| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jessica L Huebschman, Megan C Davis, Catherina Tovar Pensa, Yuhong Guo, Laura N Smit. The fragile X mental retardation protein promotes adjustments in cocaine self-administration that preserve reinforcement level. The European journal of neuroscience. vol 54. issue 3. 2021-08-20. PMID:34133054. |
later, when given access to the original acquisition dose under increasing fixed ratio (fr) schedules of reinforcement (fr1, fr3, and fr5), fmr1 ko mice earn significantly fewer cocaine infusions than wt mice. |
2021-08-20 |
2023-08-13 |
mouse |
| Jessica L Huebschman, Megan C Davis, Catherina Tovar Pensa, Yuhong Guo, Laura N Smit. The fragile X mental retardation protein promotes adjustments in cocaine self-administration that preserve reinforcement level. The European journal of neuroscience. vol 54. issue 3. 2021-08-20. PMID:34133054. |
additionally, we find an fmrp target, the activity-regulated cytoskeleton-associated protein (arc), to be significantly reduced in synaptic cellular fractions prepared from the nucleus accumbens of fmr1 ko, compared with wt, mice following operant tasks reinforced with cocaine but not food. |
2021-08-20 |
2023-08-13 |
mouse |
| Lara Costa, Alessandra Tempio, Enza Lacivita, Marcello Leopoldo, Lucia Cirann. Serotonin 5-HT7 receptors require cyclin-dependent kinase 5 to rescue hippocampal synaptic plasticity in a mouse model of Fragile X Syndrome. The European journal of neuroscience. 2021-08-18. PMID:33949019. |
electrophysiology studies in fmr1 knockout (ko) mice, a murine model of fragile x syndrome, have demonstrated alterations of synaptic plasticity, with exaggerated long-term depression induced by activation of metabotropic glutamate receptors (mglur-ltd) in fmr1 ko hippocampus. |
2021-08-18 |
2023-08-13 |
mouse |
| Lara Costa, Alessandra Tempio, Enza Lacivita, Marcello Leopoldo, Lucia Cirann. Serotonin 5-HT7 receptors require cyclin-dependent kinase 5 to rescue hippocampal synaptic plasticity in a mouse model of Fragile X Syndrome. The European journal of neuroscience. 2021-08-18. PMID:33949019. |
we have previously demonstrated that activation of serotonin 5-ht7 receptors reverses mglur-ltd in the hippocampus of wild-type and fmr1 ko mice, thus correcting a synaptic dysfunction typically observed in this disease model. |
2021-08-18 |
2023-08-13 |
mouse |
| Lara Costa, Alessandra Tempio, Enza Lacivita, Marcello Leopoldo, Lucia Cirann. Serotonin 5-HT7 receptors require cyclin-dependent kinase 5 to rescue hippocampal synaptic plasticity in a mouse model of Fragile X Syndrome. The European journal of neuroscience. 2021-08-18. PMID:33949019. |
here we show that pharmacological inhibition of cyclin-dependent kinase 5 (cdk5, a signaling molecule recently shown to be a modulator of brain synaptic plasticity) enhanced mglur-ltd in wild-type hippocampal neurons, which became comparable to exaggerated mglur-ltd observed in fmr1 ko neurons. |
2021-08-18 |
2023-08-13 |
mouse |
| Lara Costa, Alessandra Tempio, Enza Lacivita, Marcello Leopoldo, Lucia Cirann. Serotonin 5-HT7 receptors require cyclin-dependent kinase 5 to rescue hippocampal synaptic plasticity in a mouse model of Fragile X Syndrome. The European journal of neuroscience. 2021-08-18. PMID:33949019. |
5-ht7 receptors require cdk5 to modulate synaptic plasticity in wild-type and rescue abnormal plasticity in fmr1 ko neurons, pointing out cdk5 as a possible novel target in fragile x syndrome. |
2021-08-18 |
2023-08-13 |
mouse |
| C A Cea-Del Rio, A Nunez-Parra, S M Freedman, J K Kushner, A L Alexander, D Restrepo, M M Huntsma. Disrupted inhibitory plasticity and homeostasis in Fragile X syndrome. Neurobiology of disease. vol 142. 2021-07-27. PMID:32512151. |
