| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Rukiye Nalan Tiftik, Meryem Temiz-Reşitoğlu, Demet Sinem Güden, Gülsen Bayrak, İsmail Ün, Şakir Necat Yılmaz, Seyhan Şahan-Fıra. Involvement of Rho-kinase/IκB-α/NF-κB activation in IL-1β-induced inflammatory response and oxidative stress in human chondrocytes. Canadian journal of physiology and pharmacology. vol 99. issue 4. 2021-10-27. PMID:33769089. |
to test this hypothesis, we focused on determining rock-ii, iκb-α, p-iκb-α, nf-κb p65, p-nf-κb p65, il-6, tumor necrosis factor alpha (tnf-α), cyclooxygenase-2 (cox-2), p22 |
2021-10-27 |
2023-08-13 |
human |
| Cihan Gur, Fatih Mehmet Kandemir, Ekrem Darendelioglu, Cuneyt Caglayan, Sefa Kucukler, Ozge Kandemir, Mustafa Ileritur. Morin protects against acrylamide-induced neurotoxicity in rats: an investigation into different signal pathways. Environmental science and pollution research international. vol 28. issue 36. 2021-09-20. PMID:33939091. |
biochemical and western blot analyses showed that acr increased malondialdehyde (mda), p38α mitogen-activated protein kinase (p38α mapk), nuclear factor kappa-b (nf-κb), tumor necrosis factor alpha (tnf-α), interleukin-1 beta (il-1β), interleukin-6 (il-6), cyclooxygenase-2 (cox-2), p53, caspase-3, bcl-2 associated x protein (bax), beclin-1, light chain 3a (lc3a), and light chain 3b (lc3b) levels and decreased those of superoxide dismutase (sod), catalase (cat), glutathione peroxidase (gpx), glutathione (gsh), b-cell lymphoma-2 (bcl-2), mammalian target of rapamycin (mtor), phosphoinositide 3-kinase (pi3k), and protein kinase b (akt) in brain tissue and therefore induced neurotoxicity by causing oxidative stress, inflammation, apoptosis, and autophagy. |
2021-09-20 |
2023-08-13 |
rat |
| Gui-Yan He, Ying-Dan Duan, Fang Hong, Bo-Yang Yu, Cheng-Zhi Cha. [Role of Puerariae Lobatae Radix in Gegen Decoction for treatment of primary dysmenorrhea]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 46. issue 15. 2021-09-03. PMID:34472269. |
western blot method was adopted to detect cyclooxygenase-2(cox-2) and estrogen receptor alpha(er_α) expression levels in uterine tissues. |
2021-09-03 |
2023-08-13 |
mouse |
| Aya M Helal, Mohamed S Abdel-Latif, Mosleh Mohammed Abomughaid, Doaa A Ghareeb, Mohamed M El-Saye. Potential therapeutic effects of Ulva lactuca water fraction on monosodium glutamate-induced testicular and prostatic tissue damage in rats. Environmental science and pollution research international. vol 28. issue 23. 2021-06-28. PMID:33559824. |
in addition, relative expression of pro-inflammatory genes (inducible nitric oxide synthase (i-nos), cyclooxygenase-2 (cox-2), tumor necrosis factor-α alpha (tnf-α), and tumor protein (p53)) were assessed in testicular and prostatic tissues. |
2021-06-28 |
2023-08-13 |
rat |
| Chenglong Xie, Haiwei Ma, Yifeng Shi, Junli Li, Hongqiang Wu, Ben Wang, Zhenxuan Shao, Chongan Huang, Jiaoxiang Chen, Liaojun Sun, Yifei Zhou, Naifeng Tian, Yaosen Wu, Weiyang Gao, Aimin Wu, Xiangyang Wang, Xiaolei Zhan. Cardamonin protects nucleus pulposus cells against IL-1β-induced inflammation and catabolism via Nrf2/NF-κB axis. Food & function. vol 12. issue 6. 2021-06-01. PMID:33666626. |
we explored the car treatment's inhibition of the expression of inflammatory factors such as cyclooxygenase-2 (cox-2), inducible nitric oxide synthase (inos), prostaglandin e2 (pge2), nitric oxide (no), tumor necrosis factor alpha (tnf-α) and interleukin-6 (il-6) in rat np cells. |
