| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Shoupeng Wei, Sarah Hertle, Rainer Spanagel, Ainhoa Bilba. NMDA Receptors in Accumbal D1 Neurons Influence Chronic Sugar Consumption and Relapse. eNeuro. vol 8. issue 3. 2021-07-02. PMID:33906970. |
although well-established for drugs of abuse, it is not clear whether glutamate receptors within the mesolimbic system are involved in mediating chronic consumption and relapse following abstinence from a non-drug reward. |
2021-07-02 |
2023-08-13 |
mouse |
| Ewa Galaj, Robert Ranald. Neurobiology of reward-related learning. Neuroscience and biobehavioral reviews. vol 124. 2021-06-25. PMID:33581225. |
we propose that vta da neurons receive both a strong unconditioned stimulus signal (acetylcholine stimulation of da cells) from the primary reward capable of unconditionally activating da cells and a weak stimulus signal (glutamate stimulation of da cells) from the neutral stimulus. |
2021-06-25 |
2023-08-13 |
Not clear |
| Zahra Ebrahimi, Nazanin Kahvandi, Alireza Komaki, Seyed Asaad Karimi, Marzieh Naderishahab, Abdolrahman Sarih. The role of mGlu4 receptors within the nucleus accumbens in acquisition and expression of morphine-induced conditioned place preference in male rats. BMC neuroscience. vol 22. issue 1. 2021-06-17. PMID:33743609. |
in addition, metabotropic glutamate receptors (mglurs) in nac play important roles in the reward pathways. |
2021-06-17 |
2023-08-13 |
rat |
| Li-Min Mao, John Q Wan. Linkage of Non-receptor Tyrosine Kinase Fyn to mGlu5 Receptors in Striatal Neurons in a Depression Model. Neuroscience. vol 433. 2021-05-14. PMID:32145272. |
the sfk member fyn is enriched at synaptic sites in the limbic reward circuit and plays a pivotal role in the regulation of glutamate receptors. |
2021-05-14 |
2023-08-13 |
rat |
| Francisca Villavicencio-Tejo, Osvaldo Flores-Bastías, Lucas Marambio-Ruiz, Diliana Pérez-Reytor, Eduardo Karahania. Fenofibrate (a PPAR-α Agonist) Administered During Ethanol Withdrawal Reverts Ethanol-Induced Astrogliosis and Restores the Levels of Glutamate Transporter in Ethanol-Administered Adolescent Rats. Frontiers in pharmacology. vol 12. 2021-05-08. PMID:33959021. |
neuroinflammation decreases glutamate transporter (glt-1) expression, increasing levels of glutamate that trigger dopamine release at the corticolimbic reward areas, driving long-term drinking behavior. |
2021-05-08 |
2023-08-13 |
rat |
| Solange Bandiera, Felipe Borges Almeida, Alana Witt Hansen, Rianne Remus Pulcinelli, Greice Caletti, Leonardo Fernandes de Paula, Mauricio Schüler Nin, Fernanda Urruth Fontella, Roberto Farina Almeida, Helena Maria Tannhauser Barros, Rosane Gome. Combined use of alcohol and cigarette increases locomotion and glutamate levels in the cerebrospinal fluid without changes on GABA Behavioural brain research. vol 380. 2021-05-03. PMID:31866463. |
combined use of alcohol and cigarette increases locomotion and glutamate levels in the cerebrospinal fluid without changes on gaba interactions on neurotransmitter systems in the reward pathways may explain the high frequency of combined use of alcohol and cigarettes in humans. |
2021-05-03 |
2023-08-13 |
rat |
| Francesca Mottarlini, Giorgia Bottan, Benedetta Tarenzi, Alessandra Colciago, Fabio Fumagalli, Lucia Caffin. Activity-Based Anorexia Dynamically Dysregulates the Glutamatergic Synapse in the Nucleus Accumbens of Female Adolescent Rats. Nutrients. vol 12. issue 12. 2021-04-21. PMID:33260714. |
since evidence exists that a dysregulation of the glutamate system in the nac influences reward and taking advantage of the activity-based anorexia (aba) rat model, which closely mimics the hallmarks of an, we investigated the involvement of the glutamatergic signaling in the nac in this experimental model. |
