| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Li Luo, Le Yang, Kun Zhang, Shi-Meng Zhou, Yan Wang, Liu-Kun Yang, Bin Feng, Shui-Bing Liu, Yu-Mei Wu, Ming-Gao Zhao, Qi Yan. Caveolin-1-Mediated Cholesterol Accumulation Contributes to Exaggerated mGluR-Dependent Long-Term Depression and Impaired Cognition in Fmr1 Knockout Mice. Molecular neurobiology. 2023-03-01. PMID:36854997. |
moreover, hippocampal cav1 expression in fmr1 ko mice induced excessive endocytosis of the α-amino-3-hydroxyl-5-methyl-4-isoxazolepropionate (ampa) receptor subunit glua2. |
2023-03-01 |
2023-08-14 |
mouse |
| Li Luo, Le Yang, Kun Zhang, Shi-Meng Zhou, Yan Wang, Liu-Kun Yang, Bin Feng, Shui-Bing Liu, Yu-Mei Wu, Ming-Gao Zhao, Qi Yan. Caveolin-1-Mediated Cholesterol Accumulation Contributes to Exaggerated mGluR-Dependent Long-Term Depression and Impaired Cognition in Fmr1 Knockout Mice. Molecular neurobiology. 2023-03-01. PMID:36854997. |
importantly, injection of the cholesterol scavenger methyl-β-cyclodextrin (mβ-cd) recovered ampa receptor trafficking and markedly alleviated hyperactivity, hippocampus-dependent fear memory, and spatial memory defects in fmr1 ko mice. |
2023-03-01 |
2023-08-14 |
mouse |
| Antonella Borreca, Mariassunta De Luca, Antonella Ferrante, Zaira Boussadia, Annabella Pignataro, Alberto Martire, Martine Ammassari-Teul. Fmr1-KO mice failure to detect object novelty associates with a post-test decrease of structural and synaptic plasticity upstream of the hippocampus. Scientific reports. vol 13. issue 1. 2023-01-14. PMID:36641518. |
we trained fmr1 knockout (ko) and wild-type c57bl/6j (wt) mice in the novel object recognition (nor) paradigm with 1 h or 24 h training-to-test intervals and then assessed whether varying the time between the presentation of similar and different objects modulates nor performance and plasticity along the entorhinal cortex-hippocampus axis. |
2023-01-14 |
2023-08-14 |
mouse |
| Yujeong Kim, Se Jin Jeon, Edson Luck Gonzales, Dongpil Shin, Chilly Gay Remonde, TaeJin Ahn, Chan Young Shi. Pirenperone relieves the symptoms of fragile X syndrome in Fmr1 knockout mice. Scientific reports. vol 12. issue 1. 2022-12-05. PMID:36470953. |
moreover, pirenperone rescued the behavioral deficits in fmr1 ko mice including hyperactivity, spatial memory, and impulsivity. |
2022-12-05 |
2023-08-14 |
mouse |
| X Tao, A Newman-Tancredi, M A Varney, K A Raza. Acute and Repeated Administration of NLX-101, a Selective Serotonin-1A Receptor Biased Agonist, Reduces Audiogenic Seizures in Developing Fmr1 Knockout Mice. Neuroscience. 2022-11-21. PMID:36410632. |
the midbrain inferior colliculus (ic) is critically involved in generating audiogenic seizures and ic neurons are hyper-responsive to sounds in developing fmr1 ko mice. |
2022-11-21 |
2023-08-14 |
mouse |
| Se Jin Jeon, Huiyoung Kwon, Ho Jung Bae, Edson Luck Gonzales, Junhyeong Kim, Hye Jin Chung, Dong Hyun Kim, Jong Hoon Ryu, Chan Young Shi. Agmatine relieves behavioral impairments in Fragile X mice model. Neuropharmacology. 2022-09-03. PMID:36057317. |
based on the recent successful demonstration of an endogenous polyamine, agmatine, to improve the autism-like symptoms in the valproic acid animal model of autism, we investigated the effects of agmatine against fxs symptoms using fmr1 knockout (ko) mice. |
2022-09-03 |
2023-08-14 |
mouse |
| Nicole K Morrill, Aurelie Joly-Amado, Qingyou Li, Sahana Prabhudeva, Edwin J Weeber, Kevin R Nas. Reelin central fragment supplementation improves cognitive deficits in a mouse model of Fragile X Syndrome. Experimental neurology. 2022-07-21. PMID:35863501. |
