| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Binyuan Yang, Gang Zhai, Yulong Gong, Jingzhi Su, Dong Han, Zhan Yin, Shouqi Xi. Depletion of insulin receptors leads to β-cell hyperplasia in zebrafish. Science bulletin. vol 62. issue 7. 2023-01-20. PMID:36659257. |
given the importance of insulin receptors in glucose homeostasis and embryonic development, transcriptome analysis was used to provide an important model of defective insulin signaling and to study its developmental consequences in zebrafish. |
2023-01-20 |
2023-08-14 |
zebrafish |
| William A Banks, Cassidy Noonan, Elizabeth M Rhe. Evidence for an alternative insulin transporter at the blood-brain barrier. Aging pathobiology and therapeutics. vol 4. issue 4. 2023-01-16. PMID:36644126. |
accumulating evidence suggests there is an alternative insulin transporter besides the insulin receptor at the blood-brain barrier (bbb), responsible for shuttling insulin from the circulation into the brain. |
2023-01-16 |
2023-08-14 |
Not clear |
| Marta Lubos, Jan Pícha, Irena Selicharová, Jíří Žák, Miloš Buděšínský, Katarína Mitrová, Lenka Žáková, Jiří Jiráče. Modulation of the antagonistic properties of an insulin mimetic peptide by disulfide bridge modifications. Journal of peptide science : an official publication of the European Peptide Society. 2023-01-12. PMID:36633503. |
insulin is a peptide responsible for regulating the metabolic homeostasis of the organism; it elicits its effects through binding to the transmembrane insulin receptor (ir). |
2023-01-12 |
2023-08-14 |
Not clear |
| Jiayi Wu, Stella Hayoung Park, Eunhee Cho. The insulin receptor endocytosis. Progress in molecular biology and translational science. vol 194. 2023-01-11. PMID:36631202. |
at the cell surface, insulin binds and activates the insulin receptor (ir), a receptor tyrosine kinase. |
2023-01-11 |
2023-08-14 |
Not clear |
| Lu Yu, Fang Yu, Zongrui Ma, Huilin Lu, Jian Luo, Ting Sun, Qin Liu, Shenglian Ga. INSR novel mutations identified in a Chinese family with severe INSR-related insulin resistance syndromes: A case report. Medicine. vol 101. issue 49. 2023-01-10. PMID:36626508. |
severe insulin receptor gene (insr)-related insulin resistance syndromes (sir) include donohue syndrome (ds), rabson-mendenhall syndrome (rms), and type a insulin resistance. |
2023-01-10 |
2023-08-14 |
Not clear |
| Hirofumi Nagao, Ashok Kumar Jayavelu, Weikang Cai, Hui Pan, Jonathan M Dreyfuss, Thiago M Batista, Bruna B Brandão, Matthias Mann, C Ronald Kah. Unique ligand and kinase-independent roles of the insulin receptor in regulation of cell cycle, senescence and apoptosis. Nature communications. vol 14. issue 1. 2023-01-04. PMID:36599833. |
insulin acts through the insulin receptor (ir) tyrosine kinase to exert its classical metabolic and mitogenic actions. |
2023-01-04 |
2023-08-14 |
Not clear |
| Jinli Pei, Baochun Wang, Dayong Wan. Current Studies on Molecular Mechanisms of Insulin Resistance. Journal of diabetes research. vol 2022. 2023-01-02. PMID:36589630. |
the fundamental molecular factor of insulin resistance may be impaired cell signal transduction mediated by the insulin receptor (ir). |
2023-01-02 |
2023-08-14 |
Not clear |
| Ji Hyeong Baek, Hyeonwi Son, Jae Soon Kang, Dae Young Yoo, Hye Jin Chung, Dong Kun Lee, Hyun Joon Ki. Long-Term Hyperglycemia Causes Depressive Behaviors in Mice with Hypoactive Glutamatergic Activity in the Medial Prefrontal Cortex, Which Is Not Reversed by Insulin Treatment. Cells. vol 11. issue 24. 2022-12-23. PMID:36552776. |
