| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Anantha Krishnan Dhanabalan, Praveen Kumar, Saranya Vasudevan, Arkadiusz Chworos, Devadasan Velmuruga. Identification of a novel drug molecule for neurodegenerative disease from marine algae through Journal of biomolecular structure & dynamics. 2024-03-08. PMID:38456260. |
identification of a novel drug molecule for neurodegenerative disease from marine algae through cognitive functions are lost due to the rapid hydrolysis of acetylcholine including acetylcholinesterase (ache) and butyrylcholinesterase (bche). |
2024-03-08 |
2024-03-10 |
Not clear |
| Showkat Ahmad Mir, Binata Nayak, Andleeb Khan, Mohammad Imran Khan, Basmah M Eldakhakhny, Deema O Ari. An exploration of binding of Hesperidin, Rutin, and Thymoquinone to acetylcholinesterase enzyme using multi-level computational approaches. Journal of biomolecular structure & dynamics. 2023-10-09. PMID:37811769. |
acetylcholinesterase (ache) is a widely chosen therapeutic target for the development of early prevention and effective management of neurodegenerative diseases. |
2023-10-09 |
2023-10-15 |
Not clear |
| Elif Tugce Karoglu-Eravsar, Melek Umay Tuz-Sasik, Aysenur Karaduman, Ayse Gokce Keskus, Ayca Arslan-Ergul, Ozlen Konu, Hulusi Kafaligonul, Michelle M Adam. Long-term Acetylcholinesterase Depletion Alters the Levels of Key Synaptic Proteins while Maintaining Neuronal Markers in the Aging Zebrafish (Danio rerio) Brain. Gerontology. 2023-10-04. PMID:37793352. |
interventions targeting cholinergic neurotransmission like acetylcholinesterase (ache) inhibition distinguish potential mechanisms to delay age-related impairments and attenuate deficits related to neurodegenerative diseases. |
2023-10-04 |
2023-10-07 |
zebrafish |
| Agnieszka Szewczyk, Filip Pęcze. Furoquinoline Alkaloids: Insights into Chemistry, Occurrence, and Biological Properties. International journal of molecular sciences. vol 24. issue 16. 2023-08-26. PMID:37628986. |
of great interest is their potential as acetylcholinesterase inhibitors and anti-inflammatory agents in neurodegenerative diseases. |
2023-08-26 |
2023-09-07 |
Not clear |
| Damijan Knez, Daniel Diez-Iriepa, Mourad Chioua, Andrea Gottinger, Milica Denic, Fabien Chantegreil, Florian Nachon, Xavier Brazzolotto, Anna Skrzypczak-Wiercioch, Anže Meden, Anja Pišlar, Janko Kos, Simon Žakelj, Jure Stojan, Kinga Sałat, Julia Serrano, Ana Patricia Fernández, Aitana Sánchez-García, Ricardo Martínez-Murillo, Claudia Binda, Francisco López-Muñoz, Stanislav Gobec, José Marco-Contelle. 8-Hydroxyquinolylnitrones as multifunctional ligands for the therapy of neurodegenerative diseases. Acta pharmaceutica Sinica. B. vol 13. issue 5. 2023-05-30. PMID:37250172. |
we describe the development of quinolylnitrones (qns) as multifunctional ligands inhibiting cholinesterases (ches: acetylcholinesterase and butyrylcholinesterase-hbche) and monoamine oxidases (hmao-a/b) for the therapy of neurodegenerative diseases. |
2023-05-30 |
2023-08-14 |
Not clear |
| Ahmed H E Hassan, Hyeon Jeong Kim, Keontae Park, Yeonwoo Choi, Suyeon Moon, Chae Hyeon Lee, Yeon Ju Kim, Soo Bin Cho, Min Sung Gee, Danbi Lee, Jong-Hyun Park, Jong Kil Lee, Jong Hoon Ryu, Ki Duk Park, Yong Sup Le. Synthesis and Biological Evaluation of Antioxidants (Basel, Switzerland). vol 12. issue 5. 2023-05-27. PMID:37237899. |
in addition, acetylcholinesterase activity and neuroinflammation are involved in neurodegenerative diseases. |
2023-05-27 |
2023-08-14 |
Not clear |
| Pratap G Kenchappa, Yalpi Karthik, Poornima D Vijendra, Raghavendra L S Hallur, Ajay S Khandagale, Ashok K Pandurangan, Sathisha G Jayanna, Mohammed Ali Alshehri, Abdulrahman Alasmari, Samy Sayed, Manjula Shantaram, Muntazir Mushta. Frontiers in pharmacology. vol 14. 2023-05-26. PMID:37234712. |
