| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Mosaad A Soltan, Ramdan S Shewita, Omaima A Matroud, Lamya Ahmed Alkeridis, Samy Sayed, Mustafa Shukry, Set A El-Shoboksh. Lignocellulose and probiotic supplementation in broiler chicken diet: effect on growth performance, digestive health, litter quality, and genes expression. Poultry science. vol 103. issue 6. 2024-04-23. PMID:38652957. |
dietary inclusion of lc and or b. subtilis supplementation significantly (p < 0.001) up-regulated hepatic growth-related genes (growth hormone receptor (ghr) and insulin growth factor1 (igf-1)) and antioxidant-related genes (superoxide dismutase 1 (sod1), glutathione peroxidase (gpx1) and uncoupling protein (ucp) and down-regulated (p < 0.001) splenic toll-like receptor 4 (tlrp) gene expression while had no significant effect on splenic interleukin 8 (il8) and tumor necrosis factor (tnf) with the best-obtained results with 1.0% followed by 0.5% lc with b. subtilis supplementation. |
2024-04-23 |
2024-04-26 |
chicken |
| Mari C Vázquez-Borrego, Mercedes Del Río-Moreno, Maxim Pyatkov, André Sarmento-Cabral, Mariyah Mahmood, Natalie Pelke, Magdalena Wnek, Jose Cordoba-Chacon, David J Waxman, Michelle A Puchowicz, Owen P McGuinness, Rhonda D Kinema. Direct and systemic actions of growth hormone receptor (GHR)-signaling on hepatic glycolysis, de novo lipogenesis and insulin sensitivity, associated with steatosis. Metabolism: clinical and experimental. 2023-05-14. PMID:37182789. |
direct and systemic actions of growth hormone receptor (ghr)-signaling on hepatic glycolysis, de novo lipogenesis and insulin sensitivity, associated with steatosis. |
2023-05-14 |
2023-08-14 |
Not clear |
| Andrzej Bartke, Holly Brown-Bor. Mutations Affecting Mammalian Aging: GH and GHR vs IGF-1 and Insulin. Frontiers in genetics. vol 12. 2021-12-13. PMID:34899820. |
mutations affecting mammalian aging: gh and ghr vs igf-1 and insulin. |
2021-12-13 |
2023-08-13 |
Not clear |
| Mari C Vázquez-Borrego, Mercedes Del Rio-Moreno, Rhonda D Kinema. Towards Understanding the Direct and Indirect Actions of Growth Hormone in Controlling Hepatocyte Carbohydrate and Lipid Metabolism. Cells. vol 10. issue 10. 2021-12-11. PMID:34685512. |
gh acts through its gh receptor (ghr) to modulate the production and function of insulin-like growth factor 1 (igf1) and insulin. |
2021-12-11 |
2023-08-13 |
Not clear |
| Silvana Duran-Ortiz, Edward O List, Yuji Ikeno, Jonathan Young, Reetobrata Basu, Stephen Bell, Todd McHugh, Kevin Funk, Samuel Mathes, Yanrong Qian, Prateek Kulkarni, Shoshana Yakar, Darlene E Berryman, John J Kopchic. Growth hormone receptor gene disruption in mature-adult mice improves male insulin sensitivity and extends female lifespan. Aging cell. 2021-11-23. PMID:34811874. |
we previously demonstrated that ghr ablation starting at puberty (1.5 months), improved insulin sensitivity and female lifespan but results in markedly reduced body size. |
2021-11-23 |
2023-08-13 |
mouse |
| G F Bomfim, G K F Merighe, S A de Oliveira, J A Negra. Acute and chronic effects of cortisol on milk yield, the expression of key receptors, and apoptosis of mammary epithelial cells in Saanen goats. Journal of dairy science. 2021-11-10. PMID:34756435. |
the objective of this study was to investigate the relationship between cort, insulin, prolactin, growth hormone, and insulin-like growth factor-1 in milk as well as the effect of cort on the expression of receptors of insulin (insr), prolactin (prlr), growth hormone (ghr); we also studied the insulin-like growth factor-1 (igf1r), glucocorticoid (nr3c1), mineralocorticoid (nr3c2), b-cell lymphoma 2 (bcl2), bcl-2-like protein x (bax) genes, and the apoptosis rate of mammary epithelial cells of lactating saanen goats in vivo and in vitro. |
2021-11-10 |
2023-08-13 |
Not clear |
| Willian O Dos Santos, Daniela O Gusmao, Frederick Wasinski, Edward O List, John J Kopchick, Jose Donat. Effects of Growth Hormone Receptor Ablation in Corticotropin-Releasing Hormone Cells. International journal of molecular sciences. vol 22. issue 18. 2021-10-22. PMID:34576072. |
