| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Chengbin Wang, Pingfeng Zhang, Yanni Li, Xiong Wang, Lingzhi Guo, Jingluan Li, Huihui Jia. Downregulation of TRIM27 alleviates hypoxic-ischemic encephalopathy through inhibiting inflammation and microglia cell activation by regulating STAT3/HMGB1 axis. Journal of chemical neuroanatomy. 2023-02-16. PMID:36796734. |
in addition, overexpression of hmgb1 impaired the effects of trim27 downregulation on improving ogd-induced cell viability, inhibiting inflammatory reactions and microglia activation. |
2023-02-16 |
2023-08-14 |
rat |
| Ge Shi, Chunhui Zhang, Guoliang Li, Kaidong Wang, Qian Cai, Min Huan. Atrazine induces phagocytotic dysfunction of microglia depends on nucleocytoplasmic translocation of acetylated HMGB1. Ecotoxicology and environmental safety. vol 252. 2023-02-03. PMID:36736232. |
atrazine induces phagocytotic dysfunction of microglia depends on nucleocytoplasmic translocation of acetylated hmgb1. |
2023-02-03 |
2023-08-14 |
Not clear |
| Yangyang Shan, Panmiao Liu, Yanbo Zhou, Xin Ding, Hongtao Liu, Jianjun Yan. Prenatal Sevoflurane Exposure Impairs the Learning and Memory of Rat Offspring via HMGB1-Induced NLRP3/ASC Inflammasome Activation. ACS chemical neuroscience. 2023-01-31. PMID:36718586. |
maternal intraperitoneal injection of glycyrrhizin (an inhibitor of hmgb1) attenuated the sevoflurane-induced microglia and nlrp3/asc inflammasome activation and cognitive impairment of offspring. |
2023-01-31 |
2023-08-14 |
rat |
| Yizhang Mo, Kebing Che. Review: The role of HMGB1 in spinal cord injury. Frontiers in immunology. vol 13. 2023-01-30. PMID:36713448. |
after spinal cord injury, hmgb1 is rapidly expressed by neurons, microglia and ependymal cells, and it is either actively or passively released into the extracellular matrix and blood circulation; furthermore, it also participates in the pathophysiological process of spinal cord injury. |
2023-01-30 |
2023-08-14 |
Not clear |
| Yizhang Mo, Kebing Che. Review: The role of HMGB1 in spinal cord injury. Frontiers in immunology. vol 13. 2023-01-30. PMID:36713448. |
hmgb1 can regulate the activation of m1 microglia, exacerbate the inflammatory response, and regulate the expression of inflammatory factors through rage and tlr2/4, resulting in neuronal death. |
2023-01-30 |
2023-08-14 |
Not clear |
| Dusica Maysinger, Issan Zhang, Pei You Wu, Marten Kagelmacher, Haiming Daniel Luo, Jayachandran N Kizhakkedathu, Jens Dernedde, Matthias Ballauf, Rainer Haag, Adeola Shobo, Gerhard Multhaup, R Anne McKinne. Sulfated Hyperbranched and Linear Polyglycerols Modulate HMGB1 and Morphological Plasticity in Neural Cells. ACS chemical neuroscience. 2023-01-30. PMID:36717083. |
(ii) dpgs can normalize hmgb1 compartmentalization in microglia exposed to lps and prevent dendritic spine loss in the excitatory hippocampal neurons. |
2023-01-30 |
2023-08-14 |
Not clear |
| Zhong Luo, Meng Xu, Linhai Zhang, Haiqing Zhang, Zucai Xu, Zhongxiang X. Glycyrrhizin regulates the HMGB1/P38MAPK signalling pathway in status epilepticus. Molecular medicine reports. vol 27. issue 2. 2023-01-12. PMID:36633134. |
in the hippocampus, the protein expression levels of hmgb1 were assessed using western blotting, the neuronal damage was evaluated using haematoxylin and eosin staining and transmission electron microscopy, and the activation of microglia was assessed using immunochemistry and immunofluorescence. |
2023-01-12 |
2023-08-14 |
rat |
