laura C Ornelas, Giorgia Boero, Kalynn Van Voorhies, Todd K O'Buckley, Joyce Besheer, A Leslie Morro. Pharmacological administration of 3α,5α-THP into nucleus accumbens core increases 3α,5α-THP expression and reduces alcohol self-administration. Alcoholism, clinical and experimental research. 2023-01-01. PMID:36587947. |
alcohol affects multiple circuits in the brain, mainly disrupting the delicate balance between inhibitory γ-aminobutyric acid (gaba) transmission and excitatory glutamate signaling in brain areas involved in reward circuits, such as amygdala, nucleus accumbens (acb) and ventral tegmental area (vta), causing loss of control in circuits that regulate behavioral control of craving, alcohol-seeking and intake. |
2023-01-01 |
2023-08-14 |
human |
| Li-Min Mao, Nirav Mathur, John Q Wan. An allosteric potentiator of metabotropic glutamate (mGlu) 2 receptors reduces the cocaine-stimulated ERK1/2 phosphorylation in the mouse striatum. Neuroscience letters. 2022-12-24. PMID:36565803. |
metabotropic glutamate (mglu) receptors are involved in the experience-dependent neuroplasticity in the mesolimbic reward circuit. |
2022-12-24 |
2023-08-14 |
mouse |
| Samuel A Barnes, Daniel G Dillon, Jared W Young, Michael L Thomas, Lauren Faget, Ji Hoon Yoo, Andre Der-Avakian, Thomas S Hnasko, Mark A Geyer, Dhakshin S Ramanatha. Modulation of ventromedial orbitofrontal cortical glutamatergic activity affects the explore-exploit balance and influences value-based decision-making. Cerebral cortex (New York, N.Y. : 1991). 2022-12-06. PMID:36472411. |
our findings support the premise that pharmacological interventions that normalize aberrant vmofc glutamate activity during reward feedback processing may attenuate deficits in value-based decision-making. |
2022-12-06 |
2023-08-14 |
rat |
| Daozhong Jin, Hong Chen, Shao-Rui Chen, Hui-Lin Pa. α2δ-1 Protein drives opioid-induced conditioned reward and synaptic NMDA receptor hyperactivity in the nucleus accumbens. Journal of neurochemistry. 2022-10-12. PMID:36222452. |
glutamate nmda receptors (nmdars) in the nucleus accumbens (nac) are critically involved in drug dependence and reward. |
2022-10-12 |
2023-08-14 |
mouse |
| Shuo Li, Xiao-Qin Zhang, Chuan-Chuan Liu, Zhi-Yuan Wang, Guan-Yi Lu, Hao-Wei Shen, Ning Wu, Jin Li, Fei L. IRAS/Nischarin modulates morphine reward by glutamate receptor activation in the nucleus accumbens of mouse brain. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 153. 2022-09-09. PMID:36076473. |
iras/nischarin modulates morphine reward by glutamate receptor activation in the nucleus accumbens of mouse brain. |
2022-09-09 |
2023-08-14 |
mouse |
| Yi He, Graziella Madeo, Ying Liang, Cindy Zhang, Briana Hempel, Xiaojie Liu, Lianwei Mu, Shui Liu, Guo-Hua Bi, Ewa Galaj, Hai-Ying Zhang, Hui Shen, Ross A McDevitt, Eliot L Gardner, Qing-Song Liu, Zheng-Xiong X. A red nucleus-VTA glutamate pathway underlies exercise reward and the therapeutic effect of exercise on cocaine use. Science advances. vol 8. issue 35. 2022-09-02. PMID:36054363. |
a red nucleus-vta glutamate pathway underlies exercise reward and the therapeutic effect of exercise on cocaine use. |
2022-09-02 |
2023-08-14 |
Not clear |
| Cayque Brietzke, Julio Cesar Silva Cesario, Florentina Johanna Hettinga, Flavio Oliveira Pire. The reward for placebos: mechanisms underpinning placebo-induced effects on motor performance. European journal of applied physiology. 2022-08-25. PMID:36006479. |
alterations in the dopamine, opioid, and glutamate metabolism are the neural representation converting reward-derived declarative forms into an attractive and wanted behavior, thereby changing the activation in reward subcortical and cortical structures involved in motor planning, motor execution, and emotional-cognitive attributes of decision-making. |
2022-08-25 |
2023-08-14 |
Not clear |
| Wei-Yi Ong, Damien Meng-Kiat Leow, Deron R Herr, Crystal Jing-Jing Ye. What Do Randomized Controlled Trials Inform Us About Potential Disease-Modifying Strategies for Parkinson's Disease? Neuromolecular medicine. 2022-07-01. PMID:35776238. |
randomised controlled trials indicate promising effects of mao-b inhibitors, dopamine agonists, nmda receptor antagonists, metabotropic glutamate receptor antagonists, therapies related to improving glucose utilization and energy production, therapies related to reduction of excitotoxicity and oxidative stress, statin use, therapies related to iron chelation, therapies related to the use of phytochemicals, and therapies related to physical exercise and brain reward pathway on slowing pd progression. |
2022-07-01 |
2023-08-14 |
human |
| Deborah J Luessen, P Jeffrey Con. Allosteric Modulators of Metabotropic Glutamate Receptors as Novel Therapeutics for Neuropsychiatric Disease. Pharmacological reviews. vol 74. issue 3. 2022-06-16. PMID:35710132. |
metabotropic glutamate (mglu) receptors, a family of g-protein-coupled receptors, have been identified as novel therapeutic targets based on extensive research supporting their diverse contributions to cell signaling and physiology throughout the nervous system and important roles in regulating complex behaviors, such as cognition, reward, and movement. |