in particular, levels of insulin receptor beta subunit (irβ), irs-1, vesicular glutamate transporter 1, glutamine transporter snat2, phosphate-activated glutaminase, and glut-3 were not changed by insulin. |
2022-12-23 |
2023-08-14 |
mouse |
| Mohammad Shamsul Ol. Reduced Tyrosine and Serine-632 Phosphorylation of Insulin Receptor Substrate-1 in the Gastrocnemius Muscle of Obese Zucker Rat. Current issues in molecular biology. vol 44. issue 12. 2022-12-22. PMID:36547071. |
although there is a large body of evidence on obesity-induced insulin resistance in various skeletal muscles, the molecular mechanism of insulin resistance due to a disruption in insulin receptor signaling, specifically in the gastrocnemius skeletal muscle of obese zucker rats (ozrs), is not fully understood. |
2022-12-22 |
2023-08-14 |
human |
| Mohammad Shamsul Ol. Reduced Tyrosine and Serine-632 Phosphorylation of Insulin Receptor Substrate-1 in the Gastrocnemius Muscle of Obese Zucker Rat. Current issues in molecular biology. vol 44. issue 12. 2022-12-22. PMID:36547071. |
in addition, immunoprecipitation and immunoblotting techniques were used to determine the expression and tyrosine phosphorylation of insulin receptor substrate-1 (irs-1) and insulin receptor-β (irβ), and the activation of serine-632-irs-1 phosphorylation in the gastrocnemius muscle of zucker rats. |
2022-12-22 |
2023-08-14 |
human |
| Jayanth Jeevanandam, Esackimuthu Paramasivam, N T Saraswath. Glycation restrains open-closed conformation of Insulin. Computational biology and chemistry. vol 102. 2022-12-21. PMID:36542957. |
the closed conformation of glycated insulin impairs its binding to insulin receptor (ir). |
2022-12-21 |
2023-08-14 |
Not clear |
| Desh Deepak Singh, Ali A Shati, Mohammad Y Alfaifi, Serag Eldin I Elbehairi, Ihn Han, Eun-Ha Choi, Dharmendra K Yada. Development of Dementia in Type 2 Diabetes Patients: Mechanisms of Insulin Resistance and Antidiabetic Drug Development. Cells. vol 11. issue 23. 2022-12-11. PMID:36497027. |
we discuss the pathological and physiological mechanisms behind the association between type 2 diabetes mellitus and dementia, such as insulin resistance, insulin signaling, and sporadic forms of dementia; the relationship between insulin receptor activation and tau phosphorylation; dementia and mrna expression and downregulation of related receptors; neural modulation due to insulin secretion and glucose homeostasis; and neuronal apoptosis due to insulin resistance and type 2 diabetes mellitus. |
2022-12-11 |
2023-08-14 |
Not clear |
| Zhiqiang Tian, Lin Zhu, J P Michaud, Meng Zha, Jie Cheng, Zhongjian Shen, Xiaoming Liu, Xiaoxia Li. Metabolic reprogramming of Helicoverpa armigera larvae by HearNPV facilitates viral replication and host immune suppression. Molecular ecology. 2022-12-08. PMID:36479957. |
treatment of infected larvae with insulin increased their survival, reduced viral replication, and inhibited climbing behavior compared to a control treatment with dmso, whereas rnai suppression of the insulin receptor gene produced the opposite effects. |
2022-12-08 |
2023-08-14 |
Not clear |