| Yanyan Sun, Xing Zhu, Kaiyi Zhu, Jie Yu, Lin Cheng, Mingyan He. High-mobility Group Box 1 Contributes to Hypoxic-Ischemic Brain Damage by Facilitating Imbalance of Microglial Polarization through RAGE-PI3K/Akt Pathway in Neonatal Rats. International journal of medical sciences. vol 19. issue 14. 2022-12-09. PMID:36483598. |
high mobility group box 1 (hmgb1) is a damage-associated molecular pattern integral for hypoxic-ischemic brain damage (hibd) in neonatal rats since it regulates the phenotypic polarization of microglia, as depicted in our previous studies. |
2022-12-09 |
2023-08-14 |
rat |
| Yanyan Sun, Xing Zhu, Kaiyi Zhu, Jie Yu, Lin Cheng, Mingyan He. High-mobility Group Box 1 Contributes to Hypoxic-Ischemic Brain Damage by Facilitating Imbalance of Microglial Polarization through RAGE-PI3K/Akt Pathway in Neonatal Rats. International journal of medical sciences. vol 19. issue 14. 2022-12-09. PMID:36483598. |
since this mechanism is not clear, this study establishes an oxygen-glucose deprivation (ogd) model of highly aggressively proliferating immortalized microglia while modulating the expression of hmgb1 by plasmid transfection. |
2022-12-09 |
2023-08-14 |
rat |
| Yanyan Sun, Xing Zhu, Kaiyi Zhu, Jie Yu, Lin Cheng, Mingyan He. High-mobility Group Box 1 Contributes to Hypoxic-Ischemic Brain Damage by Facilitating Imbalance of Microglial Polarization through RAGE-PI3K/Akt Pathway in Neonatal Rats. International journal of medical sciences. vol 19. issue 14. 2022-12-09. PMID:36483598. |
the m1/m2 microglial phenotype and receptor for advanced glycation end products-phosphoinositide 3-kinase/akt (rage-pi3k/akt) activation were evaluated, showing that hmgb1 promoted the polarization of microglia to the m1 phenotype under ogd conditions. |
2022-12-09 |
2023-08-14 |
rat |
| Di Mao, Yuan Zheng, Fenfen Xu, Xiao Han, Hongyang Zha. HMGB1 in nervous system diseases: A common biomarker and potential therapeutic target. Frontiers in neurology. vol 13. 2022-11-17. PMID:36388178. |
high-mobility group box-1 (hmgb1) is a nuclear protein associated with early inflammatory changes upon extracellular secretion expressed in various cells, including neurons and microglia. |
2022-11-17 |
2023-08-14 |
Not clear |
| Yun-Fei Li, Xu Ren, Liang Zhang, Yu-Hai Wang, Tao Che. Microglial polarization in TBI: Signaling pathways and influencing pharmaceuticals. Frontiers in aging neuroscience. vol 14. 2022-08-18. PMID:35978950. |
the polarization of microglia involves many cellular signal transduction pathways, such as the tlr-4/nf-κb, jak/stat, hmgb1, mapk, and ppar-γ pathways. |
2022-08-18 |
2023-08-14 |
human |
| Seung-Woo Kim, Sang-A Oh, Song-I Seol, Dashdulam Davaanyam, Ja-Kyeong Le. Cytosolic HMGB1 Mediates LPS-Induced Autophagy in Microglia by Interacting with NOD2 and Suppresses Its Proinflammatory Function. Cells. vol 11. issue 15. 2022-08-12. PMID:35954253. |
cytosolic hmgb1 mediates lps-induced autophagy in microglia by interacting with nod2 and suppresses its proinflammatory function. |
2022-08-12 |
2023-08-14 |
Not clear |
| Seung-Woo Kim, Sang-A Oh, Song-I Seol, Dashdulam Davaanyam, Ja-Kyeong Le. Cytosolic HMGB1 Mediates LPS-Induced Autophagy in Microglia by Interacting with NOD2 and Suppresses Its Proinflammatory Function. Cells. vol 11. issue 15. 2022-08-12. PMID:35954253. |
the lps-mediated autophagy induction was significantly suppressed in bv2 cells after hmgb1 or nod2 knock-down (kd), indicating that hmgb1 contributes to nod2-mediated autophagy induction in microglia. |
2022-08-12 |
2023-08-14 |
Not clear |
| Seung-Woo Kim, Sang-A Oh, Song-I Seol, Dashdulam Davaanyam, Ja-Kyeong Le. Cytosolic HMGB1 Mediates LPS-Induced Autophagy in Microglia by Interacting with NOD2 and Suppresses Its Proinflammatory Function. Cells. vol 11. issue 15. 2022-08-12. PMID:35954253. |