here, we show that in vivo layer 2/3 of the primary somatosensory cortex of the fmr1 ko mouse exhibits basal hyperexcitability and an increase in neuronal firing rate suppression during whisker activation. |
2021-07-27 |
2023-08-13 |
mouse |
| C A Cea-Del Rio, A Nunez-Parra, S M Freedman, J K Kushner, A L Alexander, D Restrepo, M M Huntsma. Disrupted inhibitory plasticity and homeostasis in Fragile X syndrome. Neurobiology of disease. vol 142. 2021-07-27. PMID:32512151. |
specifically, we find that mglur activation sensitivity is overall diminished in the fmr1 ko mouse leading to both a decreased spontaneous inhibitory postsynaptic input to principal cells and a disrupted form of inhibitory long-term depression (i-ltd). |
2021-07-27 |
2023-08-13 |
mouse |
| Matthew Barajas, Aili Wang, Keren K Griffiths, Kenji Matsumoto, Rui Liu, Shunichi Homma, Richard J Lev. The newborn Fmr1 knockout mouse: a novel model of excess ubiquinone and closed mitochondrial permeability transition pore in the developing heart. Pediatric research. vol 89. issue 3. 2021-07-14. PMID:32674111. |
we previously found excessive proton leak in newborn fmr1 ko mouse forebrain caused by ubiquinone deficiency and increased open mptp probability. |
2021-07-14 |
2023-08-13 |
mouse |
| Alexandra Marsillo, Lovena David, Bishoy Gerges, Daniel Kerr, Rodina Sadek, Vitaliy Lasiychuk, David Salame, Youstina Soliman, Silvia Menkes, Aheli Chatterjee, Andrew Mancuso, Probal Banerje. PKC epsilon as a neonatal target to correct FXS-linked AMPA receptor translocation in the hippocampus, boost PVN oxytocin expression, and normalize adult behavior in Fmr1 knockout mice. Biochimica et biophysica acta. Molecular basis of disease. vol 1867. issue 4. 2021-07-02. PMID:33359697. |
we observed a significant suppression of protein kinase c epsilon (pkcε) (34%) in the ventral hippocampal ca1 region of postnatal day-18 (p18) male fmr1 knockout (ko) mice, which displayed social behavior deficits and hyper-anxiety in adulthood. |
2021-07-02 |
2023-08-13 |
mouse |
| Simona D'Antoni, Lidia de Bari, Daniela Valenti, Marina Borro, Carmela Maria Bonaccorso, Maurizio Simmaco, Rosa Anna Vacca, Maria Vincenza Catani. Aberrant mitochondrial bioenergetics in the cerebral cortex of the Fmr1 knockout mouse model of fragile X syndrome. Biological chemistry. vol 401. issue 4. 2021-06-24. PMID:31702995. |
we checked brain energy status and some aspects of cell bioenergetics, namely the activity of key glycolytic enzymes, glycerol-3-phosphate shuttle and mitochondrial respiratory chain (mrc) complexes, in the cerebral cortex of the fmr1 knockout (ko) mouse model of fxs. |
2021-06-24 |
2023-08-13 |
mouse |
| Alexandr Pak, Samuel T Kissinger, Alexander A Chubyki. Impaired Adaptation and Laminar Processing of the Oddball Paradigm in the Primary Visual Cortex of Fmr1 KO Mouse. Frontiers in cellular neuroscience. vol 15. 2021-06-11. PMID:34093132. |
impaired adaptation and laminar processing of the oddball paradigm in the primary visual cortex of fmr1 ko mouse. |
2021-06-11 |
2023-08-13 |
mouse |
| Jonathan W Lovelace, Maham Rais, Arnold R Palacios, Xinghao S Shuai, Steven Bishay, Otilia Popa, Patricia S Pirbhoy, Devin K Binder, David L Nelson, Iryna M Ethell, Khaleel A Raza. Deletion of Fmr1 from Forebrain Excitatory Neurons Triggers Abnormal Cellular, EEG, and Behavioral Phenotypes in the Auditory Cortex of a Mouse Model of Fragile X Syndrome. Cerebral cortex (New York, N.Y. : 1991). vol 30. issue 3. 2021-06-08. PMID:31364704. |
we previously showed that elevated levels of matrix metalloproteinase-9 (mmp-9) may contribute to these phenotypes by affecting perineuronal nets (pnns) around parvalbumin (pv) interneurons in the auditory cortex of fmr1 ko mice. |
2021-06-08 |
2023-08-13 |
