| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| P Soares-da-Silva, P C Pinto-do-O, A M Bertorell. Antagonistic actions of renal dopamine and 5-hydroxytryptamine: increase in Na+, K(+)-ATPase activity in renal proximal tubules via activation of 5-HT1A receptors. British journal of pharmacology. vol 117. issue 6. 1996-12-11. PMID:8882616. |
antagonistic actions of renal dopamine and 5-hydroxytryptamine: increase in na+, k(+)-atpase activity in renal proximal tubules via activation of 5-ht1a receptors. |
1996-12-11 |
2023-08-12 |
Not clear |
| P Soares-da-Silva, P C Pinto-do-O, A M Bertorell. Antagonistic actions of renal dopamine and 5-hydroxytryptamine: increase in Na+, K(+)-ATPase activity in renal proximal tubules via activation of 5-HT1A receptors. British journal of pharmacology. vol 117. issue 6. 1996-12-11. PMID:8882616. |
it is concluded that activation of 5-ht1a receptors increases na+, k(+)-atpase activity in renal cortical tubules; this effect may represent an important cellular mechanism, at the tubule level, responsible for the antinatriuretic effect of 5-ht. |
1996-12-11 |
2023-08-12 |
Not clear |
| A Newman-Tancredi, C Chaput, L Verrièle, M J Milla. S 15535 and WAY 100,635 antagonise 5-HT-stimulated [35S]GTP gamma S binding at cloned human 5-HT1A receptors. European journal of pharmacology. vol 307. issue 1. 1996-12-10. PMID:8831111. |
in chinese hamster ovary (cho) cells expressing cloned human 5-ht1a receptors, s 15535 (4-(benzodioxan-5-yl)1-(indan-2-yl)piperazine) exhibited high affinity (ki = 0.79 nm), similar to that of 5-ht (0.61 nm), (+/-)-8-hydroxy-3-(di-n-propylamino)tetralin ((+/-)-8-oh-dpat; 0.58 nm) and n-{2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl}-n- (2-pyridinyl)cyclo-hexanecarboxamide (way 100.635; 0.56 nm). |
1996-12-10 |
2023-08-12 |
human |
| A Newman-Tancredi, C Chaput, L Verrièle, M J Milla. S 15535 and WAY 100,635 antagonise 5-HT-stimulated [35S]GTP gamma S binding at cloned human 5-HT1A receptors. European journal of pharmacology. vol 307. issue 1. 1996-12-10. PMID:8831111. |
in conclusion, s 15535 antagonises the stimulation of 5-ht1a receptors by 5-ht, whilst itself exerting weak partial agonist activity at these sites. |
1996-12-10 |
2023-08-12 |
human |
| M L Wadenber. Serotonergic mechanisms in neuroleptic-induced catalepsy in the rat. Neuroscience and biobehavioral reviews. vol 20. issue 2. 1996-12-06. PMID:8811720. |
there is strong evidence to suggest that (1) the catalepsy produced by dopamine d1 or d2 receptor antagonists can be completely antagonized by the administration of 5-ht1a receptor agonists acting at 5-ht autoreceptors in the median raphe nucleus; (2) the catalepsy produced by a dopamine d2 receptor antagonist can be completely antagonized by treatment with a 5-ht2a/c receptor agonist; and (3) the catalepsy produced by blockade of either dopamine d1 or d2 receptors is not affected by the administration of a 5-ht2a/c receptor antagonist. |
1996-12-06 |
2023-08-12 |
rat |
| L J Larson-Prior, R M Bushey, L W Maines, J M Lakosk. Identification of central 5-HT and 5-HT1A receptors in the turtle brain (Chrysemys picta). Neuroscience letters. vol 212. issue 2. 1996-12-06. PMID:8832643. |
identification of central 5-ht and 5-ht1a receptors in the turtle brain (chrysemys picta). |
1996-12-06 |
2023-08-12 |
Not clear |
| L J Larson-Prior, R M Bushey, L W Maines, J M Lakosk. Identification of central 5-HT and 5-HT1A receptors in the turtle brain (Chrysemys picta). Neuroscience letters. vol 212. issue 2. 1996-12-06. PMID:8832643. |
