| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Thangavelu Soundara Rajan, Francesca Diomede, Placido Bramanti, Oriana Trubiani, Emanuela Mazzo. Conditioned medium from human gingival mesenchymal stem cells protects motor-neuron-like NSC-34 cells against scratch-injury-induced cell death. International journal of immunopathology and pharmacology. vol 30. issue 4. 2018-08-13. PMID:29140156. |
oxidative stress markers sod-1, inducible nitric oxide synthase (inos), cox-2, and proinflammatory cytokine tumor necrosis factor alpha (tnf-α) were activated. |
2018-08-13 |
2023-08-13 |
human |
| Shimaa M Elshazly, Dalia M Abd El Motteleb, Islam A A E-H Ibrahi. Hesperidin protects against stress induced gastric ulcer through regulation of peroxisome proliferator activator receptor gamma in diabetic rats. Chemico-biological interactions. vol 291. 2018-07-27. PMID:29944876. |
to determine the underlying mechanism of action, gastric mucosal expression of nuclear factor (erythroid-derived 2)-like 2 (nrf2), hemeoxygenase-1 (ho-1), cluster of differentiation 45 (cd45), cyclooxygenase-2 (cox-2), nuclear factor kappa b (nfκb) and inducible nitric oxide synthase (inos), gastric contents of reduced glutathione (gsh), malondialdehyde (mda), tumor necrosis factor alpha (tnf-α) and nitric oxide (no); as well as superoxide dismutase (sod) and catalase activities were measured. |
2018-07-27 |
2023-08-13 |
rat |
| Shao-Hua Su, Yi-Fang Wu, Qi Lin, Jian Ha. Cannabinoid receptor agonist WIN55,212-2 and fatty acid amide hydrolase inhibitor URB597 ameliorate neuroinflammatory responses in chronic cerebral hypoperfusion model by blocking NF-κB pathways. Naunyn-Schmiedeberg's archives of pharmacology. vol 390. issue 12. 2018-07-23. PMID:28825114. |
the protein levels of cluster of differentiation molecule 11b (ox-42), glial fibrillary acidic protein (gfap), nf-κb p65, inhibitor of kappa b alpha (iκb-a), iκb kinase a/β (ikk a/β), phosphorylated ikk a/β (p-ikk a/β), cyclooxygenase-2 (cox-2), inducible nitric oxide synthase (inos), tumor necrosis factor (tnf)-α, and interleukin-1β (il-1β) were examined by western blotting or enzyme-linked immunosorbent assay. |
2018-07-23 |
2023-08-13 |
rat |
| Kelly Yoshizaki, Jôse Mára Brito, Luiz Fernando Silva, Adriana Lino-Dos-Santos-Franco, Daniela Perroni Frias, Renata Calciolari Rossi E Silva, Luís Fernando Amato-Lourenço, Paulo Hilário Nascimento Saldiva, Iolanda de Fátima Lopes Calvo Tibério, Thais Mauad, Mariangela Macchion. The effects of particulate matter on inflammation of respiratory system: Differences between male and female. The Science of the total environment. vol 586. 2018-06-27. PMID:28174048. |
balf levels of cyclooxygenase-2(cox-2) (p=0.000), transforming growth factor alpha (tgf-α) (p=0.001) and il-8 receptor alpha (il-8rα) (p=0.014) were increased in males compared with proestrus, estrus and diestrus females, independent of exposure. |
2018-06-27 |
2023-08-13 |
mouse |
| Sachchida Nand Rai, Hareram Birla, Walia Zahra, Saumitra Sen Singh, Surya Pratap Sing. Immunomodulation of Parkinson's disease using Mucuna pruriens (Mp). Journal of chemical neuroanatomy. vol 85. 2018-06-22. PMID:28642128. |
