| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Mark Mizrachi, Kaitlin Carroll, Aida Zarfeshani, Nina Kello, Bruce Volpe, Betty Diamon. HMGB1-mediated microglial activation as a mechanism for cognitive dysfunction in neuropsychiatric lupus. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 36 Suppl 1. 2022-05-13. PMID:35556962. |
here we show that hmgb1 acts directly on microglia, where it activates microglia through rage and tlr4 signaling. |
2022-05-13 |
2023-08-13 |
mouse |
| Mark Mizrachi, Kaitlin Carroll, Aida Zarfeshani, Nina Kello, Bruce Volpe, Betty Diamon. HMGB1-mediated microglial activation as a mechanism for cognitive dysfunction in neuropsychiatric lupus. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 36 Suppl 1. 2022-05-13. PMID:35556962. |
we found that hmgb1 stimulates microglia to secrete ifna, transcriptionally upregulating interferon regulatory factors, including irf7. |
2022-05-13 |
2023-08-13 |
mouse |
| Mark Mizrachi, Kaitlin Carroll, Aida Zarfeshani, Nina Kello, Bruce Volpe, Betty Diamon. HMGB1-mediated microglial activation as a mechanism for cognitive dysfunction in neuropsychiatric lupus. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 36 Suppl 1. 2022-05-13. PMID:35556962. |
hmgb1 also stimulates microglia to secrete tnfa and il-1b, which enhances the inflammatory milieu in surrounding neurons. |
2022-05-13 |
2023-08-13 |
mouse |
| Lulu Jin, Zhixin Zhu, Liangjie Hong, Zhefeng Qian, Fang Wang, Zhengwei Ma. ROS-responsive 18β-glycyrrhetic acid-conjugated polymeric nanoparticles mediate neuroprotection in ischemic stroke through HMGB1 inhibition and microglia polarization regulation. Bioactive materials. vol 19. 2022-04-13. PMID:35415314. |
ros-responsive 18β-glycyrrhetic acid-conjugated polymeric nanoparticles mediate neuroprotection in ischemic stroke through hmgb1 inhibition and microglia polarization regulation. |
2022-04-13 |
2023-08-13 |
mouse |
| Lulu Jin, Zhixin Zhu, Liangjie Hong, Zhefeng Qian, Fang Wang, Zhengwei Ma. ROS-responsive 18β-glycyrrhetic acid-conjugated polymeric nanoparticles mediate neuroprotection in ischemic stroke through HMGB1 inhibition and microglia polarization regulation. Bioactive materials. vol 19. 2022-04-13. PMID:35415314. |
high mobility group box 1 (hmgb1) is one of the potent pro-inflammatory mediators that promotes the m1 polarization of microglia. |
2022-04-13 |
2023-08-13 |
mouse |
| Lulu Jin, Zhixin Zhu, Liangjie Hong, Zhefeng Qian, Fang Wang, Zhengwei Ma. ROS-responsive 18β-glycyrrhetic acid-conjugated polymeric nanoparticles mediate neuroprotection in ischemic stroke through HMGB1 inhibition and microglia polarization regulation. Bioactive materials. vol 19. 2022-04-13. PMID:35415314. |
to overcome the shortcomings of ga delivery and to improve the efficacy of cerebral ischemia therapy, herein, we designed reactive oxygen species (ros) responsive polymer-drug conjugate nanoparticles (dga) to manipulate microglia polarization by suppressing the translocation of nuclear hmgb1. |
2022-04-13 |
2023-08-13 |
mouse |
| Lulu Jin, Zhixin Zhu, Liangjie Hong, Zhefeng Qian, Fang Wang, Zhengwei Ma. ROS-responsive 18β-glycyrrhetic acid-conjugated polymeric nanoparticles mediate neuroprotection in ischemic stroke through HMGB1 inhibition and microglia polarization regulation. Bioactive materials. vol 19. 2022-04-13. PMID:35415314. |
