| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| J J Lucas, R He. New players in the 5-HT receptor field: genes and knockouts. Trends in pharmacological sciences. vol 16. issue 7. 1995-10-11. PMID:7667899. |
in recent years, cloning has revealed the existence of no less than 14 mammalian 5-ht receptors, as well as evidence that isoforms of the 5-ht4 and 5-ht7 receptors are generated by alternative splicing. |
1995-10-11 |
2023-08-12 |
Not clear |
| S C Pandey, J M Davis, G N Pande. Phosphoinositide system-linked serotonin receptor subtypes and their pharmacological properties and clinical correlates. Journal of psychiatry & neuroscience : JPN. vol 20. issue 3. 1995-07-27. PMID:7786883. |
serotonin (5-ht) receptors have been classified into several categories, and they are termed as 5-ht1, 5-ht2, 5-ht3, 5-ht4, 5-ht5, 5-ht6 and 5-ht7 type receptors. |
1995-07-27 |
2023-08-12 |
Not clear |
| A J Sleight, C Carolo, N Petit, C Zwingelstein, A Bourso. Identification of 5-hydroxytryptamine7 receptor binding sites in rat hypothalamus: sensitivity to chronic antidepressant treatment. Molecular pharmacology. vol 47. issue 1. 1995-02-28. PMID:7838138. |
due to the high level of expression of mrna for the 5-hydroxytrytamine (5-ht7) receptor in the hypothalamus and the high affinity of 5-ht for this receptor, [3h]5-ht binding was performed in rat hypothalamus to determine whether 5-ht7 receptor binding sites are present in animal tissue. |
1995-02-28 |
2023-08-12 |
rat |
| A J Sleight, C Carolo, N Petit, C Zwingelstein, A Bourso. Identification of 5-hydroxytryptamine7 receptor binding sites in rat hypothalamus: sensitivity to chronic antidepressant treatment. Molecular pharmacology. vol 47. issue 1. 1995-02-28. PMID:7838138. |
[3h]5-ht binding was performed in the presence of 100 nm pindolol, which is inactive at 5-ht7 receptors but prevents the binding of [3h]5-ht to 5-ht1a and 5-ht1b receptor binding sites. |
1995-02-28 |
2023-08-12 |
rat |
| A J Sleight, C Carolo, N Petit, C Zwingelstein, A Bourso. Identification of 5-hydroxytryptamine7 receptor binding sites in rat hypothalamus: sensitivity to chronic antidepressant treatment. Molecular pharmacology. vol 47. issue 1. 1995-02-28. PMID:7838138. |
these data suggest that the 5-ht7 receptor binding site is expressed in rat hypothalamus and that this receptor binding site is down-regulated after a chronic increase in the synaptic level of 5-ht. |
1995-02-28 |
2023-08-12 |
rat |
| F Kawahara, H Saito, H Katsuk. Inhibition by 5-HT7 receptor stimulation of GABAA receptor-activated current in cultured rat suprachiasmatic neurones. The Journal of physiology. vol 478 ( Pt 1). 1994-12-08. PMID:7965836. |
it is concluded that 5-ht inhibits igaba in the scn neurones, which involves the activation of 5-ht7 receptors and camp-coupled systems. |
1994-12-08 |
2023-08-12 |
rat |
| H Y Meltze. An overview of the mechanism of action of clozapine. The Journal of clinical psychiatry. vol 55 Suppl B. 1994-11-28. PMID:7961573. |
clozapine has < 10 nm affinity for the serotonin (5-ht)2a, 5-ht2c, 5-ht6, 5-ht7, d4, m1, and alpha 1-adrenergic receptor but weak affinity for the d2 receptor. |
1994-11-28 |
2023-08-12 |
Not clear |
| T W Lovenberg, B M Baron, L de Lecea, J D Miller, R A Prosser, M A Rea, P E Foye, M Racke, A L Slone, B W Siege. A novel adenylyl cyclase-activating serotonin receptor (5-HT7) implicated in the regulation of mammalian circadian rhythms. Neuron. vol 11. issue 3. 1993-11-01. PMID:8398139. |
the circadian phase of spontaneous neuronal activity of the rat suprachiasmatic nucleus of the hypothalamus advances in response to serotonin ligands with a pharmacological profile consistent exclusively with that of 5-ht7. |
1993-11-01 |
2023-08-12 |
rat |
| M Ruat, E Traiffort, R Leurs, J Tardivel-Lacombe, J Diaz, J M Arrang, J C Schwart. Molecular cloning, characterization, and localization of a high-affinity serotonin receptor (5-HT7) activating cAMP formation. Proceedings of the National Academy of Sciences of the United States of America. vol 90. issue 18. 1993-10-20. PMID:8397408. |
the deduced amino acid sequence of the 5-ht7 receptor displays limited homology with that of other 5-ht receptors. |
1993-10-20 |
2023-08-12 |
Not clear |
| M Ruat, E Traiffort, R Leurs, J Tardivel-Lacombe, J Diaz, J M Arrang, J C Schwart. Molecular cloning, characterization, and localization of a high-affinity serotonin receptor (5-HT7) activating cAMP formation. Proceedings of the National Academy of Sciences of the United States of America. vol 90. issue 18. 1993-10-20. PMID:8397408. |
the 5-ht7 receptor, stably expressed in transfected cho cells, bound [3h]5-ht with high affinity (kd = 1 nm), like receptors of the 5-ht1 subfamily from which, however, it was clearly distinguished by its pharmacology. |
1993-10-20 |
2023-08-12 |
Not clear |
| M Ruat, E Traiffort, R Leurs, J Tardivel-Lacombe, J Diaz, J M Arrang, J C Schwart. Molecular cloning, characterization, and localization of a high-affinity serotonin receptor (5-HT7) activating cAMP formation. Proceedings of the National Academy of Sciences of the United States of America. vol 90. issue 18. 1993-10-20. PMID:8397408. |
these various properties differentiate the 5-ht7 receptor from the four other subfamilies of mammalian 5-ht receptors (i.e., the 5-ht1-, 5-ht2-, 5-ht3-, and 5-ht4-like subfamilies) and, therefore, appear to define another receptor subfamily. |
1993-10-20 |
2023-08-12 |
Not clear |