| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Shuang Chen, Yanyun Sun, Fei Li, Xinyu Zhang, Xiaoyan Hu, Xiaoyun Zhao, Yixuan Li, Hui Li, Jianliang Zhang, Wenlan Liu, Guo-Qing Zheng, Xinchun Ji. Modulation of α7nAchR by Melatonin Alleviates Ischemia and Reperfusion-Compromised Integrity of Blood-Brain Barrier Through Inhibiting HMGB1-Mediated Microglia Activation and CRTC1-Mediated Neuronal Loss. Cellular and molecular neurobiology. 2021-07-01. PMID:34196879. |
our results showed that i/r significantly increased bbb permeability accompanied by occludin degradation, microglia activation, and high mobility group box 1 (hmgb1) release from the neuron. |
2021-07-01 |
2023-08-13 |
mouse |
| Yoki Nakamura, Ayako Fukuta, Keita Miyashita, Fang Fang Zhang, Dengli Wang, Keyue Liu, Hidenori Wake, Kazue Hisaoka-Nakashima, Masahiro Nishibori, Norimitsu Moriok. Perineural high-mobility group box 1 induces mechanical hypersensitivity through activation of spinal microglia: Involvement of glutamate-NMDA receptor dependent mechanism in spinal dorsal horn. Biochemical pharmacology. vol 186. 2021-06-30. PMID:33667472. |
the current study shows that perineural treatment of naïve mice with recombinant hmgb1, which mimics increased hmgb1 around the injured sciatic nerve of psnl mice, significantly induced activation of microglia, but not astrocytes, in the spinal dorsal horn. |
2021-06-30 |
2023-08-13 |
mouse |
| Xiang Xu, Hu-Nan Piao, Fumie Aosai, Xiao-Yu Zeng, Jia-Hui Cheng, Yue-Xian Cui, Jing Li, Juan Ma, Hu-Ri Piao, Xuejun Jin, Lian-Xun Pia. Arctigenin protects against depression by inhibiting microglial activation and neuroinflammation via HMGB1/TLR4/NF-κB and TNF-α/TNFR1/NF-κB pathways. British journal of pharmacology. vol 177. issue 22. 2021-06-21. PMID:32964428. |
neuroinflammation can be caused by excessive production of proinflammatory cytokines in microglia via high-mobility group box 1 (hmgb1)/tlr4/nf-κb and tnf-α/tnfr1/nf-κb signalling pathways, leading to depression. |
2021-06-21 |
2023-08-13 |
Not clear |
| Judith Weiland, Alexandra Beez, Thomas Westermaier, Ekkehard Kunze, Anna-Leena Sirén, Nadine Lill. Neuroprotective Strategies in Aneurysmal Subarachnoid Hemorrhage (aSAH). International journal of molecular sciences. vol 22. issue 11. 2021-06-16. PMID:34064048. |
potential neuroprotective strategies regarding neuroinflammation target microglia activation, metalloproteases, autophagy and the pathway via toll-like receptor 4 (tlr4), high mobility group box 1 (hmgb1), nf-κb and finally the release of cytokines like tnfα or il-1. |
2021-06-16 |
2023-08-13 |
Not clear |
| Nilesh M Agalave, Resti Rudjito, Alex Bersellini Farinotti, Payam Emami Khoonsari, Katalin Sandor, Yuki Nomura, Thomas A Szabo-Pardi, Carlos Morado Urbina, Vinko Palada, Theodore J Price, Helena Erlandsson Harris, Michael D Burton, Kim Kultima, Camilla I Svensso. Sex-dependent role of microglia in disulfide high mobility group box 1 protein-mediated mechanical hypersensitivity. Pain. vol 162. issue 2. 2021-05-19. PMID:32773600. |
here, we examined whether the action of tlr4-activating, partially reduced disulfide hmgb1 on microglia induces nociceptive behaviors in a sex-dependent manner. |
2021-05-19 |
2023-08-13 |
mouse |
| Bo Wang, Xiao Huang, Xiao Pan, Ting Zhang, Cheng Hou, Wen-Jun Su, Lin-Lin Liu, Jia-Mei Li, Yun-Xia Wan. Minocycline prevents the depressive-like behavior through inhibiting the release of HMGB1 from microglia and neurons. Brain, behavior, and immunity. vol 88. 2021-04-27. PMID:32553784. |
minocycline prevents the depressive-like behavior through inhibiting the release of hmgb1 from microglia and neurons. |
2021-04-27 |
2023-08-13 |
Not clear |