such aggregation results in neuronal cell death and the presence of chronically activated glia (microglia and astroglia), leading to the production of proinflammatory cytokines like tumor necrosis factor alpha (tnf-α), interleukin-1 beta (il-1β), il-6, and enzymes such as nicotinamide adenine dinucleotide phosphate (nadph) oxidase and cyclooxygenase-2 (cox-2). |
2018-06-22 |
2023-08-13 |
Not clear |
| Karina S MacDowell, Raquel Pinacho, Juan C Leza, Joan Costa, Belén Ramos, Borja García-Buen. Differential regulation of the TLR4 signalling pathway in post-mortem prefrontal cortex and cerebellum in chronic schizophrenia: Relationship with SP transcription factors. Progress in neuro-psychopharmacology & biological psychiatry. vol 79. issue Pt B. 2018-06-12. PMID:28803924. |
in pfc, tlr4/myeloid differentiation factor 88 (myd88)/inhibitory subunit of nuclear factor kappa b alpha (iκbα) protein levels were lower in sz patients, while nuclear transcription factor-κb (nfκb) activity, cyclooxygenase-2 (cox-2) expression and the lipid peroxidation index malondialdehyde (mda) appeared increased. |
2018-06-12 |
2023-08-13 |
Not clear |
| Kuriakose Jayesh, Lal Raisa Helen, A Vysakh, Eldhose Binil, M S Lath. Ethyl acetate fraction of Terminalia bellirica (Gaertn.) Roxb. fruits inhibits proinflammatory mediators via down regulating nuclear factor-κB in LPS stimulated Raw 264.7 cells. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 95. 2018-06-07. PMID:28954384. |
the gene level expression of cox-2, tumor necrosis factor alpha (tnf-α), interleukin-6 (il-6) and nuclear factor-κb (nf-κb) were also studied in lps stimulated raw 264.7 cells. |
2018-06-07 |
2023-08-13 |
human |
| Rômulo Pillon Barcelos, Guilherme Bresciani, Maria José Cuevas, Susana Martínez-Flórez, Félix Alexandre Antunes Soares, Javier González-Galleg. Diclofenac pretreatment modulates exercise-induced inflammation in skeletal muscle of rats through the TLR4/NF-κB pathway. Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme. vol 42. issue 7. 2018-04-18. PMID:28235185. |
the inflammatory status was evaluated through mrna levels of cyclooxygenase-2 (cox-2), inducible nitric oxide synthase (inos), interleukin-6 (il-6), il-1β, and tumor necrosis factor alpha (tnf-α), and protein content of cox-2, il-6, and tnf-α in vastus lateralis muscle. |
2018-04-18 |
2023-08-13 |
rat |
| Christina L Ross, Thaleia Teli, Benjamin S Harriso. Electromagnetic Field Devices and Their Effects on Nociception and Peripheral Inflammatory Pain Mechanisms. Alternative therapies in health and medicine. vol 22. issue 3. 2017-10-09. PMID:27228272. |
exogenous influences, such as extra-low-frequency (elf) electromagnetic fields (emfs) have been shown to affect pain and inflammation by modulating g-protein coupling receptors (gpcrs), downregulating cyclooxygenase-2 (cox-2) activity, and downregulating inflammatory modulators, such as tumor necrosis factor alpha (tnf-α) and interleukin 1 beta (il-1β) as well as the transcription factor nuclear factor kappa b (nf-κb). |
2017-10-09 |
2023-08-13 |
Not clear |
| Renata M Martinez, Felipe A Pinho-Ribeiro, David L Vale, Vinicius S Steffen, Fabiana T M C Vicentini, Josiane A Vignoli, Marcela M Baracat, Sandra R Georgetti, Waldiceu A Verri, Rubia Casagrand. Trans-chalcone added in topical formulation inhibits skin inflammation and oxidative stress in a model of ultraviolet B radiation skin damage in hairless mice. Journal of photochemistry and photobiology. B, Biology. vol 171. 2017-09-20. PMID:28501692. |
