| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| M V Waikar, A P Ford, D E Clark. Evidence for an inhibitory 5-HT4 receptor in urinary bladder of rhesus and Cynomolgus monkeys. British journal of pharmacology. vol 111. issue 1. 1994-07-25. PMID:8012699. |
the 5-ht4 receptor antagonists, gr 113808 (10 nm), dau 6285 (1-10 microm) and rs 23597-190 (1 microm), produced parallel, dextral displacements of the concentration-effect curves to 5-ht and other related agonists with affinity estimates in agreement with those defined previously in other 5-ht4 receptor assay systems. |
1994-07-25 |
2023-08-12 |
monkey |
| T Doménech, J Beleta, A G Fernández, R W Gristwood, F Cruz Sánchez, E Tolosa, J M Palacio. Identification and characterization of serotonin 5-HT4 receptor binding sites in human brain: comparison with other mammalian species. Brain research. Molecular brain research. vol 21. issue 1-2. 1994-05-23. PMID:8164518. |
identification and characterization of serotonin 5-ht4 receptor binding sites in human brain: comparison with other mammalian species. |
1994-05-23 |
2023-08-12 |
human |
| P R Wade, H Tamir, A L Kirchgessner, M D Gersho. Analysis of the role of 5-HT in the enteric nervous system using anti-idiotopic antibodies to 5-HT receptors. The American journal of physiology. vol 266. issue 3 Pt 1. 1994-05-20. PMID:8166280. |
initial applications of the alpha-id mimicked each of three actions of 5-ht: a rapid depolarization, associated with a fall in input resistance (rin), which was inhibited by the 5-ht3 antagonists tropisetron (> or = 1 microm) and renzapride (100 microm); a slow membrane depolarization, associated with increased rin, that was inhibited by the 5-ht1p antagonist renzapride but was unaffected by a 5-ht4 blocking concentration of tropisetron (10 microm); and a hyperpolarization, associated with decreased rin, that was antagonized by the 5-ht1a inhibitor nan-190. |
1994-05-20 |
2023-08-12 |
Not clear |
| M B Hansen, B M Jaff. 5-HT receptor subtypes involved in luminal serotonin-induced secretion in rat intestine in vivo. The Journal of surgical research. vol 56. issue 3. 1994-05-04. PMID:8145546. |
these results suggest that (1) in both segments of the intestine, 5-ht2, 5-ht3, and/or 5-ht4 receptor subtypes are involved in the regulation of intestinal transport of water and electrolytes under basal conditions; (2) serotonin-induced water and electrolyte secretion is mediated by pathways involving 5-ht2, 5-ht3, and 5-ht4 receptor subtypes in both rat jejunum and ileum; (3) 5-ht1 receptors do not seem to be involved in the mediation of intestinal water and electrolyte transport; (4) these effects are similar to those described for systemically administered 5-ht. |
1994-05-04 |
2023-08-12 |
rat |
| H Pan, J J Galliga. 5-HT1A and 5-HT4 receptors mediate inhibition and facilitation of fast synaptic transmission in enteric neurons. The American journal of physiology. vol 266. issue 2 Pt 1. 1994-04-28. PMID:8141296. |
the actions of 5-hydroxtryptamine (5-ht)1a and 5-ht4 receptor agonists on fast excitatory postsynaptic potentials (epsps) in myenteric neurons of guinea pig ileum were studied in vitro. |
1994-04-28 |
2023-08-12 |
Not clear |
| B Costall, R J Naylor, B R Tuladha. 5-HT4 receptor mediated facilitation of the emptying phase of the peristaltic reflex in the guinea-pig isolated ileum. British journal of pharmacology. vol 110. issue 4. 1994-03-17. PMID:8306103. |
