| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Marianna Sadagurski, Taylor Landeryou, Gillian Cady, John J Kopchick, Edward O List, Darlene E Berryman, Andrzej Bartke, Richard A Mille. Growth hormone modulates hypothalamic inflammation in long-lived pituitary dwarf mice. Aging cell. vol 14. issue 6. 2016-10-25. PMID:26268661. |
mice in which the genes for growth hormone (gh) or gh receptor (ghr(-/-) ) are disrupted from conception are dwarfs, possess low levels of igf-1 and insulin, have low rates of cancer and diabetes, and are extremely long-lived. |
2016-10-25 |
2023-08-13 |
mouse |
| A C A Ferreira, C Maside, N A R Sá, D D Guerreiro, H H V Correia, J Leiva-Revilla, C H Lobo, V R Araújo, G A Apgar, F Z Brandão, J R Figueiredo, C C Campell. Balance of insulin and FSH concentrations improves the in vitro development of isolated goat preantral follicles in medium containing GH. Animal reproduction science. vol 165. 2016-10-11. PMID:26723481. |
the aim of this study was to evaluate the effect of different combinations of insulin and fsh concentrations in culture media containing gh on the in vitro follicle morphology, antrum formation, growth rates, estradiol (e2) production, oocyte viability and maturation as well as gene expression for fshr, ghr, insr, cyp19a1, cyp17, 3ßhsd. |
2016-10-11 |
2023-08-13 |
Not clear |
| Feida Li, Yong Li, Huan Liu, Xingju Zhang, Chuxin Liu, Kai Tian, Lars Bolund, Hongwei Dou, Wenxian Yang, Huanming Yang, Nicklas Heine Staunstrup, Yutao D. Transgenic Wuzhishan minipigs designed to express a dominant-negative porcine growth hormone receptor display small stature and a perturbed insulin/IGF-1 pathway. Transgenic research. vol 24. issue 6. 2016-08-23. PMID:26510874. |
gh binding to the growth hormone receptor (ghr) on hepatocytes prompts expression of insulin growth factor i (igf-1) involved in nutritionally induced compensatory hyperplasia of pancreatic β-cell islets and insulin release. |
2016-08-23 |
2023-08-13 |
human |
| Jaime Guevara-Aguirre, Arlan L Rosenbloo. Obesity, diabetes and cancer: insight into the relationship from a cohort with growth hormone receptor deficiency. Diabetologia. vol 58. issue 1. 2016-04-12. PMID:25316432. |
in ecuador there are ~100 living adults with lifelong igf-1 deficiency caused by a gh receptor (ghr) mutation who, despite a high percentage of body fat, have markedly increased insulin sensitivity compared with age- and bmi-matched control relatives, and no instances of diabetes, which is present in 6% of unaffected relatives. |
2016-04-12 |
2023-08-13 |
Not clear |
| Jaime Guevara-Aguirre, Arlan L Rosenbloo. Obesity, diabetes and cancer: insight into the relationship from a cohort with growth hormone receptor deficiency. Diabetologia. vol 58. issue 1. 2016-04-12. PMID:25316432. |
the complex inter-relationship of obesity, diabetes and cancer risk is related to excess insulin and fuel supply, in the presence of heightened anti-apoptosis and uninhibited dna damage when ghr function is normal. |
2016-04-12 |
2023-08-13 |
Not clear |
| Ilona Zawada, Michal M Masternak, Edward O List, Michael B Stout, Darlene E Berryman, Andrzej Lewinski, John J Kopchick, Andrzej Bartke, Malgorzata Karbownik-Lewinska, Adam Gesin. Gene expression of key regulators of mitochondrial biogenesis is sex dependent in mice with growth hormone receptor deletion in liver. Aging. vol 7. issue 3. 2015-07-14. PMID:25855408. |
mice with disruption of the growth hormone receptor (ghr) gene (ghr gene) in the liver (lighrko), in contrast to long-lived mice with global deletion of the ghr gene (ghrko), are characterized by lack of improved insulin sensitivity and severe hepatic steatosis. |
2015-07-14 |
2023-08-13 |
mouse |
| Eva Baquedano, Ana M Ruiz-Lopez, Elahu G Sustarsic, James Herpy, Edward O List, Julie A Chowen, Laura M Frago, John J Kopchick, Jesús Argent. The absence of GH signaling affects the susceptibility to high-fat diet-induced hypothalamic inflammation in male mice. Endocrinology. vol 155. issue 12. 2015-07-08. PMID:25237935. |