radiologand binding studies were undertaken in the turtle whole brain, cerebellum and raphe using the selective radioligands [3h]5-hydroxytryptamine trifluoroacetate ([3h]5-ht) amd [3h]+/-8-hydroxy-2-(di-n-propylamino) tetralin hydrobromide ([3h]dpat) to identify serotonin (5-ht) receptors and the specific 5-ht1a receptor subtype. |
1996-12-06 |
2023-08-12 |
Not clear |
| J R Grider, J F Kuemmerle, J G Ji. 5-HT released by mucosal stimuli initiates peristalsis by activating 5-HT4/5-HT1p receptors on sensory CGRP neurons. The American journal of physiology. vol 270. issue 5 Pt 1. 1996-12-06. PMID:8967488. |
release of cgrp induced by exogenous 5-ht or mucosal stimulation was inhibited by selective 5-ht4 and 5-ht1p antagonists but was not affected by 5-ht1a, 5-ht2, and 5-ht3 antagonists. |
1996-12-06 |
2023-08-12 |
rat |
| C Sánchez, J Arnt, E K Moltze. The antiaggressive potency of (-)-penbutolol involves both 5-HT1A and 5-HT1B receptors and beta-adrenoceptors. European journal of pharmacology. vol 297. issue 1-2. 1996-12-05. PMID:8851159. |
(-)-penbutolol had high affinity for 5-ht1a receptors and beta-adrenoceptors, and antagonized the 5-methoxy-n,n-dimethyltryptamine (5-meodmt)-induced 5-ht syndrome and the 8-hydroxy-2-(di-n-propylamin)tetralin (8-oh-dpat)-induced discriminatory stimulus in rats. |
1996-12-05 |
2023-08-12 |
mouse |
| M A Geye. Serotonergic functions in arousal and motor activity. Behavioural brain research. vol 73. issue 1-2. 1996-12-04. PMID:8788473. |
thus, studies of locomotor and investigatory responses can be used to demonstrate and differentiate the effects of direct agonists at 5-ht1a, 5-ht1b, and 5-ht2 receptors as well as indirect serotonin agonists. |
1996-12-04 |
2023-08-12 |
rat |
| D E Nichols, A Monte, X Huang, D Marona-Lewick. Stereoselective pharmacological effects of lysergic acid amides possessing chirality in the amide substituent. Behavioural brain research. vol 73. issue 1-2. 1996-12-04. PMID:8788487. |
studies of the affinities for serotonin 5-ht2a and 5-ht1a receptor subtypes of lysergic acid amides prepared from chiral 2-aminoalkanes showed a stereoselective preference at both receptor types for the amides with alkyl groups containing the r configuration. |
1996-12-04 |
2023-08-12 |
rat |
| M Skingle, D T Beattie, D I Scopes, S J Starkey, H E Connor, W Feniuk, M B Tyer. GR127935: a potent and selective 5-HT1D receptor antagonist. Behavioural brain research. vol 73. issue 1-2. 1996-12-04. PMID:8788495. |
in functional studies, gr127935 fails to affect 5-ht2 receptor-mediated 'wet dog shakes' in guinea-pigs and 5-ht1a receptor-mediated inhibition of 5-ht release in rat dorsal raphé nucleus. |
1996-12-04 |
2023-08-12 |
human |
| G Bagd. Role of the hypothalamic paraventricular nucleus in 5-HT1A, 5-HT2A and 5-HT2C receptor-mediated oxytocin, prolactin and ACTH/corticosterone responses. Behavioural brain research. vol 73. issue 1-2. 1996-12-04. PMID:8788518. |
to test the hypothesis that the mechanisms of 5-ht1 and 5-ht2 receptor-mediated hormonal responses are different, we compared the effects of hypothalamic paraventricular nucleus (pvn) lesions on the acth/corticosterone, prolactin and oxytocin responses to the 5-ht1a agonist ipsapirone (1 and 2 mg/kg), the 5-ht2c agonist m-chlorophenylpiperazine (m-cpp, 0.6 mg/kg), which also binds to other 5-ht receptors with lower affinity, and the 5-ht2a/2c agonist 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (doi, 1 mg/kg) in chronically cannulated, freely moving male rats. |
