| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| A Schneider, L F M Pfeifer, J W da Silva Neto, L T Hax, M M Antunes, F A B Del Pino, G R Paludo, M N Corrê. Effect of exogenous insulin and fasting on growth hormone receptor and IGF-I expression in the pre-ovulatory follicle of ewes. Animal : an international journal of animal bioscience. vol 5. issue 9. 2012-10-02. PMID:22440288. |
moreover, granulosa cells ghr mrna expression increased (p < 0.05) in the insulin group. |
2012-10-02 |
2023-08-12 |
Not clear |
| A Schneider, L F M Pfeifer, J W da Silva Neto, L T Hax, M M Antunes, F A B Del Pino, G R Paludo, M N Corrê. Effect of exogenous insulin and fasting on growth hormone receptor and IGF-I expression in the pre-ovulatory follicle of ewes. Animal : an international journal of animal bioscience. vol 5. issue 9. 2012-10-02. PMID:22440288. |
in conclusion, insulin administration increases ghr mrna but not igf-i mrna expression in granulosa cells of the pre-ovulatory follicle. |
2012-10-02 |
2023-08-12 |
Not clear |
| Adam Gesing, Michal M Masternak, Feiya Wang, Malgorzata Karbownik-Lewinska, Andrzej Bartk. Deletion of growth hormone receptor gene but not visceral fat removal decreases expression of apoptosis-related genes in the kidney-potential mechanism of lifespan extension. Age (Dordrecht, Netherlands). vol 34. issue 2. 2012-07-24. PMID:21431351. |
mice homozygous for the targeted disruption of the growth hormone (gh) receptor (ghr) gene (gh receptor knockout; ghrko; ko) are hypoinsulinemic, highly insulin sensitive, normoglycemic, and long-lived. |
2012-07-24 |
2023-08-12 |
mouse |
| R Manjarín, J P Steibel, R N Kirkwood, N P Taylor, N L Trottie. Transcript abundance of hormone receptors, mammalian target of rapamycin pathway-related kinases, insulin-like growth factor I, and milk proteins in porcine mammary tissue. Journal of animal science. vol 90. issue 1. 2012-05-04. PMID:21821816. |
selected genes included those encoding for receptors of gh (ghr), insulin (insr), glucocorticoid (nr3c1), prolactin (prlr), igf-i (igf-i), mtor (frap1), and p70s6 kinases (rps6kb1), and the milk proteins α-lactalbumin (lalba) and β-casein (csn2). |
2012-05-04 |
2023-08-12 |
cattle |
| M Colak, T Shimizu, N Matsunaga, C Murayama, S Nagashima, M Kataoka, C Kawashima, M Matsui, H A van Dorland, R M Bruckmaier, A Miyamot. Oestradiol enhances plasma growth hormone and insulin-like growth factor-I concentrations and increased the expression of their receptors mRNAs in the liver of ovariectomized cows. Reproduction in domestic animals = Zuchthygiene. vol 46. issue 5. 2012-02-28. PMID:21323755. |
the animals were euthanized after the experiment, and liver and adipose tissues samples were quantitatively analysed using real-time pcr for the expression of mrna for the gh (ghr), igf-i (igfr-i) and insulin (ir) receptor mrnas. |
2012-02-28 |
2023-08-12 |
cattle |
| Archana Vijayakumar, YingJie Wu, Hui Sun, Xiaosong Li, Zuha Jeddy, Chengyu Liu, Gary J Schwartz, Shoshana Yakar, Derek LeRoit. Targeted loss of GHR signaling in mouse skeletal muscle protects against high-fat diet-induced metabolic deterioration. Diabetes. vol 61. issue 1. 2012-02-13. PMID:22187377. |
thus, our study implicates skeletal muscle ghr signaling in mediating insulin resistance in obesity and, more importantly, reveals a novel role of muscle ghr signaling in facilitating cross-talk between muscle and other metabolic tissues. |
2012-02-13 |
2023-08-12 |
mouse |
