| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Worarat Rojanaverawong, Navinee Wongmanee, Wanthanee Hanchan. Sacha Inchi ( Preventive nutrition and food science. vol 28. issue 1. 2023-04-17. PMID:37066030. |
furthermore, si treatment enhanced the hepatic insulin sensitivity of the diabetic rats, as shown by the increased insulin receptor substrate-1 and p-akt protein expression, decreased phosphoenolpyruvate carboxykinase-1 and glucose-6-phospatase protein expression, and increased hepatic glycogen content. |
2023-04-17 |
2023-08-14 |
rat |
| Xuefei Zhao, Xuedong An, Cunqing Yang, Wenjie Sun, Hangyu Ji, Fengmei Lia. The crucial role and mechanism of insulin resistance in metabolic disease. Frontiers in endocrinology. vol 14. 2023-04-14. PMID:37056675. |
mechanistically, any factor leading to abnormalities in the insulin signaling pathway leads to the development of ir in the host, including insulin receptor abnormalities, disturbances in the internal environment (regarding inflammation, hypoxia, lipotoxicity, and immunity), metabolic function of the liver and organelles, and other abnormalities. |
2023-04-14 |
2023-08-14 |
Not clear |
| Takanori Shinjo, Satoru Onizuka, Yumi Zaitsu, Atsushi Ishikado, Kyoungmin Park, Qian Li, Hisashi Yokomizo, Tatsuro Zeze, Kohei Sato, Ronald St-Louis, Jialin Fu, Wu I-Hsien, Koji Mizutani, Hatice Hasturk, Thomas E Van Dyke, Fusanori Nishimura, George L Kin. Dysregulation of CXCL1 expression and neutrophil recruitment in insulin resistance and diabetes-related periodontitis in male mice. Diabetes. 2023-04-14. PMID:37058471. |
this study showed that insulin resistance in the mouse gingiva due to selective deletion of smooth muscle and fibroblast insulin receptor (smirko mice) or systemic metabolic changes induced by high fat diet (hfd) in hfd-fed mice exacerbated periodontitis-induced alveolar bone loss, preceded by delayed neutrophil and monocyte recruitment and impaired bacterial clearance compared to their respective controls. |
2023-04-14 |
2023-08-14 |
mouse |
| Judith Gruber, Ruth Hanssen, Mishal Qubad, Aicha Bouzouina, Vivi Schack, Hannah Sochor, Carmen Schiweck, Mareike Aichholzer, Silke Matura, David A Slattery, Yurdaguel Zopf, Stephanie L Borgland, Andreas Reif, Sharmili Edwin Thanaraja. Impact of insulin and insulin resistance on brain dopamine signalling and reward processing- an underexplored mechanism in the pathophysiology of depression? Neuroscience and biobehavioral reviews. 2023-04-14. PMID:37059404. |
since the discovery of insulin receptors in the brain and the brain's reward system, evidence has accumulated indicating that insulin modulates dopaminergic (da) signalling and reward behaviour. |
2023-04-14 |
2023-08-14 |
human |
| Osamu Horikawa, Satoshi Ugi, Tomofumi Takayoshi, Yasushi Omura, Maya Yonishi, Daisuke Sato, Yukihiro Fujita, Tomoya Fuke, Yushi Hirota, Wataru Ogawa, Hiroshi Maegaw. A family with type A insulin resistance syndrome caused by a novel insulin receptor mutation. Endocrinology, diabetes & metabolism case reports. vol 2023. 2023-04-12. PMID:37042492. |
a family with type a insulin resistance syndrome caused by a novel insulin receptor mutation. |
2023-04-12 |
2023-08-14 |
Not clear |
| Mariia Shypshyna, Oksana Kolesnyk, Svitlana Fedulova, Nickolai Veselovsk. Insulin modulates the paired-pulse plasticity at glutamatergic synapses of hippocampal neurons under hypoinsulinemia. Frontiers in cellular neuroscience. vol 17. 2023-04-07. PMID:37025701. |
dysfunction of signaling cascades of insulin receptors under insulin deficiency can contribute to the development of cognitive disorders associated with impaired synaptic plasticity properties. |
2023-04-07 |
2023-08-14 |
Not clear |
| Angela Costagliola di Polidoro, Zahra Baghbantarghdari, Vincenza De Gregorio, Simona Silvestri, Paolo Antonio Netti, Enza Torin. Insulin Activation Mediated by Uptake Mechanisms: A Comparison of the Behavior between Polymer Nanoparticles and Extracellular Vesicles in 3D Liver Tissues. Biomacromolecules. 2023-04-06. PMID:37023462. |