gh is important in metabolic control, and mice with disruption of the gene encoding the gh receptor (ghr) and gh binding protein (ghr-/- mice) are dwarf with low serum igf-1 and insulin levels, high gh levels, and increased longevity, despite their obesity and altered lipid and metabolic profiles. |
2015-07-08 |
2023-08-13 |
mouse |
| Adam Gesing, Feiya Wang, Edward O List, Darlene E Berryman, Michal M Masternak, Andrzej Lewinski, Malgorzata Karbownik-Lewinska, John J Kopchick, Andrzej Bartk. Expression of apoptosis-related genes in liver-specific growth hormone receptor gene-disrupted mice is sex dependent. The journals of gerontology. Series A, Biological sciences and medical sciences. vol 70. issue 1. 2015-04-24. PMID:24550353. |
mice with liver-specific disruption of the growth hormone receptor (ghr) gene (ie, ghr gene) liver-specific growth hormone receptor knockout [lighrko] mice), as opposed to mice with global deletion of the ghr gene (ghrko; ghr-/-), are characterized by severe hepatic steatosis and lack of improved insulin sensitivity. |
2015-04-24 |
2023-08-12 |
mouse |
| Floryne O Buishand, Judith Visser, Marja Kik, Andrea Gröne, Rebekah I Keesler, Inge H Briaire-de Bruijn, Jolle Kirpensteij. Evaluation of prognostic indicators using validated canine insulinoma tissue microarrays. Veterinary journal (London, England : 1997). vol 201. issue 1. 2015-04-10. PMID:24878267. |
inter-observer agreement of tma immunohistochemistry scores were assessed for chromogranin a (cga), insulin, growth hormone (gh), growth hormone receptor (ghr) and ki67 index, as well as the prognostic utility of clinicopathological, histopathological and immunohistochemical criteria. |
2015-04-10 |
2023-08-13 |
Not clear |
| Ramadevi Subramani, Rebecca Lopez-Valdez, Alyssa Salcido, Thiyagarajan Boopalan, Arunkumar Arumugam, Sushmita Nandy, Rajkumar Lakshmanaswam. Growth hormone receptor inhibition decreases the growth and metastasis of pancreatic ductal adenocarcinoma. Experimental & molecular medicine. vol 46. 2015-02-20. PMID:25301264. |
interestingly, silencing ghr also suppressed the expression of insulin receptor-β and cyclo-oxygenease-2. |
2015-02-20 |
2023-08-13 |
Not clear |
| Yaqiong Ye, Shumao Lin, Heping Mu, Xiaohong Tang, Yangdan Ou, Jian Chen, Yongjiang Ma, Yugu L. Analysis of differentially expressed genes and signaling pathways related to intramuscular fat deposition in skeletal muscle of sex-linked dwarf chickens. BioMed research international. vol 2014. 2014-12-09. PMID:24757673. |
in addition, kegg pathway analysis of degs indicated that some of them (ghr, socs3, and igf2bp3) participate in adipocytokine and insulin signaling pathways. |
2014-12-09 |
2023-08-13 |
chicken |
| Pawel Lisowski, Ewa M Kościuczuk, Joanna Gościk, Mariusz Pierzchała, Barbara Rowińska, Lech Zwierzchowsk. Hepatic transcriptome profiling identifies differences in expression of genes associated with changes in metabolism and postnatal growth between Hereford and Holstein-Friesian bulls. Animal genetics. vol 45. issue 2. 2014-11-07. PMID:24304134. |
in h bulls, we observed up-regulation of genes involved in fatty acid biosynthesis and lipid metabolism (cd36, cat, hsd3b1, fabp1, acaa1) and involved in insulin signaling (insr, insig2, nr4a1) and down-regulation of genes involved in somatotropic axis signaling (igf1, ghr, igfbp3) as compared to hf. |
2014-11-07 |
2023-08-12 |
cat |
| Yao Huang, Yongchang Chan. Regulation of pancreatic islet beta-cell mass by growth factor and hormone signaling. Progress in molecular biology and translational science. vol 121. 2014-07-10. PMID:24373242. |
notably, somatolactogenic hormones including growth hormone (gh), prolactin (prl), and insulin-like growth factor-1 (igf-1) and their receptors (ghr, prlr, and igf-1r) are critically involved in beta-cell growth, survival, differentiation, and insulin secretion. |
2014-07-10 |
2023-08-12 |
Not clear |