we demonstrate here that reelin signaling enhancement via a single intracerebroventricular injection of the reelin central fragment into fmr1 ko mice can profoundly rescue cognitive deficits in hidden platform water maze and fear conditioning, as well as hyperactivity during the open field. |
2022-07-21 |
2023-08-14 |
mouse |
| Libiao Pan, Lu Zheng, Xiaotong Wu, Zhenggang Zhu, Siyu Wang, Yi Lu, Yang He, Qian Yang, Xiaolin Ma, Xiaomeng Wang, Hongbin Yang, Li Zhan, Yujian Luo, Xiangyao Li, Yudong Zhou, Xiaodong Wang, Jianhong Luo, Lang Wang, Shumin Duan, Hao Wan. A short period of early life oxytocin treatment rescues social behavior dysfunction via suppression of hippocampal hyperactivity in male mice. Molecular psychiatry. 2022-07-15. PMID:35840800. |
social behavior deficits in a fragile x syndrome mouse model (fmr1 ko mice) could also be recovered by early life oxt treatment, through negating dca3 over-activation. |
2022-07-15 |
2023-08-14 |
mouse |
| Keegan Flanagan, Alireza Baradaran-Heravi, Qi Yin, Khanh Dao Duc, Allan C Spradling, Ethan J Greenblat. FMRP-dependent production of large dosage-sensitive proteins is highly conserved. Genetics. 2022-06-22. PMID:35731217. |
the steady state levels of several fmrp targets were reduced in the fmr1 ko mouse cortex, including a ∼2-fold reduction of auts2, a gene implicated in an autosomal dominant autism spectrum disorder. |
2022-06-22 |
2023-08-14 |
mouse |
| Renate Kat, María Arroyo-Araujo, Rob B M de Vries, Marthe A Koopmans, Sietse F de Boer, Martien J H Ka. Translational validity and methodological underreporting in animal research: a systematic review and meta-analysis of the Fragile X syndrome (Fmr1 KO) rodent model. Neuroscience and biobehavioral reviews. 2022-06-11. PMID:35690123. |
translational validity and methodological underreporting in animal research: a systematic review and meta-analysis of the fragile x syndrome (fmr1 ko) rodent model. |
2022-06-11 |
2023-08-14 |
Not clear |
| Jee-Yeon Hwang, Hannah R Monday, Jingqi Yan, Andrea Gompers, Adina R Buxbaum, Kirsty J Sawicka, Robert H Singer, Pablo E Castillo, R Suzanne Zuki. CPEB3-dependent increase in GluA2 subunits impairs excitatory transmission onto inhibitory interneurons in a mouse model of fragile X. Cell reports. vol 39. issue 10. 2022-06-08. PMID:35675768. |
using single-molecule mrna detection, we show that mrna encoding the ampar subunit glua2 (but not glua1) is elevated in dendrites and at transcription sites of hippocampal neurons of fmr1 ko mice, indicating elevated glua2 transcription. |
2022-06-08 |
2023-08-14 |
mouse |
| AndrewJ Holley, Aleya Shedd, Anna Boggs, Jonathan Lovelace, Craig Erickson, Christina Gross, Miranda Jankovic, Khaleel Razak, Kimberly Huber, Jay R Gibso. A sound-driven cortical phase-locking change in the Fmr1 KO mouse requires Fmr1 deletion in a subpopulation of brainstem neurons. Neurobiology of disease. 2022-05-19. PMID:35588990. |
a sound-driven cortical phase-locking change in the fmr1 ko mouse requires fmr1 deletion in a subpopulation of brainstem neurons. |
2022-05-19 |
2023-08-13 |
mouse |
| Jessica L Armstrong, Clinton E Cana. Targeting 5-HT FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 36 Suppl 1. 2022-05-13. PMID:35554052. |
for example, we show significantly decreased pnn density in hippocampal ca2 in juvenile fmr1 knockout (ko) mice, a neural system critical for social memory, compared to wild-type (wt) mice (p=0.0043, n=8 and 7, respectively). |
