| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Iksoo Lee, Bora Ahn, Jaesue Choi, Masao Hattori, Byungsun Min, Kihwan Ba. Selective cholinesterase inhibition by lanostane triterpenes from fruiting bodies of Ganoderma lucidum. Bioorganic & medicinal chemistry letters. vol 21. issue 21. 2012-01-31. PMID:21924611. |
because new compounds exhibiting specific anti-acetylcholinesterase activity are being sought as possible drug candidates for the treatment of alzheimer's and related neurodegenerative diseases, compounds 1-18 were examined for their inhibitory activities against acetylcholinesterase and butyrylcholinesterase. |
2012-01-31 |
2023-08-12 |
Not clear |
| Francisco J Carvajal, Nibaldo C Inestros. Interactions of AChE with Aβ Aggregates in Alzheimer's Brain: Therapeutic Relevance of IDN 5706. Frontiers in molecular neuroscience. vol 4. 2011-11-10. PMID:21949501. |
acetylcholinesterase (ache; ec 3.1.1.7) plays a crucial role in the rapid hydrolysis of the neurotransmitter acetylcholine, in the central and peripheral nervous system and might also participate in non-cholinergic mechanism related to neurodegenerative diseases. |
2011-11-10 |
2023-08-12 |
mouse |
| Eftim Milkani, Christopher R Lambert, W Grant McGimpse. Direct detection of acetylcholinesterase inhibitor binding with an enzyme-based surface plasmon resonance sensor. Analytical biochemistry. vol 408. issue 2. 2011-03-01. PMID:20849808. |
acetylcholinesterase (ache) inhibitors are potentially lethal but also have applications as therapeutic drugs for neurodegenerative diseases such as alzheimer's. |
2011-03-01 |
2023-08-12 |
Not clear |
| L B Pagliosa, S C Monteiro, K B Silva, J P de Andrade, J Dutilh, J Bastida, M Cammarota, J A S Zuanazz. Effect of isoquinoline alkaloids from two Hippeastrum species on in vitro acetylcholinesterase activity. Phytomedicine : international journal of phytotherapy and phytopharmacology. vol 17. issue 8-9. 2010-12-03. PMID:19969445. |
the treatment of neurological disorders and neurodegenerative diseases is related to the levels of acetylcholine (ach) through the inhibition of acetylcholinesterase (ache). |
2010-12-03 |
2023-08-12 |
Not clear |
| Laura E Paraoanu, Paul G Laye. Acetylcholinesterase in cell adhesion, neurite growth and network formation. The FEBS journal. vol 275. issue 4. 2008-06-17. PMID:18205832. |
the expression of acetylcholinesterase is not restricted to cholinergically innervated tissues and relates to both neurotransmission and multiple biological aspects, including neural development, stress response and neurodegenerative diseases. |
2008-06-17 |
2023-08-12 |
mouse |
| Eun Kyoung Ryu, Xiaoyuan Che. Development of Alzheimer's disease imaging agents for clinical studies. Frontiers in bioscience : a journal and virtual library. vol 13. 2007-12-11. PMID:17981587. |
alzheimer's disease (ad) is a neurodegenerative disease characterized by a progressive loss of neurotransmitters, as well as acetylcholinesterase and nicotinic acetylcholine receptors in the central nervous system that leads to learning and memory deficits, among other problems. |
2007-12-11 |
2023-08-12 |
human |
| Ella H Sklan, Erez Podoly, Hermona Sore. RACK1 has the nerve to act: structure meets function in the nervous system. Progress in neurobiology. vol 78. issue 2. 2006-05-25. PMID:16457939. |
when bound to the stress-induced acetylcholinesterase variant ache-r, rack1 is implicated in stress responses and behavior, compatible with reports of rack1 modulations in brain ageing and in various neurodegenerative diseases. |
2006-05-25 |
2023-08-12 |
Not clear |
| F H Calderón, R von Bernhardi, G De Ferrari, S Luza, R Aldunate, N C Inestros. Toxic effects of acetylcholinesterase on neuronal and glial-like cells in vitro. Molecular psychiatry. vol 3. issue 3. 1998-10-08. PMID:9672900. |
acetylcholinesterase (ache), the enzyme involved in the hydrolysis of the neurotransmitter acetylcholine, has been implicated in non-cholinergic actions which may play a role in neurodegenerative diseases such as alzheimer's disease. |
1998-10-08 |
2023-08-12 |
Not clear |
| C Llanes, R G Collman, R Hrin, D L Kolso. Acetylcholinesterase expression in NTera 2 human neuronal cells: a model for developmental expression in the nervous system. Journal of neuroscience research. vol 42. issue 6. 1996-10-22. PMID:8847741. |
these observations indicate that ntera 2 cells provide a useful human model system for studies of expression of cell-associated and soluble cell-free ache in developing and mature human neurons and for elucidating the potential role(s) of acetylcholinesterase metabolism in both normal development and neurodegenerative disease states. |
1996-10-22 |
2023-08-12 |
human |
| B S McEwen, E Gould, M Orchinik, N G Weiland, C S Woolle. Oestrogens and the structural and functional plasticity of neurons: implications for memory, ageing and neurodegenerative processes. Ciba Foundation symposium. vol 191. 1996-03-20. PMID:8582205. |
this paper describes three actions of oestrogens that are especially relevant to brain mechanisms involved in memory processes and their alterations during ageing and neurodegenerative diseases: (1) the regulation of cholinergic neurons by oestradiol in the rat basal forebrain, involving induction of choline acetyltransferase and acetylcholinesterase according to a sexually dimorphic pattern; (2) the regulation of synaptogenesis in the ca1 region of the hippocampus by oestrogens and progestins during the four- to five-day oestrus cycle of the female rat. |
1996-03-20 |
2023-08-12 |
rat |
| M Ruberg, A Villageois, A M Bonnet, B Pillon, F Rieger, Y Agi. Acetylcholinesterase and butyrylcholinesterase activity in the cerebrospinal fluid of patients with neurodegenerative diseases involving cholinergic systems. Journal of neurology, neurosurgery, and psychiatry. vol 50. issue 5. 1987-07-07. PMID:2953866. |
acetylcholinesterase and butyrylcholinesterase activity in the cerebrospinal fluid of patients with neurodegenerative diseases involving cholinergic systems. |
1987-07-07 |
2023-08-11 |
human |
| M Ruberg, A Villageois, A M Bonnet, B Pillon, F Rieger, Y Agi. Acetylcholinesterase and butyrylcholinesterase activity in the cerebrospinal fluid of patients with neurodegenerative diseases involving cholinergic systems. Journal of neurology, neurosurgery, and psychiatry. vol 50. issue 5. 1987-07-07. PMID:2953866. |
acetylcholinesterase (ache) and butyrylcholinesterase (bche) were assayed in the cerebrospinal fluid (csf) of subjects with neurodegenerative diseases (dementing and non-dementing, with and without known cholinergic lesions), to determine whether csf ache is a valid marker of central cholinergic activity. |
1987-07-07 |
2023-08-11 |
human |