alzheimer's disease (ad) is a type of neurodegenerative disease, associated with the hastening of ros, acetylcholinesterase (ache) activity, and amyloid β peptides plaques in the brain. |
2023-05-26 |
2023-08-14 |
Not clear |
| Sagnik Haldar, Satyabrata Mohapatra, Partha Ganguly, Nirankush Paul, Avinandan Ash, Rajarshi Biswas, Rahul Singh, Chandra Kant Katiya. N-Methylneolitsine as a new and potent acetylcholinesterase inhibitor of Natural product research. 2023-05-08. PMID:37154600. |
n-methylneolitsine as a new and potent acetylcholinesterase inhibitor of the rising geriatric population is expected to increase the demand for drugs treating neurodegenerative diseases. |
2023-05-08 |
2023-08-14 |
Not clear |
| Bo Pang, Lu-Lu Zhang, Bin Li, Feng-Xian Sun, Zhi-Da Wan. The sodium glucose co-transporter 2 inhibitor ertugliflozin for Alzheimer's disease: inhibition of brain insulin signaling disruption-induced tau hyperphosphorylation. Physiology & behavior. 2023-02-22. PMID:36809844. |
an antidiabetic agent sodium glucose co-transporter 2 (sglt2) inhibitor ertugliflozin has been revealed to bind to catalytic anionic site of acetylcholinesterase (ache), which is considered to be associated with the cognitive decline in neurodegenerative diseases, such as alzheimer's disease (ad). |
2023-02-22 |
2023-08-14 |
rat |
| Ashraf K El-Damasy, Jong Eun Park, Hyun Ji Kim, Jinhyuk Lee, Eun-Kyoung Bang, Hoon Kim, Gyochang Keu. Identification of New Pharmaceuticals (Basel, Switzerland). vol 16. issue 1. 2023-01-21. PMID:36678580. |
identification of new monoamine oxidase-b (mao-b), acetylcholinesterase (ache), and butyrylcholinesterase (bche) have been considered target enzymes of depression and neurodegenerative diseases, including alzheimer's disease (ad). |
2023-01-21 |
2023-08-14 |
Not clear |
| Yang Liu, Qiang Wang, Zhen Xie, Dong-Kun Zheng, Jing Li, Gui-Shan Ta. Lycopodiastrum casuarinoides: An overview of their phytochemicals, biological activities, structure-activity relationship, biosynthetic pathway and Fitoterapia. 2023-01-07. PMID:36608712. |
lycopodiastrum casuarinoides: an overview of their phytochemicals, biological activities, structure-activity relationship, biosynthetic pathway and huperzine a, a lycodine-type alkaloid, exhibits potent inhibitory activity against acetylcholinesterase (ache) and has been utilized to treat neurodegenerative diseases' symptoms. |
2023-01-07 |
2023-08-14 |
Not clear |
| Hongyu Zhang, Danjie Wang, Jingxian Sun, Yumeng Wang, Shuai Wu, Jun Wan. Huperzine-A Improved Animal Behavior in Cuprizone-Induced Mouse Model by Alleviating Demyelination and Neuroinflammation. International journal of molecular sciences. vol 23. issue 24. 2022-12-23. PMID:36555825. |
huperzine a (hupa) is a natural acetylcholinesterase inhibitor (achei) with the advantages of high efficiency, selectivity as well as reversibility and can exhibit significant therapeutic effects against certain neurodegenerative diseases. |
2022-12-23 |
2023-08-14 |
mouse |
| b' Simone Lista, Andrea Vergallo, Stefan J Teipel, Pablo Lemercier, Filippo Sean Giorgi, Audrey Gabelle, Francesco Garaci, Nicola B Mercuri, Claudio Babiloni, Bhakta Prasad Gaire, Yosef Koronyo, Maya Koronyo-Hamaoui, Harald Hampel, Robert Nistic\\xc3\\xb. Determinants of approved acetylcholinesterase inhibitor response outcomes in Alzheimer\'s disease: relevance for precision medicine in neurodegenerative diseases. Ageing research reviews. 2022-12-16. PMID:36526257.' |