dorsal skin samples were collected after uvb exposure to evaluate: i) skin edema (weight) was measured by punch biopsy; ii) spectrophotometric assays were used to measure myeloperoxidase (mpo) and catalase activities, ferric (frap) and abts cation reducing antioxidant power, superoxide anion production and levels of reduced glutathione (gsh); iii) enzymography was used to measure matrix metalloproteinase-9 (mmp-9) activity; iv) chemiluminescence was used to measure the lipid peroxidation (lpo); v) enzyme-linked immunosorbent assay (elisa) was used to measure tumor necrosis factor alpha (tnf-α) levels; vi) reverse transcription quantitative pcr (rt-qpcr) was used to measure cyclooxygenase-2 (cox-2), gp91 |
2017-09-20 |
2023-08-13 |
mouse |
| Yin He, Dehong Tan, Yan Mi, Qian Zhou, Shujuan J. Epigallocatechin-3-gallate attenuates cerebral cortex damage and promotes brain regeneration in acrylamide-treated rats. Food & function. vol 8. issue 6. 2017-09-01. PMID:28561817. |
tumour necrosis factor alpha (tnf-α), inducible nitric oxide synthase (inos), and cyclooxygenase 2 (cox-2) protein expression indicated that egcg inhibited acr-induced inflammation. |
2017-09-01 |
2023-08-13 |
rat |
| Winfred Stacey, Shreyas Bhave, Rosalie M Uh. Mechanisms by Which 17β-Estradiol (E2) Suppress Neuronal cox-2 Gene Expression. PloS one. vol 11. issue 9. 2017-08-01. PMID:27588681. |
these cells express estrogen receptors alpha (erα) and beta (erβ), and as shown here cox-2. |
2017-08-01 |
2023-08-13 |
Not clear |
| M Ratheesh, S Sandya, C Pramod, S Asha, Jose P Svenia, S Premlal, B GrishKuma. Anti-inflammatory and antioxidant effect of Kerabala: a value-added ayurvedic formulation from virgin coconut oil inhibits pathogenesis in adjuvant-induced arthritis. Inflammopharmacology. vol 25. issue 1. 2017-06-06. PMID:27878500. |
by rt-pcr, the inflammatory markers like cyclooxygenase-2 (cox-2), inducible nitric oxide synthase (inos), tumor necrosis factor alpha (tnf-α) and interleukin 6 (il-6) expressions were evaluated. |
2017-06-06 |
2023-08-13 |
rat |
| Cong-Yuan Xia, Shuai Zhang, Shi-Feng Chu, Zhen-Zhen Wang, Xiu-Yun Song, Wei Zuo, Yan Gao, Peng-Fei Yang, Nai-Hong Che. Autophagic flux regulates microglial phenotype according to the time of oxygen-glucose deprivation/reperfusion. International immunopharmacology. vol 39. 2017-04-07. PMID:27474951. |
once autophagic flux was inhibited at ogd/r 72h or at ogd/r 24h (with nh4cl), bv-2 cells mainly showed m1 phenotype with increased tumor necrosis factor alpha (tnf-α), inducible nitric oxide synthase (inos), cyclooxygenase-2 (cox-2), and decreased m2 markers including interleukin-10 (il-10), arginase 1 (arg-1), and brain derived neurotrophic factor (bdnf). |
2017-04-07 |
2023-08-13 |
Not clear |
| Tao Qian, Kun Wang, Jiesheng Cui, Yiduo He, Zaiqing Yan. Angiopoietin-Like Protein 7 Promotes an Inflammatory Phenotype in RAW264.7 Macrophages Through the P38 MAPK Signaling Pathway. Inflammation. vol 39. issue 3. 2017-03-09. PMID:26973239. |
the expression of genes encoding inflammation-associated factors cyclooxygenase-2 (cox-2), inducible nitric oxide synthase (inos), tumor necrosis factor alpha (tnf-α), interleukin-1 beta (il-1β), il-6, il-10, and transforming growth factor beta 1 (tgf-β1)) decreased after raw264.7 cells were treated with anti-angptl7 polyclonal antibody but increased after the cells were transfected with an angptl7-expressing plasmid. |