ghr ablation in crh cells did not cause significant changes in body weight, body composition, food intake, substrate oxidation, locomotor activity, glucose tolerance, insulin sensitivity, counterregulatory response to 2-deoxy-d-glucose and ghrelin-induced food intake. |
2021-10-22 |
2023-08-13 |
mouse |
| Austin J Graybeal, Andreas Kreutzer, Petra Rack, Kamiah Moss, Garrett Augsburger, Jada L Willis, Robyn Braun-Trocchio, Meena Sha. Perceptions of appetite do not match hormonal measures of appetite in trained competitive cyclists and triathletes following a ketogenic diet compared to a high-carbohydrate or habitual diet: A randomized crossover trial. Nutrition research (New York, N.Y.). vol 93. 2021-10-08. PMID:34487977. |
mixed-effects model repeated measures analysis and effect sizes and 95% confidence intervals showed that postprandial ghr and insulin were lower and glp-1 was higher following the ketogenic versus the standard and high-carbohydrate meals. |
2021-10-08 |
2023-08-13 |
human |
| Austin J Graybeal, Andreas Kreutzer, Petra Rack, Kamiah Moss, Garrett Augsburger, Jada L Willis, Robyn Braun-Trocchio, Meena Sha. Perceptions of appetite do not match hormonal measures of appetite in trained competitive cyclists and triathletes following a ketogenic diet compared to a high-carbohydrate or habitual diet: A randomized crossover trial. Nutrition research (New York, N.Y.). vol 93. 2021-10-08. PMID:34487977. |
in conclusion, both fasting and postprandial concentrations of ghr were lower and glp-1 were higher following the kd than the hc and hd, and postprandial insulin was lower on the kd. |
2021-10-08 |
2023-08-13 |
human |
| Mark A Sherida. Coordinate regulation of feeding, metabolism, and growth: Perspectives from studies in fish. General and comparative endocrinology. vol 312. 2021-08-23. PMID:34329604. |
many factors involved with the control of feeding [e.g., cholecystokinin (cck) and ghrelin (grln)], energy metabolism [e.g., insulin (ins), glucagon (glu), glucagon-like peptide (glp), and somatostatins (ss), produced in the endocrine pancreas; and leptin (lep) produced broadly], and growth [e.g., grln, growth hormone (gh), insulin-like growth factors (igfs), gh receptors (ghr), igf receptors (igfr)] interact at various levels. |
2021-08-23 |
2023-08-13 |
Not clear |
| Silvana Duran-Ortiz, Kathryn L Corbin, Ishrat Jahan, Nicholas B Whitticar, Sarah E Morris, Ania N Bartholomew, Kira G Slepchenko, Hannah L West, Ibiagbani Mercy Max Harry, Edward O List, John J Kopchick, Craig S Nunemake. Loss of growth hormone signaling in the mouse germline or in adulthood reduces islet mass and alters islet function with notable sex differences. American journal of physiology. Endocrinology and metabolism. vol 320. issue 6. 2021-07-30. PMID:33938235. |
ghr knockout (ghrko) mice have enhanced insulin sensitivity and low circulating insulin. |
2021-07-30 |
2023-08-13 |
mouse |
| Frederick Wasinski, Fernanda M Chaves, João A B Pedroso, Naira S Mansano, João Paulo Camporez, Daniela O Gusmão, Edward O List, John J Kopchick, Renata Frazão, Raphael E Szawka, Jose Donat. Growth hormone receptor in dopaminergic neurones regulates stress-induced prolactin release in male mice. Journal of neuroendocrinology. vol 33. issue 3. 2021-06-15. PMID:33769619. |
ghr deletion in dat- or th-expressing cells did not cause changes in food intake, energy expenditure, ambulatory activity, nutrient oxidation, glucose tolerance, insulin sensitivity and counter-regulatory response to hypoglycaemia in male and female mice. |
2021-06-15 |
2023-08-13 |
mouse |
| Laura Ramírez, Nora Sanguineti, Paula Scaglia, Ana Keselman, María Gabriela Ballerini, Liliana Karabatas, Estefanía Landi, Julia Castro, Sabina Domené, Patricia Pennisi, Héctor Jasper, Rodolfo A Rey, Martín Vázquez, Horacio Domené, Ignacio Bergadá, Mariana Gutiérre. A novel heterozygous STAT5B variant in a patient with short stature and partial growth hormone insensitivity (GHI). Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society. vol 50. 2021-03-16. PMID:31902742. |
