| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| D A Craig, D E Clark. Peristalsis evoked by 5-HT and renzapride: evidence for putative 5-HT4 receptor activation. British journal of pharmacology. vol 102. issue 3. 1995-01-05. PMID:1364818. |
this novel finding suggests strongly that the prokinetic action of renzapride and gut motility stimulating action of 5-hydroxytryptamine are mediated via agonism at the putative 5-ht4 receptor. |
1995-01-05 |
2023-08-11 |
Not clear |
| R M Eglen, D W Bonhaus, R D Clark, L G Johnson, C H Lee, E Leung, W L Smith, E H Wong, R L Whitin. (R) and (S) RS 56532: mixed 5-HT3 and 5-HT4 receptor ligands with opposing enantiomeric selectivity. Neuropharmacology. vol 33. issue 3-4. 1994-12-30. PMID:7984291. |
at 5-ht4 receptors mediating tachycardia in the pig, 5-ht induced a dose-dependent tachycardia (ed50 = 3 micrograms kg-1, i.v. |
1994-12-30 |
2023-08-12 |
rat |
| G B Schiavi, S Brunet, C A Rizzi, H Ladinsk. Identification of serotonin 5-HT4 recognition sites in the porcine caudate nucleus by radioligand binding. Neuropharmacology. vol 33. issue 3-4. 1994-12-30. PMID:7984293. |
identification of serotonin 5-ht4 recognition sites in the porcine caudate nucleus by radioligand binding. |
1994-12-30 |
2023-08-12 |
Not clear |
| G B Schiavi, S Brunet, C A Rizzi, H Ladinsk. Identification of serotonin 5-HT4 recognition sites in the porcine caudate nucleus by radioligand binding. Neuropharmacology. vol 33. issue 3-4. 1994-12-30. PMID:7984293. |
specific binding for the serotonin 5-ht4 receptor (5-ht4r) radioligand [3h]gr 113808 was identified in pig caudate nucleus and characterized by serotonin subtype selective drugs. |
1994-12-30 |
2023-08-12 |
Not clear |
| S Roychowdhury, H Haas, E G Anderso. 5-HT1A and 5-HT4 receptor colocalization on hippocampal pyramidal cells. Neuropharmacology. vol 33. issue 3-4. 1994-12-30. PMID:7984294. |
the 5-ht3 & 4 antagonist, ics 205-930 antagonized the excitatory responses to 5-ht, alpha-methyl 5-ht, and cisapride, indicating the excitatory response is mediated, in part, by 5-ht4 receptors. |
1994-12-30 |
2023-08-12 |
Not clear |
| S Y Yuan, J C Bornstein, J B Furnes. Investigation of the role of 5-HT3 and 5-HT4 receptors in ascending and descending reflexes to the circular muscle of guinea-pig small intestine. British journal of pharmacology. vol 112. issue 4. 1994-12-20. PMID:7952869. |
the present study was undertaken to ascertain whether 5-hydroxytryptamine (5-ht) acting at either 5-ht3 or 5-ht4 receptors plays a significant role in motility reflexes in the guinea-pig small intestine. |
1994-12-20 |
2023-08-12 |
Not clear |
| M Camilleri, M R Von der Oh. Drugs affecting serotonin receptors. Bailliere's clinical gastroenterology. vol 8. issue 2. 1994-12-08. PMID:7949460. |
carcinoid diarrhoea is a prototypic disease associated with deranged serotonin metabolism, and a rationale for using 5-ht3 or 5-ht4 antagonists is based on the recent appreciation of the important role of impaired gut motor function in carcinoid diarrhoea. |
1994-12-08 |
2023-08-12 |
Not clear |
| S Consolo, S Arnaboldi, S Giorgi, G Russi, H Ladinsk. 5-HT4 receptor stimulation facilitates acetylcholine release in rat frontal cortex. Neuroreport. vol 5. issue 10. 1994-11-10. PMID:7919171. |
the results provide the first evidence that serotonin facilitates ach release in frontal cortex through stimulation of 5-ht4 receptors which are not tonically activated. |
1994-11-10 |
2023-08-12 |
rat |
| J M Kellum, M R Budhoo, A K Siriwardena, E P Smith, S A Jebrail. Serotonin induces Cl- secretion in human jejunal mucosa in vitro via a nonneural pathway at a 5-HT4 receptor. The American journal of physiology. vol 267. issue 3 Pt 1. 1994-10-24. PMID:7943231. |
serotonin induces cl- secretion in human jejunal mucosa in vitro via a nonneural pathway at a 5-ht4 receptor. |
1994-10-24 |
2023-08-12 |
human |
| M B Hanse. ICS 205-930 reduces 5-methoxytryptamine-induced short-circuit current in stripped pig jejunum. Canadian journal of physiology and pharmacology. vol 72. issue 3. 1994-09-29. PMID:7915189. |
the selective 5-ht4 receptor agonist 5-meot and 5-ht both induced a concentration-dependent increase in scc. |
1994-09-29 |
2023-08-12 |
Not clear |
| M B Hanse. ICS 205-930 reduces 5-methoxytryptamine-induced short-circuit current in stripped pig jejunum. Canadian journal of physiology and pharmacology. vol 72. issue 3. 1994-09-29. PMID:7915189. |
