| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Insulin receptors, insulin resistance, diabetes and obesity. Nutrition reviews. vol 34. issue 5. 1976-07-06. PMID:177909. |
insulin receptors, insulin resistance, diabetes and obesity. |
1976-07-06 |
2023-08-11 |
Not clear |
| C Karakash, F Assimacopoulos-Jeannet, B Jeanrenau. An anomaly of insulin removal in perfused livers of obese-hyperglycemic (ob/ob) mice. The Journal of clinical investigation. vol 57. issue 5. 1976-07-06. PMID:1262459. |
the characteristics of hepatic insulin removal reported in this study, as well as the differences observed between livers of lean and ob/ob mice, may reflect changes in membrane insulin receptors and/or in processes responsible for the degradation of the horomone. |
1976-07-06 |
2023-08-11 |
mouse |
| C R Kahn, J S Flier, R S Bar, J A Archer, P Gorden, M M Martin, J Rot. The syndromes of insulin resistance and acanthosis nigricans. Insulin-receptor disorders in man. The New England journal of medicine. vol 294. issue 14. 1976-05-25. PMID:176581. |
studies of insulin receptors on circulating monocytes suggest that the insulin resistance in these patients was due to a marked decrease in insulin binding to its membrane receptors. |
1976-05-25 |
2023-08-11 |
Not clear |
| J M Olefsky, G M Reave. Effects of sulfonylurea therapy on insulin binding to mononuclear leukocytes of diabetic patients. The American journal of medicine. vol 60. issue 1. 1976-04-23. PMID:175653. |
the binding affinity for insulin was the same for both groups of cells, and the decreased binding could be accounted for by a 45 per cent decrease in the number of available insulin receptor sites per cell. |
1976-04-23 |
2023-08-11 |
human |
| J M Olefsky, G M Reave. Effects of sulfonylurea therapy on insulin binding to mononuclear leukocytes of diabetic patients. The American journal of medicine. vol 60. issue 1. 1976-04-23. PMID:175653. |
in conclusion, (1) mononuclear cells from nonobese, nonketotic, untreated adult diabetic patients with fasting hyperglycemia demonstrate a decreased ability to bind insulin due to decreased numbers of insulin receptors per cell; (2) treatment with an oral hypoglycemic agent is associated with a diminution in hyperglycemia and a return toward normal of insulin binding. |
1976-04-23 |
2023-08-11 |
human |
| J Olefsky, V C Bacon, S Bau. Insulin receptors of skeletal muscle: specific insulin binding sites and demonstration of decreased numbers of sites in obese rats. Metabolism: clinical and experimental. vol 25. issue 2. 1976-04-10. PMID:2834. |
insulin receptors of skeletal muscle: specific insulin binding sites and demonstration of decreased numbers of sites in obese rats. |
1976-04-10 |
2023-08-11 |
rat |
| R Geiger, K Geisen, H D Summ, D Lange. [(A1-D-alanine) insulin (author's transl)]. Hoppe-Seyler's Zeitschrift fur physiologische Chemie. vol 356. issue 10. 1976-04-10. PMID:1213677. |
the specific binding to insulin receptors of rat liver is decreased as, compared to insulin, but increased as compared to the l-alanine analogue. |
1976-04-10 |
2023-08-11 |
rat |
| J M Olefsk. Effect of dexamethasone on insulin binding, glucose transport, and glucose oxidation of isolated rat adipocytes. The Journal of clinical investigation. vol 56. issue 6. 1976-03-01. PMID:1202081. |
since dexamethasone treatment leads to decreased insulin binding to adipocytes in vivo, we examined the possibility that the in vitro decreases in insulin-mediated glucose transport could be due to decreased insulin receptors. |
1976-03-01 |
2023-08-11 |
rat |
| K Megyesi, C R Kahn, J Roth, D M Neville, S P Nissley, R E Humbel, E R Froesc. The NSILA-s receptor in liver plasma membranes. Characterization and comparison with the insulin receptor. The Journal of biological chemistry. vol 250. issue 23. 1976-02-09. PMID:391. |
we have demonstrated previously that liver plasma membranes possess separate receptors for nsila-s and insulin and have characterized the insulin receptor in detail. |
1976-02-09 |
2023-08-11 |
Not clear |
| K Megyesi, C R Kahn, J Roth, D M Neville, S P Nissley, R E Humbel, E R Froesc. The NSILA-s receptor in liver plasma membranes. Characterization and comparison with the insulin receptor. The Journal of biological chemistry. vol 250. issue 23. 1976-02-09. PMID:391. |
with the insulin receptor, nsila-s and insulin analogues compete for binding in proportion to their insulin-like potency: insulin greater than proinsulin greater than nsila-s. with the nsila-s receptor, nsila-s is most potent and the order is reversed: nsila-s greater than proinsulin greater than insulin. |
