| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Kuriakose Jayesh, Raj Karishma, A Vysakh, Prasad Gopika, M S Lath. Terminalia bellirica (Gaertn.) Roxb fruit exerts anti-inflammatory effect via regulating arachidonic acid pathway and pro-inflammatory cytokines in lipopolysaccharide-induced RAW 264.7 macrophages. Inflammopharmacology. 2020-02-02. PMID:30003465. |
the mrna level expression of cox-2, tumor necrosis factor alpha (tnf-α) and interleukin-6 (il-6) were studied in lps stimulated raw 264.7 cells. |
2020-02-02 |
2023-08-13 |
Not clear |
| Bangrong Cai, Kyung-Joo Seong, Sun-Woong Bae, Min Suk Kook, Changju Chun, Jin Ho Lee, Won-Seok Choi, Ji-Yeon Jung, Won-Jae Ki. Water-Soluble Arginyl-Diosgenin Analog Attenuates Hippocampal Neurogenesis Impairment Through Blocking Microglial Activation Underlying NF-κB and JNK MAPK Signaling in Adult Mice Challenged by LPS. Molecular neurobiology. vol 56. issue 9. 2020-01-09. PMID:30740619. |
in in vitro study, arg-dg inhibited the production of nitric oxide (no), nitric oxide synthase (inos), cyclooxygenase-2 (cox-2) expression, and prostaglandin d2 production (pgd2), as well as the pro-inflammatory cytokines, such as interleukin (il)-6, il-1β, and tumor necrosis factor alpha (tnf-α). |
2020-01-09 |
2023-08-13 |
mouse |
| Kpobari W Nkpaa, Isaac A Adedara, Benjamin A Amadi, Matthew O Wegwu, Ebenezer O Faromb. Ethanol via Regulation of NF-κB/p53 Signaling Pathway Increases Manganese-Induced Inflammation and Apoptosis in Hypothalamus of Rats. Biological trace element research. vol 190. issue 1. 2019-11-18. PMID:30284675. |
the results indicated that the significant (p < 0.05) increases in pro-inflammatory cytokines, namely tumor necrosis factor alpha (tnf-α) and interleukin 1 beta (il-1β) as well as cyclooxygenase-2 (cox-2) and nuclear factor kappa b (nf-κb) activation in the hypothalamus following individual exposure to mn and etoh to rats were intensified in the co-exposure group. |
2019-11-18 |
2023-08-13 |
rat |
| Mehmet Berko. Diosmin suppresses the proinflammatory mediators in lipopolysaccharide-induced RAW264.7 macrophages via NF-κB and MAPKs signal pathways. General physiology and biophysics. vol 38. issue 4. 2019-09-11. PMID:31241043. |
the anti-inflammatory effects of diosmin was displayed via measuring prostaglandin e2 (pge2), nitric oxide (no), interleukines (il-6, il-12), tumor necrosis factor α (tnf-α) production, cyclooxygenase-2 (cox-2), inducible nitric oxide synthase (inos), il-6, il-12, tnf-α mrna levels, and phosphorylation levels of nuclear factor of kappa light polypeptide gene enhancer in b-cells inhibitor alpha (iκb-α) and mitogen-activated protein kinases (mapks); jnk, erk, and p38 in lps induced raw264.7 macrophages. |
2019-09-11 |
2023-08-13 |
Not clear |
| Wenjin Guo, Bingrun Liu, Guiqiu Hu, Xingchi Kan, Yanwei Li, Qian Gong, Dianwen Xu, He Ma, Yu Cao, Bingxu Huang, Shoupeng Fu, Juxiong Li. Vanillin protects the blood-milk barrier and inhibits the inflammatory response in LPS-induced mastitis in mice. Toxicology and applied pharmacology. vol 365. 2019-08-19. PMID:30610879. |
