| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Y Cañizares-Carmenate, N-H Nam, R Díaz-Amador, N T Thuan, P T P Dung, F Torrens, H Pham-The, F Perez-Gimenez, J A Castillo-Gari. Ligand-based discovery of new potential acetylcholinesterase inhibitors for Alzheimer's disease treatment. SAR and QSAR in environmental research. 2022-01-20. PMID:35048766. |
the enzyme acetylcholinesterase (ache) is currently a therapeutic target for the treatment of neurodegenerative diseases. |
2022-01-20 |
2023-08-13 |
Not clear |
| Ahad Banagozar Mohammadi, Saeed Sadigh-Eteghad, Mohammadali Torbati, Seyyed Mohammad Bagher Fazljou, Seyed Mehdi Vatandoust, Samad Ej Golzari, Fereshteh Farajdokht, Javad Mahmoud. Identification and applications of neuroactive silk proteins: a narrative review. Journal of applied biomedicine. vol 17. issue 3. 2021-12-15. PMID:34907702. |
the antioxidant, neuroprotective, and acetylcholinesterase inhibitory mechanisms of silk proteins could prove promising in the treatment of neurodegenerative diseases. |
2021-12-15 |
2023-08-13 |
Not clear |
| Murilo K A Yonekawa, Bruna de B Penteado, Amanda Dal'Ongaro Rodrigues, Estela M G Lourenço, Euzébio G Barbosa, Silvia C das Neves, Rodrigo J de Oliveira, Maria R Marques, Denise B Silva, Dênis P de Lima, Adilson Beatriz, Jean P Oses, Jeandre A Dos S Jaques, Edson Dos A Dos Santo. l-Hypaphorine and d-hypaphorine: Specific antiacetylcholinesterase activity in rat brain tissue. Bioorganic & medicinal chemistry letters. vol 47. 2021-11-15. PMID:34146704. |
acetylcholinesterase (acheis) inhibitors are used to treat neurodegenerative diseases like alzheimer's disease (ad). |
2021-11-15 |
2023-08-13 |
human |
| Ana Cvv Giacomini, Barbara W Bueno, Leticia Marcon, Naiara Scolari, Rafael Genario, Konstantin A Demin, Tatyana O Kolesnikova, Allan V Kalueff, Murilo S de Abre. An acetylcholinesterase inhibitor, donepezil, increases anxiety and cortisol levels in adult zebrafish. Journal of psychopharmacology (Oxford, England). vol 34. issue 12. 2021-11-04. PMID:32854587. |
a potent acetylcholinesterase inhibitor, donepezil is a cognitive enhancer clinically used to treat neurodegenerative diseases. |
2021-11-04 |
2023-08-13 |
zebrafish |
| Łucja Justyna Walczak-Nowicka, Mariola Herbe. Acetylcholinesterase Inhibitors in the Treatment of Neurodegenerative Diseases and the Role of Acetylcholinesterase in their Pathogenesis. International journal of molecular sciences. vol 22. issue 17. 2021-10-18. PMID:34502198. |
acetylcholinesterase inhibitors in the treatment of neurodegenerative diseases and the role of acetylcholinesterase in their pathogenesis. |
2021-10-18 |
2023-08-13 |
Not clear |
| Łucja Justyna Walczak-Nowicka, Mariola Herbe. Acetylcholinesterase Inhibitors in the Treatment of Neurodegenerative Diseases and the Role of Acetylcholinesterase in their Pathogenesis. International journal of molecular sciences. vol 22. issue 17. 2021-10-18. PMID:34502198. |
acetylcholinesterase (ache) plays an important role in the pathogenesis of neurodegenerative diseases by influencing the inflammatory response, apoptosis, oxidative stress and aggregation of pathological proteins. |
2021-10-18 |
2023-08-13 |
Not clear |
| Martina Kaniakova, Jan Korabecny, Kristina Holubova, Lenka Kleteckova, Marketa Chvojkova, Kristina Hakenova, Lukas Prchal, Martin Novak, Rafael Dolezal, Vendula Hepnarova, Barbora Svobodova, Tomas Kucera, Katarina Lichnerova, Barbora Krausova, Martin Horak, Karel Vales, Ondrej Souku. 7-phenoxytacrine is a dually acting drug with neuroprotective efficacy in vivo. Biochemical pharmacology. vol 186. 2021-06-30. PMID:33571502. |
motivated by currently available treatment against neurodegenerative diseases involving the inhibitors of acetylcholinesterase (ache) and nmdars, administered also in combination, we developed a dually-acting compound 7-phenoxytacrine (7-pho-tha) and evaluated its neuropsychopharmacological and drug-like properties for potential therapeutic use. |
2021-06-30 |
2023-08-13 |
Not clear |
