| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| T C Burazin, A L Gundlac. Localization of GDNF/neurturin receptor (c-ret, GFRalpha-1 and alpha-2) mRNAs in postnatal rat brain: differential regional and temporal expression in hippocampus, cortex and cerebellum. Brain research. Molecular brain research. vol 73. issue 1-2. 2000-02-14. PMID:10581409. |
recent studies have identified a multi-component receptor system for the neurotrophic factor, glial cell line-derived neurotrophic factor (gdnf) and its homolog, neurturin (ntn), comprising the signaling tyrosine kinase, ret and multiple gpi-linked binding proteins, gdnf family receptor alpha-1 and alpha-2 (gfralpha-1 and gfralpha-2). |
2000-02-14 |
2023-08-12 |
rat |
| S Homma, R W Oppenheim, H Yaginuma, S Kimur. Expression pattern of GDNF, c-ret, and GFRalphas suggests novel roles for GDNF ligands during early organogenesis in the chick embryo. Developmental biology. vol 217. issue 1. 2000-02-04. PMID:10625540. |
we have cloned a partial cdna of chicken glial cell line-derived neurotrophic factor (gdnf) and systematically examined its expression pattern as well as that of gdnf-binding components (gdnf family receptor alpha-1 and 2: gfralpha-1 and 2) and a common signal transduction receptor (c-ret protooncogene: ret) during very early developmental stages. |
2000-02-04 |
2023-08-12 |
chicken |
| M R Hoane, A G Gulwadi, S Morrison, G Hovanesian, M D Lindner, W Ta. Differential in vivo effects of neurturin and glial cell-line-derived neurotrophic factor. Experimental neurology. vol 160. issue 1. 2000-01-21. PMID:10630208. |
tissue distributions of their respective receptors, gfr alpha-1 and gfr alpha-2, reveal overlapping but distinct patterns of expression, which implies that the in vivo actions of gdnf and ntn may be different. |
2000-01-21 |
2023-08-12 |
rat |
| S Eketjäll, M Fainzilber, J Murray-Rust, C F Ibáñe. Distinct structural elements in GDNF mediate binding to GFRalpha1 and activation of the GFRalpha1-c-Ret receptor complex. The EMBO journal. vol 18. issue 21. 2000-01-04. PMID:10545102. |
we investigated ligand-receptor interactions in the glial cell-line derived neurotrophic factor (gdnf) receptor complex, formed by the c-ret receptor tyrosine kinase and the glycosylphosphatidylinositol (gpi)-anchored subunit gdnf family receptor alpha-1 (gfralpha1). |
2000-01-04 |
2023-08-12 |
Not clear |
| H Tsujino, K Mansur, S Kiryu-Seo, K Namikawa, T Kitahara, K Tanabe, T Ochi, H Kiyam. Discordant expression of c-Ret and glial cell line-derived neurotrophic factor receptor alpha-1 mRNAs in response to motor nerve injury in neonate rats. Brain research. Molecular brain research. vol 70. issue 2. 1999-09-08. PMID:10407179. |
following hypoglossal nerve axotomy in neonate rat, glial cell line-derived neurotrophic factor (gdnf) receptor alpha-1 (gfralpha-1) mrna expression was dramatically suppressed in the injured motoneurons, while a slight increase of c-ret mrna expression was observed. |
1999-09-08 |
2023-08-12 |
rat |
| S M Myers, R Salomon, A Goessling, A Pelet, C Eng, A von Deimling, S Lyonnet, L M Mulliga. Investigation of germline GFR alpha-1 mutations in Hirschsprung disease. Journal of medical genetics. vol 36. issue 3. 1999-06-11. PMID:10204848. |
we investigated the presence of mutations in another member of the ret signalling complex, gdnf family receptor alpha-1 (gfr alpha-1), in a panel of 269 independent cases of hscr. |
1999-06-11 |
2023-08-12 |
Not clear |
| Y Okada, H Takeyama, M Sato, M Morikawa, K Sobue, K Asai, T Tada, T Kato, T Manab. Experimental implication of celiac ganglionotropic invasion of pancreatic-cancer cells bearing c-ret proto-oncogene with reference to glial-cell-line-derived neurotrophic factor (GDNF). International journal of cancer. vol 81. issue 1. 1999-03-31. PMID:10077155. |
