| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jing Wang, Lisha Li, Jing Zhou, Xinyao Pan, Qing Qi, Hongmei Sun, Ling Wan. Yishen Huatan Huoxue decoction and quercetin ameliorate decidualization dysfunction in polycystic ovary syndrome: A comprehensive investigation combining clinical trial and experimental studies. Drug discoveries & therapeutics. 2024-04-21. PMID:38644207. |
quercetin could alleviate effect of high insulin levels and restore the low expression of insulin receptor substrate1/2 (irs1/2) and glucose transporte 4 (glut4) in t-hescs, demonstrating its potential to mitigate hyperinsulin-induced decidualization dysfunction via the glut4 signaling pathway mediated by irs1/2. |
2024-04-21 |
2024-04-24 |
mouse |
| Martin J Kelly, Edward J Wagne. Canonical transient receptor potential channels and hypothalamic control of homeostatic functions. Journal of neuroendocrinology. 2024-04-17. PMID:38631680. |
in addition to neurotransmitters, circulating hormones like insulin and leptin signal through insulin receptor (insr) and leptin receptor (lrb), respectively, to activate trpc 5 channels in hypothalamic arcuate nucleus pro-opiomelanocortin (pomc) and kisspeptin (arcuate kiss1 [kiss1 |
2024-04-17 |
2024-04-20 |
Not clear |
| Andrew L Zhou, Suresh K Swaminathan, Vrishali S Salian, Lushan Wang, Geoffry L Curran, Hoon-Ki Min, Val J Lowe, Karunya K Kandimall. Insulin Signaling Differentially Regulates the Trafficking of Insulin and Amyloid Beta Peptides at the Blood-Brain Barrier. Molecular pharmaceutics. 2024-04-16. PMID:38625027. |
thus, we investigated the impact of insulin-like growth factor and insulin receptor (igf1r and ir) signaling on aβ and insulin trafficking at the bbb. |
2024-04-16 |
2024-04-18 |
mouse |
| Álan Gomes Pöppl, José Lucas Xavier Lopes, Taís Bock Nogueira, Denise Iparraguirre da Silva, Bruna Dos Santos Machad. Progesterone-Related Diabetes Mellitus in the Bitch: Current Knowledge, the Role of Pyometra, and Relevance in Practice. Animals : an open access journal from MDPI. vol 14. issue 6. 2024-03-28. PMID:38539988. |
the estrus cycle's hormone fluctuations seem to modulate peripheric insulin sensibility by influencing insulin receptor (ir) affinity and its binding capacity, as well as modulating tyrosine kinase activity. |
2024-03-28 |
2024-03-30 |
Not clear |
| Marcin Drozd, Ewa Kobylska, Małgorzata Żmieńko, Michał Chud. Sensitive and label-free SPR biosensing platforms for high-throughput screening of plasma membrane receptors interactions with insulin-like targets of hypoglycaemic activity. Talanta. vol 274. 2024-03-27. PMID:38537356. |
preclinical screening of new medicines superior to insulin should include the verification of their affinity to the membrane receptors naturally stimulated by this hormone: insulin receptor isoforms a and b and insulin-like growth factor receptor. |
2024-03-27 |
2024-03-30 |
human |
| Laura Schwartz, Kristin Salamon, Aaron Simoni, Tad Eichler, Ashley R Jackson, Matthew Murtha, Brian Becknell, Andrew Kauffman, Sarah Linn-Peirano, Natalie Holdsworth, Vidhi Tyagi, Hancong Tang, Steve Rust, Hanna Cortado, Irina Zabbarova, Anthony Kanai, John David Spence. Insulin receptor signaling engages bladder urothelial defenses that limit urinary tract infection. Cell reports. vol 43. issue 4. 2024-03-22. PMID:38517889. |
to better understand the mechanisms that predispose diabetics to utis, we employ diabetic mouse models and altered insulin signaling to show that insulin receptor (ir) shapes uti defenses. |
2024-03-22 |
2024-03-25 |
