| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| D L Li, R M Simmons, S Iyenga. 5HT1A receptor antagonists enhance the functional activity of fluoxetine in a mouse model of feeding. Brain research. vol 781. issue 1-2. 1998-04-29. PMID:9507085. |
a combination of a 5ht1a receptor antagonist and fluoxetine has been previously reported to enhance extracellular levels of serotonin over what is obtained with fluoxetine alone. |
1998-04-29 |
2023-08-12 |
mouse |
| D L Li, R M Simmons, S Iyenga. 5HT1A receptor antagonists enhance the functional activity of fluoxetine in a mouse model of feeding. Brain research. vol 781. issue 1-2. 1998-04-29. PMID:9507085. |
a 10 mg/kg dose of fluoxetine, which was ineffective by itself, was then combined either with 5-hydroxytryptophan (5htp), a serotonin precursor, or with s(-) pindolol, a 5ht1a/beta adrenergic receptor antagonist or with ly206130, a more selective 5ht1a receptor antagonist. |
1998-04-29 |
2023-08-12 |
mouse |
| D L Willins, H Y Meltze. Serotonin 5-HT2C agonists selectively inhibit morphine-induced dopamine efflux in the nucleus accumbens. Brain research. vol 781. issue 1-2. 1998-04-29. PMID:9507167. |
in order to determine if inhibition of the firing of 5-ht neurons contributes to the serotonin agonist-mediated inhibition of morphine-induced accumbens da release, rats were pretreated with the 5-ht1a agonist, 8-ohdpat. |
1998-04-29 |
2023-08-12 |
rat |
| I Nagaoka, M Sasa, S Yamawak. 5-HT1A receptor-mediated inhibition of nucleus accumbens neurons activated by stimulation of parafascicular nucleus of thalamus. Psychopharmacology. vol 135. issue 3. 1998-04-23. PMID:9498725. |
extracellular neuronal activities were recorded in acc using a glass microelectrode attached along a seven-barreled micropipette, each barrel of which was filled with dopamine, 5-ht, 8-hydroxy-2-(di-n-propylamino)tetralin (8-oh-dpat: 5-ht1a agonist) hydrobromide, 1-(2-methoxyphenyl)-4-[4-(2-phthalimido)butyl]-piperazine (nan-190: 5-ht1a antagonist) hydrobromide, glutamate and 2 m nacl. |
1998-04-23 |
2023-08-12 |
rat |
| I Nagaoka, M Sasa, S Yamawak. 5-HT1A receptor-mediated inhibition of nucleus accumbens neurons activated by stimulation of parafascicular nucleus of thalamus. Psychopharmacology. vol 135. issue 3. 1998-04-23. PMID:9498725. |
these findings suggest that the dopamine-sensitive acc neurons receiving input from pf are inhibited by 5-ht via 5-ht1a receptors located on postsynaptic acc neurons. |
1998-04-23 |
2023-08-12 |
rat |
| H Nagayama, J Q L. Circadian and circannual rhythms in the function of central 5-HT1A receptors in laboratory rats. Psychopharmacology. vol 135. issue 3. 1998-04-23. PMID:9498731. |
in order to elucidate whether a circannual rhythm exists in the function of the central serotonin (5-ht) system, we examined the responsiveness of rats to a selective 5-ht1a agonist, 8-hydroxy-2-(di-n-propylamino) tetralin (8-oh-dpat), at different hours of the day in different seasons. |
1998-04-23 |
2023-08-12 |
rat |
| S Kostic-Rajacic, V Soskic, J Joksimovi. Mixed dopaminergic/serotonergic properties of several 2-substituted 4-[2-(5-benzimidazole)ethyl]-1-arylpiperazines. Archiv der Pharmazie. vol 331. issue 1. 1998-04-16. PMID:9507698. |