there was no detectable expression of another gdnf receptor component, a glycosyl-phosphatidylinositol-linked receptor (gfr alpha-1), in pancreatic-cancer cell lines, suggesting that the neural invasion of pancreatic-cancer cells spreads along a concentration gradient of gdnf produced from peripheral ganglions through direct interaction of gdnf with its receptor, the c-ret proto-oncogene product. |
1999-03-31 |
2023-08-12 |
human |
| B Franke, M Figiel, J Engel. CNS glia are targets for GDNF and neurturin. Histochemistry and cell biology. vol 110. issue 6. 1999-02-18. PMID:9860258. |
both gdnf and ntn signal through a receptor complex consisting of the signal transducing subunit, ret, and a ligand-specific binding subunit, termed gdnf family receptor (gfr)alpha-1 and gfralpha-2, respectively. |
1999-02-18 |
2023-08-12 |
Not clear |
| Y Enokido, F de Sauvage, J A Hongo, N Ninkina, A Rosenthal, V L Buchman, A M Davie. GFR alpha-4 and the tyrosine kinase Ret form a functional receptor complex for persephin. Current biology : CB. vol 8. issue 18. 1998-12-07. PMID:9740802. |
gdnf and neurturin signal through multicomponent receptors that consist of the ret receptor tyrosine kinase and one of two structurally related glycosyl-phosphatidylinositol (gpi)-linked ligand-binding subunits: gfr alpha-1 is the preferred ligand-binding subunit for gdnf, and gfr alpha-2 is the preferred ligand-binding subunit for neurturin. |
1998-12-07 |
2023-08-12 |
Not clear |
| M Trupp, C Raynoschek, N Belluardo, C F Ibáñe. Multiple GPI-anchored receptors control GDNF-dependent and independent activation of the c-Ret receptor tyrosine kinase. Molecular and cellular neurosciences. vol 11. issue 1-2. 1998-08-07. PMID:9608533. |
glial cell line-derived neurotrophic factor (gdnf) mediates neuronal survival through a receptor complex composed of the c-retproto-oncogene and gfr alpha-1, a member of a family of gpi-anchored receptors. |
1998-08-07 |
2023-08-12 |
rat |
| M Trupp, C Raynoschek, N Belluardo, C F Ibáñe. Multiple GPI-anchored receptors control GDNF-dependent and independent activation of the c-Ret receptor tyrosine kinase. Molecular and cellular neurosciences. vol 11. issue 1-2. 1998-08-07. PMID:9608533. |
using chemical crosslinking we demonstrate here a specific interaction between gdnf and gfr alpha-2 expressed in cos cells, albeit of a lower affinity than the one between gdnf and gfr alpha-1. |
1998-08-07 |
2023-08-12 |
rat |
| M Trupp, C Raynoschek, N Belluardo, C F Ibáñe. Multiple GPI-anchored receptors control GDNF-dependent and independent activation of the c-Ret receptor tyrosine kinase. Molecular and cellular neurosciences. vol 11. issue 1-2. 1998-08-07. PMID:9608533. |
thus, all three gfr alpha receptors mediate gdnf binding to c-ret with efficiencies gfr alpha-1 > gfr alpha-2 > gfr alpha-3. |
1998-08-07 |
2023-08-12 |
rat |
| T Hishiki, Y Nimura, E Isogai, K Kondo, S Ichimiya, Y Nakamura, T Ozaki, S Sakiyama, M Hirose, N Seki, H Takahashi, N Ohnuma, M Tanabe, A Nakagawar. Glial cell line-derived neurotrophic factor/neurturin-induced differentiation and its enhancement by retinoic acid in primary human neuroblastomas expressing c-Ret, GFR alpha-1, and GFR alpha-2. Cancer research. vol 58. issue 10. 1998-06-10. PMID:9605760. |
recently, glial cell line-derived neurotrophic factor (gdnf) and a second family member, neurturin (ntn), have been found to mediate their signals by binding to a heterotetrameric complex of c-ret tyrosine kinase receptors and glycosylphosphatidylinositol-linked proteins, gfr alpha-1 (gdnfr-alpha) or gfr alpha-2 (trnr2/gdnfr-beta/ntnr-alpha/retl2). |
1998-06-10 |
2023-08-12 |
human |
