| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| A H Soli, C R Kahn, D M Neville, J Rot. Insulin receptor deficiency in genetic and acquired obesity. The Journal of clinical investigation. vol 56. issue 4. 1975-11-22. PMID:169296. |
these findings suggest that decreased insulin binding is a characteristic feature of the insulin resistance of obesity, and that sustained hyperinsulinemia is a major factor in the control of the concentration of insulin receptors on target cells. |
1975-11-22 |
2023-08-11 |
mouse |
| M E Forgue, P Freyche. Insulin receptors in the heart muscle. Demonstration of specific binding sites and impairment of insulin binding in the plasma membrane of the obese hyperglycemic mouse. Diabetes. vol 24. issue 8. 1975-11-20. PMID:169173. |
these studies demonstrate and characterize the binding of insulin to heart muscle membranes; they extend to the heart muscle the insulin receptor defect also found in liver membranes and cells, in fat cell membranes, and in thymic lymphocytes of the ob/ob mouse. |
1975-11-20 |
2023-08-11 |
mouse |
| P Kern, J Picard, M Caron, D Veissièr. Decreased binding of insulin to liver plasma membrane receptors in hereditary diabetic mice. Biochimica et biophysica acta. vol 389. issue 2. 1975-10-10. PMID:166675. |
the decrease in insulin receptors in the kk mouse seems to correlate with the insulin resistance which they exhibit. |
1975-10-10 |
2023-08-11 |
mouse |
| A H Soll, C R Kahn, D M Nevill. Insulin binding to liver plasm membranes in the obese hyperglycemic (ob/ob) mouse. Demonstration of a decreased number of functionally normal receptors. The Journal of biological chemistry. vol 250. issue 12. 1975-09-22. PMID:167002. |
we conclude that the insulin receptor from the ob/ob mouse is a functionally normal receptor and that its presence in diminished number accounts for the observed decrease in insulin binding to liver plasma membranes. |
1975-09-22 |
2023-08-11 |
mouse |
| M D Hollenberg, P Cuatrecasa. Insulin: interaction with membrane receprots and relationship to cyclic purine nucleotides and cell growth. Federation proceedings. vol 34. issue 7. 1975-09-04. PMID:165982. |
a summary is presented of previous studies which indicate that the insulin receptor of fat and liver cells is a large glycoprotein, partially buried in the outer surface of the plasma membrane, with a high (k-d approximately 10-10 m) and specific affinity for insulin. |
1975-09-04 |
2023-08-11 |
human |
| D H Lockwood, J N Livingston, J M Amatrud. Relation of insulin receptors to insulin resistance. Federation proceedings. vol 34. issue 7. 1975-09-04. PMID:165983. |
relation of insulin receptors to insulin resistance. |
1975-09-04 |
2023-08-11 |
human |
| D H Lockwood, J N Livingston, J M Amatrud. Relation of insulin receptors to insulin resistance. Federation proceedings. vol 34. issue 7. 1975-09-04. PMID:165983. |
similar numbers of insulin receptors per cell and affinity for insulin were observed in adipocytes obtained from normal weight subjects and morbidly obese patients. |
1975-09-04 |
2023-08-11 |
human |
| J M Olefsky, G M Reave. Effects of age and obesity on insulin binding to isolated adipocytes. Endocrinology. vol 96. issue 6. 1975-08-08. PMID:165063. |
analysis of the data indicated that this decrease in insulin binding could be accounted for by decreased numbers of insulin receptor sites per cell. |
1975-08-08 |
2023-08-11 |
rat |
| J M Olefsky, G M Reave. Effects of age and obesity on insulin binding to isolated adipocytes. Endocrinology. vol 96. issue 6. 1975-08-08. PMID:165063. |
these latter studies are consistent with the concept that elevated in vivo plasma insulin levels lead to decreased insulin receptors, and further suggest a role for additonal factors in regulating the adipocyte insulin receptor. |
1975-08-08 |
2023-08-11 |
rat |
| G Tsujin. A case of leprechaunism and an analysis of some clinical manifestations of this syndrome. Zeitschrift fur Kinderheilkunde. vol 118. issue 4. 1975-07-31. PMID:1130123. |
the abnormality of the carbohydrate metabolism in leprechauism may be due to the delay of insulin-release from pancreatic islets, from the abnormality of insulin receptors, or an abnormality of the biological activity of insulin. |
1975-07-31 |
2023-08-11 |
Not clear |
| J M Amatruda, J N Livingston, D H Lockwoo. Insulin receptor: role in the resistance of human obesity to insulin. Science (New York, N.Y.). vol 188. issue 4185. 1975-06-09. PMID:164059. |
insulin receptor: role in the resistance of human obesity to insulin. |
