| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Marina Quartu, Maria Pina Serra, Marianna Boi, Maria Teresa Ferretti, Maria Letizia Lai, Marina Del Fiacc. Tissue distribution of Ret, GFRalpha-1, GFRalpha-2 and GFRalpha-3 receptors in the human brainstem at fetal, neonatal and adult age. Brain research. vol 1173. 2008-01-09. PMID:17825269. |
occurrence and localization of receptor components of the glial cell line-derived neurotrophic factor (gdnf) family ligands, the ret receptor tyrosine kinase and the gdnf family receptor (gfr) alpha-1 to -3, were examined by immunohistochemistry in the normal human brainstem at fetal, neonatal, and adult age. |
2008-01-09 |
2023-08-12 |
human |
| Yuko Suzuki, Itaru Mizoguchi, Nobuhiko Uchid. Detection of neurotrophic factors in taste buds by laser capture microdissection, immunohistochemistry, and in situ hybridization. Archives of histology and cytology. vol 70. issue 2. 2007-12-07. PMID:17827669. |
results showed mrnas of the ciliary neurotrophic factor (cntf), its receptor (cntfr), glial cell line-derived neurotrophic factor (gdnf), gdnf family receptors alpha-1 (gfralpha-1), gfralpha-2, and ret tyrosine kinase receptor (ret), neurotrophin (nt)3, nt4/5, tyrosine kinase (trk) c, nerve growth factor (ngf), and trka were expressed in the isolated taste buds. |
2007-12-07 |
2023-08-12 |
mouse |
| Katja Linher, De Wu, Julang L. Glial cell line-derived neurotrophic factor: an intraovarian factor that enhances oocyte developmental competence in vitro. Endocrinology. vol 148. issue 9. 2007-09-26. PMID:17540724. |
gdnf and both its coreceptors, gdnf family receptor alpha-1 (gfr alpha-1) and the rearranged during transformation (ret) receptor, were expressed in oocytes and their surrounding cumulus cells derived from small and large follicles. |
2007-09-26 |
2023-08-12 |
Not clear |
| Katja Linher, De Wu, Julang L. Glial cell line-derived neurotrophic factor: an intraovarian factor that enhances oocyte developmental competence in vitro. Endocrinology. vol 148. issue 9. 2007-09-26. PMID:17540724. |
the effect of gdnf was specific; this was evident because its enhancement of nuclear maturation and embryo developmental potential was blocked by an antibody against gfr alpha-1. |
2007-09-26 |
2023-08-12 |
Not clear |
| Yu-Qiang Shi, Qing-Zhong Wang, Shang-Ying Liao, Yan Zhang, Yi-Xun Liu, Chun-Sheng Ha. In vitro propagation of spermatogonial stem cells from KM mice. Frontiers in bioscience : a journal and virtual library. vol 11. 2006-06-27. PMID:16720338. |
sscs from km pups could be cultured on mef feeders in stempro-34 sfm medium supplemented with glial cell line-derived neurotrophic factor (gdnf), soluble gdnf family receptor alpha-1 (gfra1) and basic fibroblast growth factor (bfgf) for 1 month. |
2006-06-27 |
2023-08-12 |
mouse |
| Vivian Vargas-Leal, Roxana Bruno, Tobias Derfuss, Markus Krumbholz, Reinhard Hohlfeld, Edgar Mein. Expression and function of glial cell line-derived neurotrophic factor family ligands and their receptors on human immune cells. Journal of immunology (Baltimore, Md. : 1950). vol 175. issue 4. 2005-11-30. PMID:16081799. |
gdnf and ntn signaling is mediated by a two-component receptor: a signal-transducing component, ret, which is shared by both ligands, and a ligand-specific binding component, gfr alpha-1 (higher gdnf affinity) or gfr alpha-2 (higher ntn affinity). |
2005-11-30 |
2023-08-12 |
human |
