| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Dillon J McGovern, Abigail M Polter, David H Roo. Neurochemical Signaling of Reward and Aversion to Ventral Tegmental Area Glutamate Neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 41. issue 25. 2021-11-19. PMID:34001626. |
ventral tegmental area (vta) glutamate neurons signal and participate in reward and aversion-based behaviors. |
2021-11-19 |
2023-08-13 |
mouse |
| Dillon J McGovern, Abigail M Polter, David H Roo. Neurochemical Signaling of Reward and Aversion to Ventral Tegmental Area Glutamate Neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 41. issue 25. 2021-11-19. PMID:34001626. |
activity of glutamate inputs to vta glutamate neurons increased for both reward-predicting and aversion-predicting cues and aversive outcomes, but subpopulations of glutamate inputs were increased or decreased by reward. |
2021-11-19 |
2023-08-13 |
mouse |
| Dillon J McGovern, Abigail M Polter, David H Roo. Neurochemical Signaling of Reward and Aversion to Ventral Tegmental Area Glutamate Neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 41. issue 25. 2021-11-19. PMID:34001626. |
for both reward and aversion-based cues and outcomes, activity of gaba inputs to vta glutamate neurons mostly decreased. |
2021-11-19 |
2023-08-13 |
mouse |
| Dillon J McGovern, Abigail M Polter, David H Roo. Neurochemical Signaling of Reward and Aversion to Ventral Tegmental Area Glutamate Neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 41. issue 25. 2021-11-19. PMID:34001626. |
gcamp recordings showed overall population increases in vta glutamate neuron intracellular calcium during reward and aversion-based cues and outcomes. |
2021-11-19 |
2023-08-13 |
mouse |
| Kaitlin C Reeves, Megan J Kube, Gregory G Grecco, Brandon M Fritz, Braulio Muñoz, Fuqin Yin, Yong Gao, David L Haggerty, Hunter J Hoffman, Brady K Atwoo. Mu opioid receptors on vGluT2-expressing glutamatergic neurons modulate opioid reward. Addiction biology. vol 26. issue 3. 2021-11-01. PMID:32686251. |
much less is known about mor-mediated regulation of glutamate transmission in the brain and how this relates to drug reward. |
2021-11-01 |
2023-08-13 |
mouse |
| Kaitlin C Reeves, Megan J Kube, Gregory G Grecco, Brandon M Fritz, Braulio Muñoz, Fuqin Yin, Yong Gao, David L Haggerty, Hunter J Hoffman, Brady K Atwoo. Mu opioid receptors on vGluT2-expressing glutamatergic neurons modulate opioid reward. Addiction biology. vol 26. issue 3. 2021-11-01. PMID:32686251. |
these data reveal that mor-mediated regulation of glutamate transmission is a critical component of opioid reward. |
2021-11-01 |
2023-08-13 |
mouse |
| Shijing Wang, Francesco Leri, Sakina J Rizv. Anhedonia as a central factor in depression: Neural mechanisms revealed from preclinical to clinical evidence. Progress in neuro-psychopharmacology & biological psychiatry. vol 110. 2021-11-01. PMID:33631251. |
as well, serotonin, norepinephrine, opioids, glutamate, gamma aminobutyric acid (gaba), and acetylcholine are also involved in anhedonia, and medications targeting these systems may also potentially normalize reward processing in depression. |
2021-11-01 |
2023-08-13 |
Not clear |
| Sun Mi Gu, Sowoon Seo, Daejin Park, Sanghyeon Kim, Santosh Lamichhane, Kyoung-Moon Han, Young-Hoon Kim, Sangmin Lee, Jin Tae Hong, Hye Jin Cha, Jaesuk Yu. Cannabinoid Receptor Type 1 Regulates Drug Reward Behavior via Glutamate Decarboxylase 67 Transcription. International journal of molecular sciences. vol 22. issue 19. 2021-10-26. PMID:34638827. |
cannabinoid receptor type 1 regulates drug reward behavior via glutamate decarboxylase 67 transcription. |
2021-10-26 |
2023-08-13 |
mouse |
