| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| I Rajan, C Gestblom, R P Kapu. RET(Men2B)-transgene produces sympathoadrenal tumors but does not prevent intestinal aganglionosis in gdnf-/- or gfr alpha-1(-/-) mice. Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society. vol 4. issue 5. 2002-01-25. PMID:11779046. |
a relevant clinical question is whether ablation of either gdnf or gfr alpha-1 could alter penetrance or severity of the men2b syndrome. |
2002-01-25 |
2023-08-12 |
mouse |
| I Rajan, C Gestblom, R P Kapu. RET(Men2B)-transgene produces sympathoadrenal tumors but does not prevent intestinal aganglionosis in gdnf-/- or gfr alpha-1(-/-) mice. Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society. vol 4. issue 5. 2002-01-25. PMID:11779046. |
we report that ganglioneuromatous tumors caused by a ret(men2b) transgene in mice are not affected grossly or microscopically by the absence of gdnf or gfr alpha-1. |
2002-01-25 |
2023-08-12 |
mouse |
| I Rajan, C Gestblom, R P Kapu. RET(Men2B)-transgene produces sympathoadrenal tumors but does not prevent intestinal aganglionosis in gdnf-/- or gfr alpha-1(-/-) mice. Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society. vol 4. issue 5. 2002-01-25. PMID:11779046. |
loss-of-function mutations in ret, gdnf, or gfr alpha-1 cause pan-intestinal aganglionosis in mice. |
2002-01-25 |
2023-08-12 |
mouse |
| I Rajan, C Gestblom, R P Kapu. RET(Men2B)-transgene produces sympathoadrenal tumors but does not prevent intestinal aganglionosis in gdnf-/- or gfr alpha-1(-/-) mice. Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society. vol 4. issue 5. 2002-01-25. PMID:11779046. |
we find that expression of the ret(men2b) transgene in enteric neural progenitors, after they colonize the gut, does not prevent intestinal aganglionosis associated with gdnf or gfr alpha-1 deficiency. |
2002-01-25 |
2023-08-12 |
mouse |
| A Sarabi, B J Hoffer, L Olson, M Morale. GFRalpha-1 mRNA in dopaminergic and nondopaminergic neurons in the substantia nigra and ventral tegmental area. The Journal of comparative neurology. vol 441. issue 2. 2002-01-22. PMID:11745638. |
gdnf binds with high affinity to the gdnf family receptor alpha-1 (gfralpha-1), which is highly expressed in the midbrain. |
2002-01-22 |
2023-08-12 |
rat |
| A Sarabi, C F Chang, Y Wang, B J Hoffer, M Morale. Time course study of GFRalpha-1 expression in an animal model of stroke. Experimental neurology. vol 170. issue 2. 2001-09-13. PMID:11476594. |
the biological effects of gdnf are mediated by gdnf-family receptor alpha-1 (gfralpha-1) and c-ret. |
2001-09-13 |
2023-08-12 |
rat |
| S Rémy, P Naveilhan, P Brachet, I Neve. Differential regulation of GDNF, neurturin, and their receptors in primary cultures of rat glial cells. Journal of neuroscience research. vol 64. issue 3. 2001-07-19. PMID:11319768. |
glial cell line-derived neurotrophic factor (gdnf) and neurturin (ntn) bind to gfr alpha-1 and gfr alpha-2 receptors, respectively, and their neurotrophic activity is mediated by the tyrosine kinase receptor, ret. |
2001-07-19 |
2023-08-12 |
rat |
| S Rémy, P Naveilhan, P Brachet, I Neve. Differential regulation of GDNF, neurturin, and their receptors in primary cultures of rat glial cells. Journal of neuroscience research. vol 64. issue 3. 2001-07-19. PMID:11319768. |
although gdnf, ntn and ret mrna levels were at the limit of detection, rnase protection assays revealed relatively high amounts of gfr alpha-1 and gfr alpha transcripts. |
2001-07-19 |
2023-08-12 |
rat |
| S Rémy, P Naveilhan, P Brachet, I Neve. Differential regulation of GDNF, neurturin, and their receptors in primary cultures of rat glial cells. Journal of neuroscience research. vol 64. issue 3. 2001-07-19. PMID:11319768. |
interestingly, only tpa led to a coordinated increase in the levels of gdnf, gfr alpha-1 and gfr alpha-2 mrnas. |
2001-07-19 |
2023-08-12 |
rat |
| A Sarabi, B J Hoffer, L Olson, M Morale. GFR alpha-1 is expressed in parvalbumin GABAergic neurons in the hippocampus. Brain research. vol 877. issue 2. 2000-12-14. PMID:10986340. |
gdnf binds with high affinity to gdnf-family receptor alpha-1 (gfr alpha-1). |
2000-12-14 |
2023-08-12 |
Not clear |
| A Sarabi, B J Hoffer, L Olson, M Morale. GFR alpha-1 is expressed in parvalbumin GABAergic neurons in the hippocampus. Brain research. vol 877. issue 2. 2000-12-14. PMID:10986340. |
