| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| O Kubo, H Himuro, Y Kamijo, K Kitamura, R Demur. [Growth hormone, prolactin, LH and FSH secretion in tissue culture of pituitary adenomas (author's transl)]. No shinkei geka. Neurological surgery. vol 5. issue 11. 1977-12-29. PMID:917213. |
gh concentration in the culture media was markedly high in all cases with acromegaly and high also in 2 out of 7 non-acromegaly cases (case 6 and 7). |
1977-12-29 |
2023-08-11 |
Not clear |
| T Onishi, M Azukizawa, T Hashimoto, K Miyai, Y Kumahar. [Secretory mode of GH in acromegaly--reactions to various stimuli]. Horumon to rinsho. Clinical endocrinology. vol 25. issue 6. 1977-10-14. PMID:560925. |
[secretory mode of gh in acromegaly--reactions to various stimuli]. |
1977-10-14 |
2023-08-11 |
Not clear |
| B I Joffe, L A Distiller, J Sagel, M Lawson, J E Morley, H C Sefte. Luteinizing hormone-releasing hormone and serum growth hormone in insulin-dependent diabetes. South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde. vol 51. issue 26. 1977-09-29. PMID:329438. |
it seems that the gh hypersecretion of insulin-requiring diabetics does not, as is frequently noted in acromegaly, respond to the injection of lh-rh. |
1977-09-29 |
2023-08-11 |
Not clear |
| W Saege. [Classification and pathogenesis of pituitary adenomas in humans and animal experiments]. Fortschritte der Medizin. vol 95. issue 22. 1977-08-12. PMID:873431. |
undifferentiated acidophil and gh cell-adenomas mostly induce an acromegaly. |
1977-08-12 |
2023-08-11 |
human |
| H E Carlson, J R Sowers, R W Ran. Lack of effect of thyroid hormones on the growth hormone response to thyrotropin-releasing hormone in acromegaly. Metabolism: clinical and experimental. vol 26. issue 7. 1977-07-29. PMID:405552. |
serum growth hormone (gh) responses to thyrotropin-releasing hormone (trh) were evaluated in 14 patients with acromegaly following treatment with thyroid hormones. |
1977-07-29 |
2023-08-11 |
human |
| H E Carlson, J R Sowers, R W Ran. Lack of effect of thyroid hormones on the growth hormone response to thyrotropin-releasing hormone in acromegaly. Metabolism: clinical and experimental. vol 26. issue 7. 1977-07-29. PMID:405552. |
four of five additional subjects with acromegaly who had received replacement doses of thyroid hormones for an average of 6.6 yr demonstrated gh responses to trh which were similar to those seen in subjects not receiving thyroid hormones. |
1977-07-29 |
2023-08-11 |
human |
| H E Carlson, J R Sowers, R W Ran. Lack of effect of thyroid hormones on the growth hormone response to thyrotropin-releasing hormone in acromegaly. Metabolism: clinical and experimental. vol 26. issue 7. 1977-07-29. PMID:405552. |
acute or long-term administration of replacement doses of thyroid hormones seems to have minimal effect on the gh response to trh in acromegaly. |
1977-07-29 |
2023-08-11 |
human |
| R B Mims, M H Weis. Failure of selective pituitary adenomectomy to cure acromegaly. Journal of the National Medical Association. vol 69. issue 5. 1977-07-29. PMID:864768. |
this suggests that reduction of gh to normal concentrations following selective pituitary adenomectomy is not synonomous with curing acromegaly. |
1977-07-29 |
2023-08-11 |
Not clear |
| G Schwinn, H Dirks, C McIntosh, J Köbberlin. Metabolic and clinical studies on patients with acromegaly treated with bromocriptine over 22 months. European journal of clinical investigation. vol 7. issue 2. 1977-06-11. PMID:404154. |
in twenty-two patients with active acromegaly who were untreated or unsuccessfully operated or irradiated (mean growth hormone (gh) values greater than 4 ng/ml) the following investigations were performed: routine laboratory tests, tomography of pituitary fossa, oral glucose tolerance tests, trh and other pituitary function tests and gh profiles over 5-10 h before and during bromocriptine treatment with daily doses between 7.5 and 50 mg. |
1977-06-11 |
2023-08-11 |
Not clear |
| K Hanew, M Aida, T Tano, K Yoshinag. Abnormal growth hormone responses to L-dopa and thyrotropin-releasing hormone in patients with acromegaly. The Tohoku journal of experimental medicine. vol 121. issue 3. 1977-06-11. PMID:404727. |
changes in growth hormone (gh) release in response to l-dopa, trh, arginine and lh-rh were studied in 15 patients with acromegaly to investigate the mechanism of so-called 'paradoxical decrease' of gh secretion often observed in acromegalics after the administration of l-dopa. |
1977-06-11 |
2023-08-11 |
human |
| F Camanni, F Massara, L Belforte, A Rosatello, G M Molinatt. Effect of dopamine on plasma growth hormone and prolactin levels in normal and acromegalic subjects. The Journal of clinical endocrinology and metabolism. vol 44. issue 3. 1977-04-25. PMID:838847. |
