| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Mohammad Charkhpour, Ali Reza Mohajjel Nayebi, Yousef Doustar, Kambiz Hassanzade. 8-OH-DPAT prevents morphine-induced apoptosis in rat dorsal raphe nucleus: a possible mechanism for attenuating morphine tolerance. Anesthesia and analgesia. vol 111. issue 5. 2010-11-16. PMID:20736434. |
previously, we found that activation of serotonin 1a (5-ht1a) receptors in the dorsal raphe nucleus (drn) decreased the development of tolerance to the analgesic effect of morphine. |
2010-11-16 |
2023-08-12 |
rat |
| Takashi Futamura, Satoshi Akiyama, Haruhiko Sugino, Andy Forbes, Robert D McQuade, Tetsuro Kikuch. Aripiprazole attenuates established behavioral sensitization induced by methamphetamine. Progress in neuro-psychopharmacology & biological psychiatry. vol 34. issue 6. 2010-11-02. PMID:20561555. |
the attenuation effect of aripiprazole was blocked by pretreatment with the specific serotonin 5-ht1a antagonist way100635. |
2010-11-02 |
2023-08-12 |
mouse |
| Serap Erdoğa. [Quetiapine in substance use disorders, abuse and dependence possibility: a review]. Turk psikiyatri dergisi = Turkish journal of psychiatry. vol 21. issue 2. 2010-10-29. PMID:20514567. |
pharmacologically, it has antagonistic effects on serotonin 5-ht1a and 5-ht2a, dopamine d1 and d2, histamine h1, and adrenergic alpha1 and alpha2 receptors. |
2010-10-29 |
2023-08-12 |
Not clear |
| Eugene Oh, Takashi Maejima, Chen Liu, Evan Deneris, Stefan Herlitz. Substitution of 5-HT1A receptor signaling by a light-activated G protein-coupled receptor. The Journal of biological chemistry. vol 285. issue 40. 2010-10-26. PMID:20643652. |
to induce 5-ht(1a)-like targeting, vertebrate rhodopsin was tagged with the c-terminal domain (ct) of 5-ht(1a) (rh-ct(5-ht1a)). |
2010-10-26 |
2023-08-12 |
mouse |
| Eugene Oh, Takashi Maejima, Chen Liu, Evan Deneris, Stefan Herlitz. Substitution of 5-HT1A receptor signaling by a light-activated G protein-coupled receptor. The Journal of biological chemistry. vol 285. issue 40. 2010-10-26. PMID:20643652. |
rh-ct(5-ht1a) activates g protein-coupled inward rectifying k(+) channels in response to light and causes membrane hyperpolarization in hippocampal neurons, similar to the agonist-induced responses of the 5-ht(1a) receptor. |
2010-10-26 |
2023-08-12 |
mouse |
| Eugene Oh, Takashi Maejima, Chen Liu, Evan Deneris, Stefan Herlitz. Substitution of 5-HT1A receptor signaling by a light-activated G protein-coupled receptor. The Journal of biological chemistry. vol 285. issue 40. 2010-10-26. PMID:20643652. |
the intracellular distribution of rh-ct(5-ht1a) resembles that of the 5-ht(1a) receptor; rh-ct(5-ht1a) localizes to somatodendritic sites and is efficiently trafficked to distal dendritic processes. |
2010-10-26 |
2023-08-12 |
mouse |
| Eugene Oh, Takashi Maejima, Chen Liu, Evan Deneris, Stefan Herlitz. Substitution of 5-HT1A receptor signaling by a light-activated G protein-coupled receptor. The Journal of biological chemistry. vol 285. issue 40. 2010-10-26. PMID:20643652. |
additionally, neuronal expression of rh-ct(5-ht1a), but not rh, decreases 5-ht(1a) agonist sensitivity, suggesting that rh-ct(5-ht1a) and 5-ht(1a) receptors compete to interact with the same trafficking machinery. |
2010-10-26 |
2023-08-12 |
mouse |