2022-05-13 |
2023-08-13 |
mouse |
| Tanishka S Saraf, Bo Yang, Ryan P McGlynn, Raymond G Booth, Clinton E Cana. Targeting 5-HT1A Receptors to Correct Neuronal Hyperexcitability in Fmr1 Knockout Mice. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 36 Suppl 1. 2022-05-13. PMID:35554571. |
based on our observations of altered brain expression and in vivo function of serotonin 1a receptors (5-ht1ars) in fmr1 ko mice and correction of the audiogenic seizure phenotype by our novel 2-aminotetralin-type 5-ht1r modulator, fpt, we are testing the hypothesis that selectively activating 5-ht1ars prevents seizures and corrects neurophysiological abnormalities. |
2022-05-13 |
2023-08-13 |
mouse |
| Tanishka S Saraf, Bo Yang, Ryan P McGlynn, Raymond G Booth, Clinton E Cana. Targeting 5-HT1A Receptors to Correct Neuronal Hyperexcitability in Fmr1 Knockout Mice. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 36 Suppl 1. 2022-05-13. PMID:35554571. |
we also tested the antiepileptic effects of the selective 5-ht1ar agonist, nlx-112 (0.25-2.5 mg/kg), and are currently testing the effects of fpt and nlx-112 on ca1 pyramidal neuron hyperexcitability in fmr1 ko mice. |
2022-05-13 |
2023-08-13 |
mouse |
| Tanishka S Saraf, Bo Yang, Ryan P McGlynn, Raymond G Booth, Clinton E Cana. Targeting 5-HT1A Receptors to Correct Neuronal Hyperexcitability in Fmr1 Knockout Mice. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 36 Suppl 1. 2022-05-13. PMID:35554571. |
recordings from above the left somatosensory cortex showed a significantly elevated high gamma (65-100 hz) power ratio in fmr1 ko mice relative to control mice at baseline (n=16, p=0.0357) and after vehicle injection (n=16, p=0.0066), a genotype difference that fpt eliminated (n=15-16, p=0.6279). |
2022-05-13 |
2023-08-13 |
mouse |
| Tanishka S Saraf, Bo Yang, Ryan P McGlynn, Raymond G Booth, Clinton E Cana. Targeting 5-HT1A Receptors to Correct Neuronal Hyperexcitability in Fmr1 Knockout Mice. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 36 Suppl 1. 2022-05-13. PMID:35554571. |
separately, nlx-112 prevented audiogenic seizures in fmr1 ko mice (n=10-12, p≤0.0002), and preliminary data suggest nlx-112 and fpt modulate ca1 pyramidal neuron activity. |
2022-05-13 |
2023-08-13 |
mouse |
| Tanishka S Saraf, Bo Yang, Ryan P McGlynn, Raymond G Booth, Clinton E Cana. Targeting 5-HT1A Receptors to Correct Neuronal Hyperexcitability in Fmr1 Knockout Mice. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 36 Suppl 1. 2022-05-13. PMID:35554571. |
for example, fpt (10 µm) showed a reversible reduction of firing frequency of hippocampal ca1 neurons in fmr1 ko mice (n=8, p<0.05). |
2022-05-13 |
2023-08-13 |
mouse |
| Yash R Somnay, Aili Wang, Keren K Griffiths, Richard J Lev. Altered Brown Adipose Tissue Mitochondrial Function in Newborn Fragile X Syndrome Mice. Mitochondrion. 2022-05-02. PMID:35500860. |
we previously found hyperthermia in a newborn mouse model of fragile x syndrome and excessive leak in fmr1 ko forebrain mitochondria caused by coq deficiency. |
2022-05-02 |
2023-08-13 |
mouse |
| Bumwhee Lee, Laura Beuhler, Hye Young Le. The Primary Ciliary Deficits in Cerebellar Bergmann Glia of the Mouse Model of Fragile X Syndrome. Cerebellum (London, England). 2022-04-19. PMID:35438410. |
here, we discovered a reduction in the number of primary cilia and the sonic hedgehog (shh) signaling in cerebellar bergmann glia of fmr1 ko mice. |
2022-04-19 |
2023-08-13 |
mouse |