| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yu Dong, Zihan Lu, Tiantian Gao, Zhifeng Wei, Zhijie Ou, Zheng Shi, Jie She. A polypeptide derived from pilose antler ameliorates CUMS-induced depression-like behavior by SENP2-PLCβ4 signaling axis. European journal of pharmacology. 2023-12-06. PMID:38056617. |
neurogenesis in the dentate gyrus (dg) region of hippocampus was observed by immunofluorescence. |
2023-12-06 |
2023-12-10 |
Not clear |
| Hongyu Zhao, Arjan Blokland, Jos Prickaerts, Robbert Havekes, Pim R A Heckma. Treatment with the selective PDE4B inhibitor A-33 or PDE4D inhibitor zatolmilast prevents sleep deprivation-induced deficits in spatial pattern separation. Behavioural brain research. 2023-12-06. PMID:38056709. |
sleep deprivation (sd) disrupts hippocampus-dependent memory, particularly in the dentate gyrus (dg) region, an area crucial for pattern separation. |
2023-12-06 |
2023-12-10 |
mouse |
| Kaitlyn E Dorst, Ryan A Senne, Anh H Diep, Antje R de Boer, Rebecca L Suthard, Heloise Leblanc, Evan A Ruesch, Angela Y Pyo, Sara Skelton, Lucas C Carstensen, Samantha Malmberg, Olivia P McKissick, John H Bladon, Steve Ramire. Hippocampal engrams generate variable behavioral responses and brain-wide network states. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2023-12-05. PMID:38050098. |
to address this, we optogenetically reactivated a fear engram in the dentate gyrus (dg) subregion of the hippocampus across three distinct contexts in male mice. |
2023-12-05 |
2023-12-10 |
mouse |
| Yanyi Ding, Long Li, Sinuo Wang, Yajun Cao, Minguang Yang, Yaling Dai, Huawei Lin, Jianhong Li, Yulu Liu, Zhifu Wang, Weilin Liu, Jing Ta. Electroacupuncture promotes neurogenesis in the dentate gyrus and improves pattern separation in an early Alzheimer's disease mouse model. Biological research. vol 56. issue 1. 2023-12-02. PMID:38041203. |
impaired pattern separation occurs in the early stage of alzheimer's disease (ad), and hippocampal dentate gyrus (dg) neurogenesis participates in pattern separation. |
2023-12-02 |
2023-12-10 |
mouse |
| Katharina Klinger, Miguel Del Ángel, Gürsel Çalışkan, Oliver Stor. Increasing NPYergic transmission in the hippocampus rescues aging-related deficits of long-term potentiation in the mouse dentate gyrus. Frontiers in aging neuroscience. vol 15. 2023-12-01. PMID:38020778. |
here we report profound sex differences in the neuropeptide-y (npy) levels in the dorsal dentate gyrus (dg) with higher npy concentrations in the male mice compared to their female counterparts and a reduction of npy levels during aging specifically in males. |
2023-12-01 |
2023-12-07 |
mouse |
| Katharina Klinger, Miguel Del Ángel, Gürsel Çalışkan, Oliver Stor. Increasing NPYergic transmission in the hippocampus rescues aging-related deficits of long-term potentiation in the mouse dentate gyrus. Frontiers in aging neuroscience. vol 15. 2023-12-01. PMID:38020778. |
here we report profound sex differences in the neuropeptide-y (npy) levels in the dorsal dentate gyrus (dg) with higher npy concentrations in the male mice compared to their female counterparts and a reduction of npy levels during aging specifically in males. |
2023-11-29 |
2023-12-07 |
mouse |
| Anbiao Wu, Jiyan Zhan. Neuroinflammation, memory, and depression: new approaches to hippocampal neurogenesis. Journal of neuroinflammation. vol 20. issue 1. 2023-11-28. PMID:38012702. |
neuroinflammation has been reported to be involved in mdd through distinct neurobiological mechanisms, among which the dysregulation of neurogenesis in the dentate gyrus (dg) of the hippocampus (hpc) is receiving increasing attention. |
2023-11-28 |
2023-11-29 |
Not clear |
