| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| P De Deurwaerdèr. Cariprazine:New dopamine biased agonist for neuropsychiatric disorders. Drugs of today (Barcelona, Spain : 1998). vol 52. issue 2. 2016-06-02. PMID:27092339. |
at variance with some atypical antipsychotics, its affinity at 5-ht1a, 5-ht2a and histamine h1 receptors is modest compared with its three main targets. |
2016-06-02 |
2023-08-13 |
Not clear |
| Kazumasa Matsumoto-Miyai, Masaru Yoshizumi, Masahito Kawatan. Regulatory Effects of 5-Hydroxytryptamine Receptors on Voiding Function. Advances in therapy. vol 32 Suppl 1. 2016-05-25. PMID:26391372. |
5-ht2a, 5-ht2c, 5-ht3, 5-ht4, and 5-ht7 subtypes facilitate the neurogenic contraction of the detrusor by enhancing cholinergic or purinergic transmission, whereas 5-ht1a receptors might inhibit the release of acetylcholine in the detrusor. |
2016-05-25 |
2023-08-13 |
Not clear |
| Joseph McEvoy, Leslie Citrom. Brexpiprazole for the Treatment of Schizophrenia: A Review of this Novel Serotonin-Dopamine Activity Modulator. Clinical schizophrenia & related psychoses. vol 9. issue 4. 2016-05-12. PMID:26757416. |
brexpiprazole acts as a partial agonist at dopamine d2 and serotonin 5-ht1a receptors, and as an antagonist at serotonin 5-ht2a and at adrenergic alpha1b and alpha2c receptors. |
2016-05-12 |
2023-08-13 |
Not clear |
| Anna Castañé, Lucila Kargieman, Pau Celada, Analía Bortolozzi, Francesc Artiga. 5-HT2A receptors are involved in cognitive but not antidepressant effects of fluoxetine. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 25. issue 8. 2016-05-06. PMID:25914158. |
endogenous 5-ht exerts robust actions on the activity of pyramidal neurons in medial pfc (mpfc) via excitatory 5-ht2a and inhibitory 5-ht1a receptors, suggesting the involvement of 5-ht neurotransmission in cortical functions. |
2016-05-06 |
2023-08-13 |
mouse |
| Jingjing Song, Xintong Hou, Xinyu Hu, Chengyu Lu, Chungang Liu, Juan Wang, Wei Liu, Lirong Teng, Di Wan. Not only serotonergic system, but also dopaminergic system involved in albiflorin against chronic unpredictable mild stress-induced depression-like behavior in rats. Chemico-biological interactions. vol 242. 2016-05-03. PMID:26475043. |
compared to non-treated depression-like rats, the increased levels of 5-hydroxytryptamine (5-ht) and 5-hydroxyindoleacetic acid (5-htaa) in serum and hypothalamus, and the reduced expressions of 5-ht1a receptor and 5-ht2a receptor in hypothalamus were observed after af and fluoxetine oral administration indicating that af-mediated antidepressant-like effect may be related to the normalization of serotonergic system. |
2016-05-03 |
2023-08-13 |
rat |
| William H Carson, Hisashi Kitagaw. Drug development for anxiety disorders: new roles for atypical antipsychotics. Psychopharmacology bulletin. vol 38. issue 1. 2016-04-23. PMID:15278017. |
the next generation antipsychotic, aripiprazole, has a unique mechanism of action (ie, combined d2 and 5-ht1a partial agonist and 5-ht2a antagonist) and improves depressive and depressive/anxiety symptoms in patients with schizophrenia. |
2016-04-23 |
2023-08-12 |
Not clear |
| Guadalupe Mengod, José M Palacios, Roser Corté. Cartography of 5-HT1A and 5-HT2A Receptor Subtypes in Prefrontal Cortex and Its Projections. ACS chemical neuroscience. vol 6. issue 7. 2016-04-19. PMID:25739427. |
cartography of 5-ht1a and 5-ht2a receptor subtypes in prefrontal cortex and its projections. |
2016-04-19 |
2023-08-13 |
Not clear |
| Guadalupe Mengod, José M Palacios, Roser Corté. Cartography of 5-HT1A and 5-HT2A Receptor Subtypes in Prefrontal Cortex and Its Projections. ACS chemical neuroscience. vol 6. issue 7. 2016-04-19. PMID:25739427. |