mouse |
| Jonathan W Lovelace, Maham Rais, Arnold R Palacios, Xinghao S Shuai, Steven Bishay, Otilia Popa, Patricia S Pirbhoy, Devin K Binder, David L Nelson, Iryna M Ethell, Khaleel A Raza. Deletion of Fmr1 from Forebrain Excitatory Neurons Triggers Abnormal Cellular, EEG, and Behavioral Phenotypes in the Auditory Cortex of a Mouse Model of Fragile X Syndrome. Cerebral cortex (New York, N.Y. : 1991). vol 30. issue 3. 2021-06-08. PMID:31364704. |
these results indicate that fragile x mental retardation protein changes in excitatory neurons in the cortex are sufficient to elicit cellular, electrophysiological, and behavioral phenotypes in fmr1 ko mice. |
2021-06-08 |
2023-08-13 |
mouse |
| Bumwhee Lee, Shree Panda, Hye Young Le. Primary Ciliary Deficits in the Dentate Gyrus of Fragile X Syndrome. Stem cell reports. vol 15. issue 2. 2021-06-02. PMID:32735823. |
fragile x syndrome (fxs) is a common form of inheritance for intellectual disabilities with a high risk for autism spectrum disorders, and fmr1 ko mice, a mouse model for fxs, demonstrate deficits in newborn neuron differentiation, dendritic morphology, and memory formation in the dg. |
2021-06-02 |
2023-08-13 |
mouse |
| Bumwhee Lee, Shree Panda, Hye Young Le. Primary Ciliary Deficits in the Dentate Gyrus of Fragile X Syndrome. Stem cell reports. vol 15. issue 2. 2021-06-02. PMID:32735823. |
here, we found that the number of primary cilia in fmr1 ko mice is reduced, specifically in the dg of the hippocampus. |
2021-06-02 |
2023-08-13 |
mouse |
| Yi-Mei Yang, Jason Arsenault, Alaji Bah, Mickael Krzeminski, Adam Fekete, Owen Y Chao, Laura K Pacey, Alex Wang, Julie Forman-Kay, David R Hampson, Lu-Yang Wan. Identification of a molecular locus for normalizing dysregulated GABA release from interneurons in the Fragile X brain. Molecular psychiatry. vol 25. issue 9. 2021-05-14. PMID:30224722. |
here, we find that excessive gaba release from basket cells (bcs) attenuates the firing frequency of purkinje neurons (pns) in the cerebellum of fragile x mental retardation 1 (fmr1) knockout (ko) mice, a model of fragile x syndrome (fxs) with abrogated expression of the fragile x mental retardation protein (fmrp). |
2021-05-14 |
2023-08-13 |
mouse |
| Kathryn E Reynolds, Chloe R Wong, Angela L Scot. Astrocyte-mediated purinergic signaling is upregulated in a mouse model of Fragile X syndrome. Glia. vol 69. issue 7. 2021-05-11. PMID:33754385. |
in primary astrocyte cultures derived from the fmr1 knockout (ko) mouse model of fxs, we found that application of exogenous atp and utp evoked elevated intracellular calcium responses compared to wildtype levels. |
2021-05-11 |
2023-08-13 |
mouse |
| Da Shi, Su Xu, Jiachen Zhuo, Mary C McKenna, Rao P Gullapall. White Matter Alterations in Fmr1 Knockout Mice during Early Postnatal Brain Development. Developmental neuroscience. vol 41. issue 5-6. 2021-04-29. PMID:32348987. |
differences in the developmental accumulation of white matter and myelin between fmr1 ko and wt mice were observed in the corpus callosum, external and internal capsules, cerebral peduncle, and fimbria. |
2021-04-29 |
2023-08-13 |
mouse |
| Da Shi, Su Xu, Jiachen Zhuo, Mary C McKenna, Rao P Gullapall. White Matter Alterations in Fmr1 Knockout Mice during Early Postnatal Brain Development. Developmental neuroscience. vol 41. issue 5-6. 2021-04-29. PMID:32348987. |
while no significant changes in white matter volumes and t2 relaxation time between the fmr1 ko and wt mice were observed, the altered pattern of myelin staining and mtr, particularly in the external capsule, reflecting the abnormalities associated with myelin content is suggestive of a developmental delay in the white matter of fmr1 ko mouse brain. |
2021-04-29 |
2023-08-13 |
mouse |