| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| T Takahashi, J K Ward, S Tadjkarimi, M H Yacoub, P J Barnes, M G Belvis. 5-Hydroxytryptamine facilitates cholinergic bronchoconstriction in human and guinea pig airways. American journal of respiratory and critical care medicine. vol 152. issue 1. 1995-08-10. PMID:7599849. |
the rank order of potency of 5-ht agonists was 5-ht > 2-methyl-5-ht (5-ht3 selective) > 5-methoxytryptamine (5-ht4 selective) > alpha-methyl-5-ht (5-ht2 selective). |
1995-08-10 |
2023-08-12 |
human |
| H Ansanay, A Dumuis, M Sebben, J Bockaert, L Fagn. cAMP-dependent, long-lasting inhibition of a K+ current in mammalian neurons. Proceedings of the National Academy of Sciences of the United States of America. vol 92. issue 14. 1995-08-10. PMID:7604046. |
these effects were also observed after a short activation of the pituitary adenylyl cyclase-activating polypeptide, beta-adrenergic, and 5-hydroxytryptamine type 4 (5-ht4) receptors, all known to increase camp. |
1995-08-10 |
2023-08-12 |
Not clear |
| C M Franks, J Hardcastle, P T Hardcastle, G J Sange. Do 5-HT4 receptors mediate the intestinal secretory response to 5-HT in rat in-vivo? The Journal of pharmacy and pharmacology. vol 47. issue 3. 1995-08-09. PMID:7602483. |
do 5-ht4 receptors mediate the intestinal secretory response to 5-ht in rat in-vivo? |
1995-08-09 |
2023-08-12 |
rat |
| C M Franks, J Hardcastle, P T Hardcastle, G J Sange. Do 5-HT4 receptors mediate the intestinal secretory response to 5-HT in rat in-vivo? The Journal of pharmacy and pharmacology. vol 47. issue 3. 1995-08-09. PMID:7602483. |
the involvement of the recently characterized 5-ht4 receptor in the actions of 5-hydroxytryptamine (5-ht) on jejunal, ileal and colonic electrogenic ion secretion was investigated in the rat in-vivo. |
1995-08-09 |
2023-08-12 |
rat |
| C M Franks, J Hardcastle, P T Hardcastle, G J Sange. Do 5-HT4 receptors mediate the intestinal secretory response to 5-HT in rat in-vivo? The Journal of pharmacy and pharmacology. vol 47. issue 3. 1995-08-09. PMID:7602483. |
it is concluded that 5-ht4 receptors do not make a contribution to the electrically monitored 5-ht intestinal secretory response in the rat jejunum in-vivo, but may play a small role in the ileum and colon. |
1995-08-09 |
2023-08-12 |
rat |
| S Bingham, B F King, B Rushant, M I Smith, L Gaster, G J Sange. Antagonism by SB 204070 of 5-HT-evoked contractions in the dog stomach: an in-vivo model of 5-HT4 receptor function. The Journal of pharmacy and pharmacology. vol 47. issue 3. 1995-08-09. PMID:7602484. |
the ability of 5-hydroxytryptamine (5-ht) to evoke contractile activity in the gastric heidenhain pouch was measured in conscious dogs using a method in which 5-ht4 receptor-antagonist activity can be measured in-vivo. |
1995-08-09 |
2023-08-12 |
dog |
| S Kato, T Morie, N Yoshid. Synthesis and biological activities of metabolites of mosapride, a new gastroprokinetic agent. Chemical & pharmaceutical bulletin. vol 43. issue 4. 1995-08-04. PMID:7600620. |
the serotonin 5-ht4 receptor agonistic activities of the metabolites were found to be less than that of mosapride. |
1995-08-04 |
2023-08-12 |
Not clear |
| S C Pandey, J M Davis, G N Pande. Phosphoinositide system-linked serotonin receptor subtypes and their pharmacological properties and clinical correlates. Journal of psychiatry & neuroscience : JPN. vol 20. issue 3. 1995-07-27. PMID:7786883. |
serotonin (5-ht) receptors have been classified into several categories, and they are termed as 5-ht1, 5-ht2, 5-ht3, 5-ht4, 5-ht5, 5-ht6 and 5-ht7 type receptors. |
1995-07-27 |
2023-08-12 |
Not clear |
| A Lucchelli, M G Santagostino-Barbone, A Barbieri, S M Candura, M Tonin. The interaction of antidepressant drugs with central and peripheral (enteric) 5-HT3 and 5-HT4 receptors. British journal of pharmacology. vol 114. issue 5. 1995-07-14. PMID:7780635. |
in whole ileal segments, concentration-response curves to 5-ht were biphasic, with the high- and low-potency phases involving 5-ht4 and 5-ht3 receptors, respectively. |
1995-07-14 |
2023-08-12 |
Not clear |
| E H Wong, R Clark, E Leung, D Loury, D W Bonhaus, L Jakeman, H Parnes, R L Whiting, R M Egle. The interaction of RS 25259-197, a potent and selective antagonist, with 5-HT3 receptors, in vitro. British journal of pharmacology. vol 114. issue 4. 1995-07-11. PMID:7773546. |
in contrast, it exhibited low affinity (pki <6.0) at 28 other receptors in binding assays, including adrenoceptors (alpha1a, alpha 1b, alpha2a, alpha 2b ,beta1, beta2), muscarinic (m1-m4), dopamine (d1, d2), opioid and other 5-ht(5-htla, 5-htld, 5-ht2c, 5-ht4) receptors.4. |
1995-07-11 |
2023-08-12 |
human |