| b' Aleksandra M Bond\\xc5\\xbei\\xc4\\x87, Tamara D Lazarevi\\xc4\\x87-Pa\\xc5\\xa1ti, Andreja R Leskovac, Sandra \\xc5\\xbd Petrovi\\xc4\\x87, Mirjana B \\xc4\\x8colovi\\xc4\\x87, Tatjana N Parac-Vogt, Goran V Janji\\xc4\\x8. A new acetylcholinesterase allosteric site responsible for binding voluminous negatively charged molecules - the role in the mechanism of AChE inhibition. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. vol 151. 2021-06-21. PMID:32492460.' |
acetylcholinesterase (ache) inhibitors are important in the treatment of neurodegenerative diseases. |
2021-06-21 |
2023-08-13 |
human |
| Moustafa Gabr, Natarajan Arul Muruga. Discovery of biphenyl pyrazole scaffold for neurodegenerative diseases: A novel class of acetylcholinesterase-centered multitargeted ligands. Bioorganic & medicinal chemistry letters. vol 30. issue 17. 2021-06-08. PMID:32738978. |
herein, we report first-in-class dual inhibitor of acetylcholinesterase (ache) and tau aggregation as a novel class of multitargeted ligands for neurodegenerative diseases. |
2021-06-08 |
2023-08-13 |
Not clear |
| Ting Xiao, Shuang Wang, Mengxia Yan, Jianshe Huang, Xiurong Yan. A thiamine-triggered fluormetric assay for acetylcholinesterase activity and inhibitor screening based on oxidase-like activity of MnO Talanta. vol 221. 2021-05-14. PMID:33076048. |
a thiamine-triggered fluormetric assay for acetylcholinesterase activity and inhibitor screening based on oxidase-like activity of mno acetylcholinesterase (ache) plays an essential role in biological signal transmission, the aberrant expression of which could cause diverse neurodegenerative diseases. |
2021-05-14 |
2023-08-13 |
Not clear |
| Samir F de A Cavalcante, Alessandro B C Simas, Marcos C Barcellos, Victor G M de Oliveira, Roberto B Sousa, Paulo A de M Cabral, Kamil Kuča, Tanos C C Franç. Acetylcholinesterase: The "Hub" for Neurodegenerative Diseases and Chemical Weapons Convention. Biomolecules. vol 10. issue 3. 2021-03-18. PMID:32155996. |
acetylcholinesterase: the "hub" for neurodegenerative diseases and chemical weapons convention. |
2021-03-18 |
2023-08-13 |
Not clear |
| Nor Atiqah Jusril, Ain Nur Najihah Muhamad Juhari, Syahrul Imran Abu Bakar, Wan Mazlina Md Saad, Mohd Ilham Adena. Combining In Silico and In Vitro Studies to Evaluate the Acetylcholinesterase Inhibitory Profile of Different Accessions and the Biomarker Triterpenes of Molecules (Basel, Switzerland). vol 25. issue 15. 2021-03-01. PMID:32721993. |
combining in silico and in vitro studies to evaluate the acetylcholinesterase inhibitory profile of different accessions and the biomarker triterpenes of alzheimer's disease (ad) is a neurodegenerative disease and the most cause of dementia in elderly adults. |
2021-03-01 |
2023-08-13 |
Not clear |
| Raffaele Nuzzi, Alessandro Bojino, Maria Sole Polito, Chiara Luppi, Federico Tridico, Massimiliano Massai. The Pupil Diameter as a Possible Indicator of Neurodegenerative Diseases and Response to Acetylcholinesterase Inhibitors Therapy: In-Depth Measurements Following Topical Administration of Tropicamide and Pilocarpine. American journal of Alzheimer's disease and other dementias. vol 35. 2021-02-10. PMID:32875808. |
the pupil diameter as a possible indicator of neurodegenerative diseases and response to acetylcholinesterase inhibitors therapy: in-depth measurements following topical administration of tropicamide and pilocarpine. |
2021-02-10 |
2023-08-13 |
human |
| Ayodele Jacob Akinyemi, Philip Adeyemi Adeniy. Effect of Essential Oils from Ginger ( Journal of toxicology. vol 2018. 2020-09-30. PMID:30402094. |
the result revealed that essential oil from ginger and turmeric rhizomes exerts anti-inflammatory effect by preventing alterations of some cytokines/inflammatory biomarkers (il-6, il-10 and tnf-alpha) levels and inhibits both hippocampus and prefrontal cortex acetylcholinesterase (ache) and adenosine deaminase (ada) activities (important enzymes relevant in the management/prevention of neurodegenerative diseases) in cd treated rats. |
2020-09-30 |
2023-08-13 |
rat |