| Yan Cao, Pan Liu, Hongfei Bian, Sixuan Jin, Jiaqi Liu, Ning Yu, Huan Cui, Fengrun Sun, Xiaojing Qian, Wenying Qiu, Chao M. Reduced neurogenesis in human hippocampus with Alzheimer's disease. Brain pathology (Zurich, Switzerland). 2023-11-27. PMID:38012054. |
in this study, we observed a significant presence of neurogenic cells in the hippocampus's dentate gyrus (dg) region in 30 individuals, including 14 individuals diagnosed with ad-related neuropathological changes and the remaining 16 individuals without any neurological diseases. |
2023-11-27 |
2023-11-29 |
human |
| Matin Baghani, Arad Bolouri-Roudsari, Reyhaneh Askari, Abbas Haghparas. Orexin receptors in the hippocampal dentate gyrus modulated the restraint stress-induced analgesia in the animal model of chronic pain. Behavioural brain research. vol 459. 2023-11-25. PMID:37995966. |
since orexin neuropeptides are involved in pain modulation, and orexin neurons, primarily located in the lateral hypothalamus (lh), project to various hippocampal regions, such as the dentate gyrus (dg), the current study aimed to examine the role of orexin receptors within the dg region in the restraint sia in the animal model of chronic pain. |
2023-11-25 |
2023-11-28 |
rat |
| Yue Qiao, Hang Liu, Chaoying He, Ying M. ApoE Mimic Peptide COG1410 reduces Aβ deposition and improves cognitive function by inducing the transformation of A1/ A2 reactive astrocytes and increasing the BDNF concentration in brain of APP/PS1 double transgenic mice. Neuroscience. 2023-11-25. PMID:38006963. |
in this study, we studied the effect of apoe mimetic peptide cog1410 on spatial learning and memory functions, deposition of aβ in the dentate gyrus (dg) of app/ps1 transgenic mice, and the different effects of a1 and a2 subtypes of reactive astrocytes. |
2023-11-25 |
2023-11-28 |
mouse |
| Dore Loef, Indira Tendolkar, Philip F P van Eijndhoven, Jeroen J M Hoozemans, Mardien L Oudega, Annemieke J M Rozemuller, Paul J Lucassen, Annemiek Dols, Anke A Dijkstr. Electroconvulsive therapy is associated with increased immunoreactivity of neuroplasticity markers in the hippocampus of depressed patients. Translational psychiatry. vol 13. issue 1. 2023-11-20. PMID:37981649. |
in rodents, electroconvulsive shocks increase proliferation and the expression of plasticity markers in the hippocampal dentate gyrus (dg), suggesting increased neurogenesis. |
2023-11-20 |
2023-11-29 |
human |
| Abigail C Toltin, Abdelmadjid Belkadi, Laura M Gamba, Muhammad M Hossai. The Preventive Effects of Salubrinal against Pyrethroid-Induced Disruption of Adult Hippocampal Neurogenesis in Mice. International journal of molecular sciences. vol 24. issue 21. 2023-11-14. PMID:37958604. |
salubrinal prevented hippocampal er stress, as indicated by decreased levels of c/ebp-homologous protein (chop) and transcription factor 4 (atf4) and attenuated deltamethrin-induced reductions in brdu-, ki-67-, and dcx-positive cells in the dentate gyrus (dg) of the hippocampus. |
2023-11-14 |
2023-11-20 |
mouse |
| Rodrigo M M Santiago, Vítor Lopes-Dos-Santos, Emily A Aery Jones, Yadong Huang, David Dupret, Adriano B L Tor. Waveform-based classification of dentate spikes. bioRxiv : the preprint server for biology. 2023-11-14. PMID:37961150. |
synchronous excitatory discharges from the entorhinal cortex (ec) to the dentate gyrus (dg) generate fast and prominent patterns in the hilar local field potential (lfp), called dentate spikes (dss). |
2023-11-14 |
2023-11-20 |
mouse |
| Selena Singh, Suzanna Becker, Thomas Trappenberg, Abraham Nune. Granule cells perform frequency-dependent pattern separation in a computational model of the dentate gyrus. Hippocampus. 2023-11-11. PMID:37950569. |
