| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Gokhan Zengin, Dimitrina Zheleva-Dimitrova, Reneta Gevrenova, Paraskev Nedialkov, Andrei Mocan, Ana Ćirić, Jasmina Glamočlija, Marina Soković, Abdurrahman Aktumsek, M Fawzi Mahomoodall. Identification of phenolic components via LC-MS analysis and biological activities of two Centaurea species: C. drabifolia subsp. drabifolia and C. lycopifolia. Journal of pharmaceutical and biomedical analysis. vol 149. 2018-08-13. PMID:29169111. |
enzyme inhibitory potential was assessed against key enzymes linked to global health problems, namely neurodegenerative diseases (acetylcholinesterase), pigmentation (tyrosinase), and diabetes (α-amylase and α-glucosidase). |
2018-08-13 |
2023-08-13 |
Not clear |
| Andrea Jiménez-González, Cristina Quispe, Jorge Bórquez, Beatriz Sepúlveda, Felipe Riveros, Carlos Areche, Edgar Nagles, Olimpo García-Beltrán, Mario J Simirgioti. UHPLC-ESI-ORBITRAP-MS analysis of the native Mapuche medicinal plant palo negro (Leptocarpha rivularis DC. - Asteraceae) and evaluation of its antioxidant and cholinesterase inhibitory properties. Journal of enzyme inhibition and medicinal chemistry. vol 33. issue 1. 2018-05-24. PMID:29734888. |
the cholinesterase inhibitory activity was 7.38 ± 0.03 and 5.74 ± 0.06 mmol galae/kg, for the inhibition of acetylcholinesterase ache and bche, respectively, showing that this plant is a candidate for the isolation of compounds that can be useful for the treatment of neurodegenerative diseases. |
2018-05-24 |
2023-08-13 |
Not clear |
| Tamara Lazarevic-Pasti, Andreja Leskovac, Tatjana Momic, Sandra Petrovic, Vesna Vasi. Modulators of Acetylcholinesterase Activity: From Alzheimer's Disease to Anti-Cancer Drugs. Current medicinal chemistry. vol 24. issue 30. 2017-11-29. PMID:28685687. |
hence, acetylcholinesterase inhibitors, interacting with the enzyme as their primary target, are applied as relevant drugs for different neurodegenerative diseases (such as alzheimer's and parkinson's) as well as toxins. |
2017-11-29 |
2023-08-13 |
Not clear |
| Mariana Matias, Samuel Silvestre, Amílcar Falcao, Gilberto Alve. Recent Highlights on Molecular Hybrids Potentially Useful in Central Nervous System Disorders. Mini reviews in medicinal chemistry. vol 17. issue 6. 2017-09-12. PMID:27834131. |
moreover, several hybrid compounds have also been designed for the treatment of neurodegenerative diseases focusing primarily on alzheimer's disease by targeting the cholinergic neurotransmission, as acetylcholinesterase inhibitors, and the amyloid β-protein deposition. |
2017-09-12 |
2023-08-13 |
Not clear |
| Jingqian Su, Huiying Liu, Kai Guo, Long Chen, Minhe Yang, Qi Che. Research Advances and Detection Methodologies for Microbe-Derived Acetylcholinesterase Inhibitors: A Systemic Review. Molecules (Basel, Switzerland). vol 22. issue 1. 2017-05-23. PMID:28125001. |
acetylcholinesterase inhibitors (acheis) are an attractive research subject owing to their potential applications in the treatment of neurodegenerative diseases. |
2017-05-23 |
2023-08-13 |
human |
| Rati K P Tripathi, Gopal K Rai, Senthil R Ayyanna. Exploration of a Library of 3,4-(Methylenedioxy)aniline-Derived Semicarbazones as Dual Inhibitors of Monoamine Oxidase and Acetylcholinesterase: Design, Synthesis, and Evaluation. ChemMedChem. vol 11. issue 11. 2017-03-24. PMID:27135466. |
a library of 3,4-(methylenedioxy)aniline-derived semicarbazones was designed, synthesized, and evaluated as monoamine oxidase (mao) and acetylcholinesterase (ache) inhibitors for the treatment of neurodegenerative diseases. |
2017-03-24 |
2023-08-13 |
Not clear |
| Toshihiro Murata, Yoshinobu Ishikawa, Erdenebileg Saruul, Erdenechimeg Selenge, Kenroh Sasaki, Kaoru Umehara, Fumihiko Yoshizaki, Javzan Batkhu. Abietane-type diterpenoids from the roots of Caryopteris mongolica and their cholinesterase inhibitory activities. Phytochemistry. vol 130. 2017-02-24. PMID:27298275. |
to estimate the preventive effects of the isolates for neurodegenerative disease development, their inhibitory activities against acetylcholinesterase (ache) from human erythrocytes and butyrylcholinesterase (bche) from horse serum were evaluated. |
