| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| b' Jelena Nikoli\\xc4\\x87, Katarina Vukojevi\\xc4\\x87, Violeta \\xc5\\xa0olji\\xc4\\x87, Josip Mi\\xc5\\xa1kovi\\xc4\\x87, Martina Orlovi\\xc4\\x87 Vlaho, Mirna Saraga-Babi\\xc4\\x87, Natalija Filipovi\\xc4\\x8. Expression Patterns of Serotonin Receptors 5-HT1A, 5-HT2A, and 5-HT3A during Human Fetal Lung Development. International journal of molecular sciences. vol 24. issue 3. 2023-02-11. PMID:36769290.' |
we analyzed the expression of the serotonin receptors 5-ht1a, 5-ht2a, and 5-ht3a at four different stages of fetal lung development from 12 to 40 weeks of gestation, divided into four groups: the pseudoglandular stage (12-16th week of development; |
2023-02-11 |
2023-08-14 |
human |
| Faiq Amin, Mahmoud A A Ibrahim, Syed Rizwan-Ul-Hasan, Saima Khaliq, Gamal A Gabr, Muhammad, Asra Khan, Peter A Sidhom, Prashant Tikmani, Ahmed M Shawky, Saara Ahmad, Syed Hani Abid. Interactions of Apigenin and Safranal with the 5HT1A and 5HT2A Receptors and Behavioral Effects in Depression and Anxiety: A Molecular Docking, Lipid-Mediated Molecular Dynamics, and In Vivo Analysis. Molecules (Basel, Switzerland). vol 27. issue 24. 2022-12-23. PMID:36557792. |
interactions of apigenin and safranal with the 5ht1a and 5ht2a receptors and behavioral effects in depression and anxiety: a molecular docking, lipid-mediated molecular dynamics, and in vivo analysis. |
2022-12-23 |
2023-08-14 |
Not clear |
| João P F Kurita, Anderson H F F Leão, Vinicius S Bioni, Raphael Wuo-Silva, Alvaro C Lima, Murilo A Paiva-Santos, Gabriela F Marinho, Débora M G Cunha, Marcela Becegato, Leonardo B Lopes-Silva, Alessandra M Ribeiro, Regina H Silv. Memory and anxiety-like behavior of rats in the plus-maze discriminative avoidance task: Role of serotonergic transmission in the basolateral amygdala. Behavioral neuroscience. 2022-12-22. PMID:36548050. |
the results showed that an increase in serotonin (5-ht) availability or the blockade of 5ht1a and 5ht2a bla receptors impaired aversive memory formation. |
2022-12-22 |
2023-08-14 |
rat |
| Orr Shahar, Alexander Botvinnik, Noam Esh-Zuntz, Michal Brownstien, Rachel Wolf, Amit Lotan, Gilly Wolf, Bernard Lerer, Tzuri Lifschyt. Role of 5-HT2A, 5-HT2C, 5-HT1A and TAAR1 Receptors in the Head Twitch Response Induced by 5-Hydroxytryptophan and Psilocybin: Translational Implications. International journal of molecular sciences. vol 23. issue 22. 2022-11-26. PMID:36430623. |
role of 5-ht2a, 5-ht2c, 5-ht1a and taar1 receptors in the head twitch response induced by 5-hydroxytryptophan and psilocybin: translational implications. |
2022-11-26 |
2023-08-14 |
mouse |
| Ho-Geun Kang, Hee-Yun Kim, Hyunwoo Jee, Hwanseok Jun, Hosong Cho, Dongjun Park, Hyun-Jong Ahn, Hyung-Min Kim, Hyun-Ja Jeon. Compound of Cynanchum wilfordii and Humulus lupulus L. Ameliorates Menopausal Symptoms in Ovariectomized Mice. Reproductive sciences (Thousand Oaks, Calif.). 2022-11-05. PMID:36333646. |
values for hypothalamic serotonin (5-ht), dopamine, norepinephrine, estrogen receptor (er)-β, 5-ht1a, and 5-ht2a were significantly enhanced, while value for hypothalamic monoamine oxidase a was reduced in cwhl and caudatin groups compared with the ovx group. |
2022-11-05 |
2023-08-14 |
mouse |
| Bernardo Lopez-Torres, Irma Ares, Marta Martínez, Jorge-Enrique Maximiliano, María-Rosa Martínez-Larrañaga, Arturo Anadón, María-Aránzazu Martíne. Neurotoxicity induced by the pyrethroid lambda-cyhalothrin: Alterations in monoaminergic systems and dopaminergic and serotoninergic pathways in the rat brain. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2022-09-20. PMID:36126889. |
this research study also showed in hippocampus and prefrontal cortex, that lambda-cyhalothrin modified the mrna levels of da transporter gene (dat1 up-regulation), 5-ht transporter gene (sert down-regulation), da receptor genes (drd1and drd2 down-regulation), 5-ht receptor genes (5-ht1a and 5-ht2a down-regulation/up-regulation), da synthesis gene (th down-regulation), 5-ht synthesis gene (tph2 down-regulation), da and 5-ht degradation genes (maoa and maob up-regulation). |