| b' Marc Fakhoury, Giovanni Hernandez, Daniel L\\xc3\\xa9vesque, Pierre-Paul Rompr\\xc3\\xa. Modulation of brain stimulation reward and locomotor activity by ionotropic glutamate receptors of the tail of the ventral tegmental area. Behavioural brain research. vol 393. 2021-10-25. PMID:32593543.' |
modulation of brain stimulation reward and locomotor activity by ionotropic glutamate receptors of the tail of the ventral tegmental area. |
2021-10-25 |
2023-08-13 |
Not clear |
| b' Marc Fakhoury, Giovanni Hernandez, Daniel L\\xc3\\xa9vesque, Pierre-Paul Rompr\\xc3\\xa. Modulation of brain stimulation reward and locomotor activity by ionotropic glutamate receptors of the tail of the ventral tegmental area. Behavioural brain research. vol 393. 2021-10-25. PMID:32593543.' |
in light of previous evidence implicating glutamate transmission in the regulation of midbrain da neuronal activity, we first assessed the impact of intra-tvta microinjection of nbqx (0.8 nmol/side) and pppa (0.825 nmol/side), respectively ampa and nmda receptor antagonists, on reward induced by intracranial self-stimulation (icss) and on locomotor activity. |
2021-10-25 |
2023-08-13 |
Not clear |
| Y Sar. Potential therapeutic role of glutamate transporter 1 for the treatment of alcohol dependence. OA alcohol. vol 1. issue 1. 2021-10-21. PMID:24409344. |
alcohol-seeking behaviour is promoted by increased glutamate transmission in key regions of the mesocorticolimbic reward circuit, including the nucleus accumbens and prefrontal cortex. |
2021-10-21 |
2023-08-12 |
human |
| Valerie J Sydnor, Bart Larsen, Christian Kohler, Andrew J D Crow, Sage L Rush, Monica E Calkins, Ruben C Gur, Raquel E Gur, Kosha Ruparel, Joseph W Kable, Jami F Young, Sanjeev Chawla, Mark A Elliott, Russell T Shinohara, Ravi Prakash Reddy Nanga, Ravinder Reddy, Daniel H Wolf, Theodore D Satterthwaite, David R Roal. Diminished reward responsiveness is associated with lower reward network GluCEST: an ultra-high field glutamate imaging study. Molecular psychiatry. vol 26. issue 6. 2021-10-11. PMID:33479514. |
diminished reward responsiveness is associated with lower reward network glucest: an ultra-high field glutamate imaging study. |
2021-10-11 |
2023-08-13 |
human |
| Valerie J Sydnor, Bart Larsen, Christian Kohler, Andrew J D Crow, Sage L Rush, Monica E Calkins, Ruben C Gur, Raquel E Gur, Kosha Ruparel, Joseph W Kable, Jami F Young, Sanjeev Chawla, Mark A Elliott, Russell T Shinohara, Ravi Prakash Reddy Nanga, Ravinder Reddy, Daniel H Wolf, Theodore D Satterthwaite, David R Roal. Diminished reward responsiveness is associated with lower reward network GluCEST: an ultra-high field glutamate imaging study. Molecular psychiatry. vol 26. issue 6. 2021-10-11. PMID:33479514. |
this study employed ultra-high field glutamate chemical exchange saturation transfer (glucest) imaging to investigate the hypothesis that glutamatergic deficits within the reward network contribute to low rr. |
2021-10-11 |
2023-08-13 |
human |
| Valerie J Sydnor, Bart Larsen, Christian Kohler, Andrew J D Crow, Sage L Rush, Monica E Calkins, Ruben C Gur, Raquel E Gur, Kosha Ruparel, Joseph W Kable, Jami F Young, Sanjeev Chawla, Mark A Elliott, Russell T Shinohara, Ravi Prakash Reddy Nanga, Ravinder Reddy, Daniel H Wolf, Theodore D Satterthwaite, David R Roal. Diminished reward responsiveness is associated with lower reward network GluCEST: an ultra-high field glutamate imaging study. Molecular psychiatry. vol 26. issue 6. 2021-10-11. PMID:33479514. |
the glucest contrast, a measure sensitive to local glutamate concentration, was quantified in a meta-analytically defined reward network comprised of cortical, subcortical, and brainstem regions. |
2021-10-11 |
2023-08-13 |
human |
