| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jin Jin, Chonglei Fu, Jing Xia, Heyi Luo, Xianglian Wang, Si Chen, Huanhuan Mao, Kai Yuan, Lin Lu, Wei Xiong, Guichang Zo. Cannabidiol ameliorates cognitive decline in 5×FAD mouse model of Alzheimer's disease through potentiating the function of extrasynaptic glycine receptors. Molecular psychiatry. 2024-10-12. PMID:39396064. |
cbd achieves its curative effect mainly through potentiating the function of inhibitory extrasynaptic glycine receptor (glyr) in hippocampal dentate gyrus (dg). |
2024-10-12 |
2024-10-15 |
mouse |
| Alejandro Antón-Fernández, Rocío Peinado Cauchola, Félix Hernández, Jesús Ávil. Hippocampal rejuvenation by a single intracerebral injection of one-carbon metabolites in C57BL6 old wild-type mice. Aging cell. 2024-10-09. PMID:39380362. |
in summary, we report the reversal of various age-associated epigenetic changes, such as the transcription factor zic4, and several changes related to cellular rejuvenation in the dentate gyrus (dg). |
2024-10-09 |
2024-10-11 |
mouse |
| Carolyn Twible, Rober Abdo, Chelsey Zhao, Qi Zhan. Hippocampal dentate granule cells in temporal lobe epilepsy: A morphometry and transcriptomic study. Neuropathology and applied neurobiology. vol 50. issue 5. 2024-10-08. PMID:39375854. |
the dentate gyrus (dg) plays a critical role in hippocampal circuitry, providing a "gate-like" function to the downstream cornu ammonis (ca) sectors. |
2024-10-08 |
2024-10-10 |
Not clear |
| Stephen B McHugh, Vítor Lopes-Dos-Santos, Manfredi Castelli, Giuseppe P Gava, Sophie E Thompson, Shu K E Tam, Katja Hartwich, Brook Perry, Robert Toth, Timothy Denison, Andrew Sharott, David Dupre. Offline hippocampal reactivation during dentate spikes supports flexible memory. Neuron. 2024-09-25. PMID:39321790. |
hippocampal sharp-wave ripples (swrs) in the cornu ammonis (ca) region and dentate spikes (dss) in the dentate gyrus (dg) are prime candidate network events for supporting this offline process. |
2024-09-25 |
2024-09-28 |
mouse |
| Xiuting Qi, Xi Chen, Qi Luo, Lihan Liu, Dong An, Sha Sha, Yimei Du, Chunfeng Wu, Lei Che. TRPV4 Blockage Inhibits the Neurogenesis in the Adult Hippocampal Dentate Gyrus Following Pilocarpine‑Induced Status Epilepticus. Molecular neurobiology. 2024-09-23. PMID:39312069. |
aberrant neurogenesis in the adult hippocampal dentate gyrus (dg) contributes to synapse remodeling during temporal lobe epilepsy (tle). |
2024-09-23 |
2024-09-26 |
mouse |
| Ze-Ka Chen, Luis Quintanilla, Yijing Su, Ryan N Sheehy, Jeremy M Simon, Yan-Jia Luo, Ya-Dong Li, Zhe Chen, Brent Asrican, Dalton S Tart, W Todd Farmer, Guo-Li Ming, Hongjun Song, Juan Son. Septo-dentate gyrus cholinergic circuits modulate function and morphogenesis of adult neural stem cells through granule cell intermediaries. Proceedings of the National Academy of Sciences of the United States of America. vol 121. issue 40. 2024-09-23. PMID:39312657. |
here, we report that stimulation of the cholinergic circuits projected from the diagonal band of broca (db) to the dentate gyrus (dg) neurogenic niche promotes proliferation and morphological development of rnscs, resulting in increased neural stem/progenitor pool and rnscs with longer radial processes and larger busy heads. |
2024-09-23 |
2024-09-26 |
Not clear |
| Nicole M Weston, Jakob C Green, Timothy N Keoprasert, Dong Su. Dendritic morphological development of traumatic brain injury-induced new neurons in the dentate gyrus is important for post-injury cognitive recovery and is regulated by Notch1. Experimental neurology. 2024-09-20. PMID:39303845. |
it is well established that neurogenesis in the dentate gyrus (dg) of the hippocampus is important for hippocampal dependent learning and memory functions. |
2024-09-20 |
2024-09-23 |
mouse |
| J J Rodríguez, E Gardenal, F Zallo, J Cabot, X Busquet. Early PSA-NCAM reduction in the dentate gyrus and impaired plasticity in the Alzheimer´s disease 3xTg-mice model. Acta histochemica. vol 126. issue 8. 2024-09-17. PMID:39288682. |