2022-09-20 |
2023-08-14 |
rat |
| Dominique F Leitner, Sasha Devore, Juliana Laze, Daniel Friedman, James D Mills, Yan Liu, Michael Janitz, Jasper J Anink, Johannes C Baayen, Sander Idema, Erwin A van Vliet, Beate Diehl, Catherine Scott, Roland Thijs, Maromi Nei, Manor Askenazi, Shobi Sivathamboo, Terence O'Brien, Thomas Wisniewski, Maria Thom, Eleonora Aronica, Maura Boldrini, Orrin Devinsk. Serotonin Receptor Expression in Hippocampus and Temporal Cortex of TLE Patients by PGES Duration. Epilepsia. 2022-09-02. PMID:36053862. |
to better understand molecular mechanisms, pges duration was correlated to 5ht1a and 5ht2a receptor protein expression and rnaseq from resected hippocampus and temporal cortex of temporal lobe epilepsy (tle) patients with seizures recorded in preoperative evaluation. |
2022-09-02 |
2023-08-14 |
Not clear |
| I E Sorokin, V S Evsyukova, A V Kuliko. Effect of Short Photoperiod on the Behavior and Brain Serotonin System in Zebrafish Danio rerio. Bulletin of experimental biology and medicine. 2022-07-17. PMID:35844021. |
we studied changes in the behavior, content of 5-ht and its major metabolite 5-hydroxyindoleacetic acid (5-hiaa), and the expression of genes encoding the key enzymes of 5-ht metabolism, tryptophan hydroxylases tph1a, tph1b, tph2, monoamine oxidase (mao), 5-ht transporter, and 5-ht1a and 5-ht2a receptors in the brain of zebrafish reared for 60 days under short (04:20 h) compared to those reared at normal (12:12 h) photoperiod. |
2022-07-17 |
2023-08-14 |
zebrafish |
| Filipa Viegas, Tiago Ferreira, Cláudia Campo. Using Cariprazine to Ameliorate Negative Symptoms and Metabolic Side Effects of Clozapine and Paliperidone - Clinical Cases. Neuropsychiatric disease and treatment. vol 18. 2022-06-17. PMID:35712695. |
it presents distinct pharmacodynamic properties, such as d3/d2 partial agonism, preferential binding to d3 receptors, antagonism at the serotonin 5-ht2a and 5-ht2b receptors, partial agonism at 5-ht1a receptors, and low affinity to other receptors (including noradrenergic, histaminergic, and cholinergic). |
2022-06-17 |
2023-08-14 |
Not clear |
| Emanuela Dyrmishi, Marco De Pieri, Marco Ferrari, Rafael Traber, Matteo Preve, Luca De Peri, Emilio Boll. Case Report: Long-Acting Oral Cariprazine. Frontiers in psychiatry. vol 13. 2022-05-16. PMID:35573352. |
cariprazine is a partial agonist at dopamine receptors d2 and d3 and serotonin receptor 5ht1a and an antagonist at serotonin receptors 5ht2b and 5ht2a. |
2022-05-16 |
2023-08-13 |
Not clear |
| Tara P Cominski, Victoria Stiritz, Kevin D Bec. The Effects of Mild Traumatic Brain Injury (mTBI) on Serotonergic Gene Expression. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 36 Suppl 1. 2022-05-13. PMID:35554362. |
changes in expression levels of the 5ht1a and 5ht2a receptor genes were also seen in the frontal cortex, prefrontal cortex, and ventral hippocampus. |
2022-05-13 |
2023-08-13 |
human |
| Yasuhiro Kyono, Lori Ellezian, YueYue Hu, Kanella Eliadis, Junlone Moy, Elizabeth B Hirsch, Michael J Federle, Stephanie A Flower. The Atypical Antipsychotic Quetiapine Promotes Multiple Antibiotic Resistance in Escherichia coli. Journal of bacteriology. 2022-04-13. PMID:35416690. |
while aaps primarily target dopamine (d2) and serotonin (5ht2a and 5ht1a) receptors, they also exhibit intrinsic antimicrobial activity as an off-target effect. |
2022-04-13 |
2023-08-13 |
Not clear |
| Ashish Patel, Arya Patel, Darshini Patel, Krina Patel, Tushar Bambharoliy. Mini Review on Cariprazine: A Promising Antipsychotic Agent. CNS & neurological disorders drug targets. 2022-03-25. PMID:35331126. |
