| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| R S Bar, P Gorden, J Roth, C R Kahn, P De Meyt. Fluctuations in the affinity and concentration of insulin receptors on circulating monocytes of obese patients: effects of starvation, refeeding, and dieting. The Journal of clinical investigation. vol 58. issue 5. 1977-01-25. PMID:993336. |
in the basal, fed state the monocytes of obese patients with clinical insulin resistance (n= 6) bound less insulin than normals (n =10) because of a decrease in insulin receptor concentration (obese = 6,000-13,000 sites per monocyte versus normals 15,000-28,000 sites per monocyte). |
1977-01-25 |
2023-08-11 |
mouse |
| R S Bar, P Gorden, J Roth, C R Kahn, P De Meyt. Fluctuations in the affinity and concentration of insulin receptors on circulating monocytes of obese patients: effects of starvation, refeeding, and dieting. The Journal of clinical investigation. vol 58. issue 5. 1977-01-25. PMID:993336. |
when the data from this study are coupled with previous in vivo and in vitro findings they suggest that the insulin receptor of human monocytes is more sensitive to regulation by ambient insulin than the receptors of obese mice and cultured human lymphocytes. |
1977-01-25 |
2023-08-11 |
mouse |
| R S Bar, P Gorden, J Roth, C R Kahn, P De Meyt. Fluctuations in the affinity and concentration of insulin receptors on circulating monocytes of obese patients: effects of starvation, refeeding, and dieting. The Journal of clinical investigation. vol 58. issue 5. 1977-01-25. PMID:993336. |
the results further indicate than an insulin receptor undergoes in vivo modulation of its interaction with insulin by changing receptor concentration and by altering the affinity of existing receptors. |
1977-01-25 |
2023-08-11 |
mouse |
| L C Harrison, F I Martin, R A Melic. Correlation between insulin receptor binding in isolated fat cells and insulin sensitivity in obese human subjects. The Journal of clinical investigation. vol 58. issue 6. 1977-01-25. PMID:993352. |
correlation between insulin receptor binding in isolated fat cells and insulin sensitivity in obese human subjects. |
1977-01-25 |
2023-08-11 |
mouse |
| J S Flier, C R Kahn, D B Jarrett, J Rot. Characterization of antibodies to the insulin receptor: a cause of insulin-resistant diabetes in man. The Journal of clinical investigation. vol 58. issue 6. 1977-01-25. PMID:993353. |
we have characterized the circulating inhibitor of insulin receptor binding found in several patients with a new syndrome of extreme insulin resistance. |
1977-01-25 |
2023-08-11 |
Not clear |
| J S Flier, C R Kahn, D B Jarrett, J Rot. Characterization of antibodies to the insulin receptor: a cause of insulin-resistant diabetes in man. The Journal of clinical investigation. vol 58. issue 6. 1977-01-25. PMID:993353. |
evidence suggests that these antibodies are directed at determinants on or near the insulin receptor, and that they are responsible for the observed clinical insulin resistance. |
1977-01-25 |
2023-08-11 |
Not clear |
| J M Olefsk. Effects of fasting on insulin binding, glucose transport, and glucose oxidation in isolated rat adipocytes: relationships between insulin receptors and insulin action. The Journal of clinical investigation. vol 58. issue 6. 1977-01-25. PMID:993354. |
effects of fasting on insulin binding, glucose transport, and glucose oxidation in isolated rat adipocytes: relationships between insulin receptors and insulin action. |
1977-01-25 |
2023-08-11 |
rat |
| J T Harmon, R Hil. Identification and characterization of the insulin receptor in the R3230AC mammary adenocarcinoma of the rat. Cancer research. vol 36. issue 11 Pt 1. 1976-12-30. PMID:135640. |
thus, in the r3230ac mammary adenocarcinoma, data obtained on saturability, reversibility, and specificity of insulin binding indicate the existence of an insulin receptor with properties similar to those found in normal cells. |
1976-12-30 |
2023-08-11 |
rat |
| O Pedersen, H Beck-Nielse. A study of insulin receptors in human mononuclear leucocytes. Acta endocrinologica. vol 83. issue 3. 1976-12-23. PMID:185872. |
analysis of the equilibrium between insulin and its receptor revealed an apparent heterogeneity of insulin receptors. |
1976-12-23 |
2023-08-11 |
human |
| H Beck-Nielsen, O Pedersen, J P Bagger, N S Sorense. The insulin receptor in normal and obese persons. Acta endocrinologica. vol 83. issue 3. 1976-12-23. PMID:185873. |
insulin receptors in subjects were also negatively correlated to fasting plasma insulin (p less than 0.05). |
1976-12-23 |
2023-08-11 |
human |