2021-04-21 |
2023-08-13 |
rat |
| Farzaneh Saebi Rad, Abbas Haghparast, Afsaneh Eliass. Ventral Tegmental Area Microinjected-SKF38393 Increases Regular Chow Intake in 18 Hours Food-Deprived Rats. Basic and clinical neuroscience. vol 11. issue 6. 2021-04-16. PMID:33850614. |
ventral tegmental area (vta) dopamine neurons play an important role in reward mechanisms of food intake, and vta dopamine receptors exist on the terminal of glutamatergic and gabaergic neurons and regulate gamma-aminobutyric acid (gaba) and glutamate release. |
2021-04-16 |
2023-08-13 |
rat |
| Jennifer C Felger, Ebrahim Haroon, Trusharth A Patel, David R Goldsmith, Evanthia C Wommack, Bobbi J Woolwine, Ngoc-Anh Le, Rachel Feinberg, Malu G Tansey, Andrew H Mille. What does plasma CRP tell us about peripheral and central inflammation in depression? Molecular psychiatry. vol 25. issue 6. 2021-03-09. PMID:29895893. |
furthermore, increased peripheral blood crp in mdd has been associated with altered reward circuitry and increased brain glutamate in relation with symptoms of anhedonia. |
2021-03-09 |
2023-08-13 |
Not clear |
| Tadeu P D Oliveira, Bruno D C Gonçalves, Bruna S Oliveira, Antonio Carlos P de Oliveira, Helton J Reis, Claudia N Ferreira, Daniele C Aguiar, Aline S de Miranda, Fabiola M Ribeiro, Erica M L Vieira, András Palotás, Luciene B Vieir. Negative Modulation of the Metabotropic Glutamate Receptor Type 5 as a Potential Therapeutic Strategy in Obesity and Binge-Like Eating Behavior. Frontiers in neuroscience. vol 15. 2021-03-03. PMID:33642987. |
literature shows that metabotropic glutamate receptor 5 (mglur5) modulates central reward pathways. |
2021-03-03 |
2023-08-13 |
mouse |
| Andriana Kakanakova, Stefan Popov, Michael Mae. Immunological Disturbances and Neuroimaging Findings in Major Depressive Disorder (MDD) and Alcohol Use Disorder (AUD) Comorbid Patients. Current topics in medicinal chemistry. vol 20. issue 9. 2021-01-08. PMID:32108009. |
some of the contemporary brain imaging techniques are functional magnetic resonance imaging (fmri) and magnetic spectroscopy which are most commonly used to assess the brain metabolism and functional connectivity changes such as altered responses to emotional stimuli in mdd or overactivation of ventromedial prefrontal areas during delayed and underactivation of dorsolateral prefrontal regions during impulsive reward decisions in aud and dysfunction of gamma-aminobutyric acid (gaba) and/or glutamate neurotransmitter systems, low naa and myo-inositol in both mdd and aud. |
2021-01-08 |
2023-08-13 |
Not clear |
| Hasan Alhaddad, Woonyen Wong, Adam T Sari, Laura E Crotty Alexander, Youssef Sar. Effects of 3-Month Exposure to E-Cigarette Aerosols on Glutamatergic Receptors and Transporters in Mesolimbic Brain Regions of Female C57BL/6 Mice. Toxics. vol 8. issue 4. 2020-12-26. PMID:33137879. |
in this study, we evaluated the effect of three months' continuous exposure to e-cig vapor (juul pods), containing a high nicotine concentration, on the expression of glutamate receptors and transporters in drug reward brain regions such as the nucleus accumbens (nac) core (nac-core), nac shell (nac-shell) and hippocampus (hip) in female c57bl/6 mice. |
2020-12-26 |
2023-08-13 |
mouse |
| Alvaro Nuno-Perez, Manuel Mamel. In DA Club of Reinforcement: Glutamate, It's Your Birthday. Neuron. vol 107. issue 5. 2020-11-02. PMID:32910888. |
dopamine release guides reward encoding, but the contribution of glutamate remains unclear. |
2020-11-02 |
2023-08-13 |
Not clear |
