| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Amar Sahay, Ain Chung, Jason Alipio, Megha Ghosh, Liam Evans, Samara Miller, Travis Goode, Iyanah Mehta, Omar Ahme. Neotenic expansion of adult-born dentate granule cells reconfigures GABAergic inhibition to enhance social memory consolidation. Research square. 2025-04-01. PMID:40166004. |
adult-born dentate granule cells (abdgcs) contribute to hippocampal dentate gyrus (dg)-ca3/ca2 circuit functions in memory encoding, retrieval and consolidation. |
2025-04-01 |
2025-04-03 |
mouse |
| Ain Chung, Jason Bondoc Alipio, Megha Ghosh, Liam Evans, Samara M Miller, Travis D Goode, Iyanah Mehta, Omar J Ahmed, Amar Saha. Neotenic expansion of adult-born dentate granule cells reconfigures GABAergic inhibition to enhance social memory consolidation. bioRxiv : the preprint server for biology. 2025-04-01. PMID:40166333. |
adult-born dentate granule cells (abdgcs) contribute to hippocampal dentate gyrus (dg)-ca3/ca2 circuit functions in memory encoding, retrieval and consolidation. |
2025-04-01 |
2025-04-03 |
mouse |
| Olga Netsyk, Sergiy V Korol, Jin-Ping Li, Bryndis Birnir, Zhe Ji. GABA-activated slow spontaneous inhibitory postsynaptic currents are decreased in dorsal hippocampal dentate gyrus granule cells in an aged mouse model of Alzheimer's disease. Journal of Alzheimer's disease : JAD. vol 104. issue 2. 2025-04-01. PMID:39956943. |
however, the role of γ-aminobutyric acid (gaba)-mediated synaptic inhibition in ad has not been fully explored.objectivewe studied basal, gaba-activated slow spontaneous synaptic currents (sipscs) in dentate gyrus (dg) granule cells in the dorsal hippocampus of an ad mouse model (tg-appswe) and investigated insulin's modulatory effects.methodsgaba-activated slow sipscs were recorded in the dg granule cells by whole-cell patch--clamp recordings in dorsal hippocampal brain slices from 5-6 (adult) and 10-12 (aged) months old wild-type (wt) and ad mice, in the presence or absence of insulin (1 nm).resultsthe median 10-90% rise time of slow sipscs significantly decreased with age (10-12 months vs. 5-6 months) only in ad mice. |
2025-04-01 |
2025-04-03 |
mouse |
| Tyler J Dause, Robert Osap, Akela A Kuwahara, Jiyeon K Denninger, Elizabeth D Kirb. Intracrine VEGF Signaling Is Required for Adult Hippocampal Neural Stem Cell Maintenance and Vascular Proximity. Molecular neurobiology. 2025-03-25. PMID:40131696. |
adult neural stem cells (nscs) in the mammalian dentate gyrus (dg) of the hippocampus rely on multiple signals for their preservation throughout the lifespan. |
2025-03-25 |
2025-03-28 |
mouse |
| Wei Liu, Xiao Chen, Chen Yang, Zequn Lin, Xinfeng Huang, Zhen Zhang, Jianjun Li. Preventive effects of xanthohumol in APP/PS1 mice based on multi-omics atlas. Brain research bulletin. 2025-03-25. PMID:40132750. |
xn improved the spatial learning and memory ability of app/ps1 mice; this was associated with an increased number of newborn neurons in the subgranular zone (sgz) and dentate gyrus (dg) and a decreased inflammatory response. |
2025-03-25 |
2025-03-28 |
mouse |
| Bing-Yao Zhou, Ze-Xuan Li, Yi-Wei Li, Jin-Nan Li, Wei-Tang Liu, Xi-Yue Liu, Zhi-Bin Hu, Li Zhao, Jia-Yin Chen, Ling Hu, Ning-Ning Song, Xue Feng, Gang Wang, Lin Xu, Yu-Qiang Din. Central Med23 deficiency leads to malformation of dentate gyrus and ADHD-like behaviors in mice. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 2025-03-21. PMID:40114018. |
in this study, emx1-cre mice were used to generate med23 conditional knockout (med23 cko) mice that showed severe hypoplasia of the dentate gyrus (dg) with malformation of the dendritic tree and spines along with impaired short-term synaptic plasticity. |
2025-03-21 |
2025-03-23 |
mouse |