they were evaluated for in vitro binding affinity at the d1 and d2 dopamine and 5-ht1a serotonin receptors using synaptosomal membranes of the bovine caudate nuclei and hippocampi, respectively. |
1998-04-16 |
2023-08-12 |
cattle |
| D Wustrow, T Belliotti, S Glase, S R Kesten, D Johnson, N Colbry, R Rubin, A Blackburn, H Akunne, A Corbin, M D Davis, L Georgic, S Whetzel, K Zoski, T Heffner, T Pugsley, L Wis. Aminopyrimidines with high affinity for both serotonin and dopamine receptors. Journal of medicinal chemistry. vol 41. issue 5. 1998-04-14. PMID:9513604. |
a series of [4-[2(4-arylpiperazin-1-yl)alkyl]cyclohexyl]pyrimidin-2-ylamine s was prepared and found to have receptor binding affinity for d2 and d3 dopamine (da) receptors and serotonin 5-ht1a receptors. |
1998-04-14 |
2023-08-12 |
Not clear |
| D Wustrow, T Belliotti, S Glase, S R Kesten, D Johnson, N Colbry, R Rubin, A Blackburn, H Akunne, A Corbin, M D Davis, L Georgic, S Whetzel, K Zoski, T Heffner, T Pugsley, L Wis. Aminopyrimidines with high affinity for both serotonin and dopamine receptors. Journal of medicinal chemistry. vol 41. issue 5. 1998-04-14. PMID:9513604. |
compound 14 (pd 158771) had a profile indicative of partial agonist activity at both d2 and 5-ht1a receptors causing partially decreased synthesis of the neurotransmitters da and 5-ht and their metabolites. |
1998-04-14 |
2023-08-12 |
Not clear |
| R Corradetti, N Laaris, N Hanoun, A M Laporte, E Le Poul, M Hamon, L Lanfume. Antagonist properties of (-)-pindolol and WAY 100635 at somatodendritic and postsynaptic 5-HT1A receptors in the rat brain. British journal of pharmacology. vol 123. issue 3. 1998-04-13. PMID:9504386. |
(-)-pindolol also prevented the 5-ht1a receptor-mediated hyperpolarization of ca1 pyramidal cells due to 5-ht (15 microm). |
1998-04-13 |
2023-08-12 |
rat |
| M Pallotta, J Segieth, P S Whitto. N-methyl-d-aspartate receptors regulate 5-HT release in the raphe nuclei and frontal cortex of freely moving rats: differential role of 5-HT1A autoreceptors. Brain research. vol 783. issue 2. 1998-04-13. PMID:9507110. |
n-methyl-d-aspartate receptors regulate 5-ht release in the raphe nuclei and frontal cortex of freely moving rats: differential role of 5-ht1a autoreceptors. |
1998-04-13 |
2023-08-12 |
rat |
| J De Vry, R Schohe-Loop, H G Heine, J M Greuel, F Mauler, B Schmidt, H Sommermeyer, T Glase. Characterization of the aminomethylchroman derivative BAY x 3702 as a highly potent 5-hydroxytryptamine1A receptor agonist. The Journal of pharmacology and experimental therapeutics. vol 284. issue 3. 1998-04-09. PMID:9495870. |
the aminomethylchroman derivative bay x 3702 (r-(-)-2-[4-[(chroman-2-ylmethyl)-amino]-butyl]-1,1-dioxo-benzo[d] isothiazolone hydrochloride) is a new high affinity 5-hydroxytryptamine (5-ht)1a receptor ligand [calf hippocampus: ki: 0.19 nm; reference compounds 8-hydroxy-2-(di-n-propylamino)-tetralin (8-oh-dpat) and ipsapirone: 0.98 and 2.56, respectively; rat cortex: 0.24 nm; rat hippocampus: 0.58 nm; human cortex and recombinant 5-ht1a receptors: 0.25 and 0.4 nm, respectively]. |
1998-04-09 |
2023-08-12 |
human |
| D Y Okuhara, S G Bec. Corticosteroids alter 5-hydroxytryptamine1A receptor-effector pathway in hippocampal subfield CA3 pyramidal cells. The Journal of pharmacology and experimental therapeutics. vol 284. issue 3. 1998-04-09. PMID:9495887. |