altogether, our work demonstrates a close association between hmgb1 and microglia polarization, suggesting potential strategies for coping with inflammatory microglia-related diseases. |
2022-04-13 |
2023-08-13 |
mouse |
| Qian Jiang, Chao-Ran Li, Wen-Feng Zeng, Hui-Jing Xu, Jia-Mei Li, Ting Zhang, Guang-Hui Deng, Yun-Xia Wan. Inhibition of Connexin 36 attenuates HMGB1-mediated depressive-like behaviors induced by chronic unpredictable mild stress. Brain and behavior. 2022-01-28. PMID:35089644. |
high mobility group box 1 (hmgb1) released by neurons and microglia was demonstrated to be an important mediator in depressive-like behaviors induced by chronic unpredictable mild stress (cums), which could lead to the imbalance of two different metabolic approaches in kynurenine pathway (kp), thus enhancing glutamate transmission and exacerbating depressive-like behaviors. |
2022-01-28 |
2023-08-13 |
Not clear |
| Ke-Bing Chen, Min-Min Chang, Sheng-Li Wang, Yong-Xin Li, Yi-Xi Wang, Zhi-Guang Xu, Hong Wang, Bing-Cheng Zhao, Wei-Ying M. High mobility group box-1 serves a pathogenic role in spinal cord injury via the promotion of pro-inflammatory cytokines. Journal of leukocyte biology. vol 110. issue 6. 2021-11-30. PMID:34402106. |
the present study aimed to characterize the temporal dynamics of hmgb1 release after sci, to investigate the role of spinal microglia activation in mediating the effects of hmgb1 on sci, and to explore the therapeutic potential of intrathecal anti-hmgb1 polyclonal antibody on alleviating sci. |
2021-11-30 |
2023-08-13 |
Not clear |
| Ke-Bing Chen, Min-Min Chang, Sheng-Li Wang, Yong-Xin Li, Yi-Xi Wang, Zhi-Guang Xu, Hong Wang, Bing-Cheng Zhao, Wei-Ying M. High mobility group box-1 serves a pathogenic role in spinal cord injury via the promotion of pro-inflammatory cytokines. Journal of leukocyte biology. vol 110. issue 6. 2021-11-30. PMID:34402106. |
in addition, the injured neuron-derived conditioned medium increased tnf-α secretion and the nf-κb pathway in the bv2 microglia cell line via hmgb1. |
2021-11-30 |
2023-08-13 |
Not clear |
| Fulton T Crews, Jian Zou, Leon G Colema. Extracellular microvesicles promote microglia-mediated pro-inflammatory responses to ethanol. Journal of neuroscience research. vol 99. issue 8. 2021-11-18. PMID:33611821. |
depletion of microglia prior to ethanol treatment prevented pro-inflammatory activity of etoh-mvs, as did incubation of etoh-mvs with the hmgb1 inhibitor glycyrrhizin. |
2021-11-18 |
2023-08-13 |
Not clear |
| Fulton T Crews, Jian Zou, Leon G Colema. Extracellular microvesicles promote microglia-mediated pro-inflammatory responses to ethanol. Journal of neuroscience research. vol 99. issue 8. 2021-11-18. PMID:33611821. |
ethanol caused hmgb1 secretion from cultured bv2 microglia in mvs through activation of pi3 kinase. |
2021-11-18 |
2023-08-13 |
Not clear |
| Chen Qiu, Min Wang, Wen Yu, Zheng Rong, He-Sheng Zheng, Ting Sun, Shui-Bing Liu, Ming-Gao Zhao, Yu-Mei W. Activation of the Hippocampal LXRβ Improves Sleep-Deprived Cognitive Impairment by Inhibiting Neuroinflammation. Molecular neurobiology. vol 58. issue 10. 2021-10-08. PMID:34278533. |
moreover, inhibition of hmgb1 by glycyrrhizin (gly) synergistic promoted gw3965-mediated anti-inflammation in activated microglia after lipopolysaccharide (lps)/atp stimulation and facilitated the cognitive improvement after gw administration by activating lxrβ. |
2021-10-08 |
2023-08-13 |
mouse |
