| Reference |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jun Shirakaw. Signaling pathways that regulate adaptive \\xce\\xb2-cell proliferation for the treatment of diabetes. Journal of diabetes investigation vol issue 2023 36871280 |
insulin and insulin receptor (ir)-mediated signaling pathways play an important role in the mechanism that increases \xce\xb2-cell mass by compensatory \xce\xb2-cell proliferation in response to chronic insulin resistance. |
2023-03-05 |
2023-03-06 |
human |
| Waldemar B Minich, Brent S Abel, Christian Schwiebert, Tim Welsink, Petra Seemann, Rebecca J Brown, Lutz Schombur. A novel in vitro assay correlates insulin receptor autoantibodies to fasting insulin in type B insulin resistance. The Journal of clinical endocrinology and metabolism vol issue 2023 36869714 |
a novel in vitro assay correlates insulin receptor autoantibodies to fasting insulin in type b insulin resistance. |
2023-03-04 |
2023-03-06 |
Not clear |
| Waldemar B Minich, Brent S Abel, Christian Schwiebert, Tim Welsink, Petra Seemann, Rebecca J Brown, Lutz Schombur. A novel in vitro assay correlates insulin receptor autoantibodies to fasting insulin in type B insulin resistance. The Journal of clinical endocrinology and metabolism vol issue 2023 36869714 |
severe insulin resistance in the presence of insulin receptor autoantibodies (insr-aab) is known as type b insulin resistance (tbir). |
2023-03-04 |
2023-03-06 |
Not clear |
| Hayder M Al-Kuraishy, Ali I Al-Gareeb, Hebatallah M Saad, Gaber El-Saber Batih. Long-term use of metformin and Alzheimer's disease: beneficial or detrimental effects. Inflammopharmacology vol issue 2023 36849855 |
t2dm and peripheral insulin resistance (ir) augment the risk of ad with the development of brain ir with inhibition of neuronal insulin receptors. |
2023-02-28 |
2023-03-06 |
Not clear |
| Jinghua Peng, Balamurugan Ramatchandirin, Alexia Pearah, Ling H. Far-western Blotting Detection of the Binding of Insulin Receptor Substrate to the Insulin Receptor. Bio-protocol vol 13 issue 4 2023 36845537 |
the binding of the insulin receptor substrate (irs) to the insulin receptor is essential for the propagation of downstream signaling after the activation of the insulin receptor by insulin. |
2023-02-27 |
2023-03-06 |
Not clear |
| Jan A Veenstr. Different neuroendocrine cell types in the pars intercerebralis of Periplaneta americana produce their own specific IGF-related peptides. General and comparative endocrinology vol issue 2023 36791825 |
the separate cellular localization of these peptides and the existence of multiple insulin receptors in this species implies a more complex regulation by insulin and igf-related peptides in cockroaches than in the fruit fly. |
2023-02-15 |
2023-03-06 |
drosophila_melanogaster |
| J\\xc3\\xa9ssica Paloma \\xc3\\x81lvarez-Rend\\xc3\\xb3n, Juan Rafael Riesgo-Escova. Activation of the Cap'n'collar C pathway (Nrf2 pathway in vertebrates) signaling in insulin pathway compromised Drosophila melanogaster flies ameliorates the diabetic state upon pro-oxidant conditions. General and comparative endocrinology vol issue 2023 36781022 |
we then tested two hypomorphic viable conditions of the insulin pathway (heteroallelic combination for the insulin receptor and the s6 kinase), challenged in the same way: whereas they also die in the pro-oxidant conditions, they fare significantly better when heterozygous for keap1, in contrast to controls. |
2023-02-13 |
2023-03-06 |
drosophila_melanogaster |
