| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| S B Auerbach, S Hjort. Effect of chronic administration of the selective serotonin (5-HT) uptake inhibitor citalopram on extracellular 5-HT and apparent autoreceptor sensitivity in rat forebrain in vivo. Naunyn-Schmiedeberg's archives of pharmacology. vol 352. issue 6. 1997-03-07. PMID:9053730. |
under these conditions, with uptake already blocked locally in the forebrain, systemic citalopram produces a decrease in extracellular 5-ht, an effect that can be inhibited by pretreatment with antagonists of 5-ht1a receptors. |
1997-03-07 |
2023-08-12 |
rat |
| L Romero, N Bel, F Artigas, C de Montigny, P Blie. Effect of pindolol on the function of pre- and postsynaptic 5-HT1A receptors: in vivo microdialysis and electrophysiological studies in the rat brain. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 15. issue 4. 1997-03-06. PMID:8887989. |
in microdialysis studies, somatodendritic 5-ht1a receptors in the dorsal raphe nucleus (drn) were activated by the local infusion of 50 microm citalopram, a selective 5-ht reuptake inhibitor (ssri). |
1997-03-06 |
2023-08-12 |
rat |
| L Romero, N Bel, F Artigas, C de Montigny, P Blie. Effect of pindolol on the function of pre- and postsynaptic 5-HT1A receptors: in vivo microdialysis and electrophysiological studies in the rat brain. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 15. issue 4. 1997-03-06. PMID:8887989. |
the inhibitory effect of lsd on 5-ht neuronal firing activity was also markedly attenuated in (-)pindolol-treated rats, indicating that somatodendritic 5-ht1a receptors were blocked by (-)pindolol. |
1997-03-06 |
2023-08-12 |
rat |
| L Romero, N Bel, F Artigas, C de Montigny, P Blie. Effect of pindolol on the function of pre- and postsynaptic 5-HT1A receptors: in vivo microdialysis and electrophysiological studies in the rat brain. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 15. issue 4. 1997-03-06. PMID:8887989. |
to determine whether (-)pindolol also blocked postsynaptic 5-ht1a receptors in hippocampus, 5-ht and the prototypical 5-ht1a agonist 8-oh-dpat were applied by microiontophoresis onto ca3 pyramidal neurons following the same treatment. |
1997-03-06 |
2023-08-12 |
rat |
| L Romero, N Bel, F Artigas, C de Montigny, P Blie. Effect of pindolol on the function of pre- and postsynaptic 5-HT1A receptors: in vivo microdialysis and electrophysiological studies in the rat brain. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 15. issue 4. 1997-03-06. PMID:8887989. |
taken together, these results indicate that (-)pindolol can potentiate the effects of an ssri on extracellular 5-ht concentration by preventing the activation of somatodendritic 5-ht1a autoreceptors resulting from the blockade of the 5-ht transporter in the raphe. |
1997-03-06 |
2023-08-12 |
rat |
| L Romero, N Bel, F Artigas, C de Montigny, P Blie. Effect of pindolol on the function of pre- and postsynaptic 5-HT1A receptors: in vivo microdialysis and electrophysiological studies in the rat brain. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 15. issue 4. 1997-03-06. PMID:8887989. |
this presumably leads to enhanced 5-ht neurotransmission because (-)pindolol would not alter the responsiveness of certain postsynaptic 5-ht1a receptors, such as those located on hippocampal ca3 pyramidal neurons. |
1997-03-06 |
2023-08-12 |
rat |
| J Herrsted. New perspectives in antiemetic treatment. Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer. vol 4. issue 6. 1997-03-06. PMID:8961471. |
a possible antiemetic effect, achieved by interference with the "serotonergic system", is not restricted to antagonism at 5-ht3 receptors, however, but also includes agonism at 5-ht1a and 5-ht2 receptors, and serotonin synthesis inhibitors. |
1997-03-06 |
2023-08-12 |
Not clear |
| M B Assie, W Koe. (-)-pindolol and (+/-)-tertatolol affect rat hippocampal 5-HT levels through mechanisms involving not only 5-HT1A, but also 5-HT1B receptors. Neuropharmacology. vol 35. issue 2. 1997-03-05. PMID:8734491. |
(-)-pindolol and (+/-)-tertatolol affect rat hippocampal 5-ht levels through mechanisms involving not only 5-ht1a, but also 5-ht1b receptors. |
1997-03-05 |
2023-08-12 |
rat |
| M B Assie, W Koe. (-)-pindolol and (+/-)-tertatolol affect rat hippocampal 5-HT levels through mechanisms involving not only 5-HT1A, but also 5-HT1B receptors. Neuropharmacology. vol 35. issue 2. 1997-03-05. PMID:8734491. |
the present work examined, using in vivo microdialysis, the effects of 0.16-10 mg/kg of the beta-adrenoceptor antagonists, (-)-pindolol and (+/-)-tertatolol, which have additional 5-ht1a receptor antagonist properties, on extracellular 5-ht levels in the ventral hippocampus of chloral hydrate-anaesthetized rats. |
1997-03-05 |
2023-08-12 |
rat |