2021-06-01 |
2023-08-13 |
rat |
| Shangkun Tang, Weijun Zhou, Xinyang Zhong, Jianchen Xu, Huasong Huang, Xinnan Zheng, Jingkang Zhang, Shuyue Yang, Ping Shang, Qian Tang, Haixiao Li. Arctigenin prevents the progression of osteoarthritis by targeting PI3K/Akt/NF-κB axis: In vitro and in vivo studies. Journal of cellular and molecular medicine. vol 24. issue 7. 2021-04-29. PMID:32090454. |
our results revealed that the atg pre-treatment effectively decreases the level of pro-inflammatory mediators, such as prostaglandin e2 (pge2), nitrous oxide (no), inducible nitric oxide synthase (inos), cyclooxygenase-2 (cox-2), il-6 and tumour necrosis factor alpha (tnf-α) in il-1β-induced human chondrocytes. |
2021-04-29 |
2023-08-13 |
mouse |
| Rahat Ullah, Muhammad Ikram, Tae Ju Park, Riaz Ahmad, Kamran Saeed, Sayed Ibrar Alam, Inayat Ur Rehman, Amjad Khan, Ibrahim Khan, Min Gi Jo, Myeong Ok Ki. Vanillic Acid, a Bioactive Phenolic Compound, Counteracts LPS-Induced Neurotoxicity by Regulating c-Jun N-Terminal Kinase in Mouse Brain. International journal of molecular sciences. vol 22. issue 1. 2021-03-25. PMID:33396372. |
we also found that systemic administration of lps-injection induced glial cells (microglia and astrocytes) activation and significantly increased expression level of nuclear factor kappa-light-chain-enhancer of activated b cells (nf-kb) and secretion of proinflammatory cytokines including tumor necrosis factor alpha (tnf-α), interleukin-1 β (il1-β), and cyclooxygenase (cox-2). |
2021-03-25 |
2023-08-13 |
mouse |
| L M C Soares, A H B Pereira, C G de Campos, L S Rocha, T Á Dos Santos, M A Souza, P C Jark, C A Pescado. Histopathological and Immunohistochemical Characteristics of Thyroid Carcinoma in the Dog. Journal of comparative pathology. vol 177. 2021-02-19. PMID:32505238. |
in the present study, we combined histopathology with immunohistochemistry (ihc) to search for the presence of oestrogen receptor alpha (orα), cox-2 and ki67 in canine thyroid carcinomas. |
2021-02-19 |
2023-08-13 |
dog |
| Basma G Eid, Ashraf B Abdel-Nai. Piceatannol Attenuates Testosterone-Induced Benign Prostatic Hyperplasia in Rats by Modulation of Nrf2/HO-1/NFκB Axis. Frontiers in pharmacology. vol 11. 2021-02-02. PMID:33519479. |
immunohistochemically, pic snedds protected against the testosterone-induced increased expression of tumor necrosis factor alpha (tnf-α), interleukin-6 (il-6), cyclooxygenase-2 (cox-2), inducible nitric oxide synthase (inos), nuclear factor kappa b (nfκb) and also offered protection against the decline in nrf2 expression. |
2021-02-02 |
2023-08-13 |
rat |
| Zeng Lin, Changchang Fu, Zijian Yan, Yifan Wu, Jingdi Zhan, Zhiling Lou, Xin Liao, Jun Pa. The protective effect of hesperetin in osteoarthritis: an in vitro and in vivo study. Food & function. vol 11. issue 3. 2021-01-04. PMID:32159191. |
in vitro, il-1β-induced expression of inducible nitric oxide synthase (inos), cyclooxygenase-2 (cox-2), nitric oxide (no), tumor necrosis factor alpha (tnf-α), prostaglandin e2 (pge2), and interleukin-6 (il-6) were inhibited by hesperetin. |
2021-01-04 |
2023-08-13 |
Not clear |
| Ren-Hao Jiang, Jia-Jing Xu, Ding-Chao Zhu, Jia-Feng Li, Chen-Xi Zhang, Nan Lin, Wei-Yang Ga. Glycyrrhizin inhibits osteoarthritis development through suppressing the PI3K/AKT/NF-κB signaling pathway in vivo and in vitro. Food & function. vol 11. issue 3. 2020-12-10. PMID:32073014. |