however, due to the partial agonist action on dopamine d2, d3 receptors, and serotonin 5-ht1a receptors as well as antagonist effect on 5-ht2a, 5-ht2b, and h1 receptors, cariprazine differentiate pharmacologically from other apds, both typical and atypical. |
2022-03-25 |
2023-08-13 |
Not clear |
| Lila Wollman, Andrew Hill, Brady Hasse, Christina Young, Giovanni Hernandez-De La Pena, Richard B Levine, Ralph F Fregos. Influence of developmental nicotine exposure on serotonergic control of breathing-related motor output. Developmental neurobiology. 2022-01-11. PMID:35016263. |
we applied 5ht alone, or together with antagonists of 5ht1a, 5ht2a or 5ht7 receptor subtypes. |
2022-01-11 |
2023-08-13 |
rat |
| Tomasz Pawlowski, Dariusz Pawlak, Malgorzata Inglot, Malgorzata Zalewska, Dominik Marciniak, Jolanta Bugajska, Justyna Janocha-Litwin, Krzysztof Malyszcza. The role of anthranilic acid in the increase of depressive symptoms and major depressive disorder during treatment for hepatitis C with pegylated interferon-α2a and oral ribavirin. Journal of psychiatry & neuroscience : JPN. vol 46. issue 1. 2021-10-26. PMID:33464780. |
dysregulation of serotonergic transmission can stem from the direct influence of interferon-α on the activity of serotonergic receptors 5-ht1a and 5-ht2a, and from its indirect effect on tryptophan metabolism. |
2021-10-26 |
2023-08-13 |
Not clear |
| João Castelhano, Gisela Lima, Marta Teixeira, Carla Soares, Marta Pais, Miguel Castelo-Branc. The Effects of Tryptamine Psychedelics in the Brain: A meta-Analysis of Functional and Review of Molecular Imaging Studies. Frontiers in pharmacology. vol 12. 2021-10-22. PMID:34658876. |
we did indeed find that regions with changed connectivity and/or activation patterns match regions with high density of 5ht2a receptors, namely visual ba19, visual fusiform regions in ba37, dorsal anterior and posterior cingulate cortex, medial prefrontal cortex, and regions involved in theory of mind such as the surpramarginal gyrus, and temporal cortex (rich in 5ht1a receptors). |
2021-10-22 |
2023-08-13 |
Not clear |
| Jan Terock, Antoine Weihs, Alexander Teumer, Johanna Klinger-König, Deborah Janowitz, Hans J Grab. Associations and interactions of the serotonin receptor genes 5-HT1A, 5-HT2A, and childhood trauma with alexithymia in two independent general-population samples. Psychiatry research. vol 298. 2021-08-19. PMID:33567384. |
specifically, genetic polymorphisms of the serotonin receptors 5-ht1a and 5-ht2a were found to be associated with alexithymia. |
2021-08-19 |
2023-08-13 |
human |
| Nicholas Keks, Judith Hope, Darren Schwartz, Harold McLennan, David Copolov, Graham Meadow. Comparative Tolerability of Dopamine D2/3 Receptor Partial Agonists for Schizophrenia. CNS drugs. vol 34. issue 5. 2021-08-05. PMID:32246399. |
in contrast to aripiprazole, brexpiprazole has lower intrinsic dopamine d2 activity and higher affinity for the serotonin 5-ht1a and 5-ht2a receptors, while cariprazine has the highest affinity for the dopamine d3 receptor, and the longest half-life. |
2021-08-05 |
2023-08-13 |
Not clear |
| Sun A Ki. 5-HT1A and 5-HT2A Signaling, Desensitization, and Downregulation: Serotonergic Dysfunction and Abnormal Receptor Density in Schizophrenia and the Prodrome. Cureus. vol 13. issue 6. 2021-07-27. PMID:34306878. |
5-ht1a and 5-ht2a signaling, desensitization, and downregulation: serotonergic dysfunction and abnormal receptor density in schizophrenia and the prodrome. |
2021-07-27 |
2023-08-13 |
Not clear |
| Anes Ju, Beatriz Fernandez-Arroyo, Yifan Wu, Débora Jacky, Anna Beyele. Expression of serotonin 1A and 2A receptors in molecular- and projection-defined neurons of the mouse insular cortex. Molecular brain. vol 13. issue 1. 2021-07-08. PMID:32594910. |
interestingly, recent studies in human and non-human primates have shown that the 5-ht1a and 5-ht2a binding potentials within the insular cortex (insula) are correlated to anxiety. |
2021-07-08 |
2023-08-13 |
mouse |