1976-02-09 |
2023-08-11 |
Not clear |
| I D Goldfin. Binding of insulin to thymocytes from suckling and hypophysectomized rats: evidence for two mechanisms regulating insulin sensitivity. Endocrinology. vol 97. issue 4. 1976-02-09. PMID:172319. |
thymocytes from hypophysectomized adult rats bound more insulin than did cells from sham-operated controls, suggesting that insulin sensitivity in this condition was due to an increase in the number of insulin receptors. |
1976-02-09 |
2023-08-11 |
rat |
| I Dumont, F Kruyen, F Legro. [Specific insulin binding to chloroplasts isolated from Acetabularia mediterranea]. Comptes rendus des seances de la Societe de biologie et de ses filiales. vol 169. issue 1. 1976-01-29. PMID:171035. |
kinetics of insulin fixation to chloroplasts, exponential dissociation of bound hormone, competition between radioactive and native insulins for binding and for release indicate that chloroplasts possess insulin receptors. |
1976-01-29 |
2023-08-11 |
Not clear |
| H D Sölin. [The mechanism of the acute action of insulin (author's transl)]. MMW, Munchener medizinische Wochenschrift. vol 117. issue 41. 1976-01-26. PMID:127120. |
all the known acute actions of insulin are based on the reaction of insulin with specific insulin receptors in the cell membranes of the insulin-sensitive organs. |
1976-01-26 |
2023-08-11 |
Not clear |
| D E Denni. [New developments in insulin therapy of diabetic coma (author's transl)]. MMW, Munchener medizinische Wochenschrift. vol 117. issue 41. 1976-01-26. PMID:810692. |
this form of therapy is based on recent knowledge of the physiological degree of the serum insulin level (20-200 muu/ml) and the quantity required to saturate the insulin receptors. |
1976-01-26 |
2023-08-11 |
Not clear |
| P V Clarke, A H Kissebah, H Hope-Gill, N Vydelingum, B Tulloch, T R Frase. The role of calcium in insulin action. IV. Mechanism of insulin resistance in adipose tissue of obese (ob/ob) mice and old Wistar rats. European journal of clinical investigation. vol 5. issue 4. 1975-12-29. PMID:1175674. |
response to these agents, however, was restored by prewashing the tissue, suggesting that the apparent resistance in this tissue reflected saturation of the insulin receptors to endogenous insulin. |
1975-12-29 |
2023-08-11 |
mouse |
| P V Clarke, A H Kissebah, H Hope-Gill, N Vydelingum, B Tulloch, T R Frase. The role of calcium in insulin action. IV. Mechanism of insulin resistance in adipose tissue of obese (ob/ob) mice and old Wistar rats. European journal of clinical investigation. vol 5. issue 4. 1975-12-29. PMID:1175674. |
these results suggest that the insulin response of fat cells from old rats is impaired because of a defect either in their insulin receptors or in their post-receptor responses. |
1975-12-29 |
2023-08-11 |
mouse |
| P V Clarke, A H Kissebah, H Hope-Gill, N Vydelingum, B Tulloch, T R Frase. The role of calcium in insulin action. IV. Mechanism of insulin resistance in adipose tissue of obese (ob/ob) mice and old Wistar rats. European journal of clinical investigation. vol 5. issue 4. 1975-12-29. PMID:1175674. |
the results suggest that the insulin resistance observed in old rat fat cells may be related to some by deficiency in the insulin receptors, possibly due to their lower replacement with age. |
1975-12-29 |
2023-08-11 |
mouse |
| J S Flier, C R Kahn, J Roth, R S Ba. Antibodies that impair insulin receptor binding in an unusual diabetic syndrome with severe insulin resistance. Science (New York, N.Y.). vol 190. issue 4209. 1975-12-11. PMID:170678. |
antibodies that impair insulin receptor binding in an unusual diabetic syndrome with severe insulin resistance. |
1975-12-11 |
2023-08-11 |
Not clear |
| A H Soli, C R Kahn, D M Neville, J Rot. Insulin receptor deficiency in genetic and acquired obesity. The Journal of clinical investigation. vol 56. issue 4. 1975-11-22. PMID:169296. |
we now find that concentration of insulin receptors on liver plasma membranes is decreased in the db/db mouse, another form of inherited obesity, and in normal mice that became obese after treatment with gold thioglucose, while thin mice, heterozygous for the ob mutation (ob/+), have normal insulin binding. |
1975-11-22 |
2023-08-11 |
mouse |
| A H Soli, C R Kahn, D M Neville, J Rot. Insulin receptor deficiency in genetic and acquired obesity. The Journal of clinical investigation. vol 56. issue 4. 1975-11-22. PMID:169296. |
in contrast, when fasting ob/ob mice were given exogenous insulin to maintain the hyperinsulinemia, insulin receptors failed to increase. |
1975-11-22 |
2023-08-11 |
mouse |