1975-06-09 |
2023-08-11 |
human |
| L K Starosel'tsev. [Insulin receptors and mechanism of the action of insulin in the body]. Problemy endokrinologii. vol 20. issue 5. 1975-04-19. PMID:4374697. |
[insulin receptors and mechanism of the action of insulin in the body]. |
1975-04-19 |
2023-08-11 |
Not clear |
| M P Czech, J C Lawrence, W S Lyn. Evidence for the involvement of sulfhydryl oxidation in the regulation of fat cell hexose transport by insulin. Proceedings of the National Academy of Sciences of the United States of America. vol 71. issue 10. 1975-02-06. PMID:4372610. |
this protective effect on transport rates appears to reside at a site that is altered by insulin subsequent to hormone-receptor interaction, since prior treatment of fat cells with insulin did not prevent the partial inhibitory effect of n-ethylmaleimide on insulin receptors. |
1975-02-06 |
2023-08-11 |
Not clear |
| P Freyche. The interactions of proinsulin with insulin receptors on the plasma membrane of the liver. The Journal of clinical investigation. vol 54. issue 5. 1975-01-10. PMID:4421396. |
proinsulin was only 3-5% as potent as insulin in binding to insulin receptors. |
1975-01-10 |
2023-08-11 |
rat |
| P Freyche. The interactions of proinsulin with insulin receptors on the plasma membrane of the liver. The Journal of clinical investigation. vol 54. issue 5. 1975-01-10. PMID:4421396. |
quantitative data derived from steady-state and transient-state comparative binding studies of both [(125)i]proinsulin and [(125)i]insulin indicated that a 20-fold lower association rate constant essentially accounts for the reduced affinity of proinsulin for the insulin receptors. |
1975-01-10 |
2023-08-11 |
rat |
| G Illiano, G P Tell, M E Siegel, P Cuatrecasa. Guanosine 3':5'-cyclic monophosphate and the action of insulin and acetylcholine. Proceedings of the National Academy of Sciences of the United States of America. vol 70. issue 8. 1974-08-27. PMID:4365701. |
insulin does not alter cyclic gmp concentrations in purified human peripheral lymphocytes or in rat-spleen lymphocytes, cells which possess few insulin receptors and which are insensitive to the metabolic effects of the hormone. |
1974-08-27 |
2023-08-11 |
human |
| J R Gavin, J Roth, D M Neville, P de Meyts, D N Buel. Insulin-dependent regulation of insulin receptor concentrations: a direct demonstration in cell culture. Proceedings of the National Academy of Sciences of the United States of America. vol 71. issue 1. 1974-03-22. PMID:4359334. |
chronic (5-16 hr) exposure of cultured human lymphocytes to 10(-8) m insulin at 37 degrees in vitro produced a decrease in insulin receptor concentrations unaccounted for by simple occupancy of sites; acute exposure (0-2 hr) was without effect. |
1974-03-22 |
2023-08-11 |
mouse |
| J R Gavin, J Roth, D M Neville, P de Meyts, D N Buel. Insulin-dependent regulation of insulin receptor concentrations: a direct demonstration in cell culture. Proceedings of the National Academy of Sciences of the United States of America. vol 71. issue 1. 1974-03-22. PMID:4359334. |
these results reproduced observations in vivo where chronic hyperinsulinemia (e.g., 10(-8) m insulin in the circulation of obese insulinresistant hyperglycemic mice) is associated with a substantial reduction in the concentration of insulin receptors per cell, while acute hyperinsulinemia in vivo has no effect on receptor concentration. |
1974-03-22 |
2023-08-11 |
mouse |
| J R Gavin, J Roth, D M Neville, P de Meyts, D N Buel. Insulin-dependent regulation of insulin receptor concentrations: a direct demonstration in cell culture. Proceedings of the National Academy of Sciences of the United States of America. vol 71. issue 1. 1974-03-22. PMID:4359334. |
these data suggest a reciprocal relationship between insulin in the extracellular fluid and the concentration of insulin receptors per cell, which is mediated at the target cell itself by intracellular insulin-sensitive regulatory processes and directly affects target-cell sensitivity to hormone. |
1974-03-22 |
2023-08-11 |
mouse |
| H J Eisen, I D Goldfine, W H Glinsman. Regulation of hepatic glycogen synthesis during fetal development: roles of hydrocortisone, insulin, and insulin receptors. Proceedings of the National Academy of Sciences of the United States of America. vol 70. issue 12. 1974-02-13. PMID:4357871. |
regulation of hepatic glycogen synthesis during fetal development: roles of hydrocortisone, insulin, and insulin receptors. |
1974-02-13 |
2023-08-11 |
rat |