| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| William L Bennett, Shaonin Ji, Joseph L Messin. Insulin regulation of growth hormone receptor gene expression. Evidence for a transcriptional mechanism of down-regulation in rat hepatoma cells. Molecular and cellular endocrinology. vol 274. issue 1-2. 2007-10-23. PMID:17658679. |
furthermore, with insulin, extended time of exposure may be necessary for appreciable reduction of ghr. |
2007-10-23 |
2023-08-12 |
rat |
| A Kempa, B Krzyzanowska-Swiniarska, T Miazgowski, K Pilarsk. Not insulin but insulin sensitivity, leptin, and cortisol are major factors regulating serum acylated ghrelin level in healthy women. Journal of endocrinological investigation. vol 30. issue 8. 2007-10-23. PMID:17923797. |
the study was performed on 32 healthy, normal-weight, non-pregnant women with normal [body mass index (bmi) 18.9-24.2 kg/m2] and stable (the difference between two measurements performed within 1 month being less than 0.5 kg) body weight, aged 22-47 yr. leptin, ghr, gh, igf-i, cortisol, insulin, and glucose were measured in the early follicular phase of the menstruation cycle. |
2007-10-23 |
2023-08-12 |
Not clear |
| A Kempa, B Krzyzanowska-Swiniarska, T Miazgowski, K Pilarsk. Not insulin but insulin sensitivity, leptin, and cortisol are major factors regulating serum acylated ghrelin level in healthy women. Journal of endocrinological investigation. vol 30. issue 8. 2007-10-23. PMID:17923797. |
we found a positive linear correlation between leptin and ghr (r=0.375; p=0.034) and negative correlation between insulin and ghr (r=-0.374; p=0.034). |
2007-10-23 |
2023-08-12 |
Not clear |
| A Kempa, B Krzyzanowska-Swiniarska, T Miazgowski, K Pilarsk. Not insulin but insulin sensitivity, leptin, and cortisol are major factors regulating serum acylated ghrelin level in healthy women. Journal of endocrinological investigation. vol 30. issue 8. 2007-10-23. PMID:17923797. |
our results suggest that in healthy women basal ghr level is regulated by multiple factors, mainly by insulin sensitivity, leptin, and adrenal glands activity. |
2007-10-23 |
2023-08-12 |
Not clear |
| Verónica Mericq, Rossana Román, Germán Iñiguez, Bárbara Angel, Teresa Salazar, Alejandra Avila, Francisco Perez-Bravo, Fernando Cassorl. Relationship between nocturnal growth hormone concentrations, serum IGF-I/IGFBP-3 levels, insulin sensitivity and GH receptor allelic variant in small for gestational age children. Hormone research. vol 68. issue 3. 2007-09-04. PMID:17347571. |
we hypothesized that nocturnal growth hormone concentrations, basal igf-i and igfbp-3 levels, and insulin sensitivity might show variations among individuals depending on their ghr allelic variant. |
2007-09-04 |
2023-08-12 |
Not clear |
| Verónica Mericq, Rossana Román, Germán Iñiguez, Bárbara Angel, Teresa Salazar, Alejandra Avila, Francisco Perez-Bravo, Fernando Cassorl. Relationship between nocturnal growth hormone concentrations, serum IGF-I/IGFBP-3 levels, insulin sensitivity and GH receptor allelic variant in small for gestational age children. Hormone research. vol 68. issue 3. 2007-09-04. PMID:17347571. |
in addition, we did not observe any significant differences in serum igf-i sds (-0.49 +/- 0.26 vs. -0.40 +/- 0.35) or igfbp-3 sds (-1.21 +/- 0.24 vs. -0.89 +/- 0.21) nor in insulin sensitivity (wibsi: 12 +/- 1.2 vs. 10.8 +/- 1.1) in lbw children with full length ghr compared to children carrying at least one ghrd3 allele. |
2007-09-04 |
2023-08-12 |
Not clear |
| Verónica Mericq, Rossana Román, Germán Iñiguez, Bárbara Angel, Teresa Salazar, Alejandra Avila, Francisco Perez-Bravo, Fernando Cassorl. Relationship between nocturnal growth hormone concentrations, serum IGF-I/IGFBP-3 levels, insulin sensitivity and GH receptor allelic variant in small for gestational age children. Hormone research. vol 68. issue 3. 2007-09-04. PMID:17347571. |
