| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| H Saito, M Matsumoto, H Togashi, M Yoshiok. Functional interaction between serotonin and other neuronal systems: focus on in vivo microdialysis studies. Japanese journal of pharmacology. vol 70. issue 3. 1997-01-15. PMID:8935715. |
some microdialysis studies have predicted that the combination of a 5-ht-uptake inhibitor and 5-ht1a-autoreceptor antagonist might produce much greater availability of 5-ht in the synaptic cleft in terms of much faster induction of subsensitivity of 5-ht1a autoreceptors. |
1997-01-15 |
2023-08-12 |
rat |
| A M Gardier, I Malagié, A C Trillat, C Jacquot, F Artiga. Role of 5-HT1A autoreceptors in the mechanism of action of serotoninergic antidepressant drugs: recent findings from in vivo microdialysis studies. Fundamental & clinical pharmacology. vol 10. issue 1. 1997-01-13. PMID:8900496. |
this could be explained by simultaneous activation of somatodendritic 5-ht1a autoreceptors by endogenous 5-ht in the raphe nuclei, thereby limiting the corticofrontal effects of the antidepressant. |
1997-01-13 |
2023-08-12 |
rat |
| R Fenrick, C Pou, M Beliveau, A Fargi. The human 5-hydroxytryptamine 1A receptor differentially modulates phospholipase C and adenylyl cyclase activities. General pharmacology. vol 27. issue 2. 1997-01-10. PMID:8919640. |
in this study, we quantitate and compare the ability of the 5-hydroxytryptamine 1a (5-ht1a) receptor to modulate the activities of phospholipase c and adenylyl cyclase as a function of receptor concentration. |
1997-01-10 |
2023-08-12 |
human |
| R Fenrick, C Pou, M Beliveau, A Fargi. The human 5-hydroxytryptamine 1A receptor differentially modulates phospholipase C and adenylyl cyclase activities. General pharmacology. vol 27. issue 2. 1997-01-10. PMID:8919640. |
we conclude that the 5-ht1a receptor modulates these two pathways differently, and that the overall response to challenge with serotonin, in terms of both phosphatidyl inositol hydrolysis and cyclic amp production, is dependent upon receptor number. |
1997-01-10 |
2023-08-12 |
human |
| T Obradovic, K M Imel, S R Whit. Methylenedioxymethamphetamine-induced inhibition of neuronal firing in the nucleus accumbens is mediated by both serotonin and dopamine. Neuroscience. vol 74. issue 2. 1997-01-06. PMID:8865198. |
serotonin and serotonin agonists with relative selectivity for the receptor subtypes 5-ht1a, 5-ht1b, 5-ht2a/2c and 5-ht3 all significantly (p < 0.01) inhibited glutamate-evoked firing of cells in the nucleus accumbens compared to the effects of an acidic saline control solution (30-60 na, 60 s ejection currents for all). |
1997-01-06 |
2023-08-12 |
Not clear |
| T Obradovic, K M Imel, S R Whit. Methylenedioxymethamphetamine-induced inhibition of neuronal firing in the nucleus accumbens is mediated by both serotonin and dopamine. Neuroscience. vol 74. issue 2. 1997-01-06. PMID:8865198. |
the current (dose)-dependent inhibition produced by the serotonin agonists did not differ significantly from the inhibition produced by mdma except for the 5-ht1a agonist 8-hydroxy-(2-di-n-propylamino) tetralin, which inhibited glutamate-evoked firing significantly more than mdma or any of the other serotonin agonists. |
1997-01-06 |
2023-08-12 |
Not clear |
| M H Norman, F Navas, J B Thompson, G C Rigdo. Synthesis and evaluation of heterocyclic carboxamides as potential antipsychotic agents. Journal of medicinal chemistry. vol 39. issue 24. 1997-01-06. PMID:8941382. |
