| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Gregory M James, Gregor Gryglewski, Thomas Vanicek, Neydher Berroterán-Infante, Cécile Philippe, Alexander Kautzky, Lukas Nics, Chrysoula Vraka, Godber M Godbersen, Jakob Unterholzner, Helen L Sigurdardottir, Marie Spies, René Seiger, Georg S Kranz, Andreas Hahn, Markus Mitterhauser, Wolfgang Wadsak, Andreas Bauer, Marcus Hacker, Siegfried Kasper, Rupert Lanzenberge. Parcellation of the Human Cerebral Cortex Based on Molecular Targets in the Serotonin System Quantified by Positron Emission Tomography In vivo. Cerebral cortex (New York, N.Y. : 1991). vol 29. issue 1. 2020-03-03. PMID:30357321. |
positron emission tomography was carried out for the quantification of serotonin 1a (5-ht1a, n = 30) and 5-ht2a receptors (n = 22), the serotonin-degrading enzyme monoamine oxidase a (mao-a, n = 32) and the serotonin transporter (5-htt, n = 24) in healthy participants. |
2020-03-03 |
2023-08-13 |
human |
| Kathryn Lanza, Christopher Bisho. Serotonergic targets for the treatment of L-DOPA-induced dyskinesia. Journal of neural transmission (Vienna, Austria : 1996). vol 125. issue 8. 2019-11-04. PMID:29305656. |
this review discusses the rationale for continued investigation of several potential anti-dyskinetic strategies including 5-ht stimulation of 5-ht1a and 5-ht1b receptors and blockade of 5-ht2a receptors and sert. |
2019-11-04 |
2023-08-13 |
Not clear |
| Marianna Mazza, Giuseppe Marano, Gianandrea Traversi, Valentina Carocci, Benedetta Romano, Luigi Janir. Cariprazine in Bipolar Depression and Mania: State of the Art. CNS & neurological disorders drug targets. vol 17. issue 10. 2019-10-14. PMID:30152291. |
high affinity for d3 dopamine receptors and observed actions on 5ht1a, 5ht2a and alpha 1b receptors differentiate it pharmacologically from other antipsychotics. |
2019-10-14 |
2023-08-13 |
Not clear |
| Sourav Das, Ravi Gupta, Mohan Dhyani, Divyashree Sah, Jitamanyu Mait. Role of 5HT1A and 5HT2A receptors and default mode network in olanzapine-induced somnambulism. Neurology India. vol 65. issue 2. 2019-07-15. PMID:28290400. |
role of 5ht1a and 5ht2a receptors and default mode network in olanzapine-induced somnambulism. |
2019-07-15 |
2023-08-13 |
Not clear |
| Yong Kee Choi, Nika Adham, Béla Kiss, István Gyertyán, Frank I Taraz. Long-term effects of aripiprazole exposure on monoaminergic and glutamatergic receptor subtypes: comparison with cariprazine. CNS spectrums. vol 22. issue 6. 2019-06-28. PMID:28059046. |
this study examined the chronic effects of aripiprazole and cariprazine on serotonin (5-ht1a and 5-ht2a) and glutamate (nmda and ampa) receptor subtypes. |
2019-06-28 |
2023-08-13 |
Not clear |
| Li Liu, Mengsi Fu, Siran Pei, Liangliang Zhou, Jing Shan. R-Fluoxetine Increases Melanin Synthesis Through a 5-HT1A/2A Receptor and p38 MAPK Signaling Pathways. International journal of molecular sciences. vol 20. issue 1. 2019-04-03. PMID:30585252. |
in addition, we found that r-fluoxetine induced melanin synthesis through the serotonin1a receptor (5-ht1a) and serotonin 2a receptor (5-ht2a). |
2019-04-03 |
2023-08-13 |
human |
| Mingjun Xiang, Yuting Jiang, Zhiying Hu, Yang Yang, Benson O A Botchway, Marong Fan. Stimulation of Anxiety-Like Behavior via ERK Pathway by Competitive Serotonin Receptors 2A and 1A in Post-Traumatic Stress Disordered Mice. Neuro-Signals. vol 25. issue 1. 2019-03-05. PMID:28977803. |
serotonin 5ht2a and 5ht1a receptors (5ht2ar, 5ht1ar) have the closest connection to anxiety-like behavior in post-traumatic stress disorder (ptsd). |