| Bruna R de Lima, Juliana M Lima, Jéssica B Maciel, Carolina Q Valentim, Rita de Cássia S Nunomura, Emerson S Lima, Hector H F Koolen, Afonso Duarte L de Souza, Maria Lúcia B Pinheiro, Quezia B Cass, Felipe Moura A da Silv. Synthesis and Inhibition Evaluation of New Benzyltetrahydroprotoberberine Alkaloids Designed as Acetylcholinesterase Inhibitors. Frontiers in chemistry. vol 7. 2020-09-30. PMID:31620424. |
secondary metabolites from natural products are a potential source of acetylcholinesterase inhibitors (acheis), which is a key enzyme in the treatment of many neurodegenerative diseases. |
2020-09-30 |
2023-08-13 |
Not clear |
| b' Ivana \\xc5\\xa0agud, Nikolina Ma\\xc4\\x8dek Hrvat, Ana Grgi\\xc4\\x8devi\\xc4\\x87, Tena \\xc4\\x8cade\\xc5\\xbe, Josipa Hodak, Milena Dragojevi\\xc4\\x87, Kornelija Lasi\\xc4\\x87, Zrinka Kovarik, Irena \\xc5\\xa0kori\\xc4\\x8. Design, synthesis and cholinesterase inhibitory properties of new oxazole benzylamine derivatives. Journal of enzyme inhibition and medicinal chemistry. vol 35. issue 1. 2020-03-05. PMID:31899981.' |
the enzymes acetylcholinesterase (ache) and butyrylcholinesterase (bche) are primary targets in attenuating the symptoms of neurodegenerative diseases. |
2020-03-05 |
2023-08-13 |
Not clear |
| Rajib Paul, Anupom Bora. Global loss of acetylcholinesterase activity with mitochondrial complexes inhibition and inflammation in brain of hypercholesterolemic mice. Scientific reports. vol 7. issue 1. 2019-08-21. PMID:29263397. |
as cognitive impairment, diminished brain acetylcholinesterase activity, mitochondrial dysfunctions, and inflammation are the prima facie pathologies of neurodegenerative diseases, the findings impose hypercholesterolemia as potential risk factor towards brain dysfunction. |
2019-08-21 |
2023-08-13 |
mouse |
| Anita Bosak, Alma Ramić, Tamara Šmidlehner, Tomica Hrenar, Ines Primožič, Zrinka Kovari. Design and evaluation of selective butyrylcholinesterase inhibitors based on Cinchona alkaloid scaffold. PloS one. vol 13. issue 10. 2019-04-05. PMID:30289893. |
five cinchonidine derivatives displayed 95-510 times higher inhibition selectivity to butyrylcholinesterase over acetylcholinesterase and four were potent butyrylcholinesterase inhibitors with ki constants up to 100 nm, of which n-para-bromobenzyl cinchonidinium bromide can be considered a lead for further modifications and optimizations for possible use in the treatment of neurodegenerative diseases. |
2019-04-05 |
2023-08-13 |
human |
| Ewelina Koziol, Ilkay Erdogan Orhan, F Sezer Senol, Kalina Alipieva, Milen Georgiev, Krystyna Skalicka-Woinia. Development of an Efficient Protocol for Cimifugin Isolation from Peucedanum schottii and Evaluation of Enzyme Inhibitory Activity. Natural product communications. vol 11. issue 8. 2019-03-18. PMID:30725569. |
cimifugin and the crude dcm extract were evaluated using elisa microtiter assays for their inhibitory potential against the cholinesterases (acetylcholinesterase - ache and butyrylcholinesterase - bche), and tyrosinase (tyr), which are key enzymes for the treatment of some neurodegenerative diseases, i.e. |
2019-03-18 |
2023-08-13 |
Not clear |
| Stephen Adeniyi Adefegh. Functional Foods and Nutraceuticals as Dietary Intervention in Chronic Diseases; Novel Perspectives for Health Promotion and Disease Prevention. Journal of dietary supplements. vol 15. issue 6. 2018-11-07. PMID:29281341. |
this review explains the interaction of functional food bioactive compounds including polyphenols (phenolic acids [hydroxybenzoic acids and hydroxycinnamic acids], flavonoids [flavonols, flavones, flavanols, flavanones, isoflavones, proanthocyanidins], stilbenes, and lignans), terpenoids, carotenoids, alkaloids, omega-3 and polyunsaturated fatty acids, among others with critical enzymes (α- amylase, α- glucosidase, angiotensin-i converting enzyme [ace], acetylcholinesterase [ache], and arginase) linked to some degenerative diseases (type-2 diabetes, cardiovascular diseases [hypertension], neurodegenerative diseases [alzheimer's disease] and erectile dysfunction). |
2018-11-07 |
2023-08-13 |
Not clear |