| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| F Ferriere, N A Khan, D Troutaud, P Deschau. Serotonin modulation of lymphocyte proliferation via 5-HT1A receptors in rainbow trout (Oncorhynchus mykiss). Developmental and comparative immunology. vol 20. issue 4. 1997-02-06. PMID:8915629. |
serotonin modulation of lymphocyte proliferation via 5-ht1a receptors in rainbow trout (oncorhynchus mykiss). |
1997-02-06 |
2023-08-12 |
Not clear |
| F Ferriere, N A Khan, D Troutaud, P Deschau. Serotonin modulation of lymphocyte proliferation via 5-HT1A receptors in rainbow trout (Oncorhynchus mykiss). Developmental and comparative immunology. vol 20. issue 4. 1997-02-06. PMID:8915629. |
8-oh-dpat (an agonist of 5-ht1a receptors) mimicked the inhibitory effects of serotonin on lymphocyte proliferation, whereas addition of spiperone (an antagonist of 5-ht1a and 5-ht1b receptors) reversed these inhibitory effects, indicating that 5-ht1a receptors may be implicated in serotonin-induced immunosuppression. |
1997-02-06 |
2023-08-12 |
Not clear |
| G Hansson, I Alafuzoff, B Winblad, J Marcusso. Intact brain serotonin system in vascular dementia. Dementia (Basel, Switzerland). vol 7. issue 4. 1997-01-30. PMID:8835882. |
the 5-ht uptake site was used as a presynaptic marker for 5-ht terminals and 5-ht1a and 5ht2 receptors were used as postsynaptic markers. |
1997-01-30 |
2023-08-12 |
Not clear |
| I Sylte, O Edvardsen, S G Dah. Molecular modelling of UH-301 and 5-HT(1a) receptor interactions. Protein engineering. vol 9. issue 2. 1997-01-29. PMID:9005436. |
the simulations indicated that the 5-ht(1a) receptor agonists, (r)- and (s)-8-oh-dpat and (r)-uh-301, interacted with the receptor at a site closer to asp82 in tmh2 than did (s)-uh-301, which is a 5-ht1a receptor antagonist. |
1997-01-29 |
2023-08-12 |
human |
| N A Darmani, S L Reeve. The mechanism by which the selective 5-HT1A receptor antagonist S-(-) UH 301 produces head-twitches in mice. Pharmacology, biochemistry, and behavior. vol 55. issue 1. 1997-01-23. PMID:8870031. |
electrophysiological studies indicate that certain 5-ht1a receptor antagonists increase the basal firing rate of some but not all raphe neurons by antagonizing the inhibitory endogenous serotonin tone operating on the somatodendritic pulse-modulating presynaptic 5-ht1a autoreceptors. |
1997-01-23 |
2023-08-12 |
mouse |
| N A Darmani, S L Reeve. The mechanism by which the selective 5-HT1A receptor antagonist S-(-) UH 301 produces head-twitches in mice. Pharmacology, biochemistry, and behavior. vol 55. issue 1. 1997-01-23. PMID:8870031. |
however, in vivo microdialysis studies show that generally such 5-ht1a antagonists by themselves do not increase the basal 5-ht release but potentiate the ability of serotonin reuptake blockers to increase the neuronal serotonin terminal output in the rat brain via the above mechanism. |
1997-01-23 |
2023-08-12 |
mouse |
| N A Darmani, S L Reeve. The mechanism by which the selective 5-HT1A receptor antagonist S-(-) UH 301 produces head-twitches in mice. Pharmacology, biochemistry, and behavior. vol 55. issue 1. 1997-01-23. PMID:8870031. |
the purpose of the present study was to determine whether antagonism of the proposed endogenous serotonin tone on the 5-ht1a autoreceptors can potentiate the activity of other postsynaptic serotonin receptors. |
1997-01-23 |
2023-08-12 |
mouse |
| N A Darmani, S L Reeve. The mechanism by which the selective 5-HT1A receptor antagonist S-(-) UH 301 produces head-twitches in mice. Pharmacology, biochemistry, and behavior. vol 55. issue 1. 1997-01-23. PMID:8870031. |
in addition, disinhibition of pulse-modulating 5-ht1a autoreceptors by s-(-)uh 301 can potentiate the synaptic effects of serotonin reuptake blockers as well as the serotonin precursor 5-htp. |
1997-01-23 |
2023-08-12 |
mouse |
| N N Osborne, G Chidlo. Do beta-adrenoceptors and serotonin 5-HT1A receptors have similar functions in the control of intraocular pressure in the rabbit? Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift fur Augenheilkunde. vol 210. issue 5. 1997-01-23. PMID:8878215. |
do beta-adrenoceptors and serotonin 5-ht1a receptors have similar functions in the control of intraocular pressure in the rabbit? |
1997-01-23 |
2023-08-12 |
rabbit |
| J R Brubacher, R S Hoffman, M J Luri. Serotonin syndrome from venlafaxine-tranylcypromine interaction. Veterinary and human toxicology. vol 38. issue 5. 1997-01-21. PMID:8888541. |
excessive stimulation of serotonin 5ht1a receptors causes a syndrome of serotonin excess that consists of shivering, muscle rigidity, salivation, confusion, agitation and hyperthermia. |
1997-01-21 |
2023-08-12 |
Not clear |
| B H Zhu, Y Saka. Alteration of contractile properties to serotonin in gastric fundus smooth muscle isolated from streptozotocin (STZ)-induced diabetic rats. Journal of smooth muscle research = Nihon Heikatsukin Gakkai kikanshi. vol 32. issue 4. 1997-01-21. PMID:8910254. |