| Ekaterine E Kipiani, Maia A Burjanadze, Manana G Dashniani, Nino C Chkhikvishvili, Temur L Naneishvili, Mariam R Chighladze, Barbare G Nozadze, Gela V Beseli. Medial septum deep brain stimulation enhances memory and hippocampal neurogenesis in the D-galactose induced rat model of aging: behavioral and immunohistochemical study. Experimental brain research. vol 243. issue 4. 2025-03-18. PMID:40100345. |
the immunohistochemical studies showed that in the dentate gyrus (dg) of rats with d-gal administration or d-gal combined with electrode implantation, the number of neun (neuronal nuclear antigen) or doublecortin-immunopositive cells decreased (doublecortin - a biomarker for the post-mitotic phase of cells); ms stimulation increases the number of these cells in the dg to levels comparable to the control group. |
2025-03-18 |
2025-03-21 |
rat |
| Ram Prajit, Nataya Sritawan, Anusara Aranarochana, Apiwat Sirichoat, Wanassanun Pannangrong, Peter Wigmore, Jariya Umka Welba. Chrysin alleviates the impeded neurogenesis in accelerated brain aging by D-galactose in rats. Biogerontology. vol 26. issue 2. 2025-03-14. PMID:40085327. |
aged-related cognitive impairments are associated with molecular neurodegenerations and impeded neurogenesis in the dentate gyrus (dg) of the damaged hippocampus. |
2025-03-14 |
2025-03-17 |
rat |
| Ane Rodríguez-Bodero, Paolo Bonifazi, Jan Tønnesen, Juan Manuel Encinas-Pére. Picrotoxin-Induced Epileptogenic Hippocampal Organotypic Slice Cultures (hOTCs). Methods in molecular biology (Clifton, N.J.). vol 2899. 2025-03-11. PMID:40067635. |
this model offers significant advantages over traditional in vitro methods, as they allow the examination of mid to long-term manipulations while preserving the structure of the dentate gyrus (dg) in the hippocampus. |
2025-03-11 |
2025-03-14 |
mouse |
| Anne-Sophie Sack, Esperanza Garcia, Terrance P Snutc. Maturational Stage Dependent Contributions of the Cav3.2 T-type Calcium Channel to Dentate Gyrus Granule Cell Excitability. eNeuro. 2025-03-11. PMID:40068874. |
cav3.2 channels are highly expressed in the dentate gyrus (dg) of the hippocampus, and mice lacking cav3.2 (ko) exhibit impairments in hippocampal dependent learning and memory tasks, as well as attenuated development of pilocarpine induced epilepsy. |
2025-03-11 |
2025-03-14 |
mouse |
| Phi T Nguyen, Shogo Tamura, Emily Sun, Yuecheng Shi, Yang Xiao, Clay Lacefield, Gergely F Turi, René He. Antidepressants reactivate developmental plasticity through remodeling of extracellular matrix. bioRxiv : the preprint server for biology. 2025-03-10. PMID:40060538. |
here, we show that chronic treatment with the ssri fluoxetine reinstates a developmental plasticity program in the dentate gyrus (dg) by remodeling the extracellular matrix (ecm). |
2025-03-10 |
2025-03-12 |
Not clear |
| Stefania Bartoletti, Federica Raimondi, Beatrice Casadei Garofani, Elisa Ren, Francesca Ciarpella, Arianna Capodiferro, Gemma Palazzolo, Antonietta Vilella, Giuseppina Leo, Michele Zoli, Ilaria Decimo, Giulia Curi. Two minimally invasive strategies to implant guide cannulas for multiple injections in deep brain areas. Methods (San Diego, Calif.). 2025-03-10. PMID:40064209. |
to overcome this problem, we developed, in tle adult rats, two novel approaches to implant guide cannulas more superficially: the "above dentate gyrus (dg)" and the "above hippocampus (hpc)" strategies. |
2025-03-10 |
2025-03-13 |
rat |
| Ziqi Liang, Nuomeng Jin, Weixiang Gu. Neural stem cell heterogeneity in adult hippocampus. Cell regeneration (London, England). vol 14. issue 1. 2025-03-07. PMID:40053275. |
adult neurogenesis is a unique cellular process of the ongoing generation of new neurons throughout life, which primarily occurs in the subgranular zone (sgz) of the dentate gyrus (dg) and the subventricular zone (svz) of the lateral ventricle. |
2025-03-07 |
2025-03-09 |
Not clear |