| M B Assie, W Koe. (-)-pindolol and (+/-)-tertatolol affect rat hippocampal 5-HT levels through mechanisms involving not only 5-HT1A, but also 5-HT1B receptors. Neuropharmacology. vol 35. issue 2. 1997-03-05. PMID:8734491. |
although the antagonism of the 8-oh-dpat-induced decrease of 5-ht levels by (-)-pindolol and (+/-)-tertatolol is likely to be related to their 5-ht1a antagonist properties, their ability to increase extracellular 5-ht levels when given alone may involve interactions with 5-ht1b receptors at hippocampal 5-ht terminals. |
1997-03-05 |
2023-08-12 |
rat |
| T Sharp, V Umbers, S Hjort. The role of 5-HT1A autoreceptors and alpha 1-adrenoceptors in the inhibition of 5-HT release--II NAN-190 and SDZ 216-525. Neuropharmacology. vol 35. issue 6. 1997-03-05. PMID:8887982. |
the role of 5-ht1a autoreceptors and alpha 1-adrenoceptors in the inhibition of 5-ht release--ii nan-190 and sdz 216-525. |
1997-03-05 |
2023-08-12 |
rat |
| T Sharp, V Umbers, S Hjort. The role of 5-HT1A autoreceptors and alpha 1-adrenoceptors in the inhibition of 5-HT release--II NAN-190 and SDZ 216-525. Neuropharmacology. vol 35. issue 6. 1997-03-05. PMID:8887982. |
novel 5-ht1a receptor antagonists, way 100135 and way 100635, were used to test the involvement of 5-ht1a receptors in the decrease of hippocampal extracellular 5-ht induced by the 5-ht1a/alpha 1 ligands, nan-190 and sdz 216-525. |
1997-03-05 |
2023-08-12 |
rat |
| T Sharp, V Umbers, S Hjort. The role of 5-HT1A autoreceptors and alpha 1-adrenoceptors in the inhibition of 5-HT release--II NAN-190 and SDZ 216-525. Neuropharmacology. vol 35. issue 6. 1997-03-05. PMID:8887982. |
using microdialysis in anaesthetized rats, it was found that way 100135 (3 mg/kg s.c.) and way 100635 (0.3 mg/kg s.c.) antagonised the decrease of 5-ht induced by the 5-ht1a receptor agonist 8-oh-dpat (0.025 mg/kg s.c.) but did not alter 5-ht when administered alone. |
1997-03-05 |
2023-08-12 |
rat |
| M R Pranzatelli, I Galvan, P T Tailo. Human brainstem serotonin receptors: characterization and implications for subcortical myoclonus. Clinical neuropharmacology. vol 19. issue 6. 1997-03-05. PMID:8937789. |
in the cortex, the rank order of 5-ht receptor subtype bmax was 5-ht2a (low-affinity), 5-ht1a, 5-ht uptake sites, 5-ht1d, 5-ht2c, 5-ht1e/f, and 5-ht2a (high-affinity) sites. |
1997-03-05 |
2023-08-12 |
human |
| M R Pranzatelli, I Galvan, P T Tailo. Human brainstem serotonin receptors: characterization and implications for subcortical myoclonus. Clinical neuropharmacology. vol 19. issue 6. 1997-03-05. PMID:8937789. |
in the brainstem, the rank order was 5-ht uptake sites, 5-ht1d, 5-ht2c, 5-ht1a, and 5-ht2a(l) sites. |
1997-03-05 |
2023-08-12 |
human |
| M R Pranzatelli, I Galvan, P T Tailo. Human brainstem serotonin receptors: characterization and implications for subcortical myoclonus. Clinical neuropharmacology. vol 19. issue 6. 1997-03-05. PMID:8937789. |
in competition studies, 5-ht had high affinity for 5-ht1a and 5-ht2c sites in the brainstem and cortex, but l-5-htp was > 1,000-fold less active. |
1997-03-05 |
2023-08-12 |
human |
| P Netter, J Hennig, I S Roe. Serotonin and dopamine as mediators of sensation seeking behavior. Neuropsychobiology. vol 34. issue 3. 1997-03-04. PMID:8916073. |
in studies 1 and 2 responsivity to a serotonergic (5-ht) challenge by a 5-ht1a receptor agonist (ipsapirone) was investigated by drug-induced prolactin (prl) and cortisol responses, as well as by emotional states and behavioral measures. |
1997-03-04 |
2023-08-12 |
human |
| P Netter, J Hennig, I S Roe. Serotonin and dopamine as mediators of sensation seeking behavior. Neuropsychobiology. vol 34. issue 3. 1997-03-04. PMID:8916073. |
these findings were found compatible with the idea of a generally low responsivity of the serotonergic system in high es as well as in high dis types of sensation seekers of 5-ht1a subsensitivity in high dis and subsensitivity of other postsynaptic 5-ht receptors in high es. |
1997-03-04 |
2023-08-12 |
human |
| S Dryden, Q Wang, H M Frankish, G William. Differential effects of the 5-HT 1B/2C receptor agonist mCPP and the 5-HT1A agonist flesinoxan on hypothalamic neuropeptide Y in the rat: evidence that NPY may mediate serotonin's effects on food intake. Peptides. vol 17. issue 6. 1997-03-03. PMID:8899812. |
differential effects of the 5-ht 1b/2c receptor agonist mcpp and the 5-ht1a agonist flesinoxan on hypothalamic neuropeptide y in the rat: evidence that npy may mediate serotonin's effects on food intake. |
1997-03-03 |
2023-08-12 |
rat |
| J Recio, P Pévet, M Masson-Péve. Serotonergic modulation of photically induced increase in melatonin receptor density and Fos immunoreactivity in the suprachiasmatic nuclei of the rat. Journal of neuroendocrinology. vol 8. issue 11. 1997-03-03. PMID:8933361. |
the aim of this study was to assess whether, in rats, these two phenomena were regulated by serotonin, acting via 5-ht1a receptors. |
1997-03-03 |
2023-08-12 |
rat |