| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Z Cohen, I Bouchelet, A Olivier, J G Villemure, R Ball, D B Stanimirovic, E Hame. Multiple microvascular and astroglial 5-hydroxytryptamine receptor subtypes in human brain: molecular and pharmacologic characterization. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. vol 19. issue 8. 1999-09-10. PMID:10458598. |
in contrast, messages for all 5-ht receptors tested were detected in human brain astrocytes with a predominance of the 5-ht2a and 5-ht7 subtypes. |
1999-09-10 |
2023-08-12 |
human |
| D A Clemett, D A Kendall, M I Cockett, C A Marsden, K C Fon. Pindolol-insensitive [3H]-5-hydroxytryptamine binding in the rat hypothalamus; identity with 5-hydroxytryptamine7 receptors. British journal of pharmacology. vol 127. issue 1. 1999-09-01. PMID:10369478. |
intracerebroventricular pretreatment with the serotonergic neurotoxin 5,7-dihydroxytryptamine, 5,7-dht, elevated the [3h]-5-ht bmax 2 fold, indicating that the hypothalamic 5-ht7 receptor is post-synaptic to 5-ht nerve terminals and regulated by synaptic 5-ht levels. |
1999-09-01 |
2023-08-12 |
rat |
| J A Terrón, A Falcón-Ner. Pharmacological evidence for the 5-HT7 receptor mediating smooth muscle relaxation in canine cerebral arteries. British journal of pharmacology. vol 127. issue 3. 1999-09-01. PMID:10401550. |
we investigated in the present study whether 5-ht is able to exert direct relaxant responses in canine basilar and middle cerebral arteries via the 5-ht7 receptor. |
1999-09-01 |
2023-08-12 |
dog |
| J A Terrón, A Falcón-Ner. Pharmacological evidence for the 5-HT7 receptor mediating smooth muscle relaxation in canine cerebral arteries. British journal of pharmacology. vol 127. issue 3. 1999-09-01. PMID:10401550. |
in dog basilar artery, pre-incubated with gr127935 (1 microm) and ketanserin (0.1 microm) and precontracted with prostaglandin f2 alpha (2 microm), the 5-ht7 ligands, clozapine (1 microm), mesulergine (0.3 microm), methiothepin (3 nm), risperidone (3 nm), spiperone (1 microm) and ly215840 (10-100 nm), produced significant rightward shifts of the concentration-response curves for 5-ht and 5-ct. only methiothepin and risperidone reduced significantly the maximum relaxant response (emax), whilst the other drugs behaved as competitive antagonists with affinity values (pkb) that significantly correlated with their binding affinity (pki) at recombinant 5-ht7 receptors. |
1999-09-01 |
2023-08-12 |
dog |
| J A Terrón, A Falcón-Ner. Pharmacological evidence for the 5-HT7 receptor mediating smooth muscle relaxation in canine cerebral arteries. British journal of pharmacology. vol 127. issue 3. 1999-09-01. PMID:10401550. |
these data disclosing the involvement of the 5-ht7 receptor in cerebrovascular relaxation may be strongly relevant in the light of: (1) the involvement of 5-ht in migraine; (2) the putative linkage between cephalovascular vasodilatation and migraine headache; and (3) the relatively high 5-ht7 receptor affinity of migraine prophylactic 5-ht antagonists. |
1999-09-01 |
2023-08-12 |
dog |
| P De Vries, P A De Visser, J P Heiligers, C M Villalón, P R Saxen. Changes in systemic and regional haemodynamics during 5-HT7 receptor-mediated depressor responses in rats. Naunyn-Schmiedeberg's archives of pharmacology. vol 359. issue 4. 1999-07-23. PMID:10344532. |
the 5-hydroxytryptamine (5-ht)-induced late depressor response in rats is mainly mediated by vascular 5-ht7 receptors. |
1999-07-23 |
2023-08-12 |
rat |