since dopamine does not readily cross the blood-brain barrier, these results suggest that the stimulating effect of dopaminergic drugs on gh secretion in the normal subject is exerted via the cns, whereas in acromegaly there is a direct action on structures lying outside the blood-brain barrier, probably in the hypophysis. |
1977-04-25 |
2023-08-11 |
human |
| S Matsukura, T Kakita, Y Hirata, H Yoshimi, M Fukas. Adenylate cyclase of GH and ACTH producing tumors of human: activation by non-specific hormones and other bioactive substances. The Journal of clinical endocrinology and metabolism. vol 44. issue 2. 1977-04-15. PMID:190256. |
out of 4 gh producing pituitary adenomas obtained from patients with active acromegaly at hypophysectomy two were stimulated by trh, two by lh-rh, three by norepinephrine, one by dopamine, four by pge1 and none by serotonin. |
1977-04-15 |
2023-08-11 |
human |
| S Matsukura, T Kakita, Y Hirata, H Yoshimi, M Fukas. Adenylate cyclase of GH and ACTH producing tumors of human: activation by non-specific hormones and other bioactive substances. The Journal of clinical endocrinology and metabolism. vol 44. issue 2. 1977-04-15. PMID:190256. |
these results indicate the presence of multiple hormone receptors in gh or acth producing pituitary adenomas and ectopic acth producing tumors, and suggest that the paradoxical gh or acth release after trh and/or lh-rh injection in acromegaly and cushing's syndrome might be caused by an alteration of the cellular membrane receptors of the pituitary adenomas. |
1977-04-15 |
2023-08-11 |
human |
| K Nakagawa, T Obar. Failure of growth hormone-suppressing agents to affect TSH-releasing hormone- and LH-releasing hormone-induced growth hormone release in acromegaly. The Journal of clinical endocrinology and metabolism. vol 44. issue 1. 1977-03-21. PMID:401823. |
in patients with acromegaly whose basal plasma gh levels were suppressed with 9 mg/day of dexamethasone for 2 days, trh-(6 cases) and lhrh-(1 case) induced gh release were unaffected when the responses were compared to the basal levels. |
1977-03-21 |
2023-08-11 |
Not clear |
| K Nakagawa, T Obar. Failure of growth hormone-suppressing agents to affect TSH-releasing hormone- and LH-releasing hormone-induced growth hormone release in acromegaly. The Journal of clinical endocrinology and metabolism. vol 44. issue 1. 1977-03-21. PMID:401823. |
they also support the concept that trh and lhrh act directly on pituitary tumor cells to release gh in acromegaly. |
1977-03-21 |
2023-08-11 |
Not clear |
| K Haniu, T Taya, M Aida, K Yoshinag. [Abnormal reaction of GH to TRH and l-dopa stimulation in acromegaly]. Horumon to rinsho. Clinical endocrinology. vol 24. issue 11. 1977-03-15. PMID:827402. |
[abnormal reaction of gh to trh and l-dopa stimulation in acromegaly]. |
1977-03-15 |
2023-08-11 |
Not clear |
| K Nakagawa, T Obar. Suppression of plasma growth hormone levels with glucose infusion in patients with acromegaly. Clinical endocrinology. vol 5. issue 6. 1977-03-15. PMID:1009678. |
these results appear to indicate that the suppressibility with hyperglycaemia is partially retained or restored in some, if not all, patients of acromegaly with lower gh secreting activity. |
1977-03-15 |
2023-08-11 |
Not clear |
| K Hanew, M Aida, T Tano, M Ojima, K Nishizat. Differences in autonomity of growth hormone secretion in patients with acromegaly. The Tohoku journal of experimental medicine. vol 120. issue 2. 1977-01-03. PMID:824758. |
thirteen patients with acromegaly were subjected to the examination of autonomity in growth hormone (gh) secretion. |
1977-01-03 |
2023-08-11 |
Not clear |
| G Verde, G Oppizzi, G Colussi, G Cremascoli, L Botalla, E E Müller, F Silvestrini, P G Chiodini, A Liuzz. Effect of dopamine infusion on plasma levels of growth hormone in normal subjects and in agromegalic patients. Clinical endocrinology. vol 5. issue 4. 1976-12-03. PMID:971548. |
since dopamine does not cross the blood-brain barrier, these results, although not excluding a site of action at median eminence level, support the thesis that the inhibitory effect of dopaminergic stimulation on gh release in acromegaly possibly involves receptors present on gh-secreting cells. |
1976-12-03 |
2023-08-11 |
human |
| J Takahara, N Ogawa, H Hosogi, Y Aoki, J Yamauch. [Comparison with growth hormone responses to various drugs or substances in patients with active acromegaly (author's transl)]. Nihon Naibunpi Gakkai zasshi. vol 51. issue 10. 1976-10-29. PMID:821792. |
growth hormone (gh) responses to l-dopa, 2-br-alpha-ergocryptine (cb-154), thyrotropine-releasing hormone (trh), luteinizing hormone-releasing hormone (lh-rh), glucagon and glucose were investigated in six patients with active acromegaly. |
1976-10-29 |
2023-08-11 |
Not clear |