results showed that vanillin suppressed the inflammatory response by a) inhibiting myeloperoxidase activity; b) decreasing the production of pro-inflammatory mediators which include tumor necrosis factor alpha (tnf-α; from 128.5 ± 14.59 to 67.51 ± 10.88,pg/ml, p < 0.01), interleukin-6 (il-6; from 531.5 ± 196.4 to 109.3 ± 24.14, pg/ml, p < 0.05), interleukin-1β (il-1β; from 2569 ± 1648 to 731.8 ± 171.7, pg/ml, p < 0.05), inducible nitric oxide synthase (inos), and cyclooxygenase-2 (cox-2); and c) repairing the blood-milk barrier by increasing the protein levels of the tight junction proteins, including zona occludens 1 (zo-1), claudin-3, and occludin. |
2019-08-19 |
2023-08-13 |
mouse |
| Zucheng Luo, Binbin Zheng, Bingjie Jiang, Xinghe Xue, Enxing Xue, Yulong Zho. Peiminine inhibits the IL-1β induced inflammatory response in mouse articular chondrocytes and ameliorates murine osteoarthritis. Food & function. vol 10. issue 4. 2019-08-14. PMID:30942801. |
il-1β-induced expression of nitric oxide (no), prostaglandin e2 (pge2), cyclooxygenase-2 (cox-2), tumor necrosis factor alpha (tnf-α), inducible nitric oxide synthase (inos) and interleukin-6 (il-6) were all inhibited significantly by pm pretreatment in vitro. |
2019-08-14 |
2023-08-13 |
mouse |
| Na-Rae Shin, Chul Kim, Chang-Seob Seo, Je-Won Ko, Young-Kwon Cho, In-Sik Shin, Joong-Sun Ki. Galgeun-tang Attenuates Cigarette Smoke and Lipopolysaccharide Induced Pulmonary Inflammation via IκBα/NF-κB Signaling. Molecules (Basel, Switzerland). vol 23. issue 10. 2019-07-16. PMID:30274192. |
ggwe reduced the expression of inducible nitric oxide synthase (inos) and cyclooxygenase-2 (cox-2), as well as the phosphorylation of inhibitor of kappa-b subunit alpha (iκbα) and nuclear factor kappa-b (nf-κb) in cs- and lps-exposed mice. |
2019-07-16 |
2023-08-13 |
mouse |
| Babajide O Ajayi, Isaac A Adedara, Ebenezer O Faromb. 6-Gingerol abates benzo[a]pyrene-induced colonic injury via suppression of oxido-inflammatory stress responses in BALB/c mice. Chemico-biological interactions. vol 307. 2019-06-26. PMID:31004597. |
moreover, colonic concentration of epoxide hydrolase (epxh), tumor necrosis factor alpha (tnf-α), interleukin-1 β (il-1β), cyclooxygenase-2 (cox-2) and inducible nitric oxide synthase (inos) were assessed using elisa. |
2019-06-26 |
2023-08-13 |
mouse |
| Siwei Wang, Yuejuan Fang, Xinfen Yu, Lu Guo, Xiaoxi Zhang, Daozong Xi. The flavonoid-rich fraction from rhizomes of Smilax glabra Roxb. ameliorates renal oxidative stress and inflammation in uric acid nephropathy rats through promoting uric acid excretion. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 111. 2019-06-13. PMID:30579255. |
sgf treatment obviously suppressed the inflammatory factors of interleukin-6 (il-6), tumor necrosis factor alpha (tnf-α), interleukin-1β (il-1β), cyclooxygenase-2 (cox-2) and the profibrotic factors of basic fibroblast growth factor (bfgf), transforming growth factor-β |
2019-06-13 |
2023-08-13 |
rat |
| Pâmella Recco Álvares, José Alcides Almeida de Arruda, Leni Verônica Oliveira Silva, Leorik Pereira da Silva, George João Ferreira do Nascimento, Marcia Maria Fonseca da Silveira, Ana Paula Veras Sobra. Immunohistochemical Analysis of Cyclooxygenase-2 and Tumor Necrosis Factor Alpha in Periapical Lesions. Journal of endodontics. vol 44. issue 12. 2019-03-25. PMID:30477664. |
the purpose of this study was to evaluate the expression of cyclooxygenase-2 (cox-2) and tumor necrosis factor alpha (tnf-α) in periapical granuloma (pg) and radicular cyst (rc) samples and to correlate it with the type of lesion, the intensity of the inflammatory infiltrate, and the thickness of the epithelial lining. |