| Jaime Guevara-Aguirre, Priya Balasubramanian, Marco Guevara-Aguirre, Min Wei, Federica Madia, Chia-Wei Cheng, David Hwang, Alejandro Martin-Montalvo, Jannette Saavedra, Sue Ingles, Rafael de Cabo, Pinchas Cohen, Valter D Long. Growth hormone receptor deficiency is associated with a major reduction in pro-aging signaling, cancer, and diabetes in humans. Science translational medicine. vol 3. issue 70. 2011-05-26. PMID:21325617. |
we also observed reduced insulin concentrations (1.4 μu/ml versus 4.4 μu/ml in unaffected relatives) and a very low homa-ir (homeostatic model assessment-insulin resistance) index (0.34 versus 0.96 in unaffected relatives) in individuals with ghr deficiency, indicating higher insulin sensitivity, which could explain the absence of diabetes in these subjects. |
2011-05-26 |
2023-08-12 |
mouse |
| Mahendra D Mavalli, Douglas J DiGirolamo, Yong Fan, Ryan C Riddle, Kenneth S Campbell, Thomas van Groen, Stuart J Frank, Mark A Sperling, Karyn A Esser, Marcas M Bamman, Thomas L Clemen. Distinct growth hormone receptor signaling modes regulate skeletal muscle development and insulin sensitivity in mice. The Journal of clinical investigation. vol 120. issue 11. 2010-12-07. PMID:20921627. |
strikingly, mice lacking ghr developed metabolic features that were not observed in the igf-1r mutants, including marked peripheral adiposity, insulin resistance, and glucose intolerance. |
2010-12-07 |
2023-08-12 |
mouse |
| Vita Birzniece, Akira Sata, Ken K Y H. Growth hormone receptor modulators. Reviews in endocrine & metabolic disorders. vol 10. issue 2. 2009-08-24. PMID:18622706. |
insulin, thyroid hormones and sex hormones are among hormones that modulate ghr through some of these mechanisms. |
2009-08-24 |
2023-08-12 |
Not clear |
| Takashi Shimizu, Chiaki Murayama, Natsuko Sudo, Chiho Kawashima, Masa Tetsuka, Akio Miyamot. Involvement of insulin and growth hormone (GH) during follicular development in the bovine ovary. Animal reproduction science. vol 106. issue 1-2. 2008-07-08. PMID:17507188. |
our results suggest that the increase in the expression of ghr may be a turning point for follicles to enter the ovulatory phase during final follicular development and that the insulin system may support the maturation of preovulatory follicles. |
2008-07-08 |
2023-08-12 |
cattle |
| William L Bennett, Adam B Keeton, Shaonin Ji, Jie Xu, Joseph L Messin. Insulin regulation of growth hormone receptor gene expression: involvement of both the PI-3 kinase and MEK/ERK signaling pathways. Endocrine. vol 32. issue 2. 2008-03-07. PMID:18040895. |
the mechanism(s) of insulin's effects on growth hormone receptor (ghr) gene expression are poorly understood. |
2008-03-07 |
2023-08-12 |
rat |
| William L Bennett, Adam B Keeton, Shaonin Ji, Jie Xu, Joseph L Messin. Insulin regulation of growth hormone receptor gene expression: involvement of both the PI-3 kinase and MEK/ERK signaling pathways. Endocrine. vol 32. issue 2. 2008-03-07. PMID:18040895. |
using rat hepatoma cells, we have previously shown that insulin treatment reduces ghr mrna and protein in a time- and concentration-dependent manner, at least in part via down-regulation of ghr transcription. |
2008-03-07 |
2023-08-12 |
rat |
| William L Bennett, Adam B Keeton, Shaonin Ji, Jie Xu, Joseph L Messin. Insulin regulation of growth hormone receptor gene expression: involvement of both the PI-3 kinase and MEK/ERK signaling pathways. Endocrine. vol 32. issue 2. 2008-03-07. PMID:18040895. |
inhibition of the pi-3 kinase pathway partially blocked insulin's reduction of ghr mrna, as did inhibition of the mek/erk pathway, resulting in higher ghr mrna levels. |
