| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Anes Ju, Beatriz Fernandez-Arroyo, Yifan Wu, Débora Jacky, Anna Beyele. Expression of serotonin 1A and 2A receptors in molecular- and projection-defined neurons of the mouse insular cortex. Molecular brain. vol 13. issue 1. 2021-07-08. PMID:32594910. |
as an initial step to define the function of 5-ht transmission in the insula, we quantified the proportion of specific neuronal populations of the insula expressing 5-ht1a or 5-ht2a. |
2021-07-08 |
2023-08-13 |
mouse |
| Anes Ju, Beatriz Fernandez-Arroyo, Yifan Wu, Débora Jacky, Anna Beyele. Expression of serotonin 1A and 2A receptors in molecular- and projection-defined neurons of the mouse insular cortex. Molecular brain. vol 13. issue 1. 2021-07-08. PMID:32594910. |
these observations suggest that most glutamatergic neurons can respond to 5-ht through 5-ht1a or 5-ht2a in the insula, and that 5-ht directly affects a limited number of gabaergic neurons. |
2021-07-08 |
2023-08-13 |
mouse |
| Zohre Azimi, Ruxandra Barzan, Katharina Spoida, Tatjana Surdin, Patric Wollenweber, Melanie D Mark, Stefan Herlitze, Dirk Janck. Separable gain control of ongoing and evoked activity in the visual cortex by serotonergic input. eLife. vol 9. 2021-03-24. PMID:32252889. |
5-ht1a receptors promote divisive suppression of spontaneous activity, while 5-ht2a receptors act divisively on visual response gain and largely account for normalization of population responses over a range of visual contrasts in awake and anesthetized states. |
2021-03-24 |
2023-08-13 |
mouse |
| Matheus Libarino-Santos, Ana Catherine Gomes de Santana Santos, Elisangela G Cata-Preta, Thaísa Barros-Santos, Nina Rosa Nunes Brandão, Aurea Lorena Nunes Borges, Renan Santos-Baldaia, André W Hollais, Marilia A Baldaia, Laís F Berro, Eduardo A V Marinho, Roberto Frussa-Filho, Alexandre J Oliveira-Lim. Role of the treatment environment in the effects of aripiprazole on ethanol-induced behavioral sensitization and conditioned place preference in female mice. Drug and alcohol dependence. vol 208. 2021-01-18. PMID:31954952. |
evidence suggests that aripiprazole, a partial dopamine d2 and serotonin 5-ht1a receptor agonist and 5-ht2a receptor antagonist, show significant efficacy in reducing alcohol use. |
2021-01-18 |
2023-08-13 |
mouse |
| Tina Becher Østerbøg, Doan Minh On, Ignasi Oliveras, Cristóbal Río-Álamos, Ana Sanchez-Gonzalez, Carles Tapias-Espinosa, Adolf Tobeña, Javier González-Maeso, Alberto Fernández-Teruel, Susana Azna. Metabotropic Glutamate Receptor 2 and Dopamine Receptor 2 Gene Expression Predict Sensorimotor Gating Response in the Genetically Heterogeneous NIH-HS Rat Strain. Molecular neurobiology. vol 57. issue 3. 2020-12-04. PMID:31782106. |
expression levels of glutamate metabotropic receptor 2 (grm2), dopamine receptor d2 (drd2), dopamine receptor d1 (drd1), serotonin receptor 1a (htr1a), serotonin receptor 2a (htr2a) and homer scaffolding protein 1 (homer1) were investigated in prefrontal cortex (pfc) and striatum (str). |
2020-12-04 |
2023-08-13 |
rat |
| Dasiel O Borroto-Escuela, Xiang Li, Alexander O Tarakanov, David Savelli, Manuel Narváez, Kirill Shumilov, Yuniesky Andrade-Talavera, Antonio Jimenez-Beristain, Bartosz Pomierny, Zaida Díaz-Cabiale, Riccardo Cuppini, Patrizia Ambrogini, Maria Lindskog, Kjell Fux. Existence of Brain 5-HT1A-5-HT2A Isoreceptor Complexes with Antagonistic Allosteric Receptor-Receptor Interactions Regulating 5-HT1A Receptor Recognition. ACS omega. vol 2. issue 8. 2020-10-01. PMID:28920103. |
there are many 5-ht subtypes involved; some need to be blocked (e.g., 5-ht2a, 5-ht3, and 5-ht7), whereas others need to be activated (e.g., postjunctional 5-ht1a and 5-ht4). |
2020-10-01 |
2023-08-13 |
Not clear |