insulin is activated by interacting with insulin receptors exposed on the liver cell membrane that triggers the uptake and storage of glucose. |
2023-04-06 |
2023-08-14 |
Not clear |
| Dakshita Hardatt, Manju Dahiya, Sonal Vyas, Gurvinder Singh, Jyoti Jain, Sumeet Gupta, Meenakshi Dhanawa. Effect of Vitamin D on Retinoblastoma Protein in Prediabetic Individuals. Current diabetes reviews. 2023-04-03. PMID:37005543. |
vitamin d affects insulin sensitivity by increasing insulin receptors or the sensitivity of insulin receptors to insulin. |
2023-04-03 |
2023-08-14 |
Not clear |
| H Wang, Y W Zhu, J Yang, X Y Wang, Y C Zhan, W C Wang, L Yan. Research Note: Developmental changes of glucose metabolism are associated with insulin signaling in goose embryo. Poultry science. vol 102. issue 5. 2023-04-01. PMID:37003171. |
the hepatic mrna expression related to glucose catabolism (hexokinase, phosphofructokinase, and pyruvate kinase) and insulin signaling (insulin receptor, insulin receptor substrate protein, src homology collagen protein, extracellular signal-regulated kinase, and ribosomal protein s6 kinase, 70 ku) increased quadratically from embryonic day 19 to day of hatchment. |
2023-04-01 |
2023-08-14 |
Not clear |
| H Wang, Y W Zhu, J Yang, X Y Wang, Y C Zhan, W C Wang, L Yan. Research Note: Developmental changes of glucose metabolism are associated with insulin signaling in goose embryo. Poultry science. vol 102. issue 5. 2023-04-01. PMID:37003171. |
serum glucose levels were positively related to serum insulin (r = 1.00) and free triiodothyronine (r = 0.90) levels, as well as the hepatic mrna expression of insulin receptor (r = 1.00), insulin receptor substrate protein (r = 0.64), extracellular signal-regulated kinase (r = 0.81), and ribosomal protein s6 kinase, 70 ku (r = 0.81) related to insulin signaling. |
2023-04-01 |
2023-08-14 |
Not clear |
| Gitit Kra, Jayasimha Rayalu Daddam, Uzi Moallem, Hadar Kamer, Batel Mualem, Yishai Levin, Radka Kočvarová, Alina Nemirovski, Andres G Contreras, Joseph Tam, Maya Zachu. Alpha-linolenic acid modulates systemic and adipose tissue-specific insulin sensitivity, inflammation, and the endocannabinoid system in dairy cows. Scientific reports. vol 13. issue 1. 2023-03-31. PMID:37002295. |
in at, the top canonical pathways, according to the differential phosphoproteome in ala, were protein-kinase-a signaling and insulin-receptor signaling; network analysis and immunoblots validated the lower phosphorylation of protein kinase b (akt), and lower abundance of insulin receptor, together suggesting reduced insulin sensitivity in ala at. |
2023-03-31 |
2023-08-14 |
Not clear |
| Jyoti C Patel, Kenneth D Carr, Margaret E Ric. Actions and Consequences of Insulin in the Striatum. Biomolecules. vol 13. issue 3. 2023-03-29. PMID:36979453. |
notably, insulin also acts in the striatum, which shows abundant expression of insulin receptors (insrs) throughout. |
2023-03-29 |
2023-08-14 |
Not clear |
| Ana Knezovic, Marija Piknjac, Jelena Osmanovic Barilar, Ana Babic Perhoc, Davor Virag, Jan Homolak, Melita Salkovic-Petrisi. Association of Cognitive Deficit with Glutamate and Insulin Signaling in a Rat Model of Parkinson's Disease. Biomedicines. vol 11. issue 3. 2023-03-29. PMID:36979662. |
the expression of tyrosine hydroxylase (th) and proteins involved in insulin (insulin receptor - ir, phosphoinositide 3 kinase - pi3k, extracellular signal-regulated kinases-erk) and glutamate receptor (α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptos-ampar, n-methyl-d-aspartate receptor - nmdar) signaling was assessed in the hippocampus (hpc), hypothalamus (hpt) and striatum (s) by immunofluorescence, western blot and enzyme-linked immunosorbent assay (elisa). |