mouse |
| Justin Flaven-Pouchon, Christin Froschauer, Bernard Moussia. Dynamics of cuticle-associated transcript profiles during moulting of the bed bug Cimexlectularius. Insect biochemistry and molecular biology. 2024-03-21. PMID:38513961. |
second, timed expression of clec-ftz-f1 seems to depend also on the insulin signalling pathway as rna interference against transcripts of the insulin receptor delays clec-ftz-f1 expression and stage transition. |
2024-03-21 |
2024-03-24 |
human |
| Surasak Wichaiyo, Pimpisid Koonyosying, Noppawan Phumala Morale. Functional Roles of Furin in Cardio-Cerebrovascular Diseases. ACS pharmacology & translational science. vol 7. issue 3. 2024-03-14. PMID:38481703. |
in diabetes, furin downregulation potentially leads to insulin resistance by reducing maturation of the insulin receptor. |
2024-03-14 |
2024-03-16 |
Not clear |
| Man-Chen Hsu, Chia-Hui Chen, Mu-Chun Wang, Wen-Hua Chen, Po-An Hu, Bei-Chia Guo, Ru-Wen Chang, Chih-Hsien Wang, Tzong-Shyuan Le. Apigenin targets fetuin-A to ameliorate obesity-induced insulin resistance. International journal of biological sciences. vol 20. issue 5. 2024-03-14. PMID:38481798. |
fetuin-a, a hepatokine secreted by hepatocytes, binds to insulin receptors and consequently impairs the activation of the insulin signaling pathway, leading to insulin resistance. |
2024-03-14 |
2024-03-16 |
mouse |
| Jianjian Shi, Lei We. ROCK1 deficiency preserves caveolar compartmentalization of signaling molecules and cell membrane integrity. FASEB bioAdvances. vol 6. issue 3. 2024-03-11. PMID:38463696. |
in cardiomyocytes and adipocytes, we detected that rock1 deficiency increased insulin signaling with increased insulin receptor activation in caveolae. |
2024-03-11 |
2024-03-14 |
mouse |
| Mairéad T Crowley, Eirena Goulden, Begona Sanchez-Lechuga, Aileen Fleming, Maria Kennelly, Ciara McDonnell, Maria M Byrn. Case report: Glycaemic management and pregnancy outcomes in a woman with an insulin receptor mutation, p.Met1180Lys. Clinical diabetes and endocrinology. vol 10. issue 1. 2024-03-09. PMID:38461278. |
heterozygous insulin receptor mutations (insr) are associated with insulin resistance, hyperglycaemia and hyperinsulinaemic hypoglycaemia in addition to hyperandrogenism and oligomenorrhoea in women. |
2024-03-09 |
2024-03-12 |
Not clear |
| Felix Schöler, Maximilian Andreas Storz, Ashkan Khavaran, Nicolas Hümmler, Maximilian Frederik Russe, Christoph-Ferdinand Wielenberg, Katharina Laubner, Jochen Seufer. Effective management of recurrent Doege-Potter syndrome with somatostatin-analogues: A case report. Cancer reports (Hoboken, N.J.). vol 7. issue 3. 2024-03-05. PMID:38441351. |
this prohormone aberrantly binds to and activates insulin receptors, with consecutive initiation of common insulin actions such as inhibition of gluconeogenesis, activation of glycolysis and stimulation of cellular glucose uptake culminating in recurrent tumor-induced hypoglycemic episodes. |
2024-03-05 |
2024-03-07 |
Not clear |
| Nidhee Chaudhary, Bellam Kiranmaye. Non-Receptor Type PTPases and their Role in Controlling Pathways Related to Diabetes and Liver Cancer Signalling. Current pharmaceutical biotechnology. 2024-02-29. PMID:38424416. |
the insulin signal transduction pathway is regulated by the steady-state phosphorylation of tyrosyl residues of the insulin receptor and post-receptor substrates. |
2024-02-29 |
2024-03-03 |
Not clear |