in the present study, we discovered that glycyrrhizin remarkably suppressed the interleukin (il)-1β-induced level of nitric oxide (no), prostaglandin e2 (pge2), tumor necrosis factor alpha (tnf-α) and interleukin-6 (il-6) and the production of cyclooxygenase-2 (cox-2), inducible nitric oxide synthase (inos), metalloproteinase3 (mmp3), metalloproteinase13 (mmp13) and a disintegrin and metalloproteinase with thrombospondin motifs5 (adamts5). |
2020-12-10 |
2023-08-13 |
mouse |
| Ya Zhao, Yuan Zeng, Anguo Wu, Chonglin Yu, Yong Tang, Xiuling Wang, Rui Xiong, Haixia Chen, Jianming Wu, Dalian Qi. Lychee Seed Fraction Inhibits Aβ(1-42)-Induced Neuroinflammation in BV-2 Cells via NF-κB Signaling Pathway. Frontiers in pharmacology. vol 9. 2020-09-30. PMID:29740316. |
the enzyme-linked immunosorbent assay, real-time pcr, and western blotting results showed that lsf could significantly reduce the release, mrna levels, and protein expressions of the pro-inflammatory cytokines such as interleukin-1β (il-1β), tumor necrosis factor alpha (tnf-α), cyclooxygenase-2 (cox-2), and inducible nitric oxide synthase (inos) in aβ(1-42)-induced bv-2 cells, which were downregulated through suppressing the nf-κb signaling pathway. |
2020-09-30 |
2023-08-13 |
Not clear |
| Mahmood Rasool, Arif Malik, Sulayman Waquar, Qura Tul-Ain, Tassadaq H Jafar, Rabia Rasool, Aasia Kalsoom, Muhammad A Ghafoor, Sheikh A Sehgal, Kalamegam Gauthaman, Muhammad I Naseer, Mohammed H Al-Qahtani, Peter N Pushpara. Frontiers in pharmacology. vol 9. 2020-09-30. PMID:30123124. |
the serum samples were further analyzed for biomarkers such as 8-hydroxydeoxyguanosine (8-ohdg), 4-hydroxynonenal (4-hne), tumor necrosis factor-alpha (tnf-α), cyclooxygenase-2 (cox-2), matrix metalloproteinase-8 (mmp-8), isoprostanes-2 alpha (isop-2α), and acetylcholine esterase (ache) using conventional enzyme linked immunosorbent assay (elisa) method. |
2020-09-30 |
2023-08-13 |
rat |
| Jialiang Lin, Jiaoxiang Chen, Zengjie Zhang, Tianzhen Xu, Zhenxuan Shao, Xiaobin Wang, Yuanzhe Ding, Naifeng Tian, Haiming Jin, Sunren Sheng, Weiyang Gao, Yan Lin, Xiaolei Zhang, Xiangyang Wan. Luteoloside Inhibits IL-1β-Induced Apoptosis and Catabolism in Nucleus Pulposus Cells and Ameliorates Intervertebral Disk Degeneration. Frontiers in pharmacology. vol 10. 2020-09-29. PMID:31427974. |
it also suppresses inflammatory mediators-nitric oxide (no), prostaglandin e2 (pge2), tumor necrosis factor alpha (tnf-α), interleukin 6 (il-6), cyclooxygenase 2 (cox-2), and inducible nitric oxide synthase (inos)-in il-1β-treated np cells. |
2020-09-29 |
2023-08-13 |
rat |
| Xiaoqiang Su, Bo Liu, Futai Gong, Jichao Yin, Qing Sun, Ye Gao, Zeyi Lv, Xiangyang Wan. Isofraxidin attenuates IL-1β-induced inflammatory response in human nucleus pulposus cells. Journal of cellular biochemistry. vol 120. issue 8. 2020-08-31. PMID:30891836. |
the results proved that isofraxidin attenuated the il-1β-induced significant increases in inflammatory mediators and cytokines including nitric oxide (no), inducible no synthase (inos), cyclooxygenase-2 (cox-2), prostaglandin e2 (pge2), tumor necrosis factor alpha (tnf-α), and il-6. |
2020-08-31 |
2023-08-13 |
human |
| Xiaoliang Bai, Wenyuan Ding, Sidong Yang, Xiaohui Gu. Higenamine inhibits IL-1β-induced inflammation in human nucleus pulposus cells. Bioscience reports. vol 39. issue 6. 2020-08-06. PMID:31213577. |
