| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Alaa H Sayed, Nadia S Mahmoud, Ola A M Mohawed, Hanaa H Ahme. Combined effect of pantoprazole and mesenchymal stem cells on experimentally induced gastric ulcer: implication of oxidative stress, inflammation and apoptosis pathways. Inflammopharmacology. 2024-04-23. PMID:38652367. |
moreover, the treated groups (panto, adscs and adscs + panto) displayed significant down-regulation (p < 0.05) in gastric nuclear factor kappa-light-chain-enhancer of activated b cells (nf-κb), tumor necrosis factor alpha (tnf-α), cyclooxygenase-2 (cox-2), intercellular adhesion molecule-1 (icam-1), matrix metallopeptidase 9 (mmp-9) and caspase-3 along with significant up-regulation (p < 0.05) in vascular endothelial growth factor (vegf) and peroxisome proliferator-activated receptor gamma (pparγ) genes expression compared to the untreated gu group. |
2024-04-23 |
2024-04-26 |
rat |
| Peng Li, Yong Huang, Lishuai Miao, Zhiqi Zhu, Zhanjun Sh. Protective effects of ectoine on articular chondrocytes and cartilage in rats for treating osteoarthritis. PloS one. vol 19. issue 2. 2024-02-29. PMID:38421984. |
rt‒qpcr was used to measure the mrna levels of cyclooxygenase-2 (cox-2), metallomatrix proteinase-3, -9 (mmp-3, -9), and collagen type ii alpha 1 (col2a1). |
2024-02-29 |
2024-03-03 |
rat |
| M U Ijaz, N Nadeem, A Hamza, M H Almutairi, U Atiqu. Didymin protects against polystyrene nanoplastic-induced hepatic damage in male albino rats by modulation of Nrf-2/Keap-1 pathway. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas. vol 57. 2024-01-24. PMID:38265346. |
moreover, inflammatory indices [interleukin-1β (il-1β), tumor necrosis factor alpha (tnf-α), interleukin-6 (il-6), nuclear factor-kappa b (nf-κb), and cyclooxygenase-2 (cox-2)] were increased in ps-nps-exposed rats. |
2024-01-24 |
2024-01-26 |
rat |
| Mozaffari Nazanin, Mazdak Razi, Javad Tolouei-Aza. Effect of running exercise training on inflammatory mediators and cytokines expression in testicular tissue; effect of exercise intensity. Life sciences. 2024-01-07. PMID:38185243. |
after 8 weeks, the expression levels of toll-like receptor-4 (tlr-4), nuclear factor-kappa-b (nf-kb), interleukin-6 (il-6), interleukin-10 (il-10), tumor necrosis factor alpha (tnf-α), cyclooxygenase-2 (cox-2), inducible nitric oxide synthase (inos), and the testicular nitric oxide (no) content were assessed and compared between groups. |
2024-01-07 |
2024-01-10 |
rat |
| Muhammad Imran Qayyum, Sami Ullah, Umer Rashid, Abdul Sadiq, Mater H Mahnashi, Saif Ullah Khan Khalil, Muhammad Masoom Akhta. N-phenyl and N-benzyl substituted succinimides: Preclinical evaluation for their antihypertensive effect and underlying mechanism. European journal of pharmacology. 2023-12-24. PMID:38142849. |
these compounds also reduced the expression of inflammatory markers, including cyclooxygenase-2 (cox-2) and tumor necrosis factor alpha (tnf-α) in heart tissues. |
2023-12-24 |
2023-12-27 |
rat |
| Norah F Alqahtani, Mohammad Y Alfaifi, Ali A Shati, Serag Eldin I Elbehairi, Reda F M Elshaarawy, Waleed M Serag, Yasser A Hassan, W N El-Saye. Exploring chondroitin the sulfate nanogel's potential in combating nephrotoxicity induced by cisplatin and doxorubicin-An in-vivo study on rats. International journal of biological macromolecules. 2023-12-22. PMID:38134998. |