| Alexandre Guillot, Kevin Toussaint, Lucrece Ebersold, Hassan ElBtaouri, Emilie Thiebault, Tarik Issad, Franck Peiretti, Pascal Maurice, Hervé Sartelet, Amar Bennasroune, Laurent Martiny, Manuel Dauchez, Laurent Duca, Vincent Durlach, Béatrice Romier, Stéphanie Baud, Sébastien Blais. Sialic acids cleavage induced by elastin-derived peptides impairs the interaction between insulin and its receptor in adipocytes 3T3-L1. Journal of physiology and biochemistry. 2024-02-23. PMID:38393636. |
the insulin receptor (ir) plays an important role in insulin signal transduction, the defect of which is believed to be the root cause of type 2 diabetes. |
2024-02-23 |
2024-02-25 |
Not clear |
| Ming Cai, Jian Wan, Keren Cai, Shuyao Li, Xinlin Du, Haihan Song, Wanju Sun, Jingyun H. The mitochondrial quality control system: a new target for exercise therapeutic intervention in the treatment of brain insulin resistance-induced neurodegeneration in obesity. International journal of obesity (2005). 2024-02-21. PMID:38379083. |
since the evidence shows that insulin resistance in brain regions abundant in insulin receptors significantly alters mitochondrial efficiency and function, strategies targeting the mitochondrial quality control system may be of therapeutic and practical value in obesity-induced cognitive decline. |
2024-02-21 |
2024-02-23 |
Not clear |
| Pallavi Asthana, Hoi Leong Xavier Won. Preventing obesity, insulin resistance and type 2 diabetes by targeting MT1-MMP. Biochimica et biophysica acta. Molecular basis of disease. 2024-02-17. PMID:38367902. |
furthermore, increased activation of mt1-mmp does not only lead to increased risk of obesity, but also causes age-associated insulin resistance by cleaving insulin receptor in major metabolic tissues. |
2024-02-17 |
2024-02-20 |
Not clear |
| Fusun Kilic, Imane Moutkine, Luc Maroteau. Association with serotonin transporter enables the phosphorylation of insulin receptor in placenta. Current topics in biochemical research. vol 20. 2024-02-08. PMID:38327526. |
upon binding to insulin, the β-subunit of insulin receptor (ir) is phosphorylated and instantly activates intracellular signaling. |
2024-02-08 |
2024-02-10 |
Not clear |
| Ziheng Zhuang, Tianwen Liu, Zhengying Liu, Dayong Wan. Polystyrene nanoparticles strengthen high glucose toxicity associated with alteration in insulin signaling pathway in C. elegans. Ecotoxicology and environmental safety. vol 272. 2024-02-01. PMID:38301579. |
in insulin signaling pathway, expressions of genes encoding insulin receptor (daf-2), kinases (age-1 and akt-1/2), and insulin peptides (ins-9, ins-6, and daf-28) were increased, and expressions of daf-16 and its target of sod-3 were decreased in high glucose treated nematodes followed by ps-np exposure. |
2024-02-01 |
2024-02-04 |
caenorhabditis_elegans |
| Xingyue Zeng, ChengYan Wu, Yongkai Cao, Huijun Li, Xiaohan Zhan. Mdm2-mediated ubiquitination of PKCβII is responsible for insulin-induced heterologous desensitization of dopamine D FEBS letters. 2024-02-01. PMID:38302840. |
the present study investigated the crosstalk between the insulin receptor (ir) and dopamine receptor and found that insulin stimulation selectively inhibits signaling of d |
2024-02-01 |
2024-02-04 |
Not clear |
| Yi Wolf Zhang, Nai-Pin Lin, Xu Guo, Nicolas Szabo-Fresnais, Peter J Ortoleva, Danny Hung-Chieh Cho. Omniligase-1-Mediated Phage-Peptide Library Modification and Insulin Engineering. ACS chemical biology. 2024-01-24. PMID:38266161. |
molecular dynamics studies of insulin analogues revealed a novel interaction between the insulin b27 residue and insulin receptor l1 domain. |
2024-01-24 |
2024-01-27 |
human |