| Valerie J Sydnor, Bart Larsen, Christian Kohler, Andrew J D Crow, Sage L Rush, Monica E Calkins, Ruben C Gur, Raquel E Gur, Kosha Ruparel, Joseph W Kable, Jami F Young, Sanjeev Chawla, Mark A Elliott, Russell T Shinohara, Ravi Prakash Reddy Nanga, Ravinder Reddy, Daniel H Wolf, Theodore D Satterthwaite, David R Roal. Diminished reward responsiveness is associated with lower reward network GluCEST: an ultra-high field glutamate imaging study. Molecular psychiatry. vol 26. issue 6. 2021-10-11. PMID:33479514. |
this study thus provides new evidence that reward network glutamate levels contribute to individual differences in rr. |
2021-10-11 |
2023-08-13 |
human |
| Natasha L Mason, Eef L Theunissen, Nadia R P W Hutten, Desmond H Y Tse, Stefan W Toennes, Jacobus F A Jansen, Peter Stiers, Johannes G Ramaeker. Reduced responsiveness of the reward system is associated with tolerance to cannabis impairment in chronic users. Addiction biology. vol 26. issue 1. 2021-10-05. PMID:31865628. |
in occasional users, cannabis induced significant neurometabolic alterations in reward circuitry, namely, decrements in functional connectivity and increments in striatal glutamate concentrations, which were associated with increases in subjective high and decreases in performance on a sustained attention task. |
2021-10-05 |
2023-08-13 |
Not clear |
| Marta Marszalek-Grabska, Irena Smaga, Paulina Surowka, Pawel Grochecki, Tymoteusz Slowik, Malgorzata Filip, Jolanta H Kotlinsk. Memantine Prevents the WIN 55,212-2 Evoked Cross-Priming of Ethanol-Induced Conditioned Place Preference (CPP). International journal of molecular sciences. vol 22. issue 15. 2021-09-09. PMID:34360704. |
the activation of the endocannabinoid system controls the release of many neurotransmitters involved in the brain reward pathways, including glutamate. |
2021-09-09 |
2023-08-13 |
Not clear |
| Ewa Niedzielska-Andres, Lucyna Pomierny-Chamioło, Michał Andres, Maria Walczak, Lori A Knackstedt, Małgorzata Filip, Edmund Przegalińsk. Cocaine use disorder: A look at metabotropic glutamate receptors and glutamate transporters. Pharmacology & therapeutics. vol 221. 2021-08-26. PMID:33359590. |
the present review summarizes the changes in glutamate levels in the reward system (the prefrontal cortex, nucleus accumbens, dorsal striatum, hippocampus, and ventral tegmental area) observed in preclinical studies at different stages of cocaine exposure and withdrawal as well as after reinstatement of cocaine-seeking behavior. |
2021-08-26 |
2023-08-13 |
Not clear |
| Sudie E Back, Kevin Gray, Elizabeth Santa Ana, Jennifer L Jones, Amber M Jarnecke, Jane E Joseph, James Prisciandaro, Therese Killeen, Delisa G Brown, Linda Taimina, Ebele Compean, Robert Malcolm, Julianne C Flanagan, Peter W Kaliva. N-acetylcysteine for the treatment of comorbid alcohol use disorder and posttraumatic stress disorder: Design and methodology of a randomized clinical trial. Contemporary clinical trials. vol 91. 2021-08-04. PMID:32087337. |
nac is a cysteine pro-drug that stimulates the cystine-glutamate exchanger, normalizes glial glutamate transporters, and restores glutamatergic tone on presynaptic receptors in reward regions of the brain. |
2021-08-04 |
2023-08-13 |
Not clear |
| Kate Beecher, Joshua Wang, Angela Jacques, Nicholas Chaaya, Fatemeh Chehrehasa, Arnauld Belmer, Selena E Bartlet. Sucrose Consumption Alters Serotonin/Glutamate Co-localisation Within the Prefrontal Cortex and Hippocampus of Mice. Frontiers in molecular neuroscience. vol 14. 2021-07-16. PMID:34262435. |
although serotonin and glutamate co-localisation has been implicated in reward processing, it is still unknown how chronic sucrose consumption changes this transmission in regions associated with executive control over feeding-such as the prefrontal cortex (pfc) and dentate gyrus (dg) of the hippocampus. |
2021-07-16 |
2023-08-13 |
mouse |