these analogues were evaluated in vitro for their binding to the dopamine d2, serotonin 5-ht2, and serotonin 5-ht1a receptors and in vivo for their ability to antagonize the apomorphine-induced climbing response in mice. |
1997-01-06 |
2023-08-12 |
mouse |
| D Goldman, J Lappalainen, N Ozak. Direct analysis of candidate genes in impulsive behaviours. Ciba Foundation symposium. vol 194. 1997-01-02. PMID:8862874. |
direct gene analyses have revealed non-conservative amino acid substitutions and structural variants (generally rare) at drd2, drd3 and drd4 dopamine receptors and 5-ht1a, 5-ht2a, 5-ht2c and 5-ht7 serotonin receptors. |
1997-01-02 |
2023-08-12 |
Not clear |
| P Blier, C de Montign. Clarifications on the effects of 5-HT1A agonists and selective 5-HT reuptake inhibitors on the 5-HT system. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 15. issue 2. 1996-12-26. PMID:8840358. |
clarifications on the effects of 5-ht1a agonists and selective 5-ht reuptake inhibitors on the 5-ht system. |
1996-12-26 |
2023-08-12 |
Not clear |
| V Hadrava, P Blier, C de Montign. Partial agonistic activity of R- and S-enantiomers of 8-OH-DPAT at 5-HT1A receptors. Journal of psychiatry & neuroscience : JPN. vol 21. issue 2. 1996-12-17. PMID:8820175. |
racemic 8-oh-dpat produced a dose-dependent hypothermia which was attenuated by the 5-ht1a antagonist pindolol, but not by the nonselective 5-ht antagonist methysergide. |
1996-12-17 |
2023-08-12 |
rat |
| M Carli, S Afkhami-Dastjerdian, T A Reade. [3H]8-OH-DPAT binding and serotonin content in rat cerebral cortex after acute fluoxetine, desipramine, or pargyline. Journal of psychiatry & neuroscience : JPN. vol 21. issue 2. 1996-12-17. PMID:8820177. |
cortical serotonin1a (5-ht1a) receptors in the rat were studied following acute (24 hours) intraperitoneal administrations of the 5-ht uptake inhibitor fluoxetine (10 mg/kg), the antidepressant desipramine (20 mg/kg), or the monoamine oxidase (mao) inhibitor pargyline (75 mg/kg). |
1996-12-17 |
2023-08-12 |
rat |
| M Carli, S Afkhami-Dastjerdian, T A Reade. [3H]8-OH-DPAT binding and serotonin content in rat cerebral cortex after acute fluoxetine, desipramine, or pargyline. Journal of psychiatry & neuroscience : JPN. vol 21. issue 2. 1996-12-17. PMID:8820177. |
the results confirm that [3h]8-oh-dpat binding is to a 2-site model, and reveal an absence of downregulation of 5-ht1a receptors following increases in tissue 5-ht after mao inhibition or antidepressant administrations. |
1996-12-17 |
2023-08-12 |
rat |
| A Haenni, H Lithel. Urapidil treatment decreases plasma fibrinogen concentration in essential hypertension. Metabolism: clinical and experimental. vol 45. issue 10. 1996-12-16. PMID:8843176. |
in a double-blind randomized parallel-group study, they were treated with atenolol 50 mg once per day (n = 25) or urapidil 60 mg twice per day (n = 17), a peripheral alpha1-receptor blocker with an additional central serotonin 1a (5ht1a) receptor agonistic effect, for 12 weeks. |
1996-12-16 |
2023-08-12 |
Not clear |
| T Oyama, M Ueda, Y Kuraishi, A Akaike, M Sato. Dual effect of serotonin on formalin-induced nociception in the rat spinal cord. Neuroscience research. vol 25. issue 2. 1996-12-13. PMID:8829149. |