moreover, nod2-rip2 interaction-mediated pro-inflammatory cytokine induction and nf-κb activity were significantly enhanced in bv2 cells after hmgb1 kd, indicating that hmgb1 plays a critical role in the modulation of nod2 function between pro-inflammation and pro-autophagy in microglia. |
2022-08-12 |
2023-08-14 |
Not clear |
| Yiping Chen, Chongyao Hao, Wenjie Chen, Wenjing Cheng, Peng Li, Junliang Shen, Tao Tong, Simin Yan, Shuqiong Huang, Tianwei He, Zhiyong Huang, Xianjun Men. Anti-depressant Effects of Acupuncture: the Insights from NLRP3 mediated Pyroptosis and Inflammation. Neuroscience letters. 2022-07-12. PMID:35820551. |
results showed that acupuncture significantly improved the depression-like behavior of cums rat, suppressed the expressions of nlrp3, asc, caspase-1, gsdmd, il-1β, il-18, hmgb1, ifn-γ, il-6 and tnf-α in the serum and hippocampus, restored the %area of microglia, astrocytes and neuronal cells in the hippocampus. |
2022-07-12 |
2023-08-14 |
rat |
| Chih-Cheng Wu, Cheng-Yi Chang, Chung-Yuh Tzeng, Jen-Hsuan Huang, Chih-Jen Hung, Wen-Ying Chen, Su-Lan Liao, Yu-Hsiang Kuan, Chun-Jung Che. Preventive Intrathecal Injection of Bupivacaine Alleviated Microglia Activation and Neuropathic Pain in a Rat Model of Chronic Constriction Injury. International journal of molecular sciences. vol 23. issue 13. 2022-07-09. PMID:35806200. |
we further identified that the interferon regulatory factor 5 (irf5)/p2x purinoceptor 4 (p2x4r) and high mobility group box 1 (hmgb1)/toll-like receptor 4 (tlr4)/nf-κb inflammatory axes may each play pivotal roles in the acquisition of microglia m1 polarization and pro-inflammatory cytokine expression under cci insult. |
2022-07-09 |
2023-08-14 |
rat |
| Lu Chen, Huili Jiang, Tuya Bao, Yu Wang, Hong Meng, Yang Sun, Pengfei Liu, Songxiao Quan, Wenshan Li, Simin Qi, Xiujun Re. Acupuncture Ameliorates Depressive Behaviors by Modulating the Expression of Hippocampal Iba-1 and HMGB1 in Rats Exposed to Chronic Restraint Stress. Frontiers in psychiatry. vol 13. 2022-06-23. PMID:35733802. |
the results have also shown that acupuncture ameliorated the crs-induced activation of microglia and hmgb1 in the hippocampus ca1 region. |
2022-06-23 |
2023-08-14 |
rat |
| Kazue Hisaoka-Nakashima, Kazuto Ohata, Natsuki Yoshimoto, Shintarou Tokuda, Nanako Yoshii, Yoki Nakamura, Dengli Wang, Keyue Liu, Hidenori Wake, Takayuki Yoshida, Yukio Ago, Kouichi Hashimoto, Masahiro Nishibori, Norimitsu Moriok. High-mobility group box 1-mediated hippocampal microglial activation induces cognitive impairment in mice with neuropathic pain. Experimental neurology. 2022-06-23. PMID:35738416. |
inhibition of microglial activation with minocycline, local hippocampal microglia depletion with clodronate liposome, or blockade of hmgb1 with either glycyrrhizic acid (gza) or anti-hmgb1 antibody in psnl mice reduced hippocampal microglia activation and ameliorated cognitive impairment. |
2022-06-23 |
2023-08-14 |
mouse |
| Meng Wu, Lin Zhao, Ye Wang, Qianqian Guo, Qi An, Jie Geng, Changsheng Zhang, Zhenggang Gu. Ketamine Regulates the Autophagy Flux and Polarization of Microglia through the HMGB1-RAGE Axis and Exerts Antidepressant Effects in Mice. Journal of neuropathology and experimental neurology. 2022-05-18. PMID:35582883. |
real-time fluorescent quantitative polymerase chain reaction was used to detect the expression of the m1/m2 microglia polarization markers, hmgb1, and rage. |
2022-05-18 |
2023-08-13 |
mouse |