the expression of gfr alpha-1 in principal neurons and in a specific sub-population of gabaergic neurons (pv-containing neurons) suggest that gdnf might modulate, in a selective manner, functions of the entire adult hippocampus. |
2000-12-14 |
2023-08-12 |
Not clear |
| D S Worley, J M Pisano, E D Choi, L Walus, C A Hession, R L Cate, M Sanicola, S J Birre. Developmental regulation of GDNF response and receptor expression in the enteric nervous system. Development (Cambridge, England). vol 127. issue 20. 2000-11-20. PMID:11003838. |
gfr alpha-1 could participate in gdnf signaling when expressed in cis on the surface of enteric precursor cells, or as a soluble protein. |
2000-11-20 |
2023-08-12 |
Not clear |
| D S Worley, J M Pisano, E D Choi, L Walus, C A Hession, R L Cate, M Sanicola, S J Birre. Developmental regulation of GDNF response and receptor expression in the enteric nervous system. Development (Cambridge, England). vol 127. issue 20. 2000-11-20. PMID:11003838. |
in addition to contributing to gdnf signaling, cell-surface gfr alpha-1 modulated the specificity of interactions between gdnf and soluble gfr alphas. |
2000-11-20 |
2023-08-12 |
Not clear |
| A Capes-Davis, S D Andrew, V J Hyland, S Twigg, D L Learoyd, T Dwight, D J Marsh, B G Robinso. Glucocorticoids differentially inhibit expression of the RET proto-oncogene. Gene expression. vol 8. issue 5-6. 2000-08-30. PMID:10947080. |
the ret proto-oncogene encodes a receptor tyrosine kinase activated by the binding of factors from the glial cell line-derived neurotrophic factor (gdnf) family to receptor-alpha components such as gdnf family receptor alpha-1 (gfr alpha-1). |
2000-08-30 |
2023-08-12 |
Not clear |
| A Hase, H Suzuki, K Arahata, C Akazaw. Expression of human GFR alpha-1 (GDNF receptor) at the neuromuscular junction and myelinated nerves. Neuroscience letters. vol 269. issue 1. 2000-06-21. PMID:10821644. |
expression of human gfr alpha-1 (gdnf receptor) at the neuromuscular junction and myelinated nerves. |
2000-06-21 |
2023-08-12 |
human |
| A Hase, H Suzuki, K Arahata, C Akazaw. Expression of human GFR alpha-1 (GDNF receptor) at the neuromuscular junction and myelinated nerves. Neuroscience letters. vol 269. issue 1. 2000-06-21. PMID:10821644. |
as one of the target-derived trophic factors, glial cell line-derived neurotrophic factor (gdnf) has been shown to exert its effects on motor neurons via a receptor complex including gdnf receptor alpha 1 (gfr alpha-1). |
2000-06-21 |
2023-08-12 |
human |
| A Hase, H Suzuki, K Arahata, C Akazaw. Expression of human GFR alpha-1 (GDNF receptor) at the neuromuscular junction and myelinated nerves. Neuroscience letters. vol 269. issue 1. 2000-06-21. PMID:10821644. |
the results suggested that gfr alpha-1 might play a key role for uptake and internalization of gdnf at the human nmj. |
2000-06-21 |
2023-08-12 |
human |
| J Widenfalk, M Parvinen, E Lindqvist, L Olso. Neurturin, RET, GFRalpha-1 and GFRalpha-2, but not GFRalpha-3, mRNA are expressed in mice gonads. Cell and tissue research. vol 299. issue 3. 2000-06-06. PMID:10772255. |
in testis, the transducing receptor ret as well as gdnf receptor alpha-1 (gfr)alpha-1 and gfralpha-2 were distributed in complementary and overlapping patterns, the former at stages xi-xii-i and the latter at stages vii and viii. |
2000-06-06 |
2023-08-12 |
mouse |
| A Matsuo, S Nakamura, I Akiguch. Immunohistochemical localization of glial cell line-derived neurotrophic factor family receptor alpha-1 in the rat brain: confirmation of expression in various neuronal systems. Brain research. vol 859. issue 1. 2000-05-09. PMID:10720615. |
the localization of glial cell line-derived neurotrophic factor (gdnf) family receptor alpha-1 (gfralpha-1) was investigated in rat brain by immunohistochemistry using a polyclonal antibody against a specific sequence of the rat protein. |
2000-05-09 |
2023-08-12 |
rat |
| N V Botchkareva, V A Botchkarev, P Welker, M Airaksinen, W Roth, P Suvanto, S Müller-Röver, I M Hadshiew, C Peters, R Pau. New roles for glial cell line-derived neurotrophic factor and neurturin: involvement in hair cycle control. The American journal of pathology. vol 156. issue 3. 2000-03-23. PMID:10702420. |
glial cell line-derived neurotrophic factor (gdnf), neurturin (ntn), and their receptors, gdnf family receptor alpha-1 (gfralpha-1) and gdnf family receptor alpha-2 (gfralpha-2), are critically important for kidney and nervous system development. |
2000-03-23 |
2023-08-12 |
mouse |