| Kaori Masai, Keita Kuroda, Nami Isooka, Ryo Kikuoka, Shinki Murakami, Sunao Kamimai, Dengli Wang, Keyue Liu, Ikuko Miyazaki, Masahiro Nishibori, Masato Asanum. Neuroprotective Effects of Anti-high Mobility Group Box-1 Monoclonal Antibody Against Methamphetamine-Induced Dopaminergic Neurotoxicity. Neurotoxicity research. vol 39. issue 5. 2021-09-10. PMID:34417986. |
meth injections induced hyperthermia, an increase in plasma hmgb1 concentration, degeneration of dopaminergic nerve terminals, accumulation of microglia, and extracellular release of neuronal hmgb1 in the striatum. |
2021-09-10 |
2023-08-13 |
mouse |
| Tarapati Rana, Tapan Behl, Vineet Mehta, Md Sahab Uddin, Simona Bunga. Molecular insights into the therapeutic promise of targeting HMGB1 in depression. Pharmacological reports : PR. vol 73. issue 1. 2021-09-08. PMID:33015736. |
microglia, which is the brain immune cell, is stimulated by hmgb1 and released inflammatory mediators and induces chronic neurodegeneration in the cns (central nervous system). |
2021-09-08 |
2023-08-13 |
Not clear |
| Zhou Zhenzhen, Liu Fenghao, Ma Meina, Li Rui, Sun Wenbo, Wang Q. Targeting HMGB1-TLR4 signaling by miR-216a-5p elevation alleviates the inflammatory behavioral hypersensitivity. Neuroscience letters. vol 759. 2021-08-06. PMID:34118309. |
here, decreases of mir-216a-5p and up-regulation of high-mobility group box1 (hmgb1) were observed in complete freund's adjuvant (cfa)-induced inflammatory pain model in mice and lsp-activated bv2 microglia. |
2021-08-06 |
2023-08-13 |
mouse |
| Zhou Zhenzhen, Liu Fenghao, Ma Meina, Li Rui, Sun Wenbo, Wang Q. Targeting HMGB1-TLR4 signaling by miR-216a-5p elevation alleviates the inflammatory behavioral hypersensitivity. Neuroscience letters. vol 759. 2021-08-06. PMID:34118309. |
additionally, lps exposure enhanced the protein expression levels of hmgb1, tlr4 and p-p65 nf-kb in microglia, which were abrogated following mir-216a-5p overexpression. |
2021-08-06 |
2023-08-13 |
mouse |
| Zhou Zhenzhen, Liu Fenghao, Ma Meina, Li Rui, Sun Wenbo, Wang Q. Targeting HMGB1-TLR4 signaling by miR-216a-5p elevation alleviates the inflammatory behavioral hypersensitivity. Neuroscience letters. vol 759. 2021-08-06. PMID:34118309. |
concomitantly, overexpressing mir-216a-5p also restrained the inflammatory response and microglia activation in cfa-induced inflammatory mouse models, concomitant with the decreases in the expression of hmgb1, tlr4 and p-p65 nf-kb in spinal cord. |
2021-08-06 |
2023-08-13 |
mouse |
| Carla Garza-Lombó, Morrent Thang, Hendrik J Greve, Christen L Mumaw, Evan J Messenger, Chandrama Ahmed, Emily Quinn, Kimberly Sullivan, Michelle L Bloc. Circulating HMGB1 is elevated in veterans with Gulf War Illness and triggers the persistent pro-inflammatory microglia phenotype in male C57Bl/6J mice. Translational psychiatry. vol 11. issue 1. 2021-08-02. PMID:34253711. |
circulating hmgb1 is elevated in veterans with gulf war illness and triggers the persistent pro-inflammatory microglia phenotype in male c57bl/6j mice. |
2021-08-02 |
2023-08-13 |
mouse |
| Hua Bai, Qifang Zhan. Role of N4-acetylcytidine for continuously activating NLRP3 inflammosome by HMGB1 pathway in microglia. Neural regeneration research. vol 16. issue 7. 2021-07-28. PMID:33318439. |
role of n4-acetylcytidine for continuously activating nlrp3 inflammosome by hmgb1 pathway in microglia. |
2021-07-28 |
2023-08-13 |
Not clear |