2017-02-24 |
2023-08-13 |
human |
| Ayodele J Akinyemi, Ganiyu Oboh, Adedayo O Ademiluy. Local salt substitutes "Obu-otoyo" activate acetylcholinesterase and butyrylcholinesterase and induce lipid peroxidation in rat brain. Interdisciplinary toxicology. vol 8. issue 3. 2016-08-03. PMID:27486373. |
this study aimed to investigate the neurotoxic potential of salt substitutes (obu-otoyo); salt a (made by burning palm kernel shaft then soaked in water overnight and the extract from the resulting residue is used as the salt substitute) and salt b (an unrefined salt mined from a local site at ilobu town, osun-state, nigeria) by assessing their effect on some key enzymes linked with neurodegenerative disease [acetylcholinesterase (ache) and butyrylcholinesterase (bche) activities] as well as on malondialdehyde (mda) content of the rat brain. |
2016-08-03 |
2023-08-13 |
rat |
| Paola Valbonesi, Silvia Franzellitti, Ferdinando Bersani, Andrea Contin, Elena Fabbr. Activity and expression of acetylcholinesterase in PC12 cells exposed to intermittent 1.8 GHz 217-GSM mobile phone signal. International journal of radiation biology. vol 92. issue 1. 2016-05-31. PMID:26630175. |
due to its role in learning, memory and in many neurodegenerative diseases, acetylcholinesterase (ache) represents an interesting endpoint to assess possible targets of exposure to radiofrequency electromagnetic fields (rf-emf) generated by mobile phones. |
2016-05-31 |
2023-08-13 |
Not clear |
| Thiago H Costa Marques, Cassio H Santos De Melo, Rusbene B Fonseca De Carvalho, Luciana M Costa, Alexandre A De Souza, Jorge M David, Juceni P De Lima David, Rivelilson M De Freita. Phytochemical profile and qualification of biological activity of an isolated fraction of Bellis perennis. Biological research. vol 46. issue 3. 2016-02-22. PMID:24346069. |
these parameters were inhibited at the highest concentration of apg at rates of 77.7%, 72% and 73.4%, respectively, in addition to inhibiting acetylcholinesterase, suggesting potential use in the treatment of neurodegenerative diseases. |
2016-02-22 |
2023-08-12 |
Not clear |
| M Pohank. The perspective of caffeine and caffeine derived compounds in therapy. Bratislavske lekarske listy. vol 116. issue 9. 2015-12-29. PMID:26435014. |
the substance is added as a supplementary to drugs and food.besides interfering on adenosine receptors, caffeine interacts with acetylcholinesterase, monoamine oxidase, phosphodiesterase, ryanodine receptors and others.current research is devoted to the role of caffeine in neurodegenerative diseases and immunity alteration. |
2015-12-29 |
2023-08-13 |
human |
| Luiz Carlos Klein, Carolina Santos Dos Passos, Aline Pereira Moraes, Vinicius Galvao Wakui, Eduardo Luis Konrath, Alessandra Nurisso, Pierre-Alain Carrupt, Cecilia Maria Alves de Oliveira, Lucilia Kato, Amelia Teresinha Henrique. Indole alkaloids and semisynthetic indole derivatives as multifunctional scaffolds aiming the inhibition of enzymes related to neurodegenerative diseases--a focus on Psychotria L. Genus. Current topics in medicinal chemistry. vol 14. issue 8. 2014-12-18. PMID:24660679. |
here, we overview the multifunctional potential of these molecules for the inhibition of enzymes related to neurodegenerative disease: acetylcholinesterase (ache), butyrylcholinesterase (bche), monoamine oxidases a and b (mao-a and mao-b). |
2014-12-18 |
2023-08-12 |
Not clear |
| Sawsan Abuhamdah, Maha Habash, Mutasem O Tah. Elaborate ligand-based modeling coupled with QSAR analysis and in silico screening reveal new potent acetylcholinesterase inhibitors. Journal of computer-aided molecular design. vol 27. issue 12. 2014-08-19. PMID:24338032. |
inhibition of the enzyme acetylcholinesterase (ache) has been shown to alleviate neurodegenerative diseases prompting several attempts to discover and optimize new ache inhibitors. |
2014-08-19 |
2023-08-12 |
Not clear |
| Qilin Huang, Hua Chen, Lili Xu, Danqin Lu, Linlin Tang, Litong Jin, Zhiai Xu, Wen Zhan. Visible-light-activated photoelectrochemical biosensor for the study of acetylcholinesterase inhibition induced by endogenous neurotoxins. Biosensors & bioelectronics. vol 45. 2013-09-23. PMID:23500378. |