| Asako Hase, Fumiaki Saito, Hiroki Yamada, Ken Arai, Teruo Shimizu, Kiichiro Matsumur. Characterization of glial cell line-derived neurotrophic factor family receptor alpha-1 in peripheral nerve Schwann cells. Journal of neurochemistry. vol 95. issue 2. 2005-11-02. PMID:16086681. |
glial cell line-derived neurotrophic factor (gdnf) family receptor alpha-1 (gfralpha-1) is a receptor component of gdnf that associates with and activates the tyrosine kinase receptor ret. |
2005-11-02 |
2023-08-12 |
rat |
| Maria Pina Serra, Marina Quartu, Francesca Mascia, Annalisa Manca, Marianna Boi, M Giuseppina Pisu, Maria Letizia Lai, Marina Del Fiacc. Ret, GFRalpha-1, GFRalpha-2 and GFRalpha-3 receptors in the human hippocampus and fascia dentata. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. vol 23. issue 5. 2005-09-26. PMID:16002253. |
the immunohistochemical occurrence and localization of the receptor components of the glial cell line-derived neurotrophic factor (gdnf) family ligands, the ret receptor tyrosine kinase and gdnf family receptor (gfr) alpha-1 to -3, is described in the human post-mortem hippocampal formation at pre- and full-term newborn, and adult age. |
2005-09-26 |
2023-08-12 |
human |
| Paul Carmillo, Lone Dagø, Eric S Day, Dane S Worley, Anthony Rossomando, Lee Walus, Olivia Orozco, Carolyn Buckley, Stephan Miller, Albert Tse, Richard L Cate, Carl Rosenblad, Dinah W Y Sah, Mette Grønborg, Adrian Whitt. Glial cell line-derived neurotrophic factor (GDNF) receptor alpha-1 (GFR alpha 1) is highly selective for GDNF versus artemin. Biochemistry. vol 44. issue 7. 2005-04-25. PMID:15709767. |
glial cell line-derived neurotrophic factor (gdnf) receptor alpha-1 (gfr alpha 1) is highly selective for gdnf versus artemin. |
2005-04-25 |
2023-08-12 |
rat |
| Paul Carmillo, Lone Dagø, Eric S Day, Dane S Worley, Anthony Rossomando, Lee Walus, Olivia Orozco, Carolyn Buckley, Stephan Miller, Albert Tse, Richard L Cate, Carl Rosenblad, Dinah W Y Sah, Mette Grønborg, Adrian Whitt. Glial cell line-derived neurotrophic factor (GDNF) receptor alpha-1 (GFR alpha 1) is highly selective for GDNF versus artemin. Biochemistry. vol 44. issue 7. 2005-04-25. PMID:15709767. |
to clarify whether glial cell line-derived neurotrophic factor (gdnf) receptor alpha-1 (gfralpha1), the glycosylphosphatidylinositol (gpi)-linked coreceptor for gdnf, is also a functional coreceptor for artemin (art), we have studied receptor binding, signaling, and neuronal survival. |
2005-04-25 |
2023-08-12 |
rat |
| Marie-Claude Hofmann, Laura Braydich-Stolle, Martin Dy. Isolation of male germ-line stem cells; influence of GDNF. Developmental biology. vol 279. issue 1. 2005-04-18. PMID:15708562. |
we show in the present study that gfr alpha-1, the receptor for gdnf (glial cell line-derived neurotrophic factor), is strongly expressed by a subset of type a spermatogonia in the basal part of the seminiferous epithelium. |
2005-04-18 |
2023-08-12 |
mouse |
| Marie-Claude Hofmann, Laura Braydich-Stolle, Martin Dy. Isolation of male germ-line stem cells; influence of GDNF. Developmental biology. vol 279. issue 1. 2005-04-18. PMID:15708562. |
the isolated cells express ret, a tyrosine kinase transmembrane receptor that mediates the intracellular response to gdnf via gfr alpha-1. |
2005-04-18 |
2023-08-12 |
mouse |
| Zhi-Qiang Dong, Fei Ma, Hong Xie, Yan-Qing Wang, Gen-Cheng W. Changes of expression of glial cell line-derived neurotrophic factor and its receptor in dorsal root ganglions and spinal dorsal horn during electroacupuncture treatment in neuropathic pain rats. Neuroscience letters. vol 376. issue 2. 2005-04-01. PMID:15698937. |