the most frequent monogenic causes of growth hormone insensitivity (ghi) include defects in genes encoding the gh receptor itself (ghr), the signal transducer and activator of transcription (stat5b), the insulin like-growth factor type i (igf1) and the acid-labile subunit (igfals). |
2021-03-16 |
2023-08-13 |
Not clear |
| Caroline S Firmenich, Nadine Schnepel, Kathrin Hansen, Marion Schmicke, Alexandra S Muscher-Bans. Modulation of growth hormone receptor-insulin-like growth factor 1 axis by dietary protein in young ruminants. The British journal of nutrition. vol 123. issue 6. 2020-12-17. PMID:31775916. |
ghr expression was down-regulated due to diminished insulin concentrations as both parameters were positively correlated. |
2020-12-17 |
2023-08-13 |
Not clear |
| Yash Chhabra, Caroline N Nelson, Monika Plescher, Johanna L Barclay, Aaron G Smith, Sof Andrikopoulos, Salvatore Mangiafico, David J Waxman, Andrew J Brooks, Michael J Water. Loss of growth hormone-mediated signal transducer and activator of transcription 5 (STAT5) signaling in mice results in insulin sensitivity with obesity. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 33. issue 5. 2020-05-12. PMID:30779881. |
growth hormone (gh) has an important function as an insulin antagonist with elevated insulin sensitivity evident in humans and mice lacking a functional gh receptor (ghr). |
2020-05-12 |
2023-08-13 |
mouse |
| Pryscila D S Teixeira, Gisele C Couto, Isadora C Furigo, Edward O List, John J Kopchick, Jose Donat. Central growth hormone action regulates metabolism during pregnancy. American journal of physiology. Endocrinology and metabolism. vol 317. issue 5. 2020-03-30. PMID:31479305. |
additionally, both brain ghr ko and lepr ghr ko mice had lower glucose tolerance and glucose-stimulated insulin secretion during pregnancy, despite presenting increased insulin sensitivity, compared with control pregnant animals. |
2020-03-30 |
2023-08-13 |
mouse |
| Silvana Duran-Ortiz, Vanessa Noboa, John J Kopchic. Disruption of the GH receptor gene in adult mice and in insulin sensitive tissues. Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society. vol 38. 2018-08-30. PMID:29198419. |
to elucidate whether a specific tissue is responsible for the beneficial health and longevity phenotype seen in growth hormone (gh) receptor (r) knockout (ghrko) mice, the ghr gene was disrupted specifically in insulin sensitive tissues; namely, liver, adipose, and muscle. |
2018-08-30 |
2023-08-13 |
mouse |
| Han Qiu, Jin-Kui Yang, Chen Che. Influence of insulin on growth hormone secretion, level and growth hormone signalling. Sheng li xue bao : [Acta physiologica Sinica]. vol 69. issue 5. 2018-08-29. PMID:29063103. |
insulin may also affect ghr sensitivity and the level of insulin-like growth factor 1 (igf-1), thus influence the level of gh. |
2018-08-29 |
2023-08-13 |
Not clear |
| Zhongbo Liu, Jose Cordoba-Chacon, Rhonda D Kineman, Bruce N Cronstein, Radhika Muzumdar, Zhenwei Gong, Haim Werner, Shoshana Yaka. Growth Hormone Control of Hepatic Lipid Metabolism. Diabetes. vol 65. issue 12. 2017-05-31. PMID:27679560. |
in mice, congenital liver-specific ablation of the gh receptor (ghr) results in reductions in circulating igf-1 and hepatic steatosis, associated with systemic insulin resistance. |
2017-05-31 |
2023-08-13 |
mouse |
| Zhongbo Liu, Jose Cordoba-Chacon, Rhonda D Kineman, Bruce N Cronstein, Radhika Muzumdar, Zhenwei Gong, Haim Werner, Shoshana Yaka. Growth Hormone Control of Hepatic Lipid Metabolism. Diabetes. vol 65. issue 12. 2017-05-31. PMID:27679560. |
we found that liver ghr ablation leads to increases in lipid uptake, de novo lipogenesis, hyperinsulinemia, and hyperglycemia accompanied with severe insulin resistance and increased body adiposity and serum lipids. |
2017-05-31 |
2023-08-13 |
mouse |