2023-03-29 |
2023-08-14 |
rat |
| Violina Kakoty, Sarathlal Kc, Shobha Kumari, Chih-Hao Yang, Sunil Kumar Dubey, Amirhossein Sahebkar, Prashant Kesharwani, Rajeev Taliya. Brain insulin resistance linked Alzheimer's and Parkinson's disease pathology: An undying implication of epigenetic and autophagy modulation. Inflammopharmacology. 2023-03-23. PMID:36952096. |
in metabolic syndrome, dysregulated signalling activity of the insulin receptor pathway in the brain due to persistent insulin resistance (ir) condition in the periphery may lead to brain ir (bir) development. |
2023-03-23 |
2023-08-14 |
Not clear |
| Dalia Cuenca, Jose Luis Ventura-Gallegos, Paloma Almeda-Valdes, María Teresa Tusié-Luna, Alfredo Reza-Albarran, Laura Ventura-Ayala, Ma Luisa Ordoñez-Sánchez, Yayoi Segura-Kato, Francisco Javier Gomez-Perez, Michelle De Puy Conte, Lizbet Ruilova Gonzalez, Alejandro Zentella-Dehes. A novel nonsense mutation in the insulin receptor gene in a patient with HAIR-AN syndrome and endometrial cancer. Molecular genetics and metabolism reports. vol 35. 2023-03-21. PMID:36941956. |
severe insulin resistance can be caused by rare genetic defects in the insulin receptor known as insulin receptoropathies. |
2023-03-21 |
2023-08-14 |
Not clear |
| Brenda De la Cruz Concepción, Yaccil Adilene Flores Cortez, Martha Isela Barragán Bonilla, Juan Miguel Mendoza Bello, Monica Espinoza Roj. Insulin: A connection between pancreatic β cells and the hypothalamus. World journal of diabetes. vol 14. issue 2. 2023-03-17. PMID:36926659. |
reactive oxygen species activate stress-sensitive kinases, such as c-jun n-terminal kinase and p38 mitogen-activated protein kinase, that induce phos-phorylation in serine residues in the insulin receptor, which blocks the insulin signaling pathway, continuing the mechanism of ir. |
2023-03-17 |
2023-08-14 |
Not clear |
| Vuong M Pham, Prashanth Komirishetty, Aparna Areti, Trevor Poitras, Nitish Thakor, Douglas W Zochodn. Combined PTEN knockdown and local insulin in chronic experimental diabetic neuropathy. Diabetes. 2023-03-17. PMID:36930748. |
ir (insulin receptor) expression was not altered by high glucose conditions in neurons or scs and insulin promoted survival of neurons and proliferation of scs in vitro. |
2023-03-17 |
2023-08-14 |
mouse |
| Yixuan Wang, Hao Hu, Xinyu Liu, Xiangyu Gu. Hypoglycemic medicines in the treatment of Alzheimer's disease: Pathophysiological links between AD and glucose metabolism. Frontiers in pharmacology. vol 14. 2023-03-13. PMID:36909158. |
binding to insulin receptor substrates, insulin can transport through the blood-brain barrier (bbb), thus mediating insulin signaling pathways to regulate physiological functions. |
2023-03-13 |
2023-08-14 |
Not clear |
| Xue-Mei Xie, Qiu-Li Cao, Yu-Jie Sun, Jie Zhang, Kai-Li Liu, Ying-Fen Qin, Wen-Jun Long, Zuo-Jie Luo, Xiao-Wei Li, Xing-Huan Liang, Guan-Dou Yuan, Xiao-Ping Luo, Xiu-Ping Xua. LRP6 Bidirectionally Regulates Insulin Sensitivity through Insulin Receptor and S6K Signaling in Rats with CG-IUGR. Current medical science. 2023-03-13. PMID:36913109. |
lrp6 bidirectionally regulates insulin sensitivity through insulin receptor and s6k signaling in rats with cg-iugr. |
2023-03-13 |
2023-08-14 |
rat |
| Kazushi Yamamoto, Masashi Yamashita, Masataka Oda, Vindy Tjendana Tjhin, Hiroyuki Inagawa, Gen-Ichiro Som. Oral Administration of Lipopolysaccharide Enhances Insulin Signaling-Related Factors in the KK/Ay Mouse Model of Type 2 Diabetes Mellitus. International journal of molecular sciences. vol 24. issue 5. 2023-03-11. PMID:36902049. |
furthermore, the expressions of factors involved in insulin signaling, such as insulin receptor, insulin receptor substrate 1, thymoma viral proto-oncogene, and glucose transporter type 4, were upregulated in the adipose tissues of kk/ay mice, where this effect was observed. |
2023-03-11 |
2023-08-14 |
mouse |