corticosteroids altered the characteristics of the 5-ht concentration-response curve for the 5-ht1a receptor. |
1998-04-09 |
2023-08-12 |
rat |
| M Rinke, E M Bomhard, H Hildebrand, K H Leser, I Loof, C Ruehl-Fehler. Serotonin (5-HT1A-receptor) agonist-induced collecting duct vacuolation and renal papillary necrosis in the rat. Toxicologic pathology. vol 26. issue 1. 1998-04-09. PMID:9502398. |
ipsapirone also represents a serotonin (5-ht1a) receptor agonist and was under development as an anxiolytic drug. |
1998-04-09 |
2023-08-12 |
mouse |
| I Shim, J Javaid, D Wirtshafte. Dissociation of hippocampal serotonin release and locomotor activity following pharmacological manipulations of the median raphe nucleus. Behavioural brain research. vol 89. issue 1-2. 1998-04-03. PMID:9475626. |
in contrast, the serotonin (5-ht1a) agonist 8-ohdpat (5 microg) produced only a small effect on locomotor activity but reduced hippocampal serotonin output by 51%. |
1998-04-03 |
2023-08-12 |
rat |
| H Onimaru, A Shamoto, I Homm. Modulation of respiratory rhythm by 5-HT in the brainstem-spinal cord preparation from newborn rat. Pflugers Archiv : European journal of physiology. vol 435. issue 4. 1998-03-31. PMID:9446695. |
in addition to effects via 5-ht1a receptors, activation of 5-ht2a and 5-ht2c receptor subtypes might be involved in excitatory effects and inhibitory effects of 5-ht respectively. |
1998-03-31 |
2023-08-12 |
rat |
| S E Welsh, W J Kachelries, A G Romano, K J Simansky, J A Harve. Effects of LSD, ritanserin, 8-OH-DPAT, and lisuride on classical conditioning in the rabbit. Pharmacology, biochemistry, and behavior. vol 59. issue 2. 1998-03-31. PMID:9476997. |
d-lysergic acid diethylamide (lsd), an agonist at the 5-ht(2a/2c) and 5-ht1a receptors, has previously been demonstrated to enhance associative learning as measured by accelerated acquisition of the rabbit's classically conditioned nictitating membrane (nm) response. |
1998-03-31 |
2023-08-12 |
rabbit |
| G Maura, M Marcoli, M Tortarolo, G C Andrioli, M Raiter. Glutamate release in human cerebral cortex and its modulation by 5-hydroxytryptamine acting at h 5-HT1D receptors. British journal of pharmacology. vol 123. issue 1. 1998-03-30. PMID:9484853. |
selective 5-ht1a receptor antagonists could not prevent the inhibition of glutamate release by 5-ht. |
1998-03-30 |
2023-08-12 |
human |
| S Maione, E Palazzo, M Pallotta, J Leyva, L Berrino, F Ross. Effects of imipramine on raphe nuclei and prefrontal cortex extracellular serotonin levels in the rat. Psychopharmacology. vol 134. issue 4. 1998-03-17. PMID:9452183. |
pretreatment with (-)pindolol (5 mg/kg s.c.), a non-selective 5-ht1a subtype receptor antagonist, 30 min before imipramine 5 mg/kg, modified the effect of the antidepressant: an increase, instead of a decrease, on prefrontal cortex dialysate 5-ht was observed. |
1998-03-17 |
2023-08-12 |
rat |
| D S Dupuis, C Palmier, F C Colpaert, P J Pauwel. Autoradiography of serotonin 5-HT1A receptor-activated G proteins in guinea pig brain sections by agonist-stimulated [35S]GTPgammaS binding. Journal of neurochemistry. vol 70. issue 3. 1998-03-12. PMID:9489749. |
autoradiography of serotonin 5-ht1a receptor-activated g proteins in guinea pig brain sections by agonist-stimulated [35s]gtpgammas binding. |
1998-03-12 |
2023-08-12 |
Not clear |