when icsng-based treatments were contrasted with the cddp and adr infected groups, they significantly increased paraoxonase-1 (pon-1), superoxide dismutase (sod), catalase (cat) and albumin activity and significantly decreased nitric oxide (no), tumor necrosis factor alpha (tnf-α), creatinine, urea, and cyclooxygenase-2 (cox-2) activity (p < 0.001). |
2023-12-22 |
2023-12-25 |
rat |
| Norhan E Khalifa, Ahmed E Noreldin, Asmaa F Khafaga, Mohamed El-Beskawy, Eman Khalifa, Ali H El-Far, Abdel-Hasseb A Fayed, Abdeldayem Zakari. Chia seeds oil ameliorate chronic immobilization stress-induced neurodisturbance in rat brains via activation of the antioxidant/anti-inflammatory/antiapoptotic signaling pathways. Scientific reports. vol 13. issue 1. 2023-12-19. PMID:38104182. |
the molecular docking showed the cso high affinity for several target proteins, including caspase-3, cox-2, corticotropin-releasing hormone binding protein, corticotropin-releasing factor receptors 1 and 2, interleukin-1 receptor types 1 and 2, interleukin-6 receptor subunits alpha and beta. |
2023-12-19 |
2023-12-21 |
human |
| Mona Raslan, Marwa M Mounie. Phytochemical profiling and compound isolation of Cissus rhombifolia Vahl. leaves aqueous methanolic extract with the evaluation of its anti-inflammatory effect using lipopolysaccharide-induced inflammation in RAW 264.7 cells. Chemistry & biodiversity. 2023-05-19. PMID:37204915. |
further, its effects on the production of intracellular no, and inflammatory cytokines cyclooxygenase-2 (cox-2), tumor necrosis factor alpha (tnf-α), and interleukin 6 (il-6) were assessed by the griess test, and cytokine enzyme-linked immunosorbent assays, respectively. |
2023-05-19 |
2023-08-14 |
Not clear |
| Priyanka Jain, Jitendra Satija, C Sudandirados. Discovery of andrographolide hit analog as a potent cyclooxygenase-2 inhibitor through consensus MD-simulation, electrostatic potential energy simulation and ligand efficiency metrics. Scientific reports. vol 13. issue 1. 2023-05-19. PMID:37208387. |
the full amino acid sequenced human alpha fold (af) cox-2 protein (604aa) was selected and validated for its accuracy against the reported cox-2 protein structures (pdb id: 5f19, 5kir, 5f1a, 5ikq and 1v0x) followed by multiple sequence alignment analysis to establish the sequence conservation. |
2023-05-19 |
2023-08-14 |
human |
| Aviral Kumar, Mangala Hegde, Dey Parama, Ajaikumar B Kunnumakkar. Curcumin: The Golden Nutraceutical on the Road to Cancer Prevention and Therapeutics. A Clinical Perspective. Critical reviews in oncogenesis. vol 27. issue 3. 2023-05-15. PMID:37183937. |
curcumin has shown a wide range of pleiotropic anti-proliferative effect in multiple cancers and is a known inhibitor of varied oncogenic elements, including nuclear factor kappa b (nf-κb), c-myc, cyclin d1, bcl-2, vegf, cox-2, nos, tumor necrosis factor alpha (tnf-α), interleukins, and mmp-9. |
2023-05-15 |
2023-08-14 |
Not clear |