neurodegenerative diseases such as alzheimer´s (ad) and physiological ageing are characterized by a decline in neurogenesis and in the polysialylated isoforms of neural cell adhesion molecule (psa-ncam) expression within the hippocampus and specifically in the dentate gyrus (dg). |
2024-09-17 |
2024-09-20 |
mouse |
| Kyoji Ohyama, Hiroshi M Shinohara, Natsumi Takayama, Rina Ogawa, Shoichiro Omura, Mio Hayashida, Tokiharu Takahash. Differentiation stage-specific expression of transcriptional regulators for epithelial mesenchymal transition in dentate granule progenitors. Frontiers in neuroscience. vol 18. 2024-09-14. PMID:39268037. |
during the development of the mouse dentate gyrus (dg), granule neuronal progenitors (gnps) arise from glial fibrillary acidic protein (gfap)-expressing neural stem cells in the dentate notch. |
2024-09-14 |
2024-09-16 |
mouse |
| Corinne J Montes-Rodríguez, Erika D Hernández-Reyes, Vanessa Piña-Díaz, Zeidy Muñoz-Torres, Itzel Pérez-Zarazúa, Emiliano Urteaga-Urías, Oscar Prospéro-Garcí. Activity-Dependent Synaptic Plasticity in the Medial Prefrontal Cortex of Male Rats Underlies Resilience-Related Behaviors to Social Adversity. Journal of neuroscience research. vol 102. issue 9. 2024-09-14. PMID:39275861. |
cfos evaluation showed that social interaction heightened plasticity in the prelimbic (prl) and infralimbic (il) cortices, dentate gyrus (dg), ca3, and ca1. |
2024-09-14 |
2024-09-17 |
rat |
| Sandeep Kumar Mishra, Vaibhav Mishr. Saroglitazar Enhances Memory Functions and Adult Neurogenesis via Up-Regulation of Wnt/β Catenin Signaling in the Rat Model of Dementia. ACS chemical neuroscience. 2024-09-12. PMID:39265183. |
a substantial increase in neurogenesis was observed in the subventricular zone (svz) and the dentate gyrus (dg), as indicated by an increase in the number of 5-bromo-2'-deoxyuridine (brdu) |
2024-09-12 |
2024-09-15 |
rat |
| Jacopo Agrimi, Lucia Bernardele, Naeem Sbaiti, Marco Brondi, Donato D'Angelo, Marta Canato, Ivan Marchionni, Christian U Oeing, Giussy Barbara, Beatrice Vignoli, Marco Canossa, Nina Kaludercic, Gaya Spolverato, Anna Raffaello, Claudia Lodovichi, Marco Dal Maschio, Nazareno Paolocc. Reiterated male-to-female violence disrupts hippocampal estrogen receptor β expression, prompting anxiety-like behavior. iScience. vol 27. issue 9. 2024-09-04. PMID:39228787. |
rmfvi prompted anxiety-like behavior in female mice whose hippocampus displayed a marked neuronal loss and hampered neurogenesis, namely reduced brdu-dcx-positive nuclei and diminished dendritic arborization in the dentate gyrus (dg): effects paralleled by a substantial downregulation of the estrogen receptor β (erβ). |
2024-09-04 |
2024-09-06 |
mouse |
| Maltesh Kambali, Yan Li, Petr Unichenko, Jessica A Feria Pliego, Rachita Yadav, Jing Liu, Patrick McGuinness, Johanna G Cobb, Muxiao Wang, Rajasekar Nagarajan, Jinrui Lyu, Vanessa Vongsouthi, Colin J Jackson, Elif Engin, Joseph T Coyle, Jaeweon Shin, Nathaniel W Hodgson, Takao K Hensch, Michael E Talkowski, Gregg E Homanics, Vadim Y Bolshakov, Christian Henneberger, Uwe Rudolp. An increased copy number of glycine decarboxylase (GLDC) associated with psychosis reduces extracellular glycine and impairs NMDA receptor function. Molecular psychiatry. 2024-08-30. PMID:39210012. |
using a chromosome-engineered allelic series in mice, we report that a triplication of the gene encoding the glycine-catabolizing enzyme glycine decarboxylase (gldc) - as found on a small supernumerary marker chromosome in patients with psychosis - reduces extracellular glycine levels as determined by optical fluorescence resonance energy transfer (fret) in dentate gyrus (dg) and suppresses long-term potentiation (ltp) in mpp-dg synapses but not in ca3-ca1 synapses, reduces the activity of biochemical pathways implicated in schizophrenia and mitochondrial bioenergetics, and displays deficits in schizophrenia-like behaviors which are in part known to be dependent on the activity of the dentate gyrus, e.g., prepulse inhibition, startle habituation, latent inhibition, working memory, sociability and social preference. |