| T Hishiki, Y Nimura, E Isogai, K Kondo, S Ichimiya, Y Nakamura, T Ozaki, S Sakiyama, M Hirose, N Seki, H Takahashi, N Ohnuma, M Tanabe, A Nakagawar. Glial cell line-derived neurotrophic factor/neurturin-induced differentiation and its enhancement by retinoic acid in primary human neuroblastomas expressing c-Ret, GFR alpha-1, and GFR alpha-2. Cancer research. vol 58. issue 10. 1998-06-10. PMID:9605760. |
here, we studied the effect of gdnf and ntn on human neuroblastomas in the short-term primary culture system, as well as the expression of c-ret, gfr alpha-1, gfr alpha-2, gdnf, and ntn. |
1998-06-10 |
2023-08-12 |
human |
| T Hishiki, Y Nimura, E Isogai, K Kondo, S Ichimiya, Y Nakamura, T Ozaki, S Sakiyama, M Hirose, N Seki, H Takahashi, N Ohnuma, M Tanabe, A Nakagawar. Glial cell line-derived neurotrophic factor/neurturin-induced differentiation and its enhancement by retinoic acid in primary human neuroblastomas expressing c-Ret, GFR alpha-1, and GFR alpha-2. Cancer research. vol 58. issue 10. 1998-06-10. PMID:9605760. |
many primary neuroblastomas expressed c-ret, gfr alpha-1, and gfr alpha-2 as well as their ligands, gdnf and ntn, suggesting the presence of a paracrine or autocrine signaling system within the tumor tissue. |
1998-06-10 |
2023-08-12 |
human |
| T Hishiki, Y Nimura, E Isogai, K Kondo, S Ichimiya, Y Nakamura, T Ozaki, S Sakiyama, M Hirose, N Seki, H Takahashi, N Ohnuma, M Tanabe, A Nakagawar. Glial cell line-derived neurotrophic factor/neurturin-induced differentiation and its enhancement by retinoic acid in primary human neuroblastomas expressing c-Ret, GFR alpha-1, and GFR alpha-2. Cancer research. vol 58. issue 10. 1998-06-10. PMID:9605760. |
these imply that the gdnf(ntn)/c-ret/gfr alpha-1(gfr alpha-2) signaling may have an important role in regulating the growth, differentiation, and cell death of neuroblastomas. |
1998-06-10 |
2023-08-12 |
human |
| L M Mulligan, T Timmer, S M Ivanchuk, B G Campling, L C Young, P H Rabbitts, V Sundaresan, R M Hofstra, C En. Investigation of the genes for RET and its ligand complex, GDNF/GFR alpha-I, in small cell lung carcinoma. Genes, chromosomes & cancer. vol 21. issue 4. 1998-05-20. PMID:9559344. |
ret activation may be mediated by a ligand complex comprising glial cell line-derived neurotrophic factor (gdnf) and gdnf family receptor alpha-1 (gfr alpha-1). |
1998-05-20 |
2023-08-12 |
Not clear |
| L M Mulligan, T Timmer, S M Ivanchuk, B G Campling, L C Young, P H Rabbitts, V Sundaresan, R M Hofstra, C En. Investigation of the genes for RET and its ligand complex, GDNF/GFR alpha-I, in small cell lung carcinoma. Genes, chromosomes & cancer. vol 21. issue 4. 1998-05-20. PMID:9559344. |
we further examined the expression pattern of ret and the genes encoding the components of its ligand complex gdnf and gfr alpha-1, in 21 sclc lines by using rt-pcr. |
1998-05-20 |
2023-08-12 |
Not clear |
| S Masure, M Cik, M N Pangalos, P Bonaventure, P Verhasselt, A S Lesage, J E Leysen, R D Gordo. Molecular cloning, expression and tissue distribution of glial-cell-line-derived neurotrophic factor family receptor alpha-3 (GFRalpha-3). European journal of biochemistry. vol 251. issue 3. 1998-03-23. PMID:9490034. |
neurturin and glial-cell-line-derived neurotrophic factor (gdnf) promote the survival and maintenance of different types of neuronal cells and signal through a receptor complex composed of a ligand binding subunit, either gdnf family receptor alpha-1 (gfralpha-1) or alpha-2 (gfralpha-2), together with the cret membrane-bound protein tyrosine kinase. |
1998-03-23 |
2023-08-12 |
human |
| A Gorodinsky, D B Zimonjic, N C Popescu, J Milbrand. Assignment of the GDNF family receptor alpha-1 (GFRA1) to human chromosome band 10q26 by in situ hybridization. Cytogenetics and cell genetics. vol 78. issue 3-4. 1998-03-04. PMID:9465905. |
assignment of the gdnf family receptor alpha-1 (gfra1) to human chromosome band 10q26 by in situ hybridization. |
1998-03-04 |
2023-08-12 |
human |