1996-12-04 |
2023-08-12 |
rat |
| S Hjorth, S B Auerbac. 5-HT1A autoreceptors and the mode of action of selective serotonin reuptake inhibitors (SSRI). Behavioural brain research. vol 73. issue 1-2. 1996-12-04. PMID:8788519. |
5-ht1a autoreceptors and the mode of action of selective serotonin reuptake inhibitors (ssri). |
1996-12-04 |
2023-08-12 |
rat |
| S Hjorth, S B Auerbac. 5-HT1A autoreceptors and the mode of action of selective serotonin reuptake inhibitors (SSRI). Behavioural brain research. vol 73. issue 1-2. 1996-12-04. PMID:8788519. |
in support of this hypothesis, pretreatment with (+/-)-pindolol or (+)-way100135, to block 5-ht1a autoreceptors, abolished the decrease in extracellular 5-ht produced by acute systemic injection of the reuptake blockers. |
1996-12-04 |
2023-08-12 |
rat |
| S Hjorth, S B Auerbac. 5-HT1A autoreceptors and the mode of action of selective serotonin reuptake inhibitors (SSRI). Behavioural brain research. vol 73. issue 1-2. 1996-12-04. PMID:8788519. |
the results suggest that the clinical efficacy of antidepressants that block 5-ht reuptake could be enhanced by co-administration of a 5-ht1a autoreceptor antagonist. |
1996-12-04 |
2023-08-12 |
rat |
| T D Patel, E C Azmitia, F C Zho. Increased 5-HT1A receptor immunoreactivity in the rat hippocampus following 5,7-dihydroxytryptamine lesions in the cingulum bundle and fimbria-fornix. Behavioural brain research. vol 73. issue 1-2. 1996-12-04. PMID:8788527. |
these findings demonstrate that 5-ht denervation in the hippocampus is followed by increased expression of the 5-ht1a receptor protein. |
1996-12-04 |
2023-08-12 |
rat |
| T D Patel, E C Azmitia, F C Zho. Increased 5-HT1A receptor immunoreactivity in the rat hippocampus following 5,7-dihydroxytryptamine lesions in the cingulum bundle and fimbria-fornix. Behavioural brain research. vol 73. issue 1-2. 1996-12-04. PMID:8788527. |
these changes in receptor expression 14 days postlesion may represent adaptive changes by postsynaptic cells following reduced 5-ht innervation and may be the molecular basis for 5-ht1a receptor supersensitivity. |
1996-12-04 |
2023-08-12 |
rat |
| E A Johnson, J L Fox, A J Azzar. The anxiolytic serotonin 5-HT1A receptor agonists buspirone, ipsapirone and gepirone are inhibitors of tyrosine hydroxylation in rat striatum. Behavioural brain research. vol 73. issue 1-2. 1996-12-04. PMID:8788529. |
the anxiolytic serotonin 5-ht1a receptor agonists buspirone, ipsapirone and gepirone are inhibitors of tyrosine hydroxylation in rat striatum. |
1996-12-04 |
2023-08-12 |
rat |
| A Fletcher, E A Forster, D J Bill, G Brown, I A Cliffe, J E Hartley, D E Jones, A McLenachan, K J Stanhope, D J Critchley, K J Childs, V C Middlefell, L Lanfumey, R Corradetti, A M Laporte, H Gozlan, M Hamon, C T Douris. Electrophysiological, biochemical, neurohormonal and behavioural studies with WAY-100635, a potent, selective and silent 5-HT1A receptor antagonist. Behavioural brain research. vol 73. issue 1-2. 1996-12-04. PMID:8788530. |
in vitro electrophysiological studies demonstrated that way-100635 had no 5-ht1a receptor agonist actions, but dose-dependently blocked the effects of agonists at both the postsynaptic 5-ht1a receptor in the ca1 region of the hippocampus, and the somatodendritic 5-ht1a receptor located on dorsal raphe 5-ht neurones. |
1996-12-04 |
2023-08-12 |
mouse |