2008-03-07 |
2023-08-12 |
rat |
| William L Bennett, Adam B Keeton, Shaonin Ji, Jie Xu, Joseph L Messin. Insulin regulation of growth hormone receptor gene expression: involvement of both the PI-3 kinase and MEK/ERK signaling pathways. Endocrine. vol 32. issue 2. 2008-03-07. PMID:18040895. |
collectively, these data suggest that insulin signaling via either the pi-3 kinase or mek/erk pathway may result in partial reduction of ghr gene expression, whereas signaling via both pathways may be required to achieve the full insulin effect. |
2008-03-07 |
2023-08-12 |
rat |
| Korinna Huber, Johanna Petzold, Charlotte Rehfeldt, Klaus Ender, Ilse Fiedle. Muscle energy metabolism: structural and functional features in different types of porcine striated muscles. Journal of muscle research and cell motility. vol 28. issue 4-5. 2008-01-25. PMID:17955334. |
ghr mrna expression was also highest in longissimus muscle indicating that an enhanced effect of growth hormone, which is described to be diabetogenic, could be involved in the lower insulin sensitivity of glycolytic muscles. |
2008-01-25 |
2023-08-12 |
Not clear |
| William L Bennett, Shaonin Ji, Joseph L Messin. Insulin regulation of growth hormone receptor gene expression. Evidence for a transcriptional mechanism of down-regulation in rat hepatoma cells. Molecular and cellular endocrinology. vol 274. issue 1-2. 2007-10-23. PMID:17658679. |
continuous insulin treatment reduces gh binding, which suggests that insulin may effect growth hormone receptor (ghr) levels. |
2007-10-23 |
2023-08-12 |
rat |
| William L Bennett, Shaonin Ji, Joseph L Messin. Insulin regulation of growth hormone receptor gene expression. Evidence for a transcriptional mechanism of down-regulation in rat hepatoma cells. Molecular and cellular endocrinology. vol 274. issue 1-2. 2007-10-23. PMID:17658679. |
the present study used rat hepatoma cells to examine the effects of insulin and gh on ghr gene expression. |
2007-10-23 |
2023-08-12 |
rat |
| William L Bennett, Shaonin Ji, Joseph L Messin. Insulin regulation of growth hormone receptor gene expression. Evidence for a transcriptional mechanism of down-regulation in rat hepatoma cells. Molecular and cellular endocrinology. vol 274. issue 1-2. 2007-10-23. PMID:17658679. |
prolonged insulin treatment (greater than 3h) significantly reduced ghr mrna, and removal of insulin led to a gradual recovery. |
2007-10-23 |
2023-08-12 |
rat |
| William L Bennett, Shaonin Ji, Joseph L Messin. Insulin regulation of growth hormone receptor gene expression. Evidence for a transcriptional mechanism of down-regulation in rat hepatoma cells. Molecular and cellular endocrinology. vol 274. issue 1-2. 2007-10-23. PMID:17658679. |
this effect of insulin occurred at physiologic concentrations, occurred many hours before the insulin-regulated decrease in ghr protein, and was mediated by reduction of ghr transcription. |
2007-10-23 |
2023-08-12 |
rat |
| William L Bennett, Shaonin Ji, Joseph L Messin. Insulin regulation of growth hormone receptor gene expression. Evidence for a transcriptional mechanism of down-regulation in rat hepatoma cells. Molecular and cellular endocrinology. vol 274. issue 1-2. 2007-10-23. PMID:17658679. |
these findings indicate that the heterologous reduction of ghr by insulin occurs via transcriptional downregulation, and the homologous reduction of ghr by gh occurs via a different mechanism. |
2007-10-23 |
2023-08-12 |
rat |