these data suggest involvement of a neuronal 5-ht4 receptor subtype and acetylcholine in 5-ht elicited scc and chloride secretion in the pig jejunum. |
1994-09-29 |
2023-08-12 |
Not clear |
| Y Xia, R H Fertel, J D Woo. Stimulation of formation of cAMP by 5-hydroxytryptamine in myenteric ganglia isolated from guinea pig small intestine. Life sciences. vol 55. issue 9. 1994-09-22. PMID:8065231. |
a putative 5-ht4 receptor agonist, 5-methoxytryptamine, stimulated formation of camp, but to a lesser extent than 5-ht. |
1994-09-22 |
2023-08-12 |
Not clear |
| D J Woollard, J C Bornstein, J B Furnes. Characterization of 5-HT receptors mediating contraction and relaxation of the longitudinal muscle of guinea-pig distal colon in vitro. Naunyn-Schmiedeberg's archives of pharmacology. vol 349. issue 5. 1994-09-19. PMID:8065459. |
the 5-ht4 antagonist, sdz 205-557 (5 x 10(-7) mol/l) substantially suppressed the responses to low concentrations of 5-ht and to 5-methoxytryptamine, but had no effect on the responses to higher concentrations of 5-ht. |
1994-09-19 |
2023-08-12 |
Not clear |
| A J Kaumann, L Sander. 5-Hydroxytryptamine causes rate-dependent arrhythmias through 5-HT4 receptors in human atrium: facilitation by chronic beta-adrenoceptor blockade. Naunyn-Schmiedeberg's archives of pharmacology. vol 349. issue 4. 1994-09-14. PMID:7914677. |
5-hydroxytryptamine causes rate-dependent arrhythmias through 5-ht4 receptors in human atrium: facilitation by chronic beta-adrenoceptor blockade. |
1994-09-14 |
2023-08-12 |
human |
| M R Budhoo, J M Kellu. Evidence for a 5-HT4 receptor pathway mediating chloride secretion in the rat distal colon. The Journal of surgical research. vol 57. issue 1. 1994-08-22. PMID:8041147. |
5-ht concentration response was measured in the presence and absence of the following 5-ht receptor antagonists: 10 microm 5-htp-dp (5-ht1p), 1 microm methysergide (5-ht1-like and 5-ht2), 0.1 microm ketanserin (5-ht2), 0.3 microm ondansetron (5-ht3) 0.1, 0.5, 1 and 3 microm ics 205-930 (5-ht3 and 5-ht4), and 0.1, 0.03, and 0.01 microm of the new selective 5-ht4 antagonist, sc 53606. |
1994-08-22 |
2023-08-12 |
rat |
| P J Johnson, J C Bornstein, J B Furness, D J Woollard, S L Orrman-Rossite. Characterization of 5-hydroxytryptamine receptors mediating mucosal secretion in guinea-pig ileum. British journal of pharmacology. vol 111. issue 4. 1994-08-17. PMID:8032611. |
the 5-ht4 receptor antagonist, sdz 205-557 (300 nm) had no effect on the response to 5-ht. |
1994-08-17 |
2023-08-12 |
Not clear |
| T Morie, S Kato, H Harada, N Yoshida, J Matsumot. Synthesis and biological activities of the optical isomers of (+/-)-4-amino-5-chloro-2-ethoxy-N-[[4-(4-fluorobenzyl)-2- morpholinyl]methyl]benzamide (mosapride). Chemical & pharmaceutical bulletin. vol 42. issue 4. 1994-08-02. PMID:8020122. |
mosapride and its enantiomers, (s)-(-)-1 and (r)-(+)-1, were essentially equipotent in serotonin 5-ht4 receptor agonistic activity on the electrically evoked contractions in isolated guinea pig ileum. |
1994-08-02 |
2023-08-12 |
Not clear |
| A Bisaga, J Sikora, W Kostowsk. The effect of drugs interacting with serotonergic 5HT3 and 5HT4 receptors on morphine place conditioning. Polish journal of pharmacology. vol 45. issue 5-6. 1994-07-28. PMID:8012474. |
these findings suggest that 5-hydroxytryptamine by means of 5ht4 receptors mediates appetitive properties of morphine induced-stimuli and suggest that 5ht4 receptor may be involved in the brain reward and reinforcement processes. |
1994-07-28 |
2023-08-12 |
Not clear |
| M V Waikar, A P Ford, D E Clark. Evidence for an inhibitory 5-HT4 receptor in urinary bladder of rhesus and Cynomolgus monkeys. British journal of pharmacology. vol 111. issue 1. 1994-07-25. PMID:8012699. |
the present study shows that 5-hydroxytryptamine (5-ht) inhibits electrically-evoked contractions of isolated urinary bladder strips from rhesus and cynomolgus monkeys via activation of 5-ht4 receptors. |
1994-07-25 |
2023-08-12 |
monkey |
| M V Waikar, A P Ford, D E Clark. Evidence for an inhibitory 5-HT4 receptor in urinary bladder of rhesus and Cynomolgus monkeys. British journal of pharmacology. vol 111. issue 1. 1994-07-25. PMID:8012699. |
however, the potency estimate for bimu 8 (pec50 = 6.5) in cynomolgus monkey was low, relative to 5-ht, indicating a possible heterogeneity of 5-ht4 receptors. |
1994-07-25 |
2023-08-12 |
monkey |