it is concluded that the rank order of potency of the 5-ht agonists from the indole and substituted benzamide series to facilitate the emptying phase of the peristaltic reflex in the guinea-pig ileum closely correlates with their published actions as 5-ht4 agonists in other systems. |
1994-03-17 |
2023-08-12 |
Not clear |
| B Costall, R J Naylor, B R Tuladha. 5-HT4 receptor mediated facilitation of the emptying phase of the peristaltic reflex in the guinea-pig isolated ileum. British journal of pharmacology. vol 110. issue 4. 1994-03-17. PMID:8306103. |
an agonist action on the 5-ht4 receptor is also supported by the potency of the 5-ht3/5-ht4 antagonist sdz 205-557 (but not the 5-ht3 antagonist ondansetron) to inhibit the effects of 5-ht. |
1994-03-17 |
2023-08-12 |
Not clear |
| F Hery, M Hamo. [Neuroleptics and serotonin]. L'Encephale. vol 19. issue 5. 1994-03-14. PMID:7905821. |
these studies not only demonstrate the existence of several classes of serotonin receptors called 5-ht1a, 5-ht1b, 5-ht1c, 5-ht1d, 5-ht2, 5-ht3 and 5-ht4, but led also to the development of novel agonists and antagonists for the stimulation or blockade of each of them. |
1994-03-14 |
2023-08-12 |
Not clear |
| M Félétou, O Dellazuana, J Duhaul. Serotoninergic receptor subtype in coronary artery smooth muscle from young and atherosclerotic rabbit. The Journal of pharmacology and experimental therapeutics. vol 268. issue 1. 1994-03-10. PMID:8301547. |
nan 190, a 5ht1a antagonist, ly 53857, a 5ht1c and 5ht2 antagonist, cyanopindolol, a 5ht1a and 5ht1b antagonist and ics 205-930, a 5ht3 and 5ht4 antagonist (up to 10(-6) m) did not inhibit the contractile response to 5ht. |
1994-03-10 |
2023-08-12 |
rabbit |
| A J Kauman. Blockade of human atrial 5-HT4 receptors by GR 113808. British journal of pharmacology. vol 110. issue 3. 1994-03-04. PMID:8298805. |
the mode of antagonism of 5-hydroxytryptamine (5-ht)-induced positive inotropic effects by the highly selective 5-ht4 receptor antagonist gr 113808 ([1-[2-methylsulphonylamino ethyl]-4-piperidinyl]methyl 1-methyl-1h-indole-3-carboxylate) was investigated on isolated preparations of human right atrium. |
1994-03-04 |
2023-08-12 |
human |
| R A Borman, D E Burleig. Evidence for the involvement of a 5-HT4 receptor in the secretory response of human small intestine to 5-HT. British journal of pharmacology. vol 110. issue 3. 1994-03-04. PMID:8298816. |
evidence for the involvement of a 5-ht4 receptor in the secretory response of human small intestine to 5-ht. |
1994-03-04 |
2023-08-12 |
human |
| R A Borman, D E Burleig. Evidence for the involvement of a 5-HT4 receptor in the secretory response of human small intestine to 5-HT. British journal of pharmacology. vol 110. issue 3. 1994-03-04. PMID:8298816. |
the competitive 5-ht4 antagonist, dau 6285 evoked a concentration-dependent, dextral and parallel shift of the concentration-response curve to 5-ht, with no alteration of the maximum response. |
1994-03-04 |
2023-08-12 |
human |
| R A Borman, D E Burleig. Evidence for the involvement of a 5-HT4 receptor in the secretory response of human small intestine to 5-HT. British journal of pharmacology. vol 110. issue 3. 1994-03-04. PMID:8298816. |
it appears that a 5-ht4 receptor may mediate the short-circuit current response of human small intestinal mucosa to 5-ht. |
1994-03-04 |
2023-08-12 |
human |