2022-06-16 |
2023-08-14 |
Not clear |
| Chelsea Brown, Jackie Beltran, Elissa Fultz, Tori Tran, Brooke Barger, Nyssa Williams, Waylon Yen, Asher Park, Tod Kippin, Karen Szumlinsk. Investigating the Role of Corticostriatal Glutamate Signaling in Methamphetamine Reward and Reinforcement. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 36 Suppl 1. 2022-05-13. PMID:35554032. |
investigating the role of corticostriatal glutamate signaling in methamphetamine reward and reinforcement. |
2022-05-13 |
2023-08-13 |
Not clear |
| Chelsea Brown, Jackie Beltran, Elissa Fultz, Tori Tran, Brooke Barger, Nyssa Williams, Waylon Yen, Asher Park, Tod Kippin, Karen Szumlinsk. Investigating the Role of Corticostriatal Glutamate Signaling in Methamphetamine Reward and Reinforcement. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 36 Suppl 1. 2022-05-13. PMID:35554032. |
while the majority of addiction research has implicated the dopamine system, the long-term neuroplasticity that maintains ma use disorder also involves drug-induced changes in glutamate signaling in reward regions of the brain like the nucleus accumbens (nac) and prefrontal cortex (pfc). |
2022-05-13 |
2023-08-13 |
Not clear |
| Chelsea Brown, Jackie Beltran, Elissa Fultz, Tori Tran, Brooke Barger, Nyssa Williams, Waylon Yen, Asher Park, Tod Kippin, Karen Szumlinsk. Investigating the Role of Corticostriatal Glutamate Signaling in Methamphetamine Reward and Reinforcement. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 36 Suppl 1. 2022-05-13. PMID:35554032. |
in order to further characterize the role of glutamate in ma reward and reinforcement, glutamate receptor scaffolding protein homer2 expression in the nac and activity in the glutamatergic projection pfc-nac were manipulated prior to place- and operant-conditioning procedures. |
2022-05-13 |
2023-08-13 |
Not clear |
| Fulvio Lauretani, Crescenzo Testa, Marco Salvi, Irene Zucchini, Beatrice Lorenzi, Sara Tagliaferri, Chiara Cattabiani, Marcello Maggi. Reward System Dysfunction and the Motoric-Cognitive Risk Syndrome in Older Persons. Biomedicines. vol 10. issue 4. 2022-04-23. PMID:35453558. |
the reward system is not an exception and its dysfunction generally includes a reduction in dopamine and glutamate activities and the loss of neurons of the ventral tegmental area (vta). |
2022-04-23 |
2023-08-13 |
Not clear |
| Hong-Ju Yang, Briana J Hempel, Guo-Hua Bi, Yi He, Hai-Ying Zhang, Eliot L Gardner, Zheng-Xiong X. Elevation of extracellular glutamate by blockade of astrocyte glutamate transporters inhibits cocaine reinforcement in rats via a NMDA-GluN2B receptor mechanism. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2022-01-29. PMID:35091501. |
however, the role of glutamate in drug reward is unclear. |
2022-01-29 |
2023-08-13 |
rat |
| Hong-Ju Yang, Briana J Hempel, Guo-Hua Bi, Yi He, Hai-Ying Zhang, Eliot L Gardner, Zheng-Xiong X. Elevation of extracellular glutamate by blockade of astrocyte glutamate transporters inhibits cocaine reinforcement in rats via a NMDA-GluN2B receptor mechanism. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2022-01-29. PMID:35091501. |
in this study, we systemically evaluated the effects of multiple glutamate transporter (glt) inhibitors on extracellular glutamate and dopamine (da) in the nucleus accumbens (nac), intravenous cocaine self-administration, intracranial brain-stimulation reward, and reinstatement of cocaine seeking in male and female rats. |
2022-01-29 |
2023-08-13 |
rat |
| Marie-Charlotte Allichon, Vanesa Ortiz, Paula Pousinha, Andry Andrianarivelo, Anna Petitbon, Nicolas Heck, Pierre Trifilieff, Jacques Barik, Peter Vanhoutt. Cell-Type-Specific Adaptions in Striatal Medium-Sized Spiny Neurons and Their Roles in Behavioral Responses to Drugs of Abuse. Frontiers in synaptic neuroscience. vol 13. 2021-12-31. PMID:34970134. |
addictive drugs promote reinforcement by increasing dopamine in the mesocorticolimbic system, which alters excitatory glutamate transmission within the reward circuitry, thereby hijacking reward processing. |
2021-12-31 |
2023-08-13 |
Not clear |
| Marie-Charlotte Allichon, Vanesa Ortiz, Paula Pousinha, Andry Andrianarivelo, Anna Petitbon, Nicolas Heck, Pierre Trifilieff, Jacques Barik, Peter Vanhoutt. Cell-Type-Specific Adaptions in Striatal Medium-Sized Spiny Neurons and Their Roles in Behavioral Responses to Drugs of Abuse. Frontiers in synaptic neuroscience. vol 13. 2021-12-31. PMID:34970134. |
within the reward circuitry, the striatum is a key target structure of drugs of abuse since it is at the crossroad of converging glutamate inputs from limbic, thalamic and cortical regions, encoding components of drug-associated stimuli and environment, and dopamine that mediates reward prediction error and incentive values. |
2021-12-31 |
2023-08-13 |
Not clear |
| Dillon J McGovern, Abigail M Polter, David H Roo. Neurochemical Signaling of Reward and Aversion to Ventral Tegmental Area Glutamate Neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 41. issue 25. 2021-11-19. PMID:34001626. |
neurochemical signaling of reward and aversion to ventral tegmental area glutamate neurons. |
2021-11-19 |
2023-08-13 |
mouse |