| Ahmed Alghamdi, Ali H Alyami, Raad M M Althaqafi, Ahmed Alzeyadi, Faisal S Alrubaei, Almuhanad A Alyami, Mohamed S Singer, Abdulelah A Saati, Wasn T Alotaibi, Maha O Alshari. Cytokines' Role in the Pathogenesis and Their Targeting for the Prevention of Frozen Shoulder: A Narrative Review. Cureus. vol 15. issue 3. 2023-04-14. PMID:37056530. |
this mechanism depends mainly on alarmins cytokines, including thymic stromal lymphopoietin (tslp), interleukin-33 (il-33), and interleukin-25 (il-25), with the stimulation of interleukin-1 α (il-1α), interleukin-1 β (il-1β), tumor necrosis alpha (tnf-α), cyclooxygenase-1 (cox-1) and cyclooxygenase-2 (cox-2) in a joint capsule. |
2023-04-14 |
2023-08-14 |
Not clear |
| Sriparna Pal, Aishwarya Sahu, Rakesh Verma, Chandana Halda. BPS-induced ovarian dysfunction: Protective actions of melatonin via modulation of SIRT-1/Nrf2/NFĸB and IR/PI3K/pAkt/GLUT-4 expressions in adult golden hamster. Journal of pineal research. 2023-04-01. PMID:37002642. |
moreover, melatonin treatment reduced inflammatory load including ovarian nuclear factor kappa-b (nfĸb), cyclooxygenase-2 (cox-2) and inducible nitric oxide synthase (inos) expressions, serum tumor necrosis factor alpha (tnfα), c-reactive protein (crp) and nitrite-nitrate levels as well as upregulated ovarian insulin receptor (ir), glucose uptake transporter-4 (glut-4), connexin-43 and proliferating cell nuclear antigen (pcna) expressions in ovary thereby ameliorating inflammatory and metabolic alterations due to bps. |
2023-04-01 |
2023-08-14 |
human |
| Jaejin Shin, Leo Sungwong Choi, Hyun Ju Jeon, Hyeong Min Lee, Sang Hyo Kim, Kwan-Woo Kim, Wonmin Ko, Hyuncheol Oh, Hyung Soon Par. Synthetic Glabridin Derivatives Inhibit LPS-Induced Inflammation via MAPKs and NF-κB Pathways in RAW264.7 Macrophages. Molecules (Basel, Switzerland). vol 28. issue 5. 2023-03-11. PMID:36903379. |
we found that the synthetic glabridin derivatives significantly and dose-dependently suppressed the production of nitric oxide (no) and prostaglandin e2 (pge2), and decreased the level of inducible nitric oxygen synthase (inos) and cyclooxygenase-2 (cox-2) and the expression of pro-inflammatory cytokines interleukin-1β (il-1β), il-6, and tumor necrosis factor alpha (tnf-α). |
2023-03-11 |
2023-08-14 |
Not clear |
| Dong Sub Kim, Hyo-Jung Lee, Deok Yong Sim, Ji Eon Park, Youngsang Park, Bonglee Kim, Bumsang Shim, Sung-Hoon Ki. The underlying hepatoprotective mechanism of PKC#963 in alcohol or carbon tetrachloride induced liver injury via inhibition of iNOS, COX-2, and p-STAT3 and enhancement of SOD and catalase. Phytotherapy research : PTR. 2022-09-24. PMID:36151597. |
consistently, pkc#963 suppressed the expression of ast, alt, p-stat3, inos, cox-2, interleukin 6 (il-6), tumor necrosis factor alpha (tnf-α) and α-smooth muscle actin (α-sma) and increased procaspase 3 in the liver tissues of ccl4 treated rats. |
2022-09-24 |
2023-08-14 |
rat |
| Yuhan Qu, Yue Shen, Li Teng, Yuehui Huang, Yuting Yang, Xi Jian, Shengli Fan, Ping Wu, Qiang F. Chicoric acid attenuates tumor necrosis factor-α-induced inflammation and apoptosis via the Nrf2/HO-1, PI3K/AKT and NF-κB signaling pathways in C28/I2 cells and ameliorates the progression of osteoarthritis in a rat model. International immunopharmacology. vol 111. 2022-08-12. PMID:35961266. |