2019-03-25 |
2023-08-13 |
Not clear |
| Cenk Nayki, Umit Nayki, Ferda Keskin Cimen, Mehmet Kulhan, Omer Erkan Yapca, Nezahat Kurt, Aslı Bilgin Ozbe. The effect of rutin on ovarian ischemia-reperfusion injury in a rat model. Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology. vol 34. issue 9. 2018-12-18. PMID:29564969. |
irg group had a significant increase in malondialdehyde (mda) levels, in the expressions of tumor necrosis factor alpha (tnf-α) and interleukin 1 beta (il-1β), and also in the activity of cyclooxygenase 2 (cox-2) unlike the significant decrease in total glutathione (tgsh) levels and the activity of cox-1 when compared to the sg group. |
2018-12-18 |
2023-08-13 |
rat |
| Zhi-Chao Hu, Zhong-Jie Xie, Qian Tang, Xiao-Bin Li, Xin Fu, Zhen-Hua Feng, Jiang-Wei Xuan, Wen-Fei Ni, Ai-Min W. Hydroxysafflor yellow A (HSYA) targets the NF-κB and MAPK pathways and ameliorates the development of osteoarthritis. Food & function. vol 9. issue 8. 2018-12-18. PMID:30070297. |
our data indicated that interleukin-1 beta (il-1β) induced over-production of pro-inflammatory cytokines, such as nitric oxide (no) and prostaglandin e2 (pge2); also, the expression of cyclooxygenase-2 (cox-2), tumor necrosis factor alpha (tnf-α), interleukin-6 (il-6) and inducible nitric oxide synthase (inos) were all inhibited by pretreatment with hsya in a dose-dependent manner (2.5 to 40 μm). |
2018-12-18 |
2023-08-13 |
mouse |
| Xiaxia Wu, Yanling Guo, Xiangjing Min, Lixia Pei, Xiuping Che. Neferine, a Bisbenzylisoquinoline Alkaloid, Ameliorates Dextran Sulfate Sodium-Induced Ulcerative Colitis. The American journal of Chinese medicine. vol 46. issue 6. 2018-12-18. PMID:30149754. |
the inhibitory effect of neferine on secretion of nitrite, cytokines tumor necrosis factor alpha (tnf-[formula: see text]) and interleukin 6 (il-6), expression of inducible nitric oxide synthase (inos) and cyclooxygenase-2 (cox-2) was determined. |
2018-12-18 |
2023-08-13 |
mouse |
| Tao Xian, Yuyang Gan, Yi Lu, Mengxi Wang, Wanwan Yuan, Yumeng Zhou, Junye Chen, Kun Wang, Shaofeng Xiong, Qiren Huan. Ameliorative effects of indomethacin at different concentrations on endothelial insulin resistance through two distinct pathways. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 106. 2018-11-26. PMID:30119183. |
intriguingly, we further identified that 0.25 mm of idmt noticeably induced the expression levels of pparγ, akt and endothelial nitric oxide synthase (enos) but failed to notably reverse the increases in expression levels of cox-2, inhibitory κb kinase (ikk) and tumor necrosis factor alpha (tnfα) induced by hg/hf; whereas 1.0 mm of idmt exerted opposite effects compared with 0.25 mm of idmt. |
2018-11-26 |
2023-08-13 |
Not clear |
| Ahmed M Fayez, Soad Zakaria, Dina Moustaf. Alpha lipoic acid exerts antioxidant effect via Nrf2/HO-1 pathway activation and suppresses hepatic stellate cells activation induced by methotrexate in rats. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 105. 2018-11-06. PMID:29879626. |
also, tumor necrosis factor alpha (tnf-α), inducible nitric oxide synthase (inos), cyclooxygenase-2 (cox-2), and caspase-3 were assessed by elisa in addition to histopathological examination of liver samples. |