the il-1β-dependent up-regulation of inflammatory molecules including inducible nitric oxide synthase (inos), nitric oxide (no), prostaglandin e2 (pge2), cyclooxygenase-2 (cox-2), tumor necrosis factor alpha (tnf-α), and il-6 was attenuated by higenamine in npcs. |
2020-08-06 |
2023-08-13 |
human |
| Isabela Machado Barbosa David, Flávia de Souza Fernandes, Juliana Barreto Dos Santos Silva Ferreira, Daniela Dero Lüdtke, Daniel Fernandes Martins, Franciane Bobinski, Thiago Bezerra Gaspar Carvalho da Silva, Luiza Daux Buffon, Maria Biatriz Rodrigues Kopper, Gustavo Silveira da Silva, Rodrigo Costa Zeferino, Rozangela Curi Pedrosa, Maicon Roberto Kviecinsk. Dietary supplementation with procyanidin-rich Pinus pinaster extract is associated with attenuated Ehrlich tumor development in mice. Nutrition research (New York, N.Y.). vol 62. 2020-05-08. PMID:30803506. |
ascitic fluid from six mice/group was evaluated by determining total volume; tumor packed cell volume; cell viability; tumor cell death type; inflammatory infiltrate; and levels of tumor necrosis factor alpha (tnf-α), interleukin 1 beta (il-1β), carbonyl proteins, lipid peroxidation, cyclooxigenase-2 (cox-2) expression and akt phosphorylation (p-akt). |
2020-05-08 |
2023-08-13 |
mouse |
| Yifan Wu, Zeng Lin, Zijian Yan, Zhanghong Wang, Xin Fu, Kehe Y. Sinomenine contributes to the inhibition of the inflammatory response and the improvement of osteoarthritis in mouse-cartilage cells by acting on the Nrf2/HO-1 and NF-κB signaling pathways. International immunopharmacology. vol 75. 2020-03-05. PMID:31310911. |
from our experiments, which include griess reaction, elisa, western blot, and immunofluorescence, we found that sin not only down-regulated the expression of pro-inflammatory factors induced by il-1β, including; inducible nitric oxide synthase (inos), cyclooxygenase-2 (cox-2), nitricoxide (no), prostaglandin e2 (pge2), tumor necrosis factor alpha (tnf-α) and interleukin-6 (il-6), but also decreased the production of il-1β-induced cartilage matrix catabolic enzymes including; adamts-5 and mmps, in mouse chondrocytes. |
2020-03-05 |
2023-08-13 |
mouse |
| Chin-Hee Song, Nayoung Kim, Sun Min Lee, Ryoung Hee Nam, Soo In Choi, So Ra Kang, Eun Shin, Dong Ho Lee, Ha-Na Lee, Young-Joon Sur. Effects of 17β-estradiol on colorectal cancer development after azoxymethane/dextran sulfate sodium treatment of ovariectomized mice. Biochemical pharmacology. vol 164. 2020-02-13. PMID:30981879. |
at week 2, e2 administration to aom/dss-treated ovx mice attenuated the histological severity of colitis by decreasing the protein and/or mrna levels of estrogen receptor alpha (erα) and nf-κb-related mediators (i.e., cox-2, tnf-α, and il-6) and by enhancing estrogen receptor beta (erβ) and nuclear nrf2 protein expression and the mrna expression of related antioxidant enzyme genes (i.e., ho-1, gclc, gclm, and nqo1). |
2020-02-13 |
2023-08-13 |
mouse |
| Xinghe Xue, Yunlin Chen, Ye Wang, Jingdi Zhan, Bin Chen, Xiangyang Wang, Xiaoyun Pa. Troxerutin suppresses the inflammatory response in advanced glycation end-product-administered chondrocytes and attenuates mouse osteoarthritis development. Food & function. vol 10. issue 8. 2020-02-05. PMID:31359010. |
it was found that tx pretreatment inhibited the age-induced production of pro-inflammatory factors in chondrocytes, such as cyclooxygenase-2 (cox-2), inducible nitric oxide synthase (inos), nitric oxide (no), prostaglandin e2 (pge2), tumor necrosis factor alpha (tnf-α), and interleukin-6 (il-6). |
2020-02-05 |
2023-08-13 |
mouse |