these results suggest that the ghr allelic variant does not play a significant role in the regulation of gh-igf-i/bp3 axis or in insulin sensitivity in prepubertal lbw children. |
2007-09-04 |
2023-08-12 |
Not clear |
| Andrzej Bartke, Michal M Masternak, Khalid A Al-Regaiey, Michael S Bonkowsk. Effects of dietary restriction on the expression of insulin-signaling-related genes in long-lived mutant mice. Interdisciplinary topics in gerontology. vol 35. 2006-12-06. PMID:17063033. |
the effects of dr partially overlapped but did not duplicate the effects of ames dwarfism or ghr deletion on the expression of genes related to insulin signaling and cell responsiveness to insulin. |
2006-12-06 |
2023-08-12 |
mouse |
| Katie Robertson, John J Kopchick, Jun-Li Li. Growth hormone receptor gene deficiency causes delayed insulin responsiveness in skeletal muscles without affecting compensatory islet cell overgrowth in obese mice. American journal of physiology. Endocrinology and metabolism. vol 291. issue 3. 2006-09-26. PMID:16621895. |
ghr gene-deficient (ghr(-/-)) mice exhibit drastically diminished insulin-like growth factor-i (igf-i) levels, proportional growth retardation, elevated insulin sensitivity, and reduced islet beta-cell mass. |
2006-09-26 |
2023-08-12 |
mouse |
| Katie Robertson, John J Kopchick, Jun-Li Li. Growth hormone receptor gene deficiency causes delayed insulin responsiveness in skeletal muscles without affecting compensatory islet cell overgrowth in obese mice. American journal of physiology. Endocrinology and metabolism. vol 291. issue 3. 2006-09-26. PMID:16621895. |
upon in vivo insulin stimulation, skeletal muscles of ghr(-/-) mice exhibit transient delayed responses in ir and irs-1 phosphorylation but normal levels of p85 association with irs-1. |
2006-09-26 |
2023-08-12 |
mouse |
| Katie Robertson, John J Kopchick, Jun-Li Li. Growth hormone receptor gene deficiency causes delayed insulin responsiveness in skeletal muscles without affecting compensatory islet cell overgrowth in obese mice. American journal of physiology. Endocrinology and metabolism. vol 291. issue 3. 2006-09-26. PMID:16621895. |
this is in contrast to normal/elevated insulin responses in hepatocytes and indicates tissue-specific effects of ghr gene deficiency. |
2006-09-26 |
2023-08-12 |
mouse |
| E C Ontsouka, C Philipona, H M Hammon, J W Blu. Abundance of mRNA encoding for components of the somatotropic axis and insulin receptor in different layers of the jejunum and ileum of neonatal calves. Journal of animal science. vol 82. issue 11. 2006-07-27. PMID:15542464. |
insulin-like growth factors-1 and -2, igfbp-2 and -3, and receptors for igf type-1 and type-2 (igf-1r, igf-2r), growth hormone (ghr), and insulin (insr) in neonatal calves are variably expressed among gastrointestinal sites and thought to exert site-specific physiological functions. |
2006-07-27 |
2023-08-12 |
Not clear |
| Darlene E Berryman, Edward O List, Douglas T Kohn, Karen T Coschigano, Randy J Seeley, John J Kopchic. Effect of growth hormone on susceptibility to diet-induced obesity. Endocrinology. vol 147. issue 6. 2006-06-22. PMID:16556764. |
mice with a deficiency in gh function due to disruption of the gh receptor/binding protein gene (ghr(-/-)) are long lived, insulin sensitive, and obese, whereas mice with excess gh function due to expression of a bovine gh transgene (bgh) are short lived, glucose intolerant, and lean. |
2006-06-22 |
2023-08-12 |
mouse |
| Jie Xu, Adam B Keeton, John L Franklin, Xin Li, Derwei Y Venable, Stuart J Frank, Joseph L Messin. Insulin enhances growth hormone induction of the MEK/ERK signaling pathway. The Journal of biological chemistry. vol 281. issue 2. 2006-02-28. PMID:16272159. |