| H Beck-Nielsen, O Pedersen, J P Bagger, N S Sorense. The insulin receptor in normal and obese persons. Acta endocrinologica. vol 83. issue 3. 1976-12-23. PMID:185873. |
a significant increase in the number of insulin receptors was observed with a simultaneous decrease in plasma insulin to normal values. |
1976-12-23 |
2023-08-11 |
human |
| H D Summ, H Schiemann, H D Volkman. [Binding of insulin analogs to partially purified insulin receptor from rat liver membrane (author's transl)]. Hoppe-Seyler's Zeitschrift fur physiologische Chemie. vol 357. issue 5. 1976-11-21. PMID:964927. |
[binding of insulin analogs to partially purified insulin receptor from rat liver membrane (author's transl)]. |
1976-11-21 |
2023-08-11 |
rat |
| J M Olefsk. The effects of spontaneous obesity on insulin binding, glucose transport, and glucose oxidation of isolated rat adipocytes. The Journal of clinical investigation. vol 57. issue 4. 1976-10-01. PMID:181402. |
maximally effective insulin levels could not overcome the defect in glucose oxidation by larger cells, and thus, even though studies of insulin binding demonstrated a 30-40% decrease in insulin receptors on the larger cells, it is probable that the defect in glucose oxidation is distal to the insulin receptor. |
1976-10-01 |
2023-08-11 |
rat |
| J M Olefsk. The effects of spontaneous obesity on insulin binding, glucose transport, and glucose oxidation of isolated rat adipocytes. The Journal of clinical investigation. vol 57. issue 4. 1976-10-01. PMID:181402. |
these findings represent a rightward shift in the insulin dose-response curve in the cells from the older, fatter animals, and this is the predicted functional sequelae of the observed decrease in insulin receptors. |
1976-10-01 |
2023-08-11 |
rat |
| M A Lesniak, J Rot. Regulation of receptor concentration by homologous hormone. Effect of human growth hormone on its receptor in IM-9 lymphocytes. The Journal of biological chemistry. vol 251. issue 12. 1976-08-23. PMID:180007. |
the concentration of insulin receptors on these cells was affected by the insulin concentration in the medium, and the concentration of growth hormone receptors was affected by growth hormone, but neither hormone had any effect on the heterologous receptors. |
1976-08-23 |
2023-08-11 |
human |
| M P Czec. Cellular basis of insulin insensitivity in large rat adipocytes. The Journal of clinical investigation. vol 57. issue 6. 1976-08-23. PMID:932192. |
it is concluded that (a) possible defects in insulin receptor components, the d-glucose transport system, and the coupling mechanism which links these entities do not significantly contribute to the apparent insulin-insensitivity of large fat cells and (b) the principal cellular defect which confers this blunted insulin response to large rat adipocytes involves one or more intracellular enzymes involved in glucose metabolism. |
1976-08-23 |
2023-08-11 |
rat |
| P DeMeyts, A R Bainco, J Rot. Site-site interactions among insulin receptors. Characterization of the negative cooperativity. The Journal of biological chemistry. vol 251. issue 7. 1976-08-02. PMID:5434. |
insulin receptor sites appear to switch from a "slow dissociating" state to a "fast dissociating" state when their occupancy increases; the proportion of sites in each state is a function of occupancy of the receptor sites by the insulin monomer as well as of the physiochemical environment. |
1976-08-02 |
2023-08-11 |
human |
| M M Rechler, J M Podskaln. Insulin receptors in cultured human fibroblasts. Diabetes. vol 25. issue 4. 1976-08-02. PMID:178554. |
in order to study human insulin resistance, we have first characterized the interaction of insulin with specific insulin receptors in cultures of normal human fibroblasts. |
1976-08-02 |
2023-08-11 |
human |
| R D Fussganger, C R Kahn, J Roth, P De Meyt. Binding and degradation of insulin by human peripheral granulocytes. Demonstration of specific receptors with high affinity. The Journal of biological chemistry. vol 251. issue 9. 1976-07-06. PMID:4460. |
in the presence of inhibitors of degradation, binding sites for insulin with high affinity were detected, which by multiple criteria were true insulin receptors. |
1976-07-06 |
2023-08-11 |
human |
| R D Fussganger, C R Kahn, J Roth, P De Meyt. Binding and degradation of insulin by human peripheral granulocytes. Demonstration of specific receptors with high affinity. The Journal of biological chemistry. vol 251. issue 9. 1976-07-06. PMID:4460. |
as shown previously for all other insulin receptors, binding was highly ph-dependent, and insulin analogues had affinities for these sites that closely correlated with their biological potencies. |
1976-07-06 |
2023-08-11 |
human |