| Eugene Oh, Takashi Maejima, Chen Liu, Evan Deneris, Stefan Herlitz. Substitution of 5-HT1A receptor signaling by a light-activated G protein-coupled receptor. The Journal of biological chemistry. vol 285. issue 40. 2010-10-26. PMID:20643652. |
finally, rh-ct(5-ht1a) is able to rescue 5-ht(1a) signaling of 5-ht(1a) ko mice in cultured neurons and in slices of the dorsal raphe showing that rh-ct(5-ht1a) is able to functionally compensate for native 5-ht(1a). |
2010-10-26 |
2023-08-12 |
mouse |
| Eugene Oh, Takashi Maejima, Chen Liu, Evan Deneris, Stefan Herlitz. Substitution of 5-HT1A receptor signaling by a light-activated G protein-coupled receptor. The Journal of biological chemistry. vol 285. issue 40. 2010-10-26. PMID:20643652. |
thus, as an optogenetic tool, rh-ct(5-ht1a) has the potential to directly correlate in vivo 5-ht(1a) signaling with 5-ht neuron activity and behavior in both normal animals and animal models of neuropsychiatric disease. |
2010-10-26 |
2023-08-12 |
mouse |
| Amélie Lothe, Claudette Boni, Nicolas Costes, Sandrine Bouvard, Philip Gorwood, Franck Lavenne, Marion Alvarez, Philippe Ryvli. 5-HT1A gene promoter polymorphism and [18F]MPPF binding potential in healthy subjects: a PET study. Behavioral and brain functions : BBF. vol 6. 2010-10-20. PMID:20609217. |
previous positron emission tomography (pet) studies of 5-ht1a receptors have shown an influence of several genetic factors, including the triallelic serotonin transporter gene-linked polymorphic region on the binding potential (bpnd) of these receptors. |
2010-10-20 |
2023-08-12 |
human |
| Bibiana M Gay, Marina Prigol, André L Stein, Cristina W Nogueir. Antidepressant-like pharmacological profile of 3-(4-fluorophenylselenyl)-2,5-diphenylselenophene: Involvement of serotonergic system. Neuropharmacology. vol 59. issue 3. 2010-10-14. PMID:20488195. |
in the fst was prevented by pretreatment of mice with pcpa (100 mg/kg, i.p., once a day for 4 consecutive days, an inhibitor of 5-ht synthesis), way 100635 (0.1 mg/kg, s.c., a selective 5-ht1a receptor antagonist), ritanserin (1 mg/kg, i.p., a 5-ht2 receptor antagonist) or ondansetron (1 mg/kg, i.p., a 5-ht3 receptor antagonist). |
2010-10-14 |
2023-08-12 |
mouse |
| Adrian Newman-Tancred. The importance of 5-HT1A receptor agonism in antipsychotic drug action: rationale and perspectives. Current opinion in investigational drugs (London, England : 2000). vol 11. issue 7. 2010-10-05. PMID:20571976. |
serotonin 5-ht1a receptors are attractive targets for the development of improved antipsychotics. |
2010-10-05 |
2023-08-12 |
Not clear |
| Gerhard Gründe. Cariprazine, an orally active D2/D3 receptor antagonist, for the potential treatment of schizophrenia, bipolar mania and depression. Current opinion in investigational drugs (London, England : 2000). vol 11. issue 7. 2010-10-05. PMID:20571978. |
cariprazine (rgh-188), which is being codeveloped by gedeon richter ltd, forest laboratories inc and mitsubishi tanabe pharma corp, is a novel putative antipsychotic drug that exerts partial agonism at dopamine d2/d3 receptors, with preferential binding to d3 receptors, and partial agonism at serotonin 5-ht1a receptors. |
2010-10-05 |
2023-08-12 |
Not clear |
| Peter Heusler, Isabelle Rauly-Lestienne, Amélie Tourette, Stéphanie Tardif, Marie-Christine Ailhaud, Guillaume Croville, Didier Cussa. Actions of the prototypical 5-HT1A receptor agonist 8-OH-DPAT at human alpha2-adrenoceptors: (+)8-OH-DPAT, but not (-)8-OH-DPAT is an alpha2B subtype preferential agonist. European journal of pharmacology. vol 640. issue 1-3. 2010-10-04. PMID:20450907. |