in this report, a novel visible-light-activated photoelectrochemical biosensor was fabricated to study the inhibition of acetylcholinesterase (ache) activity induced by two endogenous neurotoxins, 1(r)-methyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline [(r)-sal] and 1(r),2(n)-dimethyl-6,7-dihydroxy-1,2,3,4-tetra-hydroisoquinoline [(r)-nmsal], which have drawn much attention in the study of the pathogenesis of neurodegenerative diseases such as parkinson's disease. |
2013-09-23 |
2023-08-12 |
Not clear |
| Girish Beedessee, Avin Ramanjooloo, Rashmee Surnam-Boodhun, Rob W M van Soest, Daniel E P Mari. Acetylcholinesterase-inhibitory activities of the extracts from sponges collected in mauritius waters. Chemistry & biodiversity. vol 10. issue 3. 2013-09-17. PMID:23495160. |
acetylcholinesterase inhibitors from marine organisms have been rarely studied, and this study demonstrated the potential of marine sponges as a source of pharmaceutical leads against neurodegenerative diseases. |
2013-09-17 |
2023-08-12 |
Not clear |
| Hannah P Priyanka, Ran Vijay Singh, Miti Mishra, Srinivasan ThyagaRaja. Diverse age-related effects of Bacopa monnieri and donepezil in vitro on cytokine production, antioxidant enzyme activities, and intracellular targets in splenocytes of F344 male rats. International immunopharmacology. vol 15. issue 2. 2013-09-12. PMID:23257614. |
bacopa monnieri (brahmi), an ayurvedic herb, and donepezil, a reversible acetylcholinesterase inhibitor, have been used to reverse cognitive dysfunctions in several neurodegenerative diseases. |
2013-09-12 |
2023-08-12 |
rat |
| Karol Ciepluch, Monika Weber, Nadia Katir, Anne-Marie Caminade, Abdelkrim El Kadib, Barbara Klajnert, Jean Pierre Majoral, Maria Bryszewsk. Effect of viologen-phosphorus dendrimers on acetylcholinesterase and butyrylcholinesterase activities. International journal of biological macromolecules. vol 54. 2013-07-10. PMID:23237795. |
the inhibition of acetylcholinesterase (ache) and butyrylcholinesterase (bche) is the first step in checking whether new compounds can be considered as drugs for treating neurodegenerative diseases. |
2013-07-10 |
2023-08-12 |
Not clear |
| Carolina S Passos, Claudia A Simões-Pires, Alessandra Nurisso, Tatiane C Soldi, Lucilia Kato, Cecilia M A de Oliveira, Emiret O de Faria, Laurence Marcourt, Carmem Gottfried, Pierre-Alain Carrupt, Amélia T Henrique. Indole alkaloids of Psychotria as multifunctional cholinesterases and monoamine oxidases inhibitors. Phytochemistry. vol 86. 2013-05-31. PMID:23261030. |
thirteen psychotria alkaloids were evaluated regarding their interactions with acetylcholinesterase (ache), butyrylcholinesterase (bche), and monoamine oxidases a and b (mao-a and mao-b), which are enzymatic targets related with neurodegenerative diseases. |
2013-05-31 |
2023-08-12 |
Not clear |
| Ibrahim Tumen, Fatma Sezer Senol, Ilkay Erdogan Orha. Inhibitory potential of the leaves and berries of Myrtus communis L. (myrtle) against enzymes linked to neurodegenerative diseases and their antioxidant actions. International journal of food sciences and nutrition. vol 63. issue 4. 2012-09-04. PMID:22022834. |
the dichloromethane (dcm), acetone, ethyl acetate and methanol extracts of the leaves and berries of myrtus communis l. were screened against acetylcholinesterase (ache), butyrylcholinesterase (bche) and tyrosinase (tyro), the enzymes linked to neurodegenerative diseases, at 200 μg ml⁻¹. |
2012-09-04 |
2023-08-12 |
Not clear |
| Jun Wang, Fu Chen, Peng Zheng, Weijuan Deng, Jia Yuan, Bo Peng, Ruochen Wang, Wenjun Liu, Hui Zhao, Yanqing Wang, Gencheng W. Huperzine A ameliorates experimental autoimmune encephalomyelitis via the suppression of T cell-mediated neuronal inflammation in mice. Experimental neurology. vol 236. issue 1. 2012-08-07. PMID:22524989. |
huperzine a (hupa), a sesquiterpene alkaloid and a potent and reversible inhibitor of acetylcholinesterase, possesses potential anti-inflammatory properties and is used for the treatment of certain neurodegenerative diseases such as alzheimer's disease. |
2012-08-07 |
2023-08-12 |
mouse |