| A L Meulemans, L F Helsen, J A Schuurke. The role of nitric oxide (NO) in 5-HT-induced relaxations of the guinea-pig stomach. Naunyn-Schmiedeberg's archives of pharmacology. vol 348. issue 4. 1994-02-04. PMID:7506394. |
neither the 5-ht4 receptor agonist renzapride, nor the novel 5-ht4 receptor antagonist sdz 205-557, affected the relaxations to 5-ht. |
1994-02-04 |
2023-08-12 |
Not clear |
| N Yoshida, H Omoya, S Kato, T It. Pharmacological effects of the new gastroprokinetic agent mosapride citrate and its metabolites in experimental animals. Arzneimittel-Forschung. vol 43. issue 10. 1994-01-25. PMID:8267674. |
the pharmacological effects of the metabolites m1 and m2 of mosapride citrate ((+/-)-4-amino-5-chloro-2-ethoxy-n-[[4-(4-fluorobenzyl)-2-morpholi nyl] methyl]benzamide citrate, as-4370, cas 112885-42-4), a gastroprokinetic agent with serotonin 5-ht4 receptor agonist property, were compared with those of mosapride. |
1994-01-25 |
2023-08-12 |
mouse |
| H Lefebvre, V Contesse, C Delarue, C Soubrane, A Legrand, J M Kuhn, L M Wolf, H Vaudr. Effect of the serotonin-4 receptor agonist zacopride on aldosterone secretion from the human adrenal cortex: in vivo and in vitro studies. The Journal of clinical endocrinology and metabolism. vol 77. issue 6. 1994-01-24. PMID:8263156. |
we have recently shown that serotonin (5-ht) stimulates cortisol secretion from human adrenocortical tissue in vitro through activation of 5-ht4 receptors. |
1994-01-24 |
2023-08-12 |
human |
| D W Bonhaus, D N Loury, L B Jakeman, Z To, A DeSouza, R M Eglen, E H Won. [3H]BIMU-1, a 5-hydroxytryptamine3 receptor ligand in NG-108 cells, selectively labels sigma-2 binding sites in guinea pig hippocampus. The Journal of pharmacology and experimental therapeutics. vol 267. issue 2. 1994-01-06. PMID:8246171. |
]oct-3-yl)- 2,3-dihydro-3-ethyl-2-oxo-1h-benzimidazole-1-carboxamide hydrochloride ([3h]bimu-1) a benzimidazolone with high affinity for 5-hydroxytryptamine (5-ht)3 and 4 5-ht3 and 5-ht4 receptors, was characterized in ng-108 cells and guinea pig hippocampus. |
1994-01-06 |
2023-08-12 |
Not clear |
| D E Burleigh, R A Borma. Short-circuit current responses to 5-hydroxytryptamine in human ileal mucosa are mediated by a 5-HT4 receptor. European journal of pharmacology. vol 241. issue 1. 1993-12-16. PMID:7693492. |
short-circuit current responses to 5-hydroxytryptamine in human ileal mucosa are mediated by a 5-ht4 receptor. |
1993-12-16 |
2023-08-12 |
human |
| D E Burleigh, R A Borma. Short-circuit current responses to 5-hydroxytryptamine in human ileal mucosa are mediated by a 5-HT4 receptor. European journal of pharmacology. vol 241. issue 1. 1993-12-16. PMID:7693492. |
it is concluded that the effect of 5-ht on short-circuit current of human ileal mucosa appears to be due to stimulation of a 5-ht4 receptor. |
1993-12-16 |
2023-08-12 |
human |
| D C Yang, B Goldstin, A E Moormann, D L Flynn, G W Gullikso. SC-53606, a potent and selective antagonist of 5-hydroxytryptamine4 receptors in isolated rat esophageal tunica muscularis mucosae. The Journal of pharmacology and experimental therapeutics. vol 266. issue 3. 1993-10-14. PMID:8396633. |
the pa2 values for 5-ht4 antagonism against 5-ht were determined to be 6.80 +/- 0.09 for tropisetron and 7.36 +/- 0.08 for 2-methoxy-4-amino-s- chlorobenzoic acid-2-(diethylamino)ethyl ester sdz 205-557), indicating that sc-53606 is more a potent 5-ht4 antagonist than either of the reference antagonists. |
1993-10-14 |
2023-08-12 |
rat |