acetylcholinesterase inhibitors (chei) are the global standard of care for the symptomatic treatment of alzheimer's disease (ad) and show significant positive effects in neurodegenerative diseases with cognitive and behavioral symptoms. |
2022-12-16 |
2023-08-14 |
Not clear |
| b' Simone Lista, Andrea Vergallo, Stefan J Teipel, Pablo Lemercier, Filippo Sean Giorgi, Audrey Gabelle, Francesco Garaci, Nicola B Mercuri, Claudio Babiloni, Bhakta Prasad Gaire, Yosef Koronyo, Maya Koronyo-Hamaoui, Harald Hampel, Robert Nistic\\xc3\\xb. Determinants of approved acetylcholinesterase inhibitor response outcomes in Alzheimer\'s disease: relevance for precision medicine in neurodegenerative diseases. Ageing research reviews. 2022-12-16. PMID:36526257.' |
determinants of approved acetylcholinesterase inhibitor response outcomes in alzheimer's disease: relevance for precision medicine in neurodegenerative diseases. |
2022-12-16 |
2023-08-14 |
Not clear |
| Irene Gouvinhas, Juliana Garcia, Daniel Granato, Ana Barro. Seed Phytochemical Profiling of Three Olive Cultivars, Antioxidant Capacity, Enzymatic Inhibition, and Effects on Human Neuroblastoma Cells (SH-SY5Y). Molecules (Basel, Switzerland). vol 27. issue 16. 2022-08-26. PMID:36014295. |
in addition, it also appraised their potential antineurodegenerative properties on the basis of their ability to inhibit enzymes associated with neurodegenerative diseases: acetylcholinesterase (ache), butyrylcholinesterase (bche), and tyrosinase (tyr). |
2022-08-26 |
2023-08-14 |
human |
| Xiao-Ping Zhang, Wang Xu, Jian-Hua Wang, Yang Sh. MnO The Analyst. 2022-08-24. PMID:36001020. |
mno acetylcholinesterase (ache) is an essential serine hydrolase associated with neurodegenerative diseases and serves as a biomarker. |
2022-08-24 |
2023-08-14 |
Not clear |
| Jing-Ling Tan, Yun-Ling Xu, Yi-Qin Fei, Guo-Hua Zheng, Xiao-Ping Din. Simultaneous screening, identification, quantitation, and activity evaluation of six acetylcholinesterase (AChE) inhibitors in Coptidis Rhizoma by online UPLC-DAD coupled with AChE biochemical detection. Journal of pharmaceutical and biomedical analysis. vol 219. 2022-07-03. PMID:35780528. |
acetylcholinesterase (ache) inhibition is a common treatment in the early stages of dementia and neurodegenerative diseases, including alzheimer's disease (ad). |
2022-07-03 |
2023-08-14 |
Not clear |
| Ante Miličević, Goran Šink. Use of connectivity index and simple topological parameters for estimating the inhibition potency of acetylcholinesterase. Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society. vol 30. issue 4. 2022-05-09. PMID:35527825. |
acetylcholinesterase (ache) has proven to be an effective drug target in the treatment of neurodegenerative diseases such as alzheimer's, parkinson's and dementia. |
2022-05-09 |
2023-08-13 |
Not clear |
| Yiwen Xiao, Weizhong Liang, De Liu, Zhibin Zhang, Jun Chang, Du Zh. Isolation and acetylcholinesterase inhibitory activity of asterric acid derivatives produced by 3 Biotech. vol 12. issue 3. 2022-02-21. PMID:35186657. |
isolation and acetylcholinesterase inhibitory activity of asterric acid derivatives produced by alzheimer's disease (ad) is a neurodegenerative disease and the fourth leading cause of death after cardiovascular disease, tumors, and stroke. |
2022-02-21 |
2023-08-13 |
Not clear |
| Y Cañizares-Carmenate, N-H Nam, R Díaz-Amador, N T Thuan, P T P Dung, F Torrens, H Pham-The, F Perez-Gimenez, J A Castillo-Gari. Ligand-based discovery of new potential acetylcholinesterase inhibitors for Alzheimer's disease treatment. SAR and QSAR in environmental research. 2022-01-20. PMID:35048766. |
the enzyme acetylcholinesterase (ache) is currently a therapeutic target for the treatment of neurodegenerative diseases. |
2022-01-20 |
2023-08-13 |
Not clear |