we will review current knowledge regarding the cellular localization of 5-ht1a and 5-ht2a receptors in mammalian pfc and their possible functions in the neuronal circuits of the pfc. |
2016-04-19 |
2023-08-13 |
Not clear |
| Anna Gomółka, Agnieszka Ciesielska, Martyna Z Wróbel, Andrzej Chodkowski, Jerzy Kleps, Maciej Dawidowski, Agata Siwek, Małgorzata Wolak, Katarzyna Stachowicz, Anna Sławińska, Gabriel Nowak, Grzegorz Satała, Andrzej J Bojarski, Mariusz Belka, Szymon Ulenberg, Tomasz Bączek, Paweł Skowronek, Jadwiga Turło, Franciszek Herol. Novel 4-aryl-pyrido[1,2-c]pyrimidines with dual SSRI and 5-HT(1A) activity. Part 5. European journal of medicinal chemistry. vol 98. 2016-04-12. PMID:26043160. |
affinity of the novel pyrido[1,2-c]pyrimidine derivatives for 5-ht1a, 5-ht2a receptors and serotonin transporter (sert) was evaluated in an in vitro radioligand binding assay. |
2016-04-12 |
2023-08-13 |
mouse |
| H Bonilla-Jaime, G Guadarrama-Cruz, F J Alarcon-Aguilar, O Limón-Morales, G Vazquez-Palacio. Antidepressant-like activity of Tagetes lucida Cav. is mediated by 5-HT(1A) and 5-HT(2A) receptors. Journal of natural medicines. vol 69. issue 4. 2016-04-01. PMID:26062718. |
the animals were pretreated with a 5-ht1a receptor antagonist (way-100635, 0.5 mg/kg), a 5-ht2a receptor antagonist (ketanserin, 5 mg/kg), a β-noradrenergic receptor antagonist (propranolol, 200 mg/kg), and with a α2-noradrenergic receptor antagonist (yohimbine, 1 mg/kg) alone or combined with the extract and pretreated with a serotonin synthesis inhibitor (pcpa) before treatment with 8-oh-dpat + the extract of t. lucida. |
2016-04-01 |
2023-08-13 |
rat |
| Takeshi Kanno, Akito Tanaka, Tomoyuki Nishizak. Linoleic acid derivative DCP-LA ameliorates stress-induced depression-related behavior by promoting cell surface 5-HT1A receptor translocation, stimulating serotonin release, and inactivating GSK-3β. Molecular neurobiology. vol 51. issue 2. 2016-03-14. PMID:24788685. |
postsynaptic cell surface localization of 5-ht1a receptor, but not 5-ht2a receptor, in the hypothalamus for mice with restraint stress was significantly reduced as compared with that for control mice, which highly correlated to prolonged immobility time, i.e., depression-like behavior. |
2016-03-14 |
2023-08-13 |
mouse |
| N K Popova, A V Kulikov, E M Kondaurova, A S Tsybko, E A Kulikova, I B Krasnov, B S Shenkman, E Yu Bazhenova, N A Sinyakova, V S Naumenk. Risk neurogenes for long-term spaceflight: dopamine and serotonin brain system. Molecular neurobiology. vol 51. issue 3. 2016-03-08. PMID:25084757. |
however, spaceflight failed to alter the expression of tryptophan hydroxylase-2, 5-ht transporter, 5-ht1a, and 5-ht3 receptor genes, though it reduced 5-ht2a receptor gene expression in the hypothalamus. |
2016-03-08 |
2023-08-13 |
mouse |
| Denis Boulay, Sophie Ho-Van, Olivier Bergis, Patrick Avenet, Guy Griebe. Phencyclidine decreases tickling-induced 50-kHz ultrasound vocalizations in juvenile rats: a putative model of the negative symptoms of schizophrenia? Behavioural pharmacology. vol 24. issue 7. 2016-03-03. PMID:23928693. |
the 5-ht1a receptor partial agonist, buspirone (0.3 and 1 mg/kg, intraperitoneally), the dual d2/5-ht1a receptor ligand, ssr181507 (0.5-0.75 mg/kg, intraperitoneally), but not the atypical antipsychotic, aripiprazole (0.1-1 mg/kg, intraperitoneally), the 5-ht2a receptor antagonist, eplivanserin (0.3-3 mg/kg, intraperitoneally), and the glyt1 inhibitor, ssr103800 (0.3-3 mg/kg, intraperitoneally) significantly attenuated the effects of pcp on 50-khz calls. |
2016-03-03 |
2023-08-12 |
human |
| Anna Czopek, Marcin Kołaczkowski, Adam Bucki, Hanna Byrtus, Maciej Pawłowski, Grzegorz Kazek, Andrzej J Bojarski, Agata Piaskowska, Justyna Kalinowska-Tłuścik, Anna Partyka, Anna Wesołowsk. Novel spirohydantoin derivative as a potent multireceptor-active antipsychotic and antidepressant agent. Bioorganic & medicinal chemistry. vol 23. issue 13. 2016-02-26. PMID:25936259. |