2017-03-09 |
2023-08-13 |
mouse |
| G X Sun, Y Chen, C P Liu, S Li, J F. Effect of Selenium Against Lead-Induced Damage on the Gene Expression of Heat Shock Proteins and Inflammatory Cytokines in Peripheral Blood Lymphocytes of Chickens. Biological trace element research. vol 172. issue 2. 2017-02-03. PMID:26728796. |
therefore, the aim of this study was to investigate the effect of se against pb on the messenger rna (mrna) expression levels of hsps (hsp 27, 40, 60, 70, and 90); heme oxygenase-1 (ho-1); and the inflammatory cytokines nuclear factor kappa b (nf-κb), tumor necrosis factor alpha (tnf-α), cyclooxygenase-2 (cox-2), and inducible nitric oxide synthase (inos) in the peripheral blood lymphocytes of chickens. |
2017-02-03 |
2023-08-13 |
chicken |
| Fukashi Yamamichi, Katsumi Shigemura, Hosny M Behnsawy, Masuo Yamashita, Toshiro Shirakawa, Masato Fujisaw. Beta-3 adrenergic receptors could be significant factors for overactive bladder-related symptoms. International journal of clinical and experimental pathology. vol 8. issue 9. 2016-09-26. PMID:26617941. |
they were investigated quantitatively by immunohistochemical (ihc) stainings for inflammatory or immune-system (interleukin (il)-6 and cyclooxygenase-2 (cox-2)), caspase-3 apoptosis markers, angiogenesis (cd-31), epithelial-mesenchymal transition (e-cadherin) and muscarinic receptor (muscarine-2 (m)-2), adrenergic receptors (ars) (alpha 1-d (α1-d) and beta-3 (β-3)). |
2016-09-26 |
2023-08-13 |
Not clear |
| Zhi-Ying Teng, Xiao-Lan Cheng, Xue-Ting Cai, Yang Yang, Xiao-Yan Sun, Jin-Di Xu, Wu-Guang Lu, Jiao Chen, Chun-Ping Hu, Qian Zhou, Xiao-Ning Wang, Song-Lin Li, Peng Ca. Ancient Chinese Formula Qiong-Yu-Gao Protects Against Cisplatin-Induced Nephrotoxicity Without Reducing Anti-tumor Activity. Scientific reports. vol 5. 2016-09-23. PMID:26510880. |
cisplatin-mediated elevations in tumor necrosis factor alpha (tnf-α) mrna, interleukin-1 beta (il-1β) mrna, and cyclooxygenase-2 (cox-2) protein in the kidney were also significantly suppressed by qyg treatment. |
2016-09-23 |
2023-08-13 |
mouse |
| Pan Han, Yong Ji Lai, Jing Chen, Xue Nong Zhang, Jing Lou Chen, Xian Yang, Ping Ping Xue, Jin Lan Rua. Protective potential of the methanol extract of Macrothelypteris oligophlebia rhizomes for chronic non-bacterial prostatitis in rats. Pakistan journal of pharmaceutical sciences. vol 29. issue 4. 2016-09-06. PMID:27393434. |
the anti-prostatitis effect was evaluated by prostate index, the levels of interleukin-10 (il-10), tumor necrosis factor alpha (tnf-α), cyclooxygenase-2 (cox-2) and prostaglandin e2 (pge2), and histopathological examination. |
2016-09-06 |
2023-08-13 |
rat |
| Honor J Hugo, C Saunders, R G Ramsay, E W Thompso. New Insights on COX-2 in Chronic Inflammation Driving Breast Cancer Growth and Metastasis. Journal of mammary gland biology and neoplasia. vol 20. issue 3-4. 2016-08-18. PMID:26193871. |
finally we examine the potential regulation of cox-2 by c-myb, and the possible interplay between c-myb/cox-2 in proliferation, and hypoxia inducible factor-1 alpha (hif1α)/cox-2 in invasive pathways in breast cancer. |
2016-08-18 |
2023-08-13 |
Not clear |