physiological concentrations of insulin promote growth probably by modulating liver gh receptor (ghr) levels in vivo, but the possible effects of insulin on gh-induced post-ghr signaling have yet to be studied. |
2006-02-28 |
2023-08-12 |
rat |
| Qinghua Nie, Mingming Lei, Jianhua Ouyang, Hua Zeng, Guanfu Yang, Xiquan Zhan. Identification and characterization of single nucleotide polymorphisms in 12 chicken growth-correlated genes by denaturing high performance liquid chromatography. Genetics, selection, evolution : GSE. vol 37. issue 3. 2005-07-27. PMID:15823239. |
a total of 283 snp were discovered in 31 897 base pairs (bp) from 12 genes of the growth hormone (gh), growth hormone receptor (ghr), ghrelin, growth hormone secretagogue receptor (ghsr), insulin-like growth factor i and ii (igf-i and -ii), insulin-like growth factor binding protein 2 (igfbp-2), insulin, leptin receptor (lepr), pituitary-specific transcription factor-1 (pit-1), somatostatin (ss), thyroid-stimulating hormone beta subunit (tsh-beta). |
2005-07-27 |
2023-08-12 |
chicken |
| Yubin Guo, Yarong Lu, Daniel Houle, Katie Robertson, Zhengyi Tang, John J Kopchick, Ye Lauren Liu, Jun-Li Li. Pancreatic islet-specific expression of an insulin-like growth factor-I transgene compensates islet cell growth in growth hormone receptor gene-deficient mice. Endocrinology. vol 146. issue 6. 2005-06-28. PMID:15731363. |
gh receptor gene deficiency (ghr(-/-)) caused diminished pancreatic islet cell mass and serum insulin level and elevated insulin sensitivity. |
2005-06-28 |
2023-08-12 |
mouse |
| Yubin Guo, Yarong Lu, Daniel Houle, Katie Robertson, Zhengyi Tang, John J Kopchick, Ye Lauren Liu, Jun-Li Li. Pancreatic islet-specific expression of an insulin-like growth factor-I transgene compensates islet cell growth in growth hormone receptor gene-deficient mice. Endocrinology. vol 146. issue 6. 2005-06-28. PMID:15731363. |
ghr(-/-) mice exhibited 50% reduction in the ratio of islet cell mass to body weight and increased insulin sensitivity but impaired glucose tolerance. |
2005-06-28 |
2023-08-12 |
mouse |
| Yubin Guo, Yarong Lu, Daniel Houle, Katie Robertson, Zhengyi Tang, John J Kopchick, Ye Lauren Liu, Jun-Li Li. Pancreatic islet-specific expression of an insulin-like growth factor-I transgene compensates islet cell growth in growth hormone receptor gene-deficient mice. Endocrinology. vol 146. issue 6. 2005-06-28. PMID:15731363. |
compared with ghr(-/-) alone, igf-i overexpression on a ghr(-/-) background caused no change in the diminished blood glucose and serum insulin levels, pancreatic insulin contents, and insulin tolerance but improved glucose tolerance and insulin secretion. |
2005-06-28 |
2023-08-12 |
mouse |
| Jie Xu, Shaonin Ji, Derwei Y Venable, John L Franklin, Joseph L Messin. Prolonged insulin treatment inhibits GH signaling via STAT3 and STAT1. The Journal of endocrinology. vol 184. issue 3. 2005-04-18. PMID:15749807. |
previous studies in our laboratory have shown that gh induction of signal transducers and activators of transcription (stat)5b tyrosine phosphorylation is inhibited by prolonged insulin treatment, probably via downregulation of ghr. |
2005-04-18 |
2023-08-12 |
rat |
| Jun-Li Liu, Karen T Coschigano, Katie Robertson, Mark Lipsett, Yubin Guo, John J Kopchick, Ujendra Kumar, Ye Lauren Li. Disruption of growth hormone receptor gene causes diminished pancreatic islet size and increased insulin sensitivity in mice. American journal of physiology. Endocrinology and metabolism. vol 287. issue 3. 2004-09-10. PMID:15138153. |
adult ghr(-/-) mice exhibited significant reductions in the levels of blood glucose and insulin, as well as insulin mrna accumulation. |
2004-09-10 |
2023-08-12 |
mouse |