| Bin Xu, Li-Min Lang, Shuai Lian, Jing-Ru Guo, Jian-Fa Wang, Juxiong Liu, Huan-Min Yang, Shi-Ze L. Neuroinflammation induced by secretion of acetylated HMGB1 from activated microglia in hippocampi of mice following chronic cold exposure. Brain research. vol 1726. 2021-03-29. PMID:31586627. |
neuroinflammation induced by secretion of acetylated hmgb1 from activated microglia in hippocampi of mice following chronic cold exposure. |
2021-03-29 |
2023-08-13 |
mouse |
| Jiah Pearson-Leary, Darrell Eacret, Seema Bhatnaga. Interleukin-1α in the ventral hippocampus increases stress vulnerability and inflammation-related processes. Stress (Amsterdam, Netherlands). vol 23. issue 3. 2021-03-24. PMID:31559913. |
further analysis of vhpc of il1-α-injected rats showed increased density of microglia, increased expression of the pro-inflammatory cytokine hmgb1, and increases in a marker for vascular remodeling. |
2021-03-24 |
2023-08-13 |
rat |
| Susruta Manivannan, Balkis Harari, Maryam Muzaffar, Omar Elalfy, Sameera Hettipathirannahelage, Zoe James, Feras Sharouf, Chloe Ormonde, Mouhamed Alsaqati, William Gray, Malik Zabe. Glycyrrhizin Blocks the Detrimental Effects of HMGB1 on Cortical Neurogenesis After Traumatic Neuronal Injury. Brain sciences. vol 10. issue 10. 2021-02-17. PMID:33096930. |
needle-injury upregulated tnf-α/nos-2 mrna-expressions at 6 h, increased proportions of activated microglia, and caused neuronal loss at 24 h. transcriptome analysis revealed activation of hmgb1 pathway genes/canonical pathways in vivo at 24 h. a 50% increase in hmgb1 protein expression, and nuclear-to-cytoplasmic translocation of hmgb1 in neurons and microglia at 24 h post-injury was demonstrated in vitro. |
2021-02-17 |
2023-08-13 |
mouse |
| Claudia Espinosa-Garcia, Fahim Atif, Seema Yousuf, Iqbal Sayeed, Gretchen N Neigh, Donald G Stei. Progesterone Attenuates Stress-Induced NLRP3 Inflammasome Activation and Enhances Autophagy following Ischemic Brain Injury. International journal of molecular sciences. vol 21. issue 11. 2021-02-16. PMID:32466385. |
stress primes microglia, mainly by the release of alarmins such as high-mobility group box-1 (hmgb1). |
2021-02-16 |
2023-08-13 |
rat |
| Degang Han, Zheng Zhou, Jingpeng Liu, Tingting Wang, Jinbo Yi. Neuroprotective effects of isoflurane against lipopolysaccharide-induced neuroinflammation in BV2 microglial cells by regulating HMGB1/TLRs pathway. Folia neuropathologica. vol 58. issue 1. 2021-02-04. PMID:32337958. |
therefore, we suggested that isoflurane inhibits the activation of lps-induced neuro microglia and reduces the release of inflammatory factors by regulating hmgb1, suggesting that isoflurane might play a protective role in lps-induced neuroinflammation through the hmgb1 pathway. |
2021-02-04 |
2023-08-13 |
Not clear |
| Xiaoyun Gou, Junjie Ying, Yan Yue, Xia Qiu, Peng Hu, Yi Qu, Jinhui Li, Dezhi M. The Roles of High Mobility Group Box 1 in Cerebral Ischemic Injury. Frontiers in cellular neuroscience. vol 14. 2021-01-02. PMID:33384585. |
hmgb1 can be passively released from necrotic neurons or actively secreted by microglia, macrophages/monocytes, and neutrophils. |
2021-01-02 |
2023-08-13 |
Not clear |
| Yu Tian, Yuwen Cao, Rong Chen, Yufeng Jing, Lin Xia, Shiqing Zhang, Huaxi Xu, Zhaoliang S. HMGB1 A box protects neurons by potently inhibiting both microglia and T cell-mediated inflammation in a mouse Parkinson's disease model. Clinical science (London, England : 1979). vol 134. issue 15. 2020-12-29. PMID:32706028. |
hmgb1 a box protects neurons by potently inhibiting both microglia and t cell-mediated inflammation in a mouse parkinson's disease model. |
2020-12-29 |
2023-08-13 |
mouse |
| Yu Tian, Yuwen Cao, Rong Chen, Yufeng Jing, Lin Xia, Shiqing Zhang, Huaxi Xu, Zhaoliang S. HMGB1 A box protects neurons by potently inhibiting both microglia and T cell-mediated inflammation in a mouse Parkinson's disease model. Clinical science (London, England : 1979). vol 134. issue 15. 2020-12-29. PMID:32706028. |