| Kin Pong U, Lin Gao, Huan Zhang, Zeyuan Ji, Jiacheng Lin, Shenyi Peng, Xiaohu Zhang, Shaolong Xue, Weifeng Qin, Lai Ling Tsang, Yonglun Kong, Yin Xia, Patrick Ming-Kuen Tang, Tao Wang, Wayne Yuk Wai Lee, Gang Li, Xiaohua Jian. KDM3A controls postnatal hippocampal neurogenesis via dual regulation of the Wnt/β-catenin signaling pathway. Cell death and differentiation. 2025-03-03. PMID:40033066. |
hippocampal neurogenesis, the generation of new neurons in the dentate gyrus (dg) of mammalian hippocampus, is essential for cognitive and emotional processes. |
2025-03-03 |
2025-03-06 |
mouse |
| Natsumi Ageta-Ishihara, Yugo Fukazawa, Fumiko Arima-Yoshida, Hiroyuki Okuno, Yuichiro Ishii, Keizo Takao, Kohtarou Konno, Kazuto Fujishima, Hiroshi Ageta, Hiroyuki Hioki, Kunihiro Tsuchida, Yoshikatsu Sato, Mineko Kengaku, Masahiko Watanabe, Ayako M Watabe, Toshiya Manabe, Tsuyoshi Miyakawa, Kaoru Inokuchi, Haruhiko Bito, Makoto Kinoshit. Septin 3 regulates memory and L-LTP-dependent extension of endoplasmic reticulum into spines. Cell reports. 2025-03-01. PMID:40023151. |
here, we show that l-ltp induced at the perforant path-hippocampal dentate gyrus (dg) synapses accompanies cytoskeletal remodeling that involves actin and the septin subunit sept3. |
2025-03-01 |
2025-03-05 |
Not clear |
| Eden Yonatan, Orya Noa Shukha, Idit Golani, Saher Abu-Ata, Yaseen Awad-Igbaria, Nizar Khatib, Yuval Ginsberg, Eilam Palzur, Ron Beloosesky, Alon Shami. Maternal N-acetylcysteine Supplementation in Lactation Ameliorates Metabolic and Cognitive Deficits in Adult Offspring Exposed to Maternal Obesity. Neuropharmacology. 2025-03-01. PMID:40023441. |
our results demonstrate maternal obesity during gestation and lactation increased body weight, hepatic steatosis, and microglial cell density in the dentate gyrus (dg) and cortex. |
2025-03-01 |
2025-03-05 |
mouse |
| Christina Strauch, Juliane Böge, Olena Shchyglo, Valentyna Dubovyk, Denise Manahan-Vaugha. The Suprapyramidal and Infrapyramidal Blades of the Dentate Gyrus Exhibit Different GluN Subunit Content and Dissimilar Frequency-Dependent Synaptic Plasticity In Vivo. Hippocampus. vol 35. issue 2. 2025-02-25. PMID:39994965. |
the pp input to the dentate gyrus (dg) terminates in the suprapyramidal (sdg) and infrapyramidal (idg) blades. |
2025-02-25 |
2025-02-27 |
rat |
| Weijia Zhi, Jiale Tang, Mingzhao Zhang, Yong Zou, Simo Qiao, Lizhen Ma, Ji Dong, Binwei Yao, Xuelong Zhao, Zhenqi Yang, Zhongwu Lin, Xiangjun Hu, Lifeng Wan. Mechanistic insights into microwave radiation induced cognitive impairments: The role of m Ecotoxicology and environmental safety. vol 292. 2025-02-25. PMID:39999628. |
based on previous studies, we hypothesize that microwave-induced cognitive impairments and vulnerability in the hippocampal dentate gyrus (dg) region are due to abnormal synaptic plasticity regulated by both newborn and mature neurons derived from neural stem cells (nscs). |
2025-02-25 |
2025-02-28 |
human |
| Yunlai Zhu, Yongjie Zhao, Junjie Zhang, Xi Sun, Ying Zhu, Xu Zhou, Xuming Shen, Zuyu Xu, Zuheng Wu, Yuehua Da. Memristor-based circuit design of interweaving mechanism of emotional memory in a hippocamp-brain emotion learning model. Neural networks : the official journal of the International Neural Network Society. vol 186. 2025-02-20. PMID:39978138. |
leveraging the hippocampal-brain emotion learning (bel) architecture, the memristive circuit comprises seven comprehensive modules: the thalamus, sensory cortex, orbitofrontal cortex, amygdala, dentate gyrus (dg), ca3, and ca1. |
2025-02-20 |
2025-02-23 |
human |
| Yuanyuan Hou, Yao Zuo, Shaofei Song, Tong Zhan. Long-term variable photoperiod exposure impairs hippocampal synapse involving of the glutamate system and leads to memory deficits in male Wistar rats. Experimental neurology. 2025-02-19. PMID:39971149. |
to investigate the impact of circadian misalignment on hippocampal function, we measured various field excitatory postsynaptic potentials (fepsp) and golgi staining in the ca1 and dentate gyrus (dg) regions in wistar rats. |
2025-02-19 |
2025-02-23 |
human |