| M Flavia Barbano, Hui-Ling Wang, Shiliang Zhang, Jorge Miranda-Barrientos, David J Estrin, Almaris Figueroa-González, Bing Liu, David J Barker, Marisela Morale. VTA Glutamatergic Neurons Mediate Innate Defensive Behaviors. Neuron. vol 107. issue 2. 2020-10-19. PMID:32442399. |
the ventral tegmental area (vta) has dopamine, gaba, and glutamate neurons, which have been implicated in reward and aversion. |
2020-10-19 |
2023-08-13 |
Not clear |
| Karen J Hartwell, Bryan K Tolliver, Kathleen T Brad. Biologic Commonalities between Mental Illness and Addiction. Primary psychiatry. vol 16. issue 8. 2020-10-01. PMID:26030747. |
similar alterations in the dopamine-mediated reward system and various neurotransmitter systems including glutamate, γ-aminobutyric acid, and serotonin are found in both suds and numerous psychiatric disorders. |
2020-10-01 |
2023-08-13 |
Not clear |
| Ali Siahposht-Khachaki, Zahra Fatahi, Abbas Haghparas. Reduction of the Morphine Maintenance by Blockade of the NMDA Receptors during Extinction Period in Conditioned Place Preference Paradigm of Rats. Basic and clinical neuroscience. vol 7. issue 4. 2020-09-30. PMID:27872695. |
activation of n-methyl-d-aspartate (nmda) glutamate receptors in the nucleus accumbens is a component of drug-induced reward mechanism. |
2020-09-30 |
2023-08-13 |
rat |
| Pss Rao, Murali M Yallapu, Youssef Sari, Paul B Fisher, Santosh Kuma. Designing Novel Nanoformulations Targeting Glutamate Transporter Excitatory Amino Acid Transporter 2: Implications in Treating Drug Addiction. Journal of personalized nanomedicine. vol 1. issue 1. 2020-09-29. PMID:26635971. |
chronic drug abuse is associated with elevated extracellular glutamate concentration in the brain reward regions. |
2020-09-29 |
2023-08-13 |
Not clear |
| Chelsea N Brown, Elissa K Fultz, Sami Ferdousian, Sarina Rogers, Elijah Lustig, Ariana Page, John R Shahin, Daniel M Flaherty, Georg Von Jonquieres, Camron D Bryant, Tod E Kippin, Karen K Szumlinsk. Transgenic Analyses of Homer2 Function Within Nucleus Accumbens Subregions in the Regulation of Methamphetamine Reward and Reinforcement in Mice. Frontiers in psychiatry. vol 11. 2020-09-28. PMID:32116834. |
recently, we discovered an association between genetic vulnerability to ma-taking and increased expression of the glutamate receptor scaffolding protein homer2 within both the shell and core subregions of the nucleus accumbens (nac) and demonstrated a necessary role for homer2 within the shell subregion in ma reward and reinforcement in mice. |
2020-09-28 |
2023-08-13 |
mouse |
| Liran A Levi, Kineret Inbar, Noa Nachshon, Nimrod Bernat, Ava Gatterer, Dorrit Inbar, Yonatan M Kupchi. Projection-Specific Potentiation of Ventral Pallidal Glutamatergic Outputs after Abstinence from Cocaine. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 40. issue 6. 2020-08-17. PMID:31836662. |
although the majority of vp neurons are gabaergic and encode reward, recent studies revealed a novel glutamatergic neuronal population in the vp [vp neurons expressing the vesicular glutamate transporter 2 (vp |
2020-08-17 |
2023-08-13 |
Not clear |
| Hui-Ling Wang, Shiliang Zhang, Jia Qi, Huikun Wang, Roger Cachope, Carlos A Mejias-Aponte, Jorge A Gomez, Gabriel E Mateo-Semidey, Gerard M J Beaudoin, Carlos A Paladini, Joseph F Cheer, Marisela Morale. Dorsal Raphe Dual Serotonin-Glutamate Neurons Drive Reward by Establishing Excitatory Synapses on VTA Mesoaccumbens Dopamine Neurons. Cell reports. vol 26. issue 5. 2020-03-13. PMID:30699344. |
our findings suggest a path-specific input from dr serotonergic neurons to vta that promotes reward by the release of glutamate and activation of mesoaccumbens dopamine neurons. |
2020-03-13 |
2023-08-13 |
Not clear |