| Alessandra Dall'Agnese, Jesse M Platt, Ming M Zheng, Max Friesen, Giuseppe Dall'Agnese, Alyssa M Blaise, Jessica B Spinelli, Jonathan E Henninger, Erin N Tevonian, Nancy M Hannett, Charalampos Lazaris, Hannah K Drescher, Lea M Bartsch, Henry R Kilgore, Rudolf Jaenisch, Linda G Griffith, Ibrahim I Cisse, Jacob F Jeppesen, Tong I Lee, Richard A Youn. The dynamic clustering of insulin receptor underlies its signaling and is disrupted in insulin resistance. Nature communications. vol 13. issue 1. 2022-12-06. PMID:36473871. |
the dynamic clustering of insulin receptor underlies its signaling and is disrupted in insulin resistance. |
2022-12-06 |
2023-08-14 |
human |
| Zhenyang Liu, Hongwei Gao, Ziyu Zhao, Mengrui Huang, Shengnan Wang, Jiuyu Zha. Status of research on natural protein tyrosine phosphatase 1B inhibitors as potential antidiabetic agents: Update. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 157. 2022-12-02. PMID:36459712. |
ptp1b inhibitors increase insulin receptor sensitivity and have the ability to cure insulin resistance-related diseases. |
2022-12-02 |
2023-08-14 |
human |
| Gulibositan Aji, Sheng Jiang, Halmurat Obulkasim, Zhiqiang Lu, Wei Wang, Pu Xi. Sphingosine kinase 2 regulates insulin receptor trafficking in hepatocytes. Experimental biology and medicine (Maywood, N.J.). 2022-11-21. PMID:36408724. |
disturbed insulin receptor (insr) trafficking is associated with impaired insulin signaling and the development of diabetes. |
2022-11-21 |
2023-08-14 |
Not clear |
| Zhili Tang, Chao Sun, Ying Yan, Zhoumin Niu, Yuying Li, Xi Xu, Jing Zhang, Yuting Wu, Yan Li, Li Wang, Cheng Hu, Zhuoyang Li, Jingjing Jiang, Hao Yin. Aberrant elevation of FTO levels promotes liver steatosis by decreasing the m6A methylation and increasing the stability of SREBF1 and ChREBP mRNAs. Journal of molecular cell biology. 2022-11-10. PMID:36352530. |
insulin could stimulate fto transcription through a mechanism involving the action of intranuclear insulin receptor beta, while knockdown of fto abrogated the lipogenic effect of insulin. |
2022-11-10 |
2023-08-14 |
mouse |
| Bruno Hernandez-Cravero, Sofia Gallino, Jeremy Florman, Cecilia Vranych, Philippe Diaz, Ana Belén Elgoyhen, Mark J Alkema, Diego de Mendoz. Cannabinoids activate the insulin pathway to modulate mobilization of cholesterol in C. elegans. PLoS genetics. vol 18. issue 11. 2022-11-08. PMID:36346800. |
these findings indicate that 2-ag-dependent cholesterol trafficking requires the release of insulin peptides and signaling through the daf-2 insulin receptor. |
2022-11-08 |
2023-08-14 |
caenorhabditis_elegans |
| Fengxiang Lv, Yingfan Wang, Dan Shan, Sile Guo, Gengjia Chen, Li Jin, Wen Zheng, Han Feng, Xiaohu Zeng, Shuo Zhang, Yan Zhang, Xinli Hu, Rui-Ping Xia. Blocking MG53 Circulation research. 2022-11-07. PMID:36337049. |
however, it also impairs insulin signaling via its e3 ligase activity-mediated ubiquitination-dependent degradation of ir (insulin receptor) and irs1 (insulin receptor substrate 1) and its myokine function-induced allosteric blockage of ir. |
2022-11-07 |
2023-08-14 |
Not clear |
| Yubo Wang, Xiaohan Song, Yan Wang, Nan Wan. Specific interaction of insulin receptor and GLP-1 receptor mediates crosstalk between their signaling. Biochemical and biophysical research communications. vol 636. issue Pt 2. 2022-11-07. PMID:36343488. |
both glp-1 receptor (glp-1r) and insulin receptor (ir) transmit signals for insulin release and/or cellular metabolism although using distinct sets of transducing molecules and separate pathways. |
2022-11-07 |
2023-08-14 |
Not clear |