2019-03-05 |
2023-08-13 |
mouse |
| Simin Afshar, Siamak Shahidi, Ali Haeri Rohani, Alireza Komaki, Sara Soleimani As. The effect of NAD-299 and TCB-2 on learning and memory, hippocampal BDNF levels and amyloid plaques in Streptozotocin-induced memory deficits in male rats. Psychopharmacology. vol 235. issue 10. 2018-12-31. PMID:30027497. |
the serotonergic system via the 5-ht1a receptor and 5-ht2a receptor is proposed to affect the cognitive process. |
2018-12-31 |
2023-08-13 |
rat |
| Anne Sofie Eldon, Annamaria Girald. [Flibanserin as pharmacological therapy of inhibited sexual desire in women]. Ugeskrift for laeger. vol 179. issue 7. 2018-12-11. PMID:28397671. |
flibanserin was approved by the food and drug administration in the usa in august 2015 as the first drug for the treatment of american women with the dysfunction hypoactive sexual desire disorder (hsdd) and is a 5-ht1a agonist and 5-ht2a antagonist. |
2018-12-11 |
2023-08-13 |
Not clear |
| A S Tsybko, T V Ilchibaeva, D V Bazovkina, V S Naumenk. [Functional Responses to the Chronic Activation of 5-HT1A Receptors in Mice with Genetic Predisposition to Catalepsy]. Molekuliarnaia biologiia. vol 52. issue 2. 2018-12-11. PMID:29695693. |
the chronic activation of 5-ht1a receptor downregulated 5-ht1a gene expression, as well as the expression of the gene that encodes tryptophan hydroxylase 2, a key enzyme of 5-ht biosynthesis, in the midbrain and the expression of the gene that encodes the 5-ht2a receptor in the frontal cortex of cba, but not c57bl/6 mice. |
2018-12-11 |
2023-08-13 |
mouse |
| Dasiel O Borroto-Escuela, Manuel Narváez, Patrizia Ambrogini, Luca Ferraro, Ismel Brito, Wilber Romero-Fernandez, Yuniesky Andrade-Talavera, Antonio Flores-Burgess, Carmelo Millon, Belen Gago, Jose Angel Narvaez, Yuji Odagaki, Miklos Palkovits, Zaida Diaz-Cabiale, Kjell Fux. Receptor⁻Receptor Interactions in Multiple 5-HT1A Heteroreceptor Complexes in Raphe-Hippocampal 5-HT Transmission and Their Relevance for Depression and Its Treatment. Molecules (Basel, Switzerland). vol 23. issue 6. 2018-10-22. PMID:29865267. |
they may play a role in depression through an ability of 5-ht2a protomer signaling to inhibit the 5-ht1a protomer recognition and signaling. |
2018-10-22 |
2023-08-13 |
rat |
| Jennifer N Clements, Brittany Thompso. Flibanserin for hypoactive sexual desire disorder in premenopausal women. JAAPA : official journal of the American Academy of Physician Assistants. vol 31. issue 6. 2018-10-17. PMID:29846316. |
flibanserin is a mixed 5-ht1a agonist and 5-ht2a antagonist for treatment of premenopausal women with hypoactive sexual desire disorder. |
2018-10-17 |
2023-08-13 |
Not clear |
| b' Aniela-Lumin\\xc5\\xa3a Rugin\\xc4\\x83, Otilia Fr\\xc4\\x83sinariu, Violeta Streang\\xc4\\x83, I S\\xc3\\xa2rbu, A C\\xc4\\x83r\\xc4\\x83uleanu, V G Rugin\\xc4\\x8. Topicalities in the Sudden Unexpected Death Syndrome in Infants. Revista medico-chirurgicala a Societatii de Medici si Naturalisti din Iasi. vol 120. issue 4. 2018-09-21. PMID:30137751.' |
sids victims can present sign of preexisting chronic asphyxia, persistent increase in dendritic spine and delayed maturation of synapses in medullary respiratory centers, if a decreased reactivity of 5 hydroxytryptamine 1a (5-ht1a) and 5-ht2a in the dorsal nucleus of the vagus, solitary nucleus and ventrolateral medulla. |
2018-09-21 |
2023-08-13 |
Not clear |