our data show that a box up-regulated cd200-cd200r signal of microglia inhibited the activation of microglia mediated by hmgb1, and the production of tnf-α, il-1β and il-6 in vivo and in vitro mixed culture system. |
2020-12-29 |
2023-08-13 |
mouse |
| Yu Tian, Yuwen Cao, Rong Chen, Yufeng Jing, Lin Xia, Shiqing Zhang, Huaxi Xu, Zhaoliang S. HMGB1 A box protects neurons by potently inhibiting both microglia and T cell-mediated inflammation in a mouse Parkinson's disease model. Clinical science (London, England : 1979). vol 134. issue 15. 2020-12-29. PMID:32706028. |
to sum up, our results show that hmgb1 a box targeting hmgb1, which effectively reduces the activation of microglia in mptp pd model by restoring cd200-cd200r signal inhibit microglia mediated neuroinflammation and the differentiation of t cells to th17. |
2020-12-29 |
2023-08-13 |
mouse |
| Jiankai Yang, Guozhu Sun, Yuhua Hu, Jipeng Yang, Yijun Shi, Hongjiang Liu, Chen Li, Yuanyu Wang, Zhongqiang Lv, Jianxing Niu, Honglei Liu, Xuefang Shi, Haiping Wang, Pan Li, Baohua Jia. Extracellular Vesicle lncRNA Metastasis-Associated Lung Adenocarcinoma Transcript 1 Released From Glioma Stem Cells Modulates the Inflammatory Response of Microglia After Lipopolysaccharide Stimulation Through Regulating miR-129-5p/High Mobility Group Box-1 Protein Axis. Frontiers in immunology. vol 10. 2020-11-18. PMID:32117213. |
luciferase reporter assay testified the direct binding of malat1 and mir-129-5p, mir-129-5p, and hmgb1, and si-malat1 could up-regulate mir-129-5p expression and down-regulate hmgb1 expression in microglia cells. |
2020-11-18 |
2023-08-13 |
Not clear |
| Yingze Ye, Zhi Zeng, Tong Jin, Hongfei Zhang, Xiaoxing Xiong, Lijuan G. The Role of High Mobility Group Box 1 in Ischemic Stroke. Frontiers in cellular neuroscience. vol 13. 2020-09-29. PMID:31001089. |
high-mobility group box 1 protein (hmgb1) is a novel, cytokine-like, and ubiquitous, highly conserved, nuclear protein that can be actively secreted by microglia or passively released by necrotic neurons. |
2020-09-29 |
2023-08-13 |
Not clear |
| Wei He, Kaiming Yuan, Bin Ji, Yuan Han, Jun L. Protective effects of curcumin against neuroinflammation induced by Aβ25-35 in primary rat microglia: modulation of high-mobility group box 1, toll-like receptor 4 and receptor for advanced glycation end products expression. Annals of translational medicine. vol 8. issue 4. 2020-09-28. PMID:32175381. |
however, whether curcumin could effectively inhibit inflammation through the suppression of hmgb1 production or hmgb1-mediated inflammatory responses in aβ-activated microglia is still unclear. |
2020-09-28 |
2023-08-13 |
rat |
| Shi Yu, Hujing Zhang, Yue Hei, Xicai Yi, Andrius Baskys, Weiping Liu, Qianfa Lon. High mobility group box-1 (HMGB1) antagonist BoxA suppresses status epilepticus-induced neuroinflammatory responses associated with Toll-like receptor 2/4 down-regulation in rats. Brain research. vol 1717. 2020-09-24. PMID:30986405. |
hmgb1 exerts its influence on microglia via various pathways including toll-like receptor (tlr) subtypes 2 and 4. |
2020-09-24 |
2023-08-13 |
rat |
| Shi Yu, Hujing Zhang, Yue Hei, Xicai Yi, Andrius Baskys, Weiping Liu, Qianfa Lon. High mobility group box-1 (HMGB1) antagonist BoxA suppresses status epilepticus-induced neuroinflammatory responses associated with Toll-like receptor 2/4 down-regulation in rats. Brain research. vol 1717. 2020-09-24. PMID:30986405. |
in ex vivo experiments, post-se microglia cells were isolated from the hippocampal ca1 area and subjected to lipopolysaccharide (lps) stimulation followed by inflammatory cytokine il-1β and il-6 by qpcr and hmgb1, tlr2, tlr3 by western blotting. |
2020-09-24 |
2023-08-13 |
rat |