| Mingjun Xiang, Yuting Jiang, Zhiying Hu, Yang Yang, Xiaoxue Du, Benson Oa Botchway, Marong Fan. Serotonin receptors 2A and 1A modulate anxiety-like behavior in post-traumatic stress disordered mice. American journal of translational research. vol 11. issue 4. 2020-10-01. PMID:31105836. |
5-hydroxytryptamine receptors 2a and 1a (5-ht2a and 5-ht1a receptors) are most closely related to anxiety-like behavior in post-traumatic stress disorder. |
2020-10-01 |
2023-08-13 |
mouse |
| Mingjun Xiang, Yuting Jiang, Zhiying Hu, Yang Yang, Xiaoxue Du, Benson Oa Botchway, Marong Fan. Serotonin receptors 2A and 1A modulate anxiety-like behavior in post-traumatic stress disordered mice. American journal of translational research. vol 11. issue 4. 2020-10-01. PMID:31105836. |
c57bl/6 mice were exposed to conditioned fear stress combined with single-prolonged stress and injected with corresponding antagonists of 5-ht2a or 5-ht1a receptors or dmso. |
2020-10-01 |
2023-08-13 |
mouse |
| Mingjun Xiang, Yuting Jiang, Zhiying Hu, Yang Yang, Xiaoxue Du, Benson Oa Botchway, Marong Fan. Serotonin receptors 2A and 1A modulate anxiety-like behavior in post-traumatic stress disordered mice. American journal of translational research. vol 11. issue 4. 2020-10-01. PMID:31105836. |
protein expression levels of 5-ht2a and 5-ht1a receptors, erk1 and erk2, perk1, perk2 and c-myc in mice hippocampus were evaluated by western blot analysis and immunofluorescence labeling. |
2020-10-01 |
2023-08-13 |
mouse |
| Mingjun Xiang, Yuting Jiang, Zhiying Hu, Yang Yang, Xiaoxue Du, Benson Oa Botchway, Marong Fan. Serotonin receptors 2A and 1A modulate anxiety-like behavior in post-traumatic stress disordered mice. American journal of translational research. vol 11. issue 4. 2020-10-01. PMID:31105836. |
on the basis of our experimental results, we hypothesize interaction between 5-ht2a and 5-ht1a receptors in mouse hippocampus to mediate anxiety-like behavior via erk pathway. |
2020-10-01 |
2023-08-13 |
mouse |
| Harumasa Takan. Cognitive Function and Monoamine Neurotransmission in Schizophrenia: Evidence From Positron Emission Tomography Studies. Frontiers in psychiatry. vol 9. 2020-09-30. PMID:29896132. |
with regard to the serotonergic system, 5-ht1a and 5-ht2a receptors have been studied in the context of cognitive functions in schizophrenia. |
2020-09-30 |
2023-08-13 |
human |
| Siamak Shahidi, Nasrin Hashemi-Firouzi, Simin Afshar, Sara Soleimani Asl, Alireza Komak. Protective Effects of 5-HT1A Receptor Inhibition and 5-HT2A Receptor Stimulation Against Streptozotocin-Induced Apoptosis in the Hippocampus. The Malaysian journal of medical sciences : MJMS. vol 26. issue 2. 2020-09-29. PMID:31447607. |
protective effects of 5-ht1a receptor inhibition and 5-ht2a receptor stimulation against streptozotocin-induced apoptosis in the hippocampus. |
2020-09-29 |
2023-08-13 |
rat |
| Siamak Shahidi, Nasrin Hashemi-Firouzi, Simin Afshar, Sara Soleimani Asl, Alireza Komak. Protective Effects of 5-HT1A Receptor Inhibition and 5-HT2A Receptor Stimulation Against Streptozotocin-Induced Apoptosis in the Hippocampus. The Malaysian journal of medical sciences : MJMS. vol 26. issue 2. 2020-09-29. PMID:31447607. |
the present study examined the ability of selective 5-ht1a receptor antagonist (nad-299) and 5-ht2a receptor agonist (tcb-2) to attenuate the apoptosis caused by the icv-stz in the rat. |
2020-09-29 |
2023-08-13 |
rat |
| Lakshmi N Yatham, Eduard Vieta, Roger S McIntyre, Rakesh Jain, Mehul Patel, Willie Earle. Broad Efficacy of Cariprazine on Depressive Symptoms in Bipolar Disorder and the Clinical Implications. The primary care companion for CNS disorders. vol 22. issue 5. 2020-09-29. PMID:32942346. |
cariprazine, a dopamine d₃-preferring d₃/d₂ receptor partial agonist with serotonin 5-ht1a receptor partial agonist and serotonin 5-ht2a antagonist properties, is approved to treat manic and depressive episodes of bipolar disorder. |