| Nadine Bahour, Lucia Bleichmar, Cristian Abarca, Emeline Wilmann, Stephanie Sanjines, Cristina Aguayo-Mazzucat. Clearance of p16Ink4a-positive cells in a mouse transgenic model does not change \\xce\\xb2-cell mass and has limited effects on their proliferative capacity. Aging vol 15 issue 2 2023 36640267 |
clearance of p16ink4a positive subpopulation was tested in mice of different ages, males and females, and with two different insulin resistance models: high-fat diet (hfd) and insulin receptor antagonist (s961). |
2023-02-06 |
2023-03-06 |
mouse |
| Christopher Mendoza, Cameron Hanegan, Alek Sperry, Logan Vargas, Trevor Case, Benjamin Bikman, Dario Mizrach. Insulin receptor-inspired soluble insulin binder. European journal of cell biology vol 102 issue 2 2023 36739671 |
the insulin receptor (ir) is a 320\xc2\xa0kda membrane receptor tyrosine kinase mediating the pleiotropic actions of insulin, leading to phosphorylation of several intracellular substrates including serine/threonine-protein kinase (akt1), and ir autophosphorylation. |
2023-02-05 |
2023-03-06 |
Not clear |
| Tasmia Ahmed, Paola Cruz Flores, Christopher C Pan, Hannah R Ortiz, Yeon S Lee, Paul R Langlais, Karthikeyan Mythreye, Nam Y Le. EPDR1 is a noncanonical effector of insulin-mediated angiogenesis regulated by an endothelial-specific TGF-\\xce\\xb2 receptor complex. The Journal of biological chemistry vol 298 issue 9 2023 35872017 |
while the endoglin-alk1 complex normally binds to tgf-\xce\xb2 or bone morphogenetic protein 9 (bmp9) to promote gene regulation via transcription factors smad1/5, we show that insulin drives insulin receptor oligomerization with endoglin-alk1 at the cell surface to trigger rapid smad1/5 activation. |
2023-02-03 |
2023-03-06 |
Not clear |
| Nawon Lee, Jieun Jeong, Hyejin Park, Chang-Seok Ki, Jin-Kyung Ki. A case of Type A insulin resistance syndrome in a 14-year-old girl without common clinical features. Annals of pediatric endocrinology & metabolism vol issue 2023 36731506 |
type a insulin resistance syndrome is a rare congenital disorder caused by insulin receptor dysfunction arising from heterozygous mutations in the insulin receptor (insr) gene. |
2023-02-02 |
2023-03-06 |
Not clear |
| Aashutosh U Shetti, Abhirami Ramakrishnan, Liudmila Romanova, Wenping Li, Khanh Vo, Ipsita Volety, Ishara Ratnayake, Terilyn Stephen, Richard D Minshall, Stephanie M Cologna, Orly Lazaro. Reduced endothelial caveolin-1 underlies deficits in brain insulin signalling in type 2 diabetes. Brain : a journal of neurology vol issue 2023 36731883 |
interactome analysis revealed the insulin receptor interacts with cav-1 and caveolae-associated proteins, insulin degrading enzyme, and the tight junction protein zonula occludence-1 in brain endothelial cells. |
2023-02-02 |
2023-03-06 |
mouse |
| Giancarlo G M Talarico, M\\xc3\\xa9lissa Gr\\xc3\\xa9goire, Jean-Michel Weber, Jan A Mennige. The mammalian insulin antagonist S961 does not exhibit insulin receptor antagonism in rainbow trout in vivo. Journal of fish biology vol issue 2023 36704867 |
the mammalian insulin antagonist s961 does not exhibit insulin receptor antagonism in rainbow trout in vivo. |
2023-01-27 |
2023-01-31 |
cattle |
| Giancarlo G M Talarico, M\\xc3\\xa9lissa Gr\\xc3\\xa9goire, Jean-Michel Weber, Jan A Mennige. The mammalian insulin antagonist S961 does not exhibit insulin receptor antagonism in rainbow trout in vivo. Journal of fish biology vol issue 2023 36704867 |