using immunohistochemistry, western blot, and rt-pcr analysis techniques, the present study observed the effects of ea on the expression of gdnf and gdnf family receptor alpha-1 (gfralpha-1, the high-affinity receptor of gdnf) in neuropathic pain rats. |
2005-04-01 |
2023-08-12 |
rat |
| Armin Blesch, Mark H Tuszynsk. Cellular GDNF delivery promotes growth of motor and dorsal column sensory axons after partial and complete spinal cord transections and induces remyelination. The Journal of comparative neurology. vol 467. issue 3. 2004-01-23. PMID:14608602. |
glial cell line-derived neurotrophic factor (gdnf) is the prototypical member of a growth factor family that signals via the cognate receptors ret and gdnf-receptor alpha-1. |
2004-01-23 |
2023-08-12 |
Not clear |
| A Sarabi, B J Hoffer, L Olson, M Morale. Glial cell line neurotrophic factor-family receptor alpha-1 is present in central neurons with distinct phenotypes. Neuroscience. vol 116. issue 1. 2003-06-24. PMID:12535958. |
gdnf binds with high affinity to the gdnf-family receptor alpha-1 (gfralpha-1) which is expressed in different brain areas. |
2003-06-24 |
2023-08-12 |
Not clear |
| A Sarabi, C F Chang, Y Wang, A C Tomac, B J Hoffer, M Morale. Differential expression of the cell line-derived neurotrophic factor (GDNF) receptor GFRalpha1 in heterozygous Gfralpha1 null-mutant mice after stroke. Neuroscience letters. vol 341. issue 3. 2003-05-21. PMID:12697293. |
cerebral ischemia induces gene expression of gdnf, gdnf-receptor alpha-1 (gfralpha-1) and c-ret, suggesting that a gdnf signaling cascade mechanism may be involved in endogenous neuroprotection during ischemia. |
2003-05-21 |
2023-08-12 |
mouse |
| Y Wang, C F Chang, M Morales, Y H Chiang, J Hoffe. Protective effects of glial cell line-derived neurotrophic factor in ischemic brain injury. Annals of the New York Academy of Sciences. vol 962. 2002-07-26. PMID:12076993. |
we found that such neuroprotective effects are mediated through specific gdnf receptor alpha-1 (gfralpha1). |
2002-07-26 |
2023-08-12 |
Not clear |
| Wojtek P Rakowicz, Christopher S Staples, Jeffrey Milbrandt, Janice E Brunstrom, Eugene M Johnso. Glial cell line-derived neurotrophic factor promotes the survival of early postnatal spinal motor neurons in the lateral and medial motor columns in slice culture. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 22. issue 10. 2002-05-29. PMID:12019314. |
analysis of mn survival in gfralpha-1(-/-) mice demonstrated that the trophic effect of gdnf was completely mediated by its preferred coreceptor, gdnf family receptor alpha-1 (gfralpha-1). |
2002-05-29 |
2023-08-12 |
mouse |
| G Pezeshki, B Franke, J Engel. Evidence for a ligand-specific signaling through GFRalpha-1, but not GFRalpha-2, in the absence of Ret. Journal of neuroscience research. vol 66. issue 3. 2002-01-25. PMID:11746356. |
gdnf and ntn act through a two-component receptor system consisting of the ligand-specific binding subunits gdnf family receptor (gfr)alpha-1 and gfralpha-2 and the common transducing subunit c-ret. |
2002-01-25 |
2023-08-12 |
Not clear |
| I Rajan, C Gestblom, R P Kapu. RET(Men2B)-transgene produces sympathoadrenal tumors but does not prevent intestinal aganglionosis in gdnf-/- or gfr alpha-1(-/-) mice. Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society. vol 4. issue 5. 2002-01-25. PMID:11779046. |
the ligand, gdnf, stimulates ret activity through a co-receptor, gfr alpha-1. |
2002-01-25 |
2023-08-12 |
mouse |