we aim to study, in a computational model of the hippocampal dentate gyrus (dg), the network and cellular mechanisms governing this putative "u"-shaped ps relationship. |
2023-11-11 |
2023-11-20 |
Not clear |
| Shilin Xu, Keke Hao, Ying Xiong, Rui Xu, Huan Huang, Huiling Wan. Capsaicin alleviates neuronal apoptosis and schizophrenia-like behavioral abnormalities induced by early life stress. Schizophrenia (Heidelberg, Germany). vol 9. issue 1. 2023-11-07. PMID:37935716. |
ms decreased the expression of trpv1 in the frontal association cortex (fra) and in the hippocampal ca1, ca3, and dentate gyrus (dg) regions compared with the control group resulting in the increase of pro-apoptotic proteins (bax, caspase3, cleaved-caspase3) and the decrease of anti-apoptotic proteins (bcl-2). |
2023-11-07 |
2023-11-20 |
human |
| Yu Chen, Xiao-Lin Wu, Hai-Bo Hu, Shu-Nan Yang, Zi-Yi Zhang, Guan-Ling Fu, Chu-Tong Zhang, Zi-Meng Li, Feng Wu, Kai-Wei Si, Yan-Bing Ma, Sheng-Feng Ji, Jin-Song Zhou, Xiao-Yong Ren, Xin-Li Xiao, Jian-Xin Li. Neuronal MeCP2 in the dentate gyrus regulates mossy fiber sprouting of mice with temporal lobe epilepsy. Neurobiology of disease. 2023-11-06. PMID:37931884. |
in this study, a status epilepticus-induced decrease of neuronal mecp2 was observed in the dentate gyrus (dg). |
2023-11-06 |
2023-11-08 |
mouse |
| Yasunori Takahashi, Ryota Ojiro, Risako Yamashita, Saori Shimizu, Natsuno Maeda, Xinyu Zou, Qian Tang, Shunsuke Ozawa, Gye-Hyeong Woo, Toshinori Yoshida, Makoto Shibutan. Suppression of neurogranin expression by disruption of epigenetic DNA methylation in hippocampal mature granule cells after developmental exposure to neurotoxicants in rats. Toxicology letters. 2023-11-05. PMID:37926403. |
we previously performed comprehensive analyses of genes hypermethylated promoter regions and downregulated transcripts in the hippocampal dentate gyrus (dg) of rats upon weaning at postnatal day (pnd) 21 after developmental exposure to 6-propyl-2-thiouracil (ptu), valproic acid, and glycidol (gly), all of which are known to show irreversible effects on hippocampal neurogenesis in adulthood on pnd 77. |
2023-11-05 |
2023-11-08 |
rat |
| Ziwei Gao, Chao Lu, Yaping Zhu, Yuxin Liu, Yuesong Lin, Wenming Gao, Liyuan Tian, Lei W. Merazin hydrate produces rapid antidepressant effect by activating CaMKII to promote neuronal activities and proliferation in hippocampus. Brain research. 2023-11-04. PMID:37924927. |
moreover, mh could not only significantly up-regulated the expressions of cfos, but also obviously increased the number of ki67 positive cells in hippocampal dentate gyrus (dg). |
2023-11-04 |
2023-11-08 |
mouse |
| Samu N Kurki, Rakenduvadhana Srinivasan, Jens Laine, Mari A Virtanen, Tommi Ala-Kurikka, Juha Voipio, Kai Kail. Acute neuroinflammation leads to disruption of neuronal chloride regulation and consequent hyperexcitability in the dentate gyrus. Cell reports. vol 42. issue 11. 2023-11-03. PMID:37922309. |
here, we show that peripheral injection of lipopolysaccharide (lps) renders the dentate gyrus (dg) hyperexcitable to perforant pathway stimulation in vivo and increases the internal spiking propensity of dentate granule cells (dgcs) in vitro 24 h post-injection (hpi). |
2023-11-03 |
2023-11-08 |
Not clear |
| Katie J Neale, Hannah M O Reid, Barbara Sousa, Erin McDonagh, Jamie Morrison, Sandy Shultz, Eric Eyolfson, Brian R Christi. Repeated mild traumatic brain injury causes sex-specific increases in cell proliferation and inflammation in juvenile rats. Journal of neuroinflammation. vol 20. issue 1. 2023-11-01. PMID:37907981. |
r-mtbi animals exhibited an increase in brdu + (bromodeoxyuridine positive) cells in the dentate gyrus (dg), and that this increase was more robust in male animals. |
2023-11-01 |
2023-11-08 |
rat |