| C P Lawler, C Prioleau, M M Lewis, C Mak, D Jiang, J A Schetz, A M Gonzalez, D R Sibley, R B Mailma. Interactions of the novel antipsychotic aripiprazole (OPC-14597) with dopamine and serotonin receptor subtypes. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 20. issue 6. 1999-06-24. PMID:10327430. |
these studies characterized the molecular pharmacology of opc-14597, dm-1451 (its major rodent metabolite), and the related quinolinone derivative opc-4392 at each of the cloned dopamine receptors, and at serotonin 5ht6 and 5ht7 receptors. |
1999-06-24 |
2023-08-12 |
Not clear |
| E A Thomas, B F Cravatt, J G Sutcliff. The endogenous lipid oleamide activates serotonin 5-HT7 neurons in mouse thalamus and hypothalamus. Journal of neurochemistry. vol 72. issue 6. 1999-06-14. PMID:10349846. |
the endogenous lipid oleamide activates serotonin 5-ht7 neurons in mouse thalamus and hypothalamus. |
1999-06-14 |
2023-08-12 |
mouse |
| E A Thomas, B F Cravatt, J G Sutcliff. The endogenous lipid oleamide activates serotonin 5-HT7 neurons in mouse thalamus and hypothalamus. Journal of neurochemistry. vol 72. issue 6. 1999-06-14. PMID:10349846. |
in the thalamus and hypothalamus a majority of neurons induced for c-fos expression also expressed the serotonin 5-ht7 receptor, an allosteric target for oleamide in in vitro studies. |
1999-06-14 |
2023-08-12 |
mouse |
| C S Nelson, J L Marino, C N Alle. Melatonin receptor potentiation of cyclic AMP and the cystic fibrosis transmembrane conductance regulator ion channel. Journal of pineal research. vol 26. issue 2. 1999-05-17. PMID:10100738. |
in oocytes injected with crna for melatonin receptors, serotonin receptors (5-ht7), and cftr cl- channels, application of melatonin together with serotonin (5-ht) activated an additional inward current showing potentiation of adenylyl cyclases by melatonin receptors. |
1999-05-17 |
2023-08-12 |
xenopus_laevis |
| R L Stowe, N M Barne. Selective labelling of 5-HT7 receptor recognition sites in rat brain using [3H]5-carboxamidotryptamine. Neuropharmacology. vol 37. issue 12. 1999-03-23. PMID:9886684. |
in rat whole brain (minus cerebellum and striatum) homogenate, (+/-)-pindolol (10 microm)-insensitive [3h]5-ct ([3h]5-carboxamidotryptamine; 0.5 nm) specific binding (defined by 5-ht, 10 microm) displayed a pharmacological profile similar to the recombinant 5-ht7 receptor, although the hill coefficients for competition curves generated by methiothepin, ritanserin, sumatriptan, clozapine and pimozide were significantly less than unity. |
1999-03-23 |
2023-08-12 |
rat |
| D E Heidmann, P Szot, R Kohen, M W Hambli. Function and distribution of three rat 5-hydroxytryptamine7 (5-HT7) receptor isoforms produced by alternative splicing. Neuropharmacology. vol 37. issue 12. 1999-03-23. PMID:9886685. |
serotonin (5-ht7) receptor pre-mrna is alternatively spliced in rat tissue to produce three isoforms, 5-ht(7a), 5-ht(7b) and 5-ht(7c), which differ in the amino acid sequences of their carboxyl terminal tails. |
1999-03-23 |
2023-08-12 |
human |
| M A Olsen, S P Nawoschik, B R Schurman, H L Schmitt, M Burno, D L Smith, L E Schechte. Identification of a human 5-HT6 receptor variant produced by alternative splicing. Brain research. Molecular brain research. vol 64. issue 2. 1999-03-12. PMID:9931499. |
the complexity of the 5-hydroxytryptamine (5-ht) (serotonin) receptor family has been increased by the findings that isoforms or splice variants exist for subtypes such as the 5-ht2b, 5-ht2c, 5-ht4 and 5-ht7 subtypes. |