2020-09-29 |
2023-08-13 |
Not clear |
| Jaime Lee, Shane Thwaites, Andrea Gogos, Maarten van den Buus. Pharmacological Mechanisms Involved in Sensory Gating Disruption Induced by (±)-3,4-Methylene- Dioxymethamphetamine (MDMA): Relevance to Schizophrenia. Brain sciences. vol 10. issue 1. 2020-09-28. PMID:31941052. |
these and previous results suggest that mdma targets serotonergic pathways, involving both 5-ht1a and 5-ht2a receptors, leading to dopaminergic activation, involving both d1 and d2 receptors, and ultimately sensory gating deficits. |
2020-09-28 |
2023-08-13 |
rat |
| Gabriel Araujo Tavares, Amada Torres, Julliet Araujo de Souz. Early Life Stress and the Onset of Obesity: Proof of MicroRNAs' Involvement Through Modulation of Serotonin and Dopamine Systems' Homeostasis. Frontiers in physiology. vol 11. 2020-09-28. PMID:32848865. |
the first pieces of evidence highlight the presence of the mir-16 in the regulation of the serotonin transporter (sert) as well as the receptors 1a (5ht1a) and 2a (5ht2a). |
2020-09-28 |
2023-08-13 |
Not clear |
| Christoph U Correl. Current Treatment Options and Emerging Agents for Schizophrenia. The Journal of clinical psychiatry. vol 81. issue 3. 2020-09-14. PMID:32297721. |
mechanisms of action that are under investigation include dopamine d3 antagonism/serotonin 5-ht1a partial agonism; combined dopamine, serotonin, and glutamate modulation; phosphodiesterase 10a inhibition; trace amine-associated receptor-1 (taar1) agonism plus 5-ht1a agonism; 5-ht2a inverse agonism; sigma-2/5-ht2a antagonism; d-amino acid oxidase (daao) inhibition; glycine transporter-1 inhibition; vesicular monoamine transporter-2 antagonism; mu opioid antagonism added to olanzapine; and novel long-acting injectable antipsychotic formulations. |
2020-09-14 |
2023-08-13 |
Not clear |
| Betina Elfving, Heidi Kaastrup Müller, Ignasi Oliveras, Tina Becher Østerbøg, Cristobal Rio-Alamos, Ana Sanchez-Gonzalez, Adolf Tobeña, Alberto Fernandez-Teruel, Susana Azna. Differential expression of synaptic markers regulated during neurodevelopment in a rat model of schizophrenia-like behavior. Progress in neuro-psychopharmacology & biological psychiatry. vol 95. 2020-08-28. PMID:31228641. |
we performed a comprehensive characterization of the rha-i/rla-i rats by real-time qpcr and western blotting for 5-ht1a, 5-ht2a, mglu2, dopamine 1 and dopamine 2 receptors (drd1 and drd2), ampa receptor subunits gria1, gria2 and nmda receptor subunits grin1, grin2a and grin2b, as well as pre- and post-synaptic components in pfc and hippocampus (hip). |
2020-08-28 |
2023-08-13 |
rat |
| Hatylas Azevedo, Marcos Ferreira, Renata Watanabe Costa, Valter Russo, Elisa Russo, Alessandra Mascarello, Cristiano Ruch Werneck Guimarãe. Preclinical characterization of ACH-000029, a novel anxiolytic compound acting on serotonergic and alpha-adrenergic receptors. Progress in neuro-psychopharmacology & biological psychiatry. vol 95. 2020-08-26. PMID:31330215. |
this compound acts at selected serotonergic (5-ht1a and 5-ht1d partial agonism and 5-ht2a antagonism) and α-adrenergic (α-1a, 1b and 1d antagonism) receptors, with good selectivity over other g-protein-coupled receptors. |
2020-08-26 |
2023-08-13 |
Not clear |
| Louisa J. Steinberg, Mark D. Underwood, Mihran J. Bakalian, Suham A. Kassir, J. John Mann, Victoria Arang. 5-HT1A receptor, 5-HT2A receptor and serotonin transporter binding in the human auditory cortex in depression Journal of psychiatry & neuroscience : JPN. vol 44. issue 5. 2020-06-22. PMID:31120232. |
5-ht1a receptor, 5-ht2a receptor and serotonin transporter binding in the human auditory cortex in depression serotonergic system abnormalities are implicated in many psychiatric disorders, including major depression. |
2020-06-22 |
2023-08-13 |
human |