| Nasiara Karim, Imran Khan, Abeer Abdelhalim, Ajmal Khan, Sobia Ahsan Hali. Antidepressant potential of novel flavonoids derivatives from sweet violet (Viola odorata L): Pharmacological, biochemical and computational evidences for possible involvement of serotonergic mechanism. Fitoterapia. vol 128. 2018-07-20. PMID:29775777. |
and 5-ht receptor antagonists including way100635 (5-ht1a antagonist), ketanserin (a 5-ht2a antagonist) and ondansetron (5-ht3 antagonist) but not with prazosin (α1-adrenergic antagonist) and sch23390 (d1 dopaminergic antagonist) or haloperidol (d2 dopaminergic antagonist). |
2018-07-20 |
2023-08-13 |
mouse |
| b' Eldina Rizvi\\xc4\\x87, Goran Jankovi\\xc4\\x87, Sla\\xc4\\x91ana Kosti\\xc4\\x87-Raja\\xc4\\x8di\\xc4\\x87, Miroslav M Savi\\xc4\\x8. Atypical sympathomimetic drug lerimazoline mediates contractile effects in rat aorta predominantly by 5-HT2A receptors. Bosnian journal of basic medical sciences. vol 17. issue 3. 2018-07-12. PMID:28628756.' |
here, we analyzed the affinity of lerimazoline for dopamine receptor d2, serotonin 5-ht1a and 5-ht2a receptors and α1-adrenoceptor, and investigated lerimazoline contractile effects in isolated rat thoracic aorta. |
2018-07-12 |
2023-08-13 |
rat |
| Andrew M Wright, Agustin Zapata, Michael H Baumann, Joshua S Elmore, Alexander F Hoffman, Carl R Lupic. Enduring Loss of Serotonergic Control of Orbitofrontal Cortex Function Following Contingent and Noncontingent Cocaine Exposure. Cerebral cortex (New York, N.Y. : 1991). vol 27. issue 12. 2018-07-03. PMID:27733540. |
using whole-cell electrophysiology in brain slices from naïve rats we find that 5-ht1a receptors generate hyperpolarizing outward currents in layer-v ofc pyramidal neurons, and that 5-ht2a receptors increase glutamate release onto these cells. |
2018-07-03 |
2023-08-13 |
rat |
| Lyang Huh, Bong Ju Le. [Efficacy of low-Dose Aripiprazole to Treat Clozapine-Associated Tardive Dystonia in a Patient with Schizophrenia]. Turk psikiyatri dergisi = Turkish journal of psychiatry. vol 28. issue 3. 2018-05-25. PMID:28936820. |
aripiprazole is a dopamine d2 receptor partial agonist that exhibits partial agonistic activity against serotonin-1a (5-ht1a) receptors and full antagonistic activity against 5-ht2a receptors. |
2018-05-25 |
2023-08-13 |
Not clear |
| R L Carhart-Harris, D J Nut. Serotonin and brain function: a tale of two receptors. Journal of psychopharmacology (Oxford, England). vol 31. issue 9. 2018-05-17. PMID:28858536. |
in this present synthesis, we integrate previous perspectives with new and older data to create a novel bipartite model centred on the view that serotonin neurotransmission enhances two distinct adaptive responses to adversity, mediated in large part by its two most prevalent and researched brain receptors: the 5-ht1a and 5-ht2a receptors. |
2018-05-17 |
2023-08-13 |
Not clear |
| Madeline C Pelz, Kathleen D Schoolcraft, Chloe Larson, Mitchell G Spring, Hassan H Lópe. Assessing the role of serotonergic receptors in cannabidiol's anticonvulsant efficacy. Epilepsy & behavior : E&B. vol 73. 2018-03-19. PMID:28624721. |
furthermore, it tested whether cbd reduces seizure activity by interacting with either the serotonergic 5ht1a or 5ht2a receptor. |
2018-03-19 |
2023-08-13 |
human |
| Katherine M Serafine, Kenner C Rice, Charles P Franc. Characterization of the discriminative stimulus effects of lorcaserin in rats. Journal of the experimental analysis of behavior. vol 106. issue 2. 2018-01-29. PMID:27640338. |
these results suggest that, in addition to agonist properties at 5-ht2c receptors, lorcaserin also has agonist properties at 5-ht2a and 5-ht1a receptors. |
2018-01-29 |
2023-08-13 |
rat |