a series of novel spirohydantoin derivatives with arylpiperazinylbutyl moiety were synthesized and evaluated for serotonin 5-ht1a, 5-ht2a, 5-ht7 and dopamine d2 receptors. |
2016-02-26 |
2023-08-13 |
mouse |
| Katherine M Serafine, Kenner C Rice, Charles P Franc. Directly Observable Behavioral Effects of Lorcaserin in Rats. The Journal of pharmacology and experimental therapeutics. vol 355. issue 3. 2016-02-09. PMID:26384326. |
while the behavioral effects of lorcaserin in rats are consistent with it having agonist activity at 5-ht2c receptors, these data suggest that at larger doses it also has agonist activity at 5-ht2a and possibly 5-ht1a receptors. |
2016-02-09 |
2023-08-13 |
rat |
| James G Pfau. Treatment for hypoactive sexual desire. Cell. vol 163. issue 3. 2016-02-01. PMID:26496594. |
flibanserin acts at cortical, limbic, hypothalamic, and brainstem nuclei to inhibit serotonin release by binding to 5-ht1a autoreceptors and block postsynaptic action of serotonin at 5-ht2a receptors. |
2016-02-01 |
2023-08-13 |
Not clear |
| Paweł Żmudzki, Grażyna Chłoń-Rzepa, Andrzej J Bojarski, Małgorzata Zygmunt, Grzegorz Kazek, Barbara Mordyl, Maciej Pawłowsk. Structure-5-HT receptor affinity relationship in a new group of 7-arylpiperazynylalkyl and 7-tetrahydroisoquinolinylalkyl derivatives of 8-amino-1,3-dimethyl-1H-purine-2,6(3H,7H)-dione. Archiv der Pharmazie. vol 348. issue 4. 2016-01-21. PMID:25773578. |
in order to examine the influence of the substituent in the position 8 of the purine moiety on the affinity for the serotonin 5-ht1a , 5-ht2a , and 5-ht7 receptors, a series of 7-arylpiperazynylalkyl and 7-tetrahydroisoquinolinylalkyl (thiq) derivatives of 8-amino-1,3-dimethyl-1h-purine-2,6(3h,7h)-dione were synthesized. |
2016-01-21 |
2023-08-13 |
Not clear |
| Paweł Żmudzki, Grażyna Chłoń-Rzepa, Andrzej J Bojarski, Małgorzata Zygmunt, Grzegorz Kazek, Barbara Mordyl, Maciej Pawłowsk. Structure-5-HT receptor affinity relationship in a new group of 7-arylpiperazynylalkyl and 7-tetrahydroisoquinolinylalkyl derivatives of 8-amino-1,3-dimethyl-1H-purine-2,6(3H,7H)-dione. Archiv der Pharmazie. vol 348. issue 4. 2016-01-21. PMID:25773578. |
all the final compounds were investigated in in vitro competition binding experiments for serotonin 5-ht1a , 5-ht2a , and 5-ht7 receptors. |
2016-01-21 |
2023-08-13 |
Not clear |
| Grażyna Chłoń-Rzepa, Agnieszka Zagórska, Adam Bucki, Marcin Kołaczkowski, Maciej Pawłowski, Grzegorz Satała, Andrzej J Bojarski, Anna Partyka, Anna Wesołowska, Elżbieta Pękala, Karolina Słoczyńsk. New arylpiperazinylalkyl derivatives of 8-alkoxy-purine-2,6-dione and dihydro[1,3]oxazolo[2,3-f]purinedione targeting the serotonin 5-HT1A /5-HT2A /5-HT7 and dopamine D2 receptors. Archiv der Pharmazie. vol 348. issue 4. 2016-01-21. PMID:25773907. |
to obtain potential antidepressants and/or antipsychotics, a series of new long-chain arylpiperazine derivatives of 8-alkoxy-purine-2,6-dione (10-24) and dihydro[1,3]oxazolo[2,3-f]purinedione (30-34) were synthesized and their serotonin (5-ht1a , 5-ht2a , 5-ht6 , 5-ht7 ) and dopamine (d2 ) receptor affinities were determined. |
2016-01-21 |
2023-08-13 |
mouse |
| Ichiro Kusumi, Shuken Boku, Yoshito Takahash. Psychopharmacology of atypical antipsychotic drugs: From the receptor binding profile to neuroprotection and neurogenesis. Psychiatry and clinical neurosciences. vol 69. issue 5. 2016-01-18. PMID:25296946. |
a variety of serotonin (5-ht) receptors, such as 5-ht2a / 2c , 5-ht1a , 5-ht6 and 5-ht7 receptors, may contribute to the mechanisms of action of 'atypicality'. |
2016-01-18 |
2023-08-13 |
Not clear |