| A Mota, A Bento, A Peñalva, M Pombo, C Diegue. Role of the serotonin receptor subtype 5-HT1D on basal and stimulated growth hormone secretion. The Journal of clinical endocrinology and metabolism. vol 80. issue 6. 1995-07-07. PMID:7775648. |
at present, four main types of serotonin (5-ht) receptors have been identified in the brain (5-ht1, 5-ht2, 5-ht3, and 5-ht4). |
1995-07-07 |
2023-08-12 |
human |
| M R Briejer, L M Akkermans, A L Meulemans, R A Lefebvre, J A Schuurke. 5-HT-induced neurogenic relaxations of the guinea-pig proximal colon: investigation into the role of ATP and VIP in addition to nitric oxide. Naunyn-Schmiedeberg's archives of pharmacology. vol 351. issue 2. 1995-07-06. PMID:7770095. |
antagonists to block the contractile response to 5-ht via 5-ht2, 5-ht3 or 5-ht4 receptors were present throughout the experiments and methacholine was administered to precontract the strips. |
1995-07-06 |
2023-08-12 |
Not clear |
| M B Hanse. Tropisetron and octreotide reduce serotonin-induced fluid hypersecretion in pig jejunum. Pharmacology & toxicology. vol 76. issue 2. 1995-06-12. PMID:7746798. |
in vitro data suggest that the serotonin receptor subtype 4 (5-ht4) mediate part of the serotonin (5-ht)-induced intestinal secretion. |
1995-06-12 |
2023-08-12 |
Not clear |
| M B Hanse. Tropisetron and octreotide reduce serotonin-induced fluid hypersecretion in pig jejunum. Pharmacology & toxicology. vol 76. issue 2. 1995-06-12. PMID:7746798. |
5-ht, 5-methoxytryptamine (5-ht4 agonist), and tropisetron (5-ht3/5-ht4 antagonist) all induced a dose-dependent hypersecretion. |
1995-06-12 |
2023-08-12 |
Not clear |
| S Kojima, Y Shim. An enhancing effect of 5-hydroxytryptamine on electrically evoked atropine-resistant contraction of guinea-pig proximal colon. British journal of pharmacology. vol 114. issue 1. 1995-05-17. PMID:7712032. |
dau 6285 (3 microm), a 5-ht4 receptor antagonist, abolished the enhancing action of 5-ht (30 nm), but metitepine (0.03 microm), a 5-ht1/5-ht2 receptor antagonist, ketanserin (0.01 microm), a 5-ht2 receptor antagonist, and ondansetron (1 microm), a 5-ht3 receptor antagonist, had no effect on the enhancement. |
1995-05-17 |
2023-08-12 |
Not clear |
| S Kojima, Y Shim. An enhancing effect of 5-hydroxytryptamine on electrically evoked atropine-resistant contraction of guinea-pig proximal colon. British journal of pharmacology. vol 114. issue 1. 1995-05-17. PMID:7712032. |
these results indicate that in the guinea-pig proximal colon, 5-ht produced an enhancement of atropine-resistant neurogenic contraction induced by electrical field stimulation through pre-junctional mechanisms and that the enhancement is mediated by the stimulation of 5-ht4 receptors located on intramural preganglionic cholinergic neurones and tachykininergic neurones. |
1995-05-17 |
2023-08-12 |
Not clear |
| K Hagihara, T Hayakawa, T Arai, H Eguchi, S Mino, S Kawas. Antagonistic activities of N-3389, a newly synthesized diazabicyclo derivative, at 5-HT3 and 5-HT4 receptors. European journal of pharmacology. vol 271. issue 1. 1995-05-04. PMID:7698198. |
as a preliminary to investigating the effect of n-3389 on 5-ht4 receptors, we examined the contraction induced by 5-ht in guinea-pig ileum preparations. |
1995-05-04 |
2023-08-12 |
rat |
| K Hagihara, T Hayakawa, T Arai, H Eguchi, S Mino, S Kawas. Antagonistic activities of N-3389, a newly synthesized diazabicyclo derivative, at 5-HT3 and 5-HT4 receptors. European journal of pharmacology. vol 271. issue 1. 1995-05-04. PMID:7698198. |
furthermore, 5-ht3 receptor antagonism inhibited the late phase of the contraction induced by high concentrations of 5-ht (3 x 10(-6)-10(-5) m), whereas 5-ht4 receptor antagonism inhibited the early phase of the contraction induced by low concentrations of 5-ht (10(-8)-10(-6) m). |
1995-05-04 |
2023-08-12 |
rat |
| P Rondé, H Ansanay, A Dumuis, R Miller, J Bockaer. Homologous desensitization of 5-hydroxytryptamine4 receptors in rat esophagus: functional and second messenger studies. The Journal of pharmacology and experimental therapeutics. vol 272. issue 3. 1995-04-14. PMID:7891352. |
we have studied agonist-induced desensitization of 5-hydroxytryptamine (5-ht4) receptor-mediated relaxation and 5-ht4 receptor-mediated increases in camp in rat esophageal tunica muscularis mucosae. |
1995-04-14 |
2023-08-12 |
rat |
| P Rondé, H Ansanay, A Dumuis, R Miller, J Bockaer. Homologous desensitization of 5-hydroxytryptamine4 receptors in rat esophagus: functional and second messenger studies. The Journal of pharmacology and experimental therapeutics. vol 272. issue 3. 1995-04-14. PMID:7891352. |
desensitization was a receptor-mediated event because cross-desensitization was observed between two chemically unrelated 5-ht4 receptor agonists, 5-ht itself and (s)-zacopride. |
1995-04-14 |
2023-08-12 |
rat |