8-oh-dpat [8-hydroxy-2-(di-n-propylamino)tetralin] is the prototypical agonist at serotonin 5-ht1a receptors; however, activity at other targets contributes to the functional effects of the compound as well. |
2010-10-04 |
2023-08-12 |
human |
| Aranapakam M Venkatesan, O Dos Santos, John Ellingboe, Deborah A Evrard, Boyd L Harrison, Deborah L Smith, Rosemary Scerni, Geoffrey A Hornby, Lee E Schechter, Terrence H Andre. Novel benzofuran derivatives with dual 5-HT1A receptor and serotonin transporter affinity. Bioorganic & medicinal chemistry letters. vol 20. issue 3. 2010-09-20. PMID:20064720. |
novel benzofuran derivatives with dual 5-ht1a receptor and serotonin transporter affinity. |
2010-09-20 |
2023-08-12 |
Not clear |
| Andreas Nievergelt, Peter Huonker, Roland Schoop, Karl-Heinz Altmann, Jürg Gertsc. Identification of serotonin 5-HT1A receptor partial agonists in ginger. Bioorganic & medicinal chemistry. vol 18. issue 9. 2010-09-10. PMID:20363635. |
identification of serotonin 5-ht1a receptor partial agonists in ginger. |
2010-09-10 |
2023-08-12 |
human |
| V R Sela, I Hattanda, C M Albrecht, C B De Almeida, S Obici, D A Cortez, E A Aud. Effect of xanthone from Kielmeyera coriacea stems on serotonergic neurons of the median raphe nucleus. Phytomedicine : international journal of phytotherapy and phytopharmacology. vol 17. issue 3-4. 2010-08-30. PMID:19674881. |
these results suggest that xanthone acts as an antagonist at 5-ht1a autoreceptors in mrn and increases serotonin (5-ht) availability in projection regions, proving to be a prototype drug that may be useful in mood isorders such as depression, or indeed be a beneficial adjunctive treatment improving the efficacy and/or accelerating the effects of antidepressant drugs in patients with major depression. |
2010-08-30 |
2023-08-12 |
rat |
| Abigail M Polter, Xiaohua L. 5-HT1A receptor-regulated signal transduction pathways in brain. Cellular signalling. vol 22. issue 10. 2010-08-25. PMID:20363322. |
among different serotonin receptors, the serotonin 1a (5-ht1a) receptors have been tied to a variety of physiological and pathological processes, notably in anxiety, mood, and cognition. |
2010-08-25 |
2023-08-12 |
Not clear |
| Rosa I Caamaño Tubío, Jorge Pérez-Maceira, Manuel Aldegund. Homeostasis of glucose in the rainbow trout (Oncorhynchus mykiss Walbaum): the role of serotonin. The Journal of experimental biology. vol 213. issue 11. 2010-08-17. PMID:20472767. |
administration of tfmpp (a 5-ht1b agonist) did not increase the plasma levels of glucose, and the hyperglycaemic action of 5-ht was not blocked by antagonists of 5-ht1a (way 100635), 5-ht1d (brl 15572), 5-ht2b (sb 204741) or 5-ht7 (pimozide) receptors. |
2010-08-17 |
2023-08-12 |
Not clear |
| Matthew J Gdovin, Debora A Zamora, C R Marutha Ravindran, James C Leite. Serotonergic modulation of respiratory rhythmogenesis and central chemoreception. Ethnicity & disease. vol 20. issue 1 Suppl 1. 2010-08-12. PMID:20521383. |
we examined the role of serotonin 5ht1a receptors in respiratory rhythmicity and central respiratory chemosensitivity in in vitro brainstem preparations of the bullfrog tadpole, rana catesbeiana. |
2010-08-12 |
2023-08-12 |
Not clear |