| Darlene E Berryman, Ellen R Lubbers, Vishakha Magon, Edward O List, John J Kopchic. A dwarf mouse model with decreased GH/IGF-1 activity that does not experience life-span extension: potential impact of increased adiposity, leptin, and insulin with advancing age. The journals of gerontology. Series A, Biological sciences and medical sciences. vol 69. issue 2. 2014-03-26. PMID:23695394. |
gh receptor (ghr) null (ghr(-)(/-)) mice, which have a disruption in the ghr gene, are a well-studied example of mice that are insulin sensitive and long lived yet obese. |
2014-03-26 |
2023-08-12 |
mouse |
| Lucila Sackmann-Sala, Darlene E Berryman, Ellen R Lubbers, Han Zhang, Clare B Vesel, Katie M Troike, Elahu S Gosney, Edward O List, John J Kopchic. Age-related and depot-specific changes in white adipose tissue of growth hormone receptor-null mice. The journals of gerontology. Series A, Biological sciences and medical sciences. vol 69. issue 1. 2014-02-04. PMID:23873966. |
growth hormone receptor-null (ghr(-/-)) mice are dwarf, insulin sensitive, and long-lived in spite of increased adiposity. |
2014-02-04 |
2023-08-12 |
mouse |
| Lucila Sackmann-Sala, Darlene E Berryman, Ellen R Lubbers, Han Zhang, Clare B Vesel, Katie M Troike, Elahu S Gosney, Edward O List, John J Kopchic. Age-related and depot-specific changes in white adipose tissue of growth hormone receptor-null mice. The journals of gerontology. Series A, Biological sciences and medical sciences. vol 69. issue 1. 2014-02-04. PMID:23873966. |
to study wat depot-specific effects on insulin sensitivity and life span, we analyzed individual wat depots of 12- and 24-month-old ghr(-) (/-) and wild-type (wt) mice, as well as their plasma levels of selected hormones. |
2014-02-04 |
2023-08-12 |
mouse |
| Lucila Sackmann-Sala, Darlene E Berryman, Ellen R Lubbers, Han Zhang, Clare B Vesel, Katie M Troike, Elahu S Gosney, Edward O List, John J Kopchic. Age-related and depot-specific changes in white adipose tissue of growth hormone receptor-null mice. The journals of gerontology. Series A, Biological sciences and medical sciences. vol 69. issue 1. 2014-02-04. PMID:23873966. |
adipocyte sizes and plasma insulin, leptin, and adiponectin levels decreased with age in both ghr(-) (/-) and wt mice. |
2014-02-04 |
2023-08-12 |
mouse |
| Lucila Sackmann-Sala, Darlene E Berryman, Ellen R Lubbers, Han Zhang, Clare B Vesel, Katie M Troike, Elahu S Gosney, Edward O List, John J Kopchic. Age-related and depot-specific changes in white adipose tissue of growth hormone receptor-null mice. The journals of gerontology. Series A, Biological sciences and medical sciences. vol 69. issue 1. 2014-02-04. PMID:23873966. |
overall, the protein changes detected in this study offer new insights into possible mechanisms contributing to enhanced insulin sensitivity and extended life span in ghr(-) (/-) mice. |
2014-02-04 |
2023-08-12 |
mouse |
| Xin-Ling Fang, Gang Shu, Zhi-Qi Zhang, Song-Bo Wang, Xiao-Tong Zhu, Ping Gao, Qian-Yun Xi, Yong-Liang Zhang, Qing-Yan Jian. Roles of α-linolenic acid on IGF-I secretion and GH/IGF system gene expression in porcine primary hepatocytes. Molecular biology reports. vol 39. issue 12. 2013-04-04. PMID:23053988. |
insulin (1 μm) alone or co-treated with ala improved igf-i secretion and the expression of igfbp3 mrna, but decreased igfbp1 mrna versus appropriate control across ala. insulin also up-regulated the expression of ghr, ir, igfbp3, and igfbp4 mrnas, and tended to prevent the transcript levels of igf-i and igfbp4 improved by ala. |
2013-04-04 |
2023-08-12 |
Not clear |
| A Schneider, L F M Pfeifer, J W da Silva Neto, L T Hax, M M Antunes, F A B Del Pino, G R Paludo, M N Corrê. Effect of exogenous insulin and fasting on growth hormone receptor and IGF-I expression in the pre-ovulatory follicle of ewes. Animal : an international journal of animal bioscience. vol 5. issue 9. 2012-10-02. PMID:22440288. |
the aim of this study was to investigate the effect of fasting and exogenous insulin administration on the expression of growth hormone receptor (ghr) and igf-i mrna in the pre-ovulatory follicle of ewes. |
2012-10-02 |
2023-08-12 |
Not clear |