1999-03-12 |
2023-08-12 |
mouse |
| E A Thomas, M J Carson, J G Sutcliff. Oleamide-induced modulation of 5-hydroxytryptamine receptor-mediated signaling. Annals of the New York Academy of Sciences. vol 861. 1999-02-25. PMID:9928256. |
oleamide caused a potentiation of 5-ht-elicited inositol phosphate formation mediated by the 5-ht2a receptor, but inhibited the effects of 5-ht on camp production mediated by the 5-ht7 receptor. |
1999-02-25 |
2023-08-12 |
rat |
| M S Brownfield, J Yracheta, F Chu, D Lorenz, A Dia. Functional chemical neuroanatomy of serotonergic neurons and their targets: antibody production and immunohistochemistry (IHC) for 5-HT, its precursor (5-HTP) and metabolite (5-HIAA), biosynthetic enzyme (TPH), transporter (SERT), and three receptors (5-HT2A, 5-ht5a, 5-HT7). Annals of the New York Academy of Sciences. vol 861. 1999-02-25. PMID:9928261. |
functional chemical neuroanatomy of serotonergic neurons and their targets: antibody production and immunohistochemistry (ihc) for 5-ht, its precursor (5-htp) and metabolite (5-hiaa), biosynthetic enzyme (tph), transporter (sert), and three receptors (5-ht2a, 5-ht5a, 5-ht7). |
1999-02-25 |
2023-08-12 |
Not clear |
| J A Terró. Evidence for the putative 5-HT7 receptor mediating direct relaxation to 5-hydroxytryptamine in canine cerebral blood vessels. Annals of the New York Academy of Sciences. vol 861. 1999-02-25. PMID:9928292. |
evidence for the putative 5-ht7 receptor mediating direct relaxation to 5-hydroxytryptamine in canine cerebral blood vessels. |
1999-02-25 |
2023-08-12 |
Not clear |
| T Mennini, M Gobb. Serotonin 5-HT7 receptors binding to rat hypothalamic membranes. Journal of neurochemistry. vol 72. issue 2. 1999-02-11. PMID:9930767. |
serotonin 5-ht7 receptors binding to rat hypothalamic membranes. |
1999-02-11 |
2023-08-12 |
rat |
| M A Re. Photic entrainment of circadian rhythms in rodents. Chronobiology international. vol 15. issue 5. 1999-01-07. PMID:9787933. |
in addition, serotonin appears to regulate the response of the scn circadian clock to light through postsynaptic 5-ht1a or 5-ht7 receptors, as well as presynaptic 5-ht1b heteroreceptors on rht terminals. |
1999-01-07 |
2023-08-12 |
Not clear |
| L J Dupont, J L Pype, M G Demedts, P De Leyn, G Deneffe, G M Verlede. The effects of 8-hydroxy-2-(di-n-propylamino)tetralin on the cholinergic contraction in guinea pig and human airways in vitro. American journal of respiratory and critical care medicine. vol 158. issue 5 Pt 1. 1998-12-18. PMID:9817696. |
these results suggest that 8-oh-dpat inhibits the cholinergic contraction in guinea pig and human airways in vitro through stimulation of prejunctional atypical 5-ht receptors, possibly of the 5-ht7 subtype, located on postganglionic cholinergic nerves. |
1998-12-18 |
2023-08-12 |
human |
| K Nakai, T Fujii, K Fujimoto, T Suzuki, K Kawashim. Effect of WAY-100135 on the hippocampal acetylcholine release potentiated by 8-OH-DPAT, a serotonin1A receptor agonist, in normal and p-chlorophenylalanine-treated rats as measured by in vivo microdialysis. Neuroscience research. vol 31. issue 1. 1998-11-12. PMID:9704975. |
in addition, a possibility that subtypes of 5-ht receptors other than the 5-ht1a receptor, probably 5-ht7 receptor in the septum as well as postsynaptic 5-ht1a receptor in the hippocampus, are involved in the increased hippocampal ach release induced by systemically administered 8-oh-dpat is discussed. |
1998-11-12 |
2023-08-12 |
rat |