2024-08-30 |
2024-09-04 |
mouse |
| Reihaneh Mohammadkhani, Iraj Salehi, Samaneh Safari, Reza Ghahremani, Alireza Komaki, Seyed Asaad Karim. Continuous exercise training rescues hippocampal long-term potentiation in the VPA rat model of Autism: Uncovering sex-specific effects. Neuroscience. 2024-08-30. PMID:39214164. |
the aim of the present study was to investigate the effects of interval training (it) and continuous training (ct) exercises on ltp in the hippocampal dentate gyrus (dg) neurons of valproic acid (vpa) rat model of autism. |
2024-08-30 |
2024-09-04 |
rat |
| Krista A Mitchnick, Sabrina Labardo, R Shayna Rosenbau. Dissociations in perceptual discrimination following selective damage to the dentate gyrus versus CA1 subfield of the hippocampus. Cortex; a journal devoted to the study of the nervous system and behavior. vol 179. 2024-08-28. PMID:39197409. |
the current study examined the nature and extent of a double dissociation between the dentate gyrus (dg) to discrimination processes and ca1 subfield to retention/retrieval by testing two unique individuals with bilateral damage to the dg (case bl) and ca1 (case br). |
2024-08-28 |
2024-09-01 |
Not clear |
| Krista A Mitchnick, Sabrina Labardo, R Shayna Rosenbau. Dissociations in perceptual discrimination following selective damage to the dentate gyrus versus CA1 subfield of the hippocampus. Cortex; a journal devoted to the study of the nervous system and behavior. vol 179. 2024-08-28. PMID:39197409. |
separate research has demonstrated separable contributions of hpc subregions to component memory processes, with the dentate gyrus (dg) required for mnemonic discrimination of similar inputs and the ca1 subfield required for retention and retrieval, but contributions of these subregions to perceptual processes is understudied. |
2024-08-28 |
2024-09-01 |
Not clear |
| Shenjia Gao, Ruling Shen, Jie Li, Yi Jiang, Hao Sun, Xinyi Wu, Xiya Li, Changhong Miao, Miao He, Jun Wang, Wankun Che. N-acetyltransferase 10 mediates cognitive dysfunction through the acetylation of GABA Proceedings of the National Academy of Sciences of the United States of America. vol 121. issue 36. 2024-08-27. PMID:39190359. |
our findings demonstrate that clp significantly upregulates nat10 expression and mrna acetylation in the excitatory neurons of the hippocampal dentate gyrus (dg). |
2024-08-27 |
2024-08-30 |
mouse |
| Jonas Fritze, Stefan Lang, Mikael Sommarin, Shamit Soneji, Henrik Ahleniu. Single-cell RNA sequencing of aging neural progenitors reveals loss of excitatory neuron potential and a population with transcriptional immune response. Frontiers in neuroscience. vol 18. 2024-08-26. PMID:39184324. |
in the adult murine brain, neural stem cells (nscs) can be found in two main niches: the dentate gyrus (dg) and the subventricular zone (svz). |
2024-08-26 |
2024-08-28 |
Not clear |
| Zhengshan Liu, Yu H Sun, Yue Ren, Jessica Marie Perez, Daniel Scott, Carol Tamming. Upregulated solute-carrier family genes in the hippocampus of schizophrenia can be rescued by antipsychotic medications. Schizophrenia research. vol 272. 2024-08-25. PMID:39182310. |
our previous studies have found that functional changes in the hippocampal circuit from dentate gyrus (dg) to cornu ammonis 3 and 1 (ca3, ca1) are highly associated with schizophrenia (sz). |
2024-08-25 |
2024-08-28 |
human |
| Keisuke Otsubo, Naoko Sakashita, Yuki Nishimoto, Yo Sato, Takehisa Tsutsui, Katsunori Kobayashi, Kanzo Suzuki, Eri Segi-Nishid. Role of desmoplakin in supporting neuronal activity, neurogenic processes, and emotional-related behaviors in the dentate gyrus. Frontiers in neuroscience. vol 18. 2024-08-23. PMID:39176381. |
dsp is specifically expressed in the hippocampal dentate gyrus (dg) in the central nervous system. |
2024-08-23 |
2024-08-25 |
mouse |