in vitro, ca treatment significantly suppressed the overproduction of nitric oxide (no), prostaglandin e2 (pge2), inducible nitric oxide synthase (inos), cyclooxygenase-2 (cox-2), interleukin-1 beta (il-1β), interleukin-6 (il-6), and il-12 in tumor necrosis factor alpha (tnf-α)-induced human c28/i2 chondrocytes. |
2022-08-12 |
2023-08-14 |
human |
| MinGyu Kim, Hyuck Kim, Hojun Ki. Anti-Inflammatory Effect of Protopine through MAPK and NF-κB Signaling Regulation in HepG2 Cell. Molecules (Basel, Switzerland). vol 27. issue 14. 2022-07-27. PMID:35889472. |
protopine inhibited the kappa alpha (i-κbα) phosphorylation in the cytosol and blocked pma-induced inflammation via cox-2 activity inhibition. |
2022-07-27 |
2023-08-14 |
human |
| Dahae Lee, Xiaohua Wu, Ingo Lange, Shugeng Cao, Ki Sung Kan. Dual Beneficial Effects of Methylnissolin-3-O-β-d-Glucopyranoside on Obesity-Induced Inflammatory Responses in Adipocyte-Macrophage Co-Culture. Plants (Basel, Switzerland). vol 11. issue 13. 2022-07-09. PMID:35807667. |
moreover, mng inhibited the protein expression of ccaat/enhancer-binding protein alpha (c/ebpα), c/ebpβ, peroxisome proliferator-activated receptor γ (pparγ), cyclooxygenase 2 (cox-2), and inducible nitric oxide synthase (inos) under the same co-culture conditions. |
2022-07-09 |
2023-08-14 |
Not clear |
| Zhenyu Li, Huasong Shi, Yanmei Li, Wang Wang, Zhexi Li, Biao Chen, Daibang Ni. Isorhynchophylline ameliorates the progression of osteoarthritis by inhibiting the NF-κB pathway. European journal of pharmacology. 2022-04-26. PMID:35469836. |
irn treatment dose-dependently decreased the interleukin-1β (il-1β)-induced expressions of nitric oxide (no; p < 0.001), prostaglandin e2 (pge2; p < 0.001), tumor necrosis factor alpha (tnf-α; p < 0.001), interleukin-6 (il-6; p < 0.001), cyclooxygenase-2 (cox-2; p < 0.001) and inducible nitric oxide synthase (inos; p < 0.001) in chondrocytes. |
2022-04-26 |
2023-08-13 |
human |
| Heba Nageh Gad El-Hak, Hany Salah Mahmoud, Eman A Ahmed, Heba M Elnegris, Tahany Saleh Aldayel, Heba M A Abdelrazek, Mohamed T A Soliman, Menna Allah I El-Menyaw. Methanolic Nutrients. vol 14. issue 5. 2022-03-10. PMID:35268000. |
hepatic histological changes and the immunohistochemistry of cyclooxygenase-2 (cox-2), nuclear factor kappa b (nf-κb), and alpha smooth muscle actin (α-sma) were assessed. |
2022-03-10 |
2023-08-13 |
rat |
| K Chojnacka, K Owczarek, M Caban, D Sosnowska, D Polka, M Koziolkiewicz, J Fichna, U Lewandowsk. Japanese quince (Chaenomeles japonica) leaf phenol extract as modulator of the inflammatory response in lipopolysaccharide-triggered murine macrophage RAW 264.7 cells. Journal of physiology and pharmacology : an official journal of the Polish Physiological Society. vol 71. issue 6. 2021-11-10. PMID:33727430. |
similarly, jqlpe significantly attenuated expression of inducible nitric oxide synthase (inos), cyclooxygenase 2 (cox-2), interleukin-1beta (il-1β), il-6 and tumor necrosis factor alpha (tnf-α) (by 60%, 50%, 67%, 37% and 36%, respectively) at the protein level and nitric oxide (no) production in lipopolysaccharide (lps)-stimulated raw264.7. |
2021-11-10 |
2023-08-13 |
Not clear |