in addition, the inhibitory and facilitatory effects of intrathecal 5-ht were blocked by its co-administration with nan190, a 5-ht1a receptor antagonist, and granisetron, respectively. |
1996-12-13 |
2023-08-12 |
rat |
| T Oyama, M Ueda, Y Kuraishi, A Akaike, M Sato. Dual effect of serotonin on formalin-induced nociception in the rat spinal cord. Neuroscience research. vol 25. issue 2. 1996-12-13. PMID:8829149. |
these results suggest that 5-ht suppresses formalin-induced nociception in the spinal cord via the 5-ht1a receptor and facilitates it via the 5-ht3 receptor. |
1996-12-13 |
2023-08-12 |
rat |
| S Hjort. (-)-Pindolol, but not buspirone, potentiates the citalopram-induced rise in extracellular 5-hydroxytryptamine. European journal of pharmacology. vol 303. issue 3. 1996-12-11. PMID:8813565. |
this effect of (-)-pindolol probably reflects its ability to block 5-ht1a autoreceptors, thereby abating the citalopram-induced indirect activation of these sites (secondary to the inhibition of 5-ht reuptake and elevation of extracellular 5-ht in the midbrain raphe). |
1996-12-11 |
2023-08-12 |
rat |
| H Giles, S J Lansdell, M L Bolofo, H L Wilson, G R Marti. Characterization of a 5-HT1B receptor on CHO cells: functional responses in the absence of radioligand binding. British journal of pharmacology. vol 117. issue 6. 1996-12-11. PMID:8882605. |
8-oh-dpat (1 microm) and renzapride (3 microm) were without effect on forskolin-stimulated cyclic amp production and ketanserin (0.3 microm) did not antagonize the inhibition produced by 5-ht, thus excluding the involvement of 5-ht1a, 5-ht4, and 5-ht2 receptors. |
1996-12-11 |
2023-08-12 |
Not clear |
| P Soares-da-Silva, M A Vieira-Coelho, M Pestan. Antagonistic actions of renal dopamine and 5-hydroxytryptamine: endogenous 5-hydroxytryptamine, 5-HT1A receptors and antinatriuresis during high sodium intake. British journal of pharmacology. vol 117. issue 6. 1996-12-11. PMID:8882615. |
antagonistic actions of renal dopamine and 5-hydroxytryptamine: endogenous 5-hydroxytryptamine, 5-ht1a receptors and antinatriuresis during high sodium intake. |
1996-12-11 |
2023-08-12 |
rat |
| P Soares-da-Silva, M A Vieira-Coelho, M Pestan. Antagonistic actions of renal dopamine and 5-hydroxytryptamine: endogenous 5-hydroxytryptamine, 5-HT1A receptors and antinatriuresis during high sodium intake. British journal of pharmacology. vol 117. issue 6. 1996-12-11. PMID:8882615. |
the present study has examined the effect of (+)-way 100135, a selective antagonist of 5-ht1a receptors, and ketanserin, an antagonist of 5-ht2 receptors, on the urinary excretion of na+, k+, dopamine, 5-hydroxytryptamine (5-ht) and their metabolites in rats treated with the selective type a monoamine oxidase (mao-a) inhibitor, ro 41-1049 (15 mg kg-1 day-1) in conditions of normal sodium (ns) and high sodium (hs; 1.0% nacl in drinking water) intake. |
1996-12-11 |
2023-08-12 |
rat |
| P Soares-da-Silva, M A Vieira-Coelho, M Pestan. Antagonistic actions of renal dopamine and 5-hydroxytryptamine: endogenous 5-hydroxytryptamine, 5-HT1A receptors and antinatriuresis during high sodium intake. British journal of pharmacology. vol 117. issue 6. 1996-12-11. PMID:8882615. |
it is suggested that mao-a inhibition during hs intake leads to an increased availability of 5-ht in renal tissues, the effect of which is a decrease in the urinary excretion of na+, involving the activation of tubular 5-ht1a receptors. |
1996-12-11 |
2023-08-12 |
rat |