results suggest that the contractile response to 5-ht in dm is related to the altered ca2+ signal transduction system via disturbed protein kinase c (pkc) activity, and that there are alterations of receptor characteristics and of the density in 5-ht receptor subtypes, especially 5-ht1a, during dm development. |
1997-01-21 |
2023-08-12 |
rat |
| G J Kant, G R Meininger, K R Maughan, W L Wright, T N Robinson, T M Neel. Effects of the serotonin receptor agonists 8-OH-DPAT and TFMPP on learning as assessed using a novel water maze. Pharmacology, biochemistry, and behavior. vol 53. issue 2. 1997-01-16. PMID:8808148. |
we evaluated the effects of two drugs active at serotonin receptors, 8-hydroxy-2-(di-n-propylamino)tetralin (8-oh-dpat, a 5-ht1a agonist) and n-3-trifluoromethylphenyl)piperazine hydrochloride (tfmpp, a 5-ht2c agonist) on learning using a novel water maze previously characterized in our laboratory. |
1997-01-16 |
2023-08-12 |
rat |
| G M Zwicker, S J Gosselin, J L Solomon, G H Hurs. Effects found in a one-year oral toxicity study in Sprague-Dawley rats of a novel 5-HT1A receptor partial agonist for the treatment of anxiety in humans. Toxicologic pathology. vol 24. issue 2. 1997-01-16. PMID:8992611. |
a potent and selective serotonin (5-ht1a) partial agonist with potential as a human anxiolytic drug was given in oral doses of 0, 5, 15, or 50 mg/kg/day by gavage to sprague-dawley rats for 6 or 12 mo. |
1997-01-16 |
2023-08-12 |
human |
| J W Crayton, I Joshi, A Gulati, R C Arora, W A Wol. Effect of corticosterone on serotonin and catecholamine receptors and uptake sites in rat frontal cortex. Brain research. vol 728. issue 2. 1997-01-15. PMID:8864491. |
the effects of corticosterone (1 mg/kg per day for 7 days) on serotonin 5-ht1a, 5-ht2a, 5-ht uptake sites, and alpha 2-adrenergic receptor sites were measured. |
1997-01-15 |
2023-08-12 |
rat |
| J Khater-Boidin, D Rose, B Duro. Central effects of 5-HT on activity of respiratory and hypoglossally innervated muscles in newborn kittens. The Journal of physiology. vol 495 ( Pt 1). 1997-01-15. PMID:8866368. |
in decerebrate kittens (n = 29), electrical activity was studied in the 3rd intercartilaginous (inspiratory), the 9th internal intercostal (expiratory) and the hypoglossally innervated muscles (geniohyoid m. and sternohyoid m.) evoked by the application of 5-ht (n = 16) or related agents (5-ht1a agonist, 8-oh-dpat (n = 6) and 5-ht2 agonist, doi floor of the ivth ventricle. |
1997-01-15 |
2023-08-12 |
Not clear |
| S A Jones-Humble, M J Durcan, D Lyerly, R M Norton, F L Tang, A V Russell, M J Watson, P J Gengo, P F Morgan, C M Wang, B R Cooper, R F Co. Preclinical neurochemical and electrophysiological profile of 1192U90, a potential antipsychotic. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 15. issue 3. 1997-01-15. PMID:8873105. |
it bound potently at serotonin 5-ht2, dopaminergic d2, serotonin 5-ht1a, and adrenergic alpha 1 and alpha 2 receptors. |
1997-01-15 |
2023-08-12 |
rat |
| F Artigas, L Romero, C de Montigny, P Blie. Acceleration of the effect of selected antidepressant drugs in major depression by 5-HT1A antagonists. Trends in neurosciences. vol 19. issue 9. 1997-01-15. PMID:8873352. |
at clinically relevant doses, selective serotonin (5-ht) reuptake inhibitors (ssris) and mao inhibitors (maois) increase the extracellular concentration of 5-ht in the midbrain raphé nuclei, thereby activating inhibitory somatodendritic 5-ht1a autoreceptors. |
1997-01-15 |
2023-08-12 |
Not clear |
| F Artigas, L Romero, C de Montigny, P Blie. Acceleration of the effect of selected antidepressant drugs in major depression by 5-HT1A antagonists. Trends in neurosciences. vol 19. issue 9. 1997-01-15. PMID:8873352. |
overriding this feedback by using antagonists of 5-ht1a autoreceptors permits ssris to produce a marked increase of extracellular 5-ht in the forebrain. |
1997-01-15 |
2023-08-12 |
Not clear |
| F Artigas, L Romero, C de Montigny, P Blie. Acceleration of the effect of selected antidepressant drugs in major depression by 5-HT1A antagonists. Trends in neurosciences. vol 19. issue 9. 1997-01-15. PMID:8873352. |
hence, combined treatment with an ssri and a 5-ht1a antagonist increases the extracellular concentration of 5-ht more so than the former drug alone. |
1997-01-15 |
2023-08-12 |
Not clear |
| H Saito, M Matsumoto, H Togashi, M Yoshiok. Functional interaction between serotonin and other neuronal systems: focus on in vivo microdialysis studies. Japanese journal of pharmacology. vol 70. issue 3. 1997-01-15. PMID:8935715. |
5-ht release is negatively regulated not only by somatodendritic 5-ht1a and terminal 5-ht1b (5-ht1d) autoreceptors but also by alpha 2-adrenergic and mu-opioid heteroreceptors that are located on serotonergic nerve terminals. |
1997-01-15 |
2023-08-12 |
rat |