2018-11-06 |
2023-08-13 |
rat |
| Fei-Fei Gan, Ruirui Zhang, Hui-Li Ng, Muthukumar Karuppasamy, Waygene Seah, Wei Hseun Yeap, Siew-Min Ong, Eva Hadadi, Siew-Cheng Wong, Wai-Keung Chui, Eng-Hui Che. Novel dual-targeting anti-proliferative dihydrotriazine-chalcone derivatives display suppression of cancer cell invasion and inflammation by inhibiting the NF-κB signaling pathway. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. vol 116. issue Pt B. 2018-10-01. PMID:29630947. |
at similar concentrations, these chalcone-based compounds suppressed expression of inflammatory mediators inducible nitric oxide synthase (inos) and cyclooxygenase-2 (cox-2) in lipopolysaccharides (lps)-stimulated murine macrophage-like raw 264.7 cells, as well as tumor necrosis factor alpha (tnf-α) in lps-stimulated human monocytes isolated from healthy donors. |
2018-10-01 |
2023-08-13 |
human |
| Si-Wei Wang, Yi Xu, Yuan-Yuan Weng, Xue-Yu Fan, Yong-Feng Bai, Xiao-Yan Zheng, Li-Jun Lou, Feng Zhan. Astilbin ameliorates cisplatin-induced nephrotoxicity through reducing oxidative stress and inflammation. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. vol 114. 2018-09-05. PMID:29471006. |
furthermore, we found that astilbin obviously suppressed tumor necrosis factor alpha (tnf-α) expression and nf-κb activation, and also inhibited the expression of induced nitric oxide synthase (inos) and cyclooxygenase-2 (cox-2). |
2018-09-05 |
2023-08-13 |
mouse |
| Sajid Ur Rahman, Yu Li, Yingying Huang, Lei Zhu, Shibin Feng, Jinjie Wu, Xichun Wan. Treatment of inflammatory bowel disease via green tea polyphenols: possible application and protective approaches. Inflammopharmacology. vol 26. issue 2. 2018-09-05. PMID:29532213. |
green tea polyphenols (gtps) play significant roles in down regulating signaling pathways because gtps exert effective antioxidant properties and regulate toll-like receptor 4 (tlr4) expression via certain receptor, inhibited endotoxin-mediated tumor necrosis factor alpha (tnf-α) production by blocking transcription nuclear factor-kappa b (nf-kb) activation and upstream of mediated i kappa b kinase complex pathway activities, as well as intrusion with the flow of cytokines and synthesis of cyclooxygenase-2 (cox-2). |
2018-09-05 |
2023-08-13 |
Not clear |
| Sharada H Sharma, Jayasurya Suresh Kumar, David Raj Chellappan, Sangeetha Nagaraja. Molecular chemoprevention by morin - A plant flavonoid that targets nuclear factor kappa B in experimental colon cancer. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 100. 2018-08-31. PMID:29453046. |
morin supplementation to dmh administered rats down regulated nf-κb pathway and its downstream inflammatory mediators like tumor necrosis factor alpha (tnf-α), interleukin 6 (il-6), cyclooxygenase 2 (cox-2) and prostaglandin (pge-2). |
2018-08-31 |
2023-08-13 |
rat |
| E D Mohammed, R N El-Naga, R A Lotfy, A A Al-Gendy, E El-Demerdas. Anti-fibrotic potential of a Die Pharmazie. vol 72. issue 10. 2018-08-24. PMID:29441888. |
besides, itcs rich fraction showed an anti-inflammatory effect through its ability to counteract the significant increase in nuclear factor kappa b (nf-κb), cyclooxygenase-2 (cox-2) expression, tumor necrosis factor alpha (tnf-α) and interleukin-6 (il-6) levels in liver tissue that caused by ccl4 intoxication. |
2018-08-24 |
2023-08-13 |
rat |