here, we report two separate in vivo experiments to test the ability of the mammalian insulin receptor antagonist, s961, to efficiently block insulin signaling in liver and muscle in response to endogenously released insulin and to exogenously infused bovine insulin. |
2023-01-27 |
2023-01-31 |
cattle |
| Nahla E El-Ashmawy, Eman G Khedr, Nehal H Alfeky, Amera O Ibrahi. Upregulation of GLUT4 and PI3K, and downregulation of GSK3 mediate the anti-hyperglycemic effects of proanthocyanidins. Medicine international vol 2 issue 3 2023 36698506 |
the results indicated that opc ameliorated the diabetic state, as evidenced by a significant decrease in serum glucose levels, and a significant increase in the levels of insulin, amylin, insulin receptor phosphorylation, glycogen and glucose transporter-4 translocation; it also improved the lipid profile in stz-diabetic rats. |
2023-01-26 |
2023-01-31 |
rat |
| Antonella Tramutola, Simona Lanzillotta, Giuseppe Aceto, Sara Pagnotta, Gabriele Ruffolo, Pierangelo Cifelli, Federico Marini, Cristian Ripoli, Eleonora Palma, Claudio Grassi, Fabio Di Domenico, Marzia Perluigi, Eugenio Baron. Intranasal Administration of KYCCSRK Peptide Rescues Brain Insulin Signaling Activation and Reduces Alzheimer's Disease-like Neuropathology in a Mouse Model for Down Syndrome. Antioxidants (Basel, Switzerland) vol 12 issue 1 2023 36670973 |
here we tested the effects promoted in ts2cje mice by the intranasal administration of the kyccsrk peptide known to foster insulin signaling activation by directly interacting and activating the insulin receptor (ir) and the akt protein. |
2023-01-21 |
2023-01-30 |
mouse |
| Antonino Belfiore, Rosaria Valentina Rapicavoli, Rosario Le Moli, Rosamaria Lappano, Andrea Morrione, Ernestina Marianna De Francesco, Veronica Vell. IGF2: A Role in Metastasis and Tumor Evasion from Immune Surveillance? Biomedicines vol 11 issue 1 2023 36672737 |
dysregulation of the expression and function of igf2 receptors, insulin receptor isoform a (ir-a), insulin growth factor receptor 1 (igf1r), and their downstream signaling effectors drive cancer initiation and progression. |
2023-01-21 |
2023-01-30 |
Not clear |
| Yinghao Wang, Guanfu Liu, Xutao Liu, Minhua Chen, Yuping Zeng, Yuyan Li, Xiaoyun Wu, Xuanjun Wang, Jun Shen. Serpentine Enhances Insulin Regulation of Blood Glucose through Insulin Receptor Signaling Pathway. Pharmaceuticals (Basel, Switzerland) vol 16 issue 1 2023 36678512 |
serpentine enhances insulin regulation of blood glucose through insulin receptor signaling pathway. |
2023-01-21 |
2023-01-30 |
Not clear |
| Yinghao Wang, Guanfu Liu, Xutao Liu, Minhua Chen, Yuping Zeng, Yuyan Li, Xiaoyun Wu, Xuanjun Wang, Jun Shen. Serpentine Enhances Insulin Regulation of Blood Glucose through Insulin Receptor Signaling Pathway. Pharmaceuticals (Basel, Switzerland) vol 16 issue 1 2023 36678512 |
insulin sensitizers targeting insulin receptors (ir) are a potential drug for the treatment of diabetes. |
2023-01-21 |
2023-01-30 |
Not clear |
| Binyuan Yang, Gang Zhai, Yulong Gong, Jingzhi Su, Dong Han, Zhan Yin, Shouqi Xi. Depletion of insulin receptors leads to \\xce\\xb2-cell hyperplasia in zebrafish. Science bulletin vol 62 issue 7 2023 36659257 |
given the importance of insulin receptors in glucose homeostasis and embryonic development, transcriptome analysis was used to provide an important model of defective insulin signaling and